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The conclusion is that the high-fat diet triggered chronic inflammation, which in turn triggered an autoimmune response in the mice's central nervous systems. Normally this response protects the brain from invaders like bacteria, but a high-saturated fat diet knocks the process off track, resulting in damage to synapses in the brain - specifically in the hippocampus. Since the hippocampus is a brain area central to memory and learning, the eventual outcome is impaired brain function. In short, the high-fat diet caused brain damage.

The researchers isolated different subpopulations of human brain stem cells and precisely identified, which genes are active in which cell type. In doing so, they noticed the gene ARHGAP11B: it is only found in humans and in our closest relatives, the Neanderthals and Denisova-Humans, but not in chimpanzees. This gene manages to trigger brain stem cells to form a bigger pool of stem cells. In that way, during brain development more neurons can arise and the cerebrum can expand. The cerebrum is responsible for cognitive functions like speaking and thinking.

Stress isn't always a bad thing; it can be handy for a burst of extra energy and focus, like when you're playing a competitive sport or have to speak in public. But when it's continuous, it actually begins to change your brain. Madhumita Murgia shows how chronic stress can affect brain size, its structure, and how it functions, right down to the level of your genes.

In the animal kingdom, humans are known for our big brains. But not all brains are created equal, and now we have new clues as to why that is. Researchers have uncovered eight genetic variations that help determine the size of key brain regions. These variants may represent "the genetic essence of humanity," says Stephan Sanders, a geneticist and pediatrician at the University of California, San Francisco, who was not involved in the study. These results are among the first to come out of the ENIGMA (Enhancing Neuro Imaging Genetics through Meta-Analysis) collaboration, involving some 300 scientists from 33 countries. They contributed MRI scans of more than 30,000 people, along with genetic and other information, most of which had been collected for other reasons. "This paper represents a herculean effort," Sanders says.

When it comes to what you bite, chew and swallow, your choices have a direct and long-lasting effect on the most powerful organ in your body: your brain. So which foods cause you to feel so tired after lunch? Or so restless at night? Mia Nacamulli takes you into the brain to find out.

UCLA researchers now have the first evidence that bacteria ingested in food can affect brain function in humans. In an early proof-of-concept study of healthy women, they found that women who regularly consumed beneficial bacteria known as probiotics through yogurt showed altered brain function, both while in a resting state and in response to an emotion-recognition task.

Blood type may affect brain function as we age, according to a new large, long-term study. People with the rare AB blood type, present in less than 10 percent of the population, have a higher than usual risk of cognitive problems as they age.

The study is the first to examine all of the gene networks affected by fructose that result in changes to brain function and metabolism-more than 20,000 genes in total. Although the study was conducted using rats, the researchers report that the majority of the sequenced genes are comparable to those in humans, including more than 200 genes in the hippocampus, a brain area crucial to memory, and 700 in the hypothalamus, the seat of the brain's metabolic control center.

Research has shown that some older people stay sharp into old age and retain the ability to recall personal experiences with just as much accuracy as their middle-aged peers. The brains of these so-called "super-agers" look distinct, too: Their gray-matter-rich outer layer, or cortex, is thicker.

Published today (17:00BST, 03/06/2015) in the journal Neuron, their work presents strong evidence that disruption of a delicate chemical balance in the brain is heavily implicated in the disorder. In the largest ever study of its kind, the team found that disease-linked mutations disrupt specific sets of genes contributing to excitatory and inhibitory signalling, the balance of which plays a crucial role in healthy brain development and function.

If thinking about the billions of bacteria taking up residence in and on your body gives you the willies, you probably won't find it comforting that humans are also full of viruses. These maligned microbes are actually intertwined in the very fibers of our being-about 8 percent of our genetic material is made up of absorbed forms of retroviruses, the viral family to which HIV, the pathogen that causes AIDS, belongs.

I learned that gene expression is the process by which the information of genes is used to direct the function of cells. Gene expression is regulated in all cells because not all genes are needed all the time or under all circumstances. For example, brain cells need to express certain genes that are not needed in muscle cells, and muscle cells need to express certain genes that are not needed in brain cells. Likewise, bacteria need to express different genes depending on the availability of food and other aspects of their surroundings.

This case study introduces students to the structure and function of cellular organelles and seeks to show their importance by discussing diseases and disorders that can result when an organelle does not function as it should. The storyline follows a family whose joy at bringing home a new baby is soon altered by their child's sudden illness, which is eventually diagnosed as Leigh Disease. This disease occurs when defective mitochondria fail to produce energy needed by the cell, particularly affecting cells with high-energy needs like those in the brain, muscle, and gastrointestinal tract. The narrative also discusses some of the ways in which Leigh disease is inherited, treatment options, and the typical prognosis. The case was designed for an introductory non-majors biology course, but could also be used in other science or health related courses. Instructors also have the option of running the case in a "flipped classroom" in which students watch three recommended videos outside of class as a way of preparing for working on the case in class.

Panobinostat is a new type of drug that works by blocking an enzyme responsible for modifying DNA at the epigenetic level. Epigenetics refers to chemical marks on DNA itself or on the protein "spools" called histones that package DNA. These marks influence the activity of genes without changing the underlying sequence, essentially acting as volume knobs for genes. Earlier genomic studies showed that about 80 percent of DIPG tumors carry a mutation that alters a histone protein, resulting in changes to the way DNA is packaged and tagged with those chemical marks. This faulty epigenetic regulation results in activation of growth-promoting genes that should have been turned off, and shutdown of others that should have acted as brakes to cell multiplication. Cancer is the result. Panobinostat appears to work by restoring proper functioning of the cells' chemical tagging system.

Huntington disease is caused by a mutation in the HTT gene. Understanding how the mutation causes neurodegeneration might help researchers develop treatments that protect brain function. This animation describes the genetic defect that underlies Huntington disease. Created by the editors at Nature Reviews Disease Primers.

BodyMaps is an interactive visual search tool that allows users to explore the human body in 3-D. With easy-to-use navigation, users can search multiple layers of the human anatomy, view systems and organs down to their smallest parts, and understand in detail how the human body works. Using detailed 3-D models of body parts-including muscles, veins, bones, and organs-BodyMaps offers a new way to visualize and manage your health. See how the coronary artery delivers blood to the heart, and learn how plaque build-up on artery walls leads to heart disease. Locate the exact location of a pulled muscle or broken bone, and find information on how to prevent injuries. View a cross-section of the human brain, and learn which areas control certain emotions and body functions. By offering rich, detailed anatomical images alongside links to relevant and useful health information, BodyMaps allows you to leam about your body and your health in a personalized and revolutionary new way.

Some thyroid 101 background: Your thyroid gland is the butterfly-shaped gland at the base of your neck that secretes two all-important hormones that control major bodily functions (including how you use energy, regulate body temperature, and digest food) and organs (including the heart, brain, liver, kidneys and skin). But with hypothyroidism, your body can have normal to low thyroxine hormone levels and elevated thyroid stimulating hormone (TSH) levels. These high TSH levels are a result of an overworked pituitary gland that is trying to elevate the hormone levels in an inadequately responsive thyroid.

A decade-old technique that allows researchers to control brain function in lab animals could partially restore sight to the blind. In a trial sponsored by RetroSense Therapeutics, a startup company in Ann Arbor, Michigan, doctors will inject a harmless virus loaded with DNA from photoreceptive algae into the eyes of 15 patients suffering from retinitis pigmentosa. The experimental procedure represents the first human test of optogenetics, which is a technique that genetically modifies neurons to make them responsive to light. Doctors from the Retina Foundation of the Southwest will perform the procedure, and attempt to transfer the job duties of photoreceptor cells to different cells in the eye to restore sight.