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This mechanism supports basic research to increase knowledge/understanding through discovery and hypothesis generation, and should focus on providing basic fundamental knowledge that will inform and enable the future development of novel autonomous and/or robotic medical systems to care for wounded soldiers/patients through breakthrough, exploratory research. The objective is focused on addressing the following 1. Autonomous and Unmanned Medical Capability - Identify novel ideas, approaches and research towards the conceptualization of autonomous and unmanned technologies for next-generation, high-quality medical capabilities with limited or absent medical care personnel, or personnel with limited skills. Research novel concepts, plausible approaches and advanced concept designs using biologically inspired cognitive computing models, machine learning, artificial intelligence, soft robotic semi-autonomous/autonomous resuscitation concepts and advanced applications of information sciences among other innovative, exploratory research towards advancing the state-of-the-art in delivery of forward resuscitative care at the point of injury. 2. Medical Robotics Research - Identify novel ideas, approaches and research towards the conceptualization of medical robotics and real-time tele-presence capabilities exploring the limits of machine perception for tele-robotic semi-autonomous and autonomous trauma care within remote and dispersed geographic settings. This could include exploratory research in semi-autonomous robotic surgery to improve the safety profile and efficacy of tele-surgical procedures and outcomes using hard robotics in challenging situations (e.g., combat casualties on the multi-domain battlefield or mass casualty situations) and remote or austere geographic locations, among other innovative, exploratory research aims and novel concepts.

A. Research Areas of Interest SOF medical personnel place a premium on medical equipment that is small, lightweight, ruggedized, and designed for operation in extreme environments. The equipment must be easy to use, require minimum maintenance, and have low power consumption. Drugs and biologics should not require refrigeration or other special handling. All materiel and related techniques must be simple and effective. Research projects may apply existing scientific and technical knowledge for which concept and/or patient care efficacy have already been demonstrated to meet SOF requirements. 1. Damage Control Resuscitation SOF medical personnel require capabilities for far-forward medical care to reduce the mortality and morbidity associated with major battlefield wounds and injuries. The primary emphasis is to research, apply and/or develop medical techniques and materiel (medical devices, drugs, and biologics) for early intervention in life-threatening battle injuries when MEDEVAC is not possible.

The mission of the JPC-1/MSIS is to explore the implications of models and technology for medical education and for the provision, management, and support of health services in the military. The JPC-1/MSIS plans, coordinates, and oversees a responsive world-class, tri-Service science and technology program focused on two areas of research. The first area, Medical Simulation and Training, is focused on improving military medical training through medical modeling, simulation, and educational training tools. The second area, Health Informatics and Information Technologies, is focused on improving the use and sharing of health-related data for better strategic planning, process development, and software applications.

The FY17 JPC-1/MSIS TRANSfeR Award Program Announcement/Funding Opportunity is seeking research to determine whether the medical skill learned on a simulation system has a downstream beneficial effect to patients and/or the MHS in the real clinical world. The Program Announcement/Funding Opportunity seeks applications for research to demonstrate that simulation-based medical training has a measurable outcome on patient care. Previous T1 studies have shown improvement in skills in the simulated environment when deliberate practice and mastery learning (a set of group-based, individualized, learning strategies based on the belief that students will achieve a high level of understanding in a given area when given enough time) occur as part of training. The next set of studies should measure whether these same techniques translate to patient care and affect systems of care such as return-to-duty rates and morbidity and mortality statistics. Such research will involve taking the lessons learned in the laboratory and measuring outcomes in the patients who are cared for either in an operational environment or medical treatment facility. Historical patient outcome data does exist for the way medical professionals are trained now, so the variable being introduced in new studies would be simulation-based training.

This Funding Opportunity Announcement (FOA) invites grant applications from institutions/organizations that propose to build research infrastructure to promote external collaboration with the medical rehabilitation community. The aim of this FOA is to create a national network of research cores that provide access to collateral expertise in biomedical, behavioral, engineering, and/or psychosocial fields that is particularly relevant to medical rehabilitation research. We are particularly interested in supporting infrastructure programs in clinical trial design, engineering and the environment, individualized medical rehabilitation and dynamic reassessment, and applied behavioral supports for rehabilitation research and healthy outcomes. However, other areas of expertise may be proposed provided they offer unique research opportunities and have potential for promoting medical rehabilitation research and improving outcomes for people with disabilities. In response to this FOA, applicants should propose a program of research resources and collaborative opportunities in a specific research domain. This may be accomplished through a workshops, written material, and websites, consultations, collaborations, and pilot funding. In addition, the research core may support activities within the grantee institution related to technique development, adaptation, and validation. To accomplish the aims of the FOA, applicants may propose collaborations to other institutional sites, provided that they cover the appropriate administrative and logistical issues.

Recently FDA launched a series of strategic efforts designed to improve the national capacity to study use and impact of medical devices in the real-world setting.  The National Evaluation System for health Technology (NEST) was created with the goals of leveraging electronic health information captured from the routine clinical use of marketed health technology.  Since in the world of medical devices today, clinical registries collect and maintain detailed, curated clinical data on millions of patients receiving diagnostics and treatments involving health technologies, they can provide critical infrastructure that can be used for a variety of analyses related to real world patient care and outcomes.  To address some of the inherent and modifiable limitations of the registries, the model of strategically Coordinated Registry Networks (CRNs) was recommended by the National Medical Device Registry Task Force (NMDRTF) and further developed by Medical Device Epidemiology Network (MDEpiNet). 

NineSigma, representing a Global Leader in medical devices, invites proposals for technologies that can create micron scale structures on metal surfaces. The challenge is to obtain a robust micropatterned surface with a high aspect ratio that can maintain the surface characteristics in a high pressure, high temperature environment.  The approach must be applicable to curved (non planar) metal surfaces. Microstructures on the surfaces of medical devices have many advantages for the various medical application. Surface patterning imparts critical functional features to the device, such as anti-fouling, hydrophobicity, adhesion, etc. The RFP sponsor is seeking innovations that allow creating precise microstructured patterns on non-planar metal surfaces.

The NIAID Radiation/Nuclear Countermeasures Development Program supports extramural research to develop safe and effective radiological/nuclear medical countermeasures for clinical use under emergency situations. This program spans basic through applied research. The role of the endovascular network in radiation injury pathogenesis is not well understood; however, the importance of this biological system in the observed multi-organ dysfunction and failure that occurs following radiation exposure has recently been established. The purpose of the Funding Opportunity Announcement (FOA) is to provide an opportunity for academic, industry and government laboratory researchers to address gaps in the understanding of the pathophysiology of radiation injury in the vasculature, and how this damage contributes to overall mortality following radiation exposure. This funding will also advance the development of post-exposure treatment approaches targeting the vascular endothelium, with the ultimate goal of licensure of candidate medical countermeasures by the Food and Drug Administration (FDA) for the radiation/nuclear public health emergency indication.

The NIAID Radiation/Nuclear Countermeasures Development Program supports extramural research to develop safe and effective radiological/nuclear medical countermeasures for clinical use under emergency situations. This program spans basic through applied research. The role of the endovascular network in radiation injury pathogenesis is not well understood; however, the importance of this biological system in the observed multi-organ dysfunction and failure that occurs following radiation exposure has recently been established. The purpose of the Funding Opportunity Announcement (FOA) is to provide an opportunity for academic, industry and government laboratory researchers to address gaps in the understanding of the pathophysiology of radiation injury in the vasculature, and how this damage contributes to overall mortality following radiation exposure. This funding will also advance the development of post-exposure treatment approaches targeting the vascular endothelium, with the ultimate goal of licensure of candidate medical countermeasures by the Food and Drug Administration (FDA) for the radiation/nuclear public health emergency indication.

The goal of the Biophotonics program is to explore the research frontiers in photonics principles, engineering and technology that are relevant for critical problems in fields of medicine, biology and biotechnology.  Fundamental engineering research and innovation in photonics is required to lay the foundations for new technologies beyond those that are mature and ready for application in medical diagnostics and therapies.  Advances are needed in nanophotonics, optogenetics, contrast and targeting agents, ultra-thin probes, wide field imaging, and rapid biomarker screening. Low cost and minimally invasive medical diagnostics and therapies are key motivating application goals.

The goal of the Biophotonics program is to explore the research frontiers in photonics principles, engineering and technology that are relevant for critical problems in fields of medicine, biology and biotechnology.  Fundamental engineering research and innovation in photonics is required to lay the foundations for new technologies beyond those that are mature and ready for application in medical diagnostics and therapies.  Advances are needed in nanophotonics, optogenetics, contrast and targeting agents, ultra-thin probes, wide field imaging, and rapid biomarker screening. Low cost and minimally invasive medical diagnostics and therapies are key motivating application goals.

The goal of the Biophotonics program is to explore the research frontiers in photonics principles, engineering and technology that are relevant for critical problems in fields of medicine, biology and biotechnology.  Fundamental engineering research and innovation in photonics is required to lay the foundations for new technologies beyond those that are mature and ready for application in medical diagnostics and therapies.  Advances are needed in nanophotonics, optogenetics, contrast and targeting agents, ultra-thin probes, wide field imaging, and rapid biomarker screening. Low cost and minimally invasive medical diagnostics and therapies are key motivating application goals.

The goal of the Biophotonics program is to explore the research frontiers in photonics principles, engineering and technology that are relevant for critical problems in fields of medicine, biology and biotechnology.  Fundamental engineering research and innovation in photonics is required to lay the foundations for new technologies beyond those that are mature and ready for application in medical diagnostics and therapies.  Advances are needed in nanophotonics, optogenetics, contrast and targeting agents, ultra-thin probes, wide field imaging, and rapid biomarker screening. Low cost and minimally invasive medical diagnostics and therapies are key motivating application goals. 

Opioid analgesics are widely prescribed for the treatment of pain patients. The increase in prescription opioids abuse, misuse and diversion warrants the support of new approaches designed to reduce their non-medical use. Among potentially important steps towards the goal of safer opioid analgesics are the efforts to reformulate medication so that an individual would not be able (abuse resistance) or would not want (abuse deterrence) to divert the prescription drug, and to create innovative medication dispensing devices/gadgets. This FOA represents a focused effort of the National Institute on Drug Abuse (NIDA) on preventing diversion and misuse at the patient level.

The MTEC mission is to assist the U.S. Army Medical Research and Materiel Command (USAMRMC) by providing cutting-edge technologies and effective materiel life cycle management to transition medical solutions to industry that protect, treat, and optimize Warfighters' health and performance across the full spectrum of military operations. MTEC is a biomedical technology consortium collaborating with multiple government agencies under a 10-year renewable Other Transaction Agreement (OTA), Agreement No. W81XWH-15-9-0001, with the U.S. Army Medical Research Acquisition Activity (USAMRAA). MTEC currently is recruiting a broad and diverse membership that includes representatives from large businesses, small businesses, "non-traditional" government contractors, academic research institutions and not-for-profit organizations.

The intended goal of this FOA is to facilitate the development, production, and distribution of pediatric medical devices. Although the FOA is issued by the FDA's Office of Orphan Products Development, the grant application is intended to encompass devices for all pediatric diseases and conditions, not just those that are rare. Applicants will request funding to serve as a nonprofit consortium to provide expert advising and support services to innovators of pediatric medical devices. The advising and services will focus on the total product life cycle for medical devices from concept, through pre-market development, to commercialization, and replacement by subsequent generation of devices.

To that end, the foundation welcomes applications for its Research Program, which supports pioneering discoveries in science, engineering, and medical research. Through the program, grants are awarded to research universities, medical colleges, and major private independent scientific and medical research institutions in support of projects that are focused on important and emerging areas of research; have the potential to develop breakthrough technologies, instrumentation, or methodologies; are innovative, distinctive and interdisciplinary; demonstrate a high level of risk due to unconventional approaches or by challenging a prevailing paradigm; and have the potential for transformative impact (e.g., the founding of a new field of research, the enabling of observations not previously possible, or the altered perception of a previously intractable problem). The program seeks to fund high-risk/high-impact work that lays the groundwork for new paradigms, technologies, and discoveries, save lives, and adds to our collective understanding of the world.

The Department of Defense Peer Reviewed Orthopaedic Research Program (PRORP) is administered by the US Army Medical Research and Materiel Command (USAMRMC) through the Office of the Congressionally Directed Medical Research Programs (CDMRP). Congressional funds for the FY13 PRORP have not yet been appropriated, and this document is not to be construed as an obligation by the Government; there is no guarantee of funding for the program. However, the PRORP anticipates releasing program announcements in February 2013, and the information provided in this pre-announcement is intended to allow investigators time to plan and develop applications. Focus Areas: The FY13 PRORP plans to solicit research applications that address the following focus areas, which are subject to change. Information on the final focus areas and the award mechanisms to which they correspond will be included in the program announcements when they are posted

The goal of this funding opportunity announcement is to (i) foster joint activities between US and Indian scientists on affordable diagnostic and therapeutic technologies, and (ii) address medical needs in low-resource settings, taking advantage of opportunities and technological advances, to aid the development of appropriate affordable medical devices. To address needs and opportunities, Indian and U.S. scientists will undertake a coordinated program that will involve collaborative, peer-reviewed research and technology development projects. Collaboration between engineers and scientists in the U.S. and India will be based on mutual benefit, trust, and a shared commitment to development of diagnostic or therapeutic technologies for people in low-resource settings.

This Funding Opportunity Announcement (FOA) encourages Small Business Innovation Research (SBIR) grant applications from small business concerns (SBCs) that propose to develop and translate medical technologies aimed at reducing disparities in healthcare access and health outcomes.  Appropriate medical technologies should be effective, affordable, culturally acceptable, and deliverable to those who need them.  Responsive grant applications must involve a formal collaboration with a healthcare provider or other healthcare organization serving one or more health disparity populations during Phase I and Phase II.

This Funding Opportunity Announcement (FOA) encourages Small Business Innovation Research (SBIR) grant applications from small business concerns (SBCs) that propose to develop and translate medical technologies aimed at reducing disparities in healthcare access and health outcomes. Appropriate medical technologies should be effective, affordable, culturally acceptable, and deliverable to those who need them. Responsive grant applications must involve a formal collaboration with a healthcare provider or other healthcare organization serving one or more health disparity populations during Phase I and Phase II.

A. Research Areas of Interest SOF medical personnel place a premium on medical equipment that is small, lightweight, ruggedized, and designed for operation in extreme environments. The equipment must be easy to use, require minimum maintenance, and have low power consumption. Drugs and biologics should not require refrigeration or other special handling. All materiel and related techniques must be simple and effective. Research projects may apply existing scientific and technical knowledge for which concept and/or patient care efficacy have already been demonstrated to meet SOF requirements.

Biophotonics applies photonics technology to the fields of medicine, biology and biotechnology.  Basic research and innovation in photonics that is very fundamental in science and engineering is needed to lay the foundation for new technologies beyond those that are mature and ready for application in medical diagnostics and therapies.  Advances are needed in nanophotonics, optogenetics, contrast and targeting agents, ultra-thin probes, wide field imaging, and rapid biomarker screening.  Low cost and minimally invasive medical diagnostics and therapies are key goals. Examples of topics are: Macromolecule Markers - Innovative methods for labeling of macromolecules, new compositions of matter/methods of fabrication of multi-color probes such as might be used for marking and detection of specific pathological cells and push the envelope of optical sensing to the limits of detection, resolution, and identification Low Coherence Sensing at the Nanoscale - Low coherence enhanced backscattering (LEBS), n-dimensional elastic light scattering, and angle-resolved low coherence interferometry for early cancer detection (dysplasia) Neurophotonics - Studies of photon activation of neurons at the interface of nanomaterials attached to cells.  Development and application of biocompatible photonic tools such as parallel interfaces and interconnects for communicating and control of neural networks Micro- and Nano-photonic - Development and application of nanoparticle fluorescent quantum-dots; sensitive, multiplexed, high-throughput characterization of macromolecular properties of cells; nanomaterials and nanodevices for biomedicine Optogenetics - Employing light-activated channels and enzymes for manipulation of neural activity with temporal precision.