NHGRI invites applications for research developing comparative approaches that can be used to understand genome structure and function and the relationship between genomic features and phenotypes. This program supports studies that enable the use of a diverse array of species to advance our ability to understand basic biological processes related to human health and disease, as well as studies that develop novel analytical tools and resources for the comparative genomics research community.
This NOFO will build on previous PEPFAR support under the HHS/CDC HIV treatment program in Côte d'Ivoire (CI) to ensure continuity of comprehensive HIV/AIDS services to an existing pool of clients receiving HIV/AIDS care, support, and/or treatment. The program will also continue expanding access to HIV/AIDS services while building the capacity of national structures and contributing to sustainable service delivery within the health sector in CI. Specifically, it serves to increase capacity and sustainability of the response toward controlling the HIV/AIDS epidemic by initially providing support for HIV service delivery aligning with PEPFAR geographic and programmatic pivots by local indigenous organizations and ultimately providing technical assistance to the national Ministry of Health and Public Hygiene (MSHP) to sustain and expand comprehensive HIV prevention, care, and antiretroviral therapy (ART) programs. The recipient(s) will combine a facility and community-based strategy to support HIV/AIDS services. At the end of the 5-year project period, the recipient(s) should be able to collect and evaluate program data that demonstrates improved quality of HIV prevention, care, and treatment services in CI and to transition activities to MSHP and/or local organizations to sustain a basic HIV service package.
NHGRI invites applications for research developing comparative approaches that can be used to understand genome structure and function and the relationship between genomic features and phenotypes. This program supports studies that enable the use of a diverse array of species to advance our ability to understand basic biological processes related to human health and disease, as well as studies that develop novel analytical tools and resources for the comparative genomics research community.
Computational neuroscience provides a theoretical foundation and a rich set of technical approaches for understanding complex neurobiological systems, building on the theory, methods, and findings of computer science, neuroscience, and numerous other disciplines. Through the CRCNS program, the National Science Foundation (NSF), the National Institutes of Health (NIH), the German Federal Ministry of Education and Research (Bundesministerium für Bildung und Forschung, BMBF), the French National Research Agency (Agence Nationale de la Recherche, ANR), the United States-Israel Binational Science Foundation (BSF), and Japan's National Institute of Information and Communications Technology (NICT) support collaborative activities that will advance the understanding of nervous system structure and function, mechanisms underlying nervous system disorders, and computational strategies used by the nervous system.
The purpose of this Request for Proposal (RFP) is to solicit proposals from firms experienced in the development and implementation of Robotics Process Automation (RPA) solutions. BWC is interested in evaluating solutions which would enable the agency to automate structured repetitive tasks to minimize manual intervention and introduce process efficiencies. Such processes will typically require the bots to access multiple systems, various formats of data like text, excel workbooks, word, databases and subsequently retrieve, populate and generate data fields based on responses. The proposed solution must have the capability to automate end to end processes and contain inherent logic handling mechanisms with exception handling.
* interfacial plasma (i.e., low temperature plasma coming into contact with liquid to produce new chemical reactivity through a gas-liquid interface);
* interaction of plasma with biomaterials (e.g., understanding how plasma-produced chemical reactivity is delivered through multiple interfaces, such as liquid, cells, tissue, polymers);
* control of plasma-electromagnetic interaction (e.g., fundamental understanding of how radio-frequency electromagnetic power produces controllable plasmas to enable microelectronics processing);
* Plasma catalysis (e.g., understanding the plasma reactivity and catalyst selectivity);
* Plasma aided combustion (e.g., control of pulsed plasmas to improve the efficiency of chemical processing);
* Interface between plasma and solid-state physics (e.g., understanding the boundary layer between plasma and solid-state surface);
* Coherent structures (e.g., understanding electric self-organization in low temperature plasmas);
* Other emerging areas such as plasma aided aeronautics, plasma process control through machine learning, etc.
The Combinatorics program supports research on discrete structures and includes algebraic, enumerative, existential, extremal, geometric, and probabilistic combinatorics, including graph theory. Conferences Principal Investigators should carefully read the program solicitation "Conferences and Workshops in the Mathematical Sciences" (link below) to obtain important information regarding the substance of proposals for conferences, workshops, summer/winter schools, and similar activities. Conference proposals must be submitted at least six months in advance of the conference, and in the same fiscal year (which begins October 1) if possible.
The objective of this effort is to conduct exploratory and advanced research and development of materials technologies to control, manipulate, and protect against photonic energy. Research involved in the processing, structure, properties and performance of photonic materials will provide a means to mature and transition the highest priority products needed by the Air Force. These efforts will ultimately result in developed technologies that can be transitioned to legacy, developmental and future Air Force system components to provide an increase in aircrew protection, performance and efficiency while reducing cost and accelerating manufacture. The objective of this program is to increase aircrew survivability to flash-blindness and directed energy threats through unique and innovative R&D solutions, and to advance the current state-of-the-art in photonic materials technologies, interactions, and applications.
The purpose of this funding opportunity is to support the research necessary to elucidate how systematic alterations to the qualitative (Q1) and/or quantitative (Q2) composition of topical formulations impacts their physical, structural, and functional properties. A key aspect of the research relates to understanding how the thermodynamic properties of a topical dosage form change as it undergoes metamorphosis during dose application and drying on the skin, how the drug's thermodynamic activity profile during the metamorphosis of the dosage form may compare between compositionally different (non-Q1 and/or non-Q2) topical formulations, and how these and other forces may modulate the rate and extent to which topically applied drugs may become available at or near their site(s) of action in the skin. Another key aspect of the research relates to identifying and understanding other potential failure modes for bioequivalence (BE) and/or therapeutic equivalence (TE) (e.g., differences in irritation potential) that may arise between compositionally different (non-Q1 and/or non-Q2) topical formulations.
The U.S. Department of Energy seeks to understand the key technical and other barriers that may prevent long-term access to low-cost water supplies that could be best addressed through challenges and prize competitions. For the purposes of this Request for Information (RFI), challenges and prize competitions are tools and approaches the Federal government and others can use to engage a broad range of stakeholders, including the general public, in developing solutions to difficult problems. Challenges and prize competitions rely on competitive structures to drive innovation among participants and usually offer rewards (financial and/or other) to winners and/or finalists. DOE may use the information provided through this RFI to develop challenges and prize competitions to address key water issues. This RFI is not designed to solicit input on DOE's broader R&D efforts on affordable water. The purpose of this Request for Information (RFI) is to gather feedback from stakeholders prior to DOE potentially issuing a Funding Opportunity Announcement (FOA). This RFI is not a FOA; therefore, DOE is not accepting applications at this time. All responses to this RFI must be provided as an attachment (in Microsoft Word format) to an e-mail message addressed to waterprizerfi@ee.doe.gov. Responses must be received no later than 5:00 pm EDT on May 14, 2018. The full content of the announcement can be found on the EERE Exchange website at https://eere-exchange.energy.gov/
The Centers for Chemical Innovation (CCI) Program supports research centers focused on major, long-term fundamental chemical research challenges. CCIs that address these challenges will produce transformative research, lead to innovation, and attract broad scientific and public interest. CCIs are agile structures that can respond rapidly to emerging opportunities through enhanced collaborations. CCIs integrate research, innovation, education, broadening participation, and informal science communication.
The FY 2019 Phase I CCI competition is open to projects in all fields supported by the Division of Chemistry, and must have scientific focus and the potential for transformative impact in chemistry. NSF Chemistry particularly encourages fundamental chemistry projects related to one or more of NSF's 10 Big Ideas.
The CCI Program is a two-phase program. Both phases are described in this solicitation. Phase I CCIs receive significant resources to develop the science, management and broader impacts of a major research center before requesting Phase II funding. Satisfactory progress in Phase I is required for Phase II applications; Phase I proposals funded in FY 2019 will seek Phase II funding in FY 2022. This solicitation also covers the renewal application of the Phase II CCI initiated in FY 2014: the Center for Sustainable Polymers, led by the University of Minnesota.
Recent advances in communications, computation, and sensing technologies offer unprecedented opportunities for the design of cyber-physical systems with increased responsiveness, interconnectivity and automation. To meet new challenges and societal needs, the Energy, Power, Control andNetworks (EPCN) Program invests in systems and control methods for analysis and design of cyber-physical systems to ensure stability, performance, robustness, and security. Topics of interest include modeling, optimization, learning, and control of networked multi-agent systems, higher-level decision making, and dynamic resource allocation as well as risk management in the presence of uncertainty, sub-system failures and stochastic disturbances. EPCN also invests in adaptive dynamic programing, brain-like networked architectures performing real-time learning, and neuromorphic engineering. EPCN supports innovative proposals dealing with systems research in such areas as energy, transportation, and nanotechnology. EPCN places emphasis on electric power systems, including generation, transmission, storage, and integration of renewables; power electronics and drives; battery management systems; hybrid and electric vehicles; and understanding of the interplay of power systems with associated regulatory and economic structures and with consumer behavior. Also of interest are interdependencies of power and energy systems with other critical infrastructures. Topics of interest also include systems analysis and design for energy scavenging and alternate energy technologies such as solar, wind, and hydrokinetic. The program also supports innovative tools and test beds, as well as curriculum development integrating research and education. In addition to single investigator projects, EPCN encourages cross-disciplinary proposals that benefit from active collaboration of researchers with complementary skills. Proposals for the EPCN program may involve collaborative research to capture the breadth of
The Geotechnical Engineering and Materials Program (GEM) supports fundamental research in soil and rock mechanics and dynamics in support of physical civil infrastructure systems. Also supported is research on improvement of the engineering properties of geologic materials for infrastructure use by mechanical, biological, thermal, chemical, and electrical processes. The Program supports the traditional areas of foundation engineering, earth structures, underground construction, tunneling, geoenvironmental engineering, and site characterization, as well as the emerging area of bio-geo engineering, for civil engineering applications, with emphasis on sustainable geosystems. Research related to the geotechnical engineering aspects of geothermal energy and geothermal heat pump systems is also supported. The GEM program encourages knowledge dissemination and technology transfer activities that can lead to broader societal benefit and implementation for provision of physical civil infrastructure. The Program also encourages research that explores and builds upon advanced computing techniques and tools to enable major advances in Geotechnical Engineering.
The Energy, Power, Control, and Networks (EPCN) Program supports innovative research in modeling, optimization, learning, adaptation, and control of networked multi-agent systems, higher-level decision making, and dynamic resource allocation, as well as risk management in the presence of uncertainty, sub-system failures, and stochastic disturbances. EPCN also invests in novel machine learning algorithms and analysis, adaptive dynamic programming, brain-like networked architectures performing real-time learning, and neuromorphic engineering. EPCN's goal is to encourage research on emerging technologies and applications including energy, transportation, robotics, and biomedical devices & systems. EPCN also emphasizes electric power systems, including generation, transmission, storage, and integration of renewable energy sources into the grid; power electronics and drives; battery management systems; hybrid and electric vehicles; and understanding of the interplay of power systems with associated regulatory & economic structures and with consumer behavior.
The Energy, Power, Control, andNetworks (EPCN) Program supports innovative research in modeling, optimization, learning, adaptation, and control of networked multi-agent systems, higher-level decision making, and dynamic resource allocation, as well as risk management in the presence of uncertainty, sub-system failures, and stochastic disturbances. EPCN also invests in novel machine learning algorithms and analysis, adaptive dynamic programming, brain-like networked architectures performing real-time learning, and neuromorphic engineering. EPCN’s goal is to encourage research on emerging technologies and applications including energy, transportation, robotics, and biomedical devices & systems. EPCN also emphasizes electric power systems, including generation, transmission, storage, and integration of renewable energy sources into the grid; power electronics and drives; battery management systems; hybrid and electric vehicles; and understanding of the interplay of power systems with associated regulatory & economic structures and with consumer behavior.
Humanity depends upon the Earth's physical resources and natural systems for food, energy, and water (FEW). However, both the physical resources and the FEW systems are under increasing stress. It is becoming imperative that we determine how society can best integrate social, ecological, physical and built environments to provide for growing demand for food, energy and water in the short term while also maintaining appropriate ecosystem services for the future. Known stressors in FEW systems include governance challenges, population growth and migration, land use change, climate variability, and uneven resource distribution.The interconnections and interdependencies associated with the FEW Nexus pose research grand challenges. To meet these grand challenges, there is a critical need for research that enables new means of adapting societal use of FEW systems. The INFEWS program seeks to support research that conceptualizes FEW systems broadly and inclusively, incorporating social and behavioral processes (such as decision making and governance), physical processes (such as built infrastructure and new technologies for more efficient resource utilization), natural processes (such as biogeochemical and hydrologic cycles), biological processes (such as agroecosystem structure and productivity), and cyber-components (such as sensing, networking, computation and visualization for decision-making and assessment).
This Funding Opportunity Announcement (FOA) solicits applications from qualified academic institutions in Puerto Rico whose non-human primate research facilities were damaged by Hurricane Maria. Institutions may request funds to recover, restore, and modernize the physical infrastructure of non-human primate facilities. The rebuilt structures shall comply with the relevant engineering standards applicable to the requirements of the environment, the geographical location, animal welfare and care, and research-related demands. Any request must be justified by the needs of the HIV/AIDS-related NIH-funded research projects that use non-human primates raised, maintained, and housed in these facilities.
Research supported by the Division of Materials Research (DMR) focuses on advancing fundamental understanding of materials, materials discovery, design, synthesis, characterization, properties, and materials-related phenomena. DMR awards enable understanding of the electronic, atomic, and molecular structures, mechanisms, and processes that govern nanoscale to macroscale morphology and properties; manipulation and control of these properties; discovery of emerging phenomena of matter and materials; and creation of novel design, synthesis, and processing strategies that lead to new materials with unique characteristics. These discoveries and advancements transcend traditional scientific and engineering disciplines. The Division supports research and education activities in the United States through funding of individual investigators, teams, centers, facilities, and instrumentation. Projects supported by DMR are essential for the development of future technologies and industries that meet societal needs, as well preparation of the next generation of materials researchers.
This R18 Request for Application (RFA) calls for the creation and utilization of Patient Safety Learning Laboratories. These learning laboratories are places and networks where transdisciplinary teams identify closely related threats to diagnostic or treatment efforts associated with a high burden of harm and cost. Following a systems engineering methodology, the learning laboratories stretch professional boundaries, envision innovative designs, and take advantage of brainstorming and rapid prototyping techniques that other leading industries employ. Promising prototypes undergo further develop-test-revise iterations, and subsequent integration as a working system. After further improvements are made to the integrated working system, its efficacy is evaluated in a realistic simulated or clinical setting. While applicants will select the area of diagnostic or treatment focus they consider of high significance, a flexible methodology -- problem analysis, design, development, implementation, and evaluation -- is required that parallels a systems engineering process to give an underlying structure to the work undertaken.
The Cellular and Biochemical Engineering (CBE)program is part of the Engineering Biology and Health cluster, which also includes 1) Biophotonics; 2) Biosensing; 3) Disability and Rehabilitation Engineering; and 4) Engineering of Biomedical Systems. TheCellular and Biochemical Engineering program supports fundamental engineering research that advances understanding of cellular andbiomolecular processes in engineering biology. CBE-funded research eventually leads to the development of enabling technology for advanced biomanufacturing in support of the therapeutic cell, biochemical, biopharmaceutical, and biotechnology industries. Fundamental to many research projects in this area is the understanding of how biomolecules, subcellular systems, cells, and cell populations interact in the biomanufacturing environment, and how those interactions lead to changes in structure, function, and behavior. A quantitative treatment of problems related to biological processes is considered vital to successful research projects in the CBE program. The program encourages highly innovative and potentially transformative engineering research leading to novel bioprocessing and biomanufacturing approaches. The CBE program also encourages proposals that effectively integrate knowledge and practices from different disciplines while incorporating ongoing research into educational activities.
