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MiamiOH OARS

View Opportunity | GRANTS.GOV - 0 views

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    As defined by the DoD, basic research is "systematic study directed toward greater knowledge or understanding of the fundamental aspects of phenomena and of observable facts without specific applications towards processes or products in mind. It includes all scientific study and experimentation directed toward increasing fundamental knowledge and understanding in those fields of the physical, engineering, environmental, and life sciences related to long-term national security needs. It is farsighted high payoff research that provides the basis for technological progress." (DoD 7000.14-R, vol. 2B, chap. 5, para. 050105.B) The DoD's basic research program invests broadly in many scientific fields to ensure that it has early cognizance of new scientific knowledge.
MiamiOH OARS

Research Interests of the Air Force Office of Scientific Research - 0 views

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    AFOSR plans, coordinates, and executes the Air Force Research Laboratory's (AFRL) basic research program in response to technical guidance from AFRL and requirements of the Air Force. Additionally, the office fosters, supports, and conducts research within Air Force, university, and industry laboratories; and ensures transition of research results to support U.S. Air Force needs. The focus of AFOSR is on research areas that offer significant and comprehensive benefits to our national war fighting and peacekeeping capabilities. These areas are organized and managed in two scientific Departments: Engineering and Information Science (RTA) and Physical and Biological Sciences (RTB). The research activities managed within each Department are summarized in this section.
MiamiOH OARS

Defense Sciences Office (DSO) Office-Wide - Federal Business Opportunities: Opportunities - 0 views

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    The mission of the Defense Advanced Research Projects Agency (DARPA) Defense Sciences Office (DSO) is to identify and pursue high-risk, high-payoff research initiatives across a broad spectrum of science and engineering disciplines and to transform these initiatives into disruptive technologies for U.S. national security. In support of this mission, the DSO Office-wide BAA invites proposers to submit innovative basic or applied research concepts that address one or more of the following technical domains:
MiamiOH OARS

Biomechanics and Mechanobiology | NSF - National Science Foundation - 0 views

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    The BMMB Program supports fundamental research in biomechanics and mechanobiology. An emphasis is placed on multiscale mechanics approaches in the study of organisms that integrate across molecular, cell, tissue, and organ domains. The influence of in vivo mechanical forces on cell and matrix biology in the histomorphogenesis, maintenance, regeneration, and aging of tissues is an important concern. In addition, the relationships between mechanical behavior and extracellular matrix composition and organization are of interest. Funded projects may include theoretical, computational, and experimental approaches. The program encourages the consideration of diverse living tissues as smart materials that are self-designing.
MiamiOH OARS

Research Interests of the Air Force Office of Scientific Research - 0 views

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    AFOSR plans, coordinates, and executes the Air Force Research Laboratory's (AFRL) basic research program in response to technical guidance from AFRL and requirements of the Air Force. Additionally, the office fosters, supports, and conducts research within Air Force, university, and industry laboratories; and ensures transition of research results to support U.S. Air Force needs. The focus of AFOSR is on research areas that offer significant and comprehensive benefits to our national war fighting and peacekeeping capabilities. These areas are organized and managed in two scientific Departments: Engineering and Information Science (RTA) and Physical and Biological Sciences (RTB). The research activities managed within each Department are summarized in this section.
MiamiOH OARS

DARPA Biological Technologies - 0 views

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    The mission of BTO is to foster, demonstrate, and transition breakthrough fundamental research, discoveries, and applications that integrate biology, engineering, computer science, mathematics, and the physical sciences. BTO's investment portfolio goes far beyond life sciences applications in medicine to include areas of research such as human-machine interfaces, microbes as production platforms, and deep exploration of the impact of evolving ecologies and environments on U.S. readiness and capabilities. BTO's programs operate across a wide range of scales, from individual cells to the warfighter to global ecosystems. BTO responds to the urgent and long-term needs of the Department of Defense (DoD) and addresses national security priorities.
MiamiOH OARS

Cellular and Biochemical Engineering - 0 views

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    The Cellular and Biochemical Engineering (CBE)program is part of the Engineering Biology and Health cluster, which also includes 1) Biophotonics; 2) Biosensing; 3) Disability and Rehabilitation Engineering; and 4) Engineering of Biomedical Systems. TheCellular and Biochemical Engineering program supports fundamental engineering research that advances understanding of cellular andbiomolecular processes in engineering biology. CBE-funded research eventually leads to the development of enabling technology for advanced biomanufacturing in support of the therapeutic cell, biochemical, biopharmaceutical, and biotechnology industries. Fundamental to many research projects in this area is the understanding of how biomolecules, subcellular systems, cells, and cell populations interact in the biomanufacturing environment, and how those interactions lead to changes in structure, function, and behavior. A quantitative treatment of problems related to biological processes is considered vital to successful research projects in the CBE program. The program encourages highly innovative and potentially transformative engineering research leading to novel bioprocessing and biomanufacturing approaches. The CBE program also encourages proposals that effectively integrate knowledge and practices from different disciplines while incorporating ongoing research into educational activities.
MiamiOH OARS

Biosensing - 0 views

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    ) multiplex biosensing platforms that exceed the performance of current state-of-the-art devices; 2) novel transduction principles, mechanisms and sensor designs suitable for measurement in practical matrix and sample-preparation-free approaches, including error-free detection of pathogens and toxins in food matrices, waterborne pathogens, parasites, toxins, biomarkers in body fluids, neuron chemicals, and others that improve human condition; 3) biosensors that enable measurement of biomolecular interactions in their native states, transmembrane transport, intracellular transport and reactions, and other biological phenomena; 4) biosensing performance optimization for specific health applications such as point-of-care testing and personalized health monitoring; and 5) miniaturization of biosensors for lab-on-a-chip and cell/organ-on-a-chip applications to enable measurement of biological properties and functions of cell/tissues in vitro. The Biosensors Program does not encourage proposals addressing surface functionalization and modulation of bio-recognition molecules, development of basic chemical mechanisms for biosensing applications, circuit design for signal processing and amplification, computational modeling, and microfluidics for sample separation and filtration.
MiamiOH OARS

Engineering of Biomedical Systems - 0 views

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    The Engineering of Biomedical Systems (EBMS)program is part of the Engineering Biology and Health cluster, which also includes 1) Biophotonics; 2) Biosensing; 3) Cellular and Biochemical Engineering; and 4) Disability and Rehabilitation Engineering. The goal of theEBMS program is to provide research opportunities for creating discovery-level and transformative projects that integrate engineering and life sciences to solve biomedical problems and serve humanity in the long term.EBMS projects must be at the interface of engineering and biomedical sciences. They are expected to use an engineering framework (for example, design or modeling) that supports increased understanding of physiological or pathophysiological processes. The project must include objectives that advance both engineering and biomedical sciences. EMBS projects should focus on high-impact, transformative methods and technologies -- especially those that potentially will have a broad impact on biomedical challenges. Projects may include: methods, models, and enabling tools applied to understand or control living systems; fundamental improvements in deriving information from cells, tissues, organs, and organ systems; or new approaches to the design of systems that include both living and non-living components for eventual medical use in the long term. TheEBMS programsupports fundamental and transformative research in the following areas of biomedical engineering:
MiamiOH OARS

PAR-18-777: Novel Genomic Technology Development (R01 Clinical Trial Not Allowed) - 0 views

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    This Funding Opportunity Announcement (FOA) seeks grant applications to catalyze major advances in genomics through technology development (beyond developing nucleic acid sequencing technologies). The goal is to provide a mechanism for support of very novel and high impact work from across this gamut of genomics technology development. This initiative seeks to support technologies that will have a major impact in the next five to seven years.
MiamiOH OARS

Novel Genomic Technology Development (R21 Clinical Trial Not Allowed) - 0 views

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    This Funding Opportunity Announcement (FOA) seeks grant applications to develop major advances in genomic technologies. Advances in genomics and more broadly in biomedical research have been greatly facilitated by significant and sustained genomics technology throughput increases, cost decreases, and improvements in ease of use. The proposed technology development work should allow comprehensive genomic analysis of features not assayable today, or an increase of no less than an order of magnitude improvement in an existing technology in terms of data quality, throughput, efficiency or comprehensiveness (individually or in combination). This FOA explicitly excludes the development of novel technologies for DNA sequencing and for direct RNA sequencing; those projects should respond to a parallel set of FOAs (RFA-HG-18-001, RFA-HG-18-002, and RFA-HG-18-003).
MiamiOH OARS

BioEnergy Engineering for Products Synthesis (BEEPS) Funding Opportunity Announcement - 0 views

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    The U.S. Department of Energy (DOE), Office of Energy Efficiency and Renewable Energy (EERE), Bioenergy Technologies Office (BETO) announces a notice of availability of funds for financial assistance to address gaps in current research and development (R&D) which hinder better utilizing waste streams (e.g. lignin, CO2, and biosolids), improving organic and inorganic catalysts to increase conversion efficiency and decrease costs, and creating high-value performance-advantaged bioproducts to allow for more profitable biorefineries.
MiamiOH OARS

NSF/FDA Scholar-in-Residence at FDA (nsf18556) | NSF - National Science Foundation - 0 views

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    The National Science Foundation (NSF), through the Directorate for Engineering, the Directorate of Computer and Information Science and Engineering Division of Computer and Network Systems, and the Directorate for Mathematical and Physical Sciences Division of Materials Research, along with the U.S. Food and Drug Administration (FDA), through its Center for Devices and Radiological Health (CDRH), have established the NSF/FDA Scholar-in-Residence Program at FDA. This program comprises an interagency partnership for the investigation of scientific and engineering issues concerning emerging trends in medical device technology. This partnership is designed to enable investigators in science, engineering, and computer science to develop research collaborations within the intramural research environment at the FDA. This solicitation features three flexible mechanisms for support of research at the FDA: 1) Principal Investigators at FDA; 2) Postdoctoral Researchers at FDA; and 3) Graduate Students at FDA.
MiamiOH OARS

Enhancing Innovations in Emerging Technologies for Advanced Manufacturing of Complex Bi... - 0 views

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    CBER seeks to support the application of novel technologies for advanced manufacturing of complex biologic products, and innovative analytical approaches to improve product manufacturing and quality through active research.
MiamiOH OARS

Information Visualization of NSWC Crane Innovation Ecosystem as part of Naval Science a... - 0 views

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    NSWC Crane is interested in funding research to inform future science and technology investments via data mapping and information visualization techniques. Specifically, advancements beyond traditional scientometrics are desired for visualizing, understanding, and predicting naval research and development investments that yield transitioned technologies via methods that make sense of the dynamic collaborative network of academia, industry, and government partners.
MiamiOH OARS

Researcher Resources - National Ataxia Foundation - 0 views

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    The National Ataxia Foundation is committed to funding the best science relevant to hereditary and sporadic types of ataxia in both basic and translational research.

MiamiOH OARS

RFA-FD-18-014: Computational fluid dynamics (CFD) and discrete element modeling (DEM) a... - 0 views

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     Current product-specific bioequivalence (BE) guidance published by the Office of Generic Drugs for dry powder inhalers (DPIs) include in vitro testing recommendations for single actuation content and aerodynamic particle size distribution, as well as recommendations for a pharmacokinetic study and a pharmacodynamic or clinical endpoint study.  Given the extensive nature of current DPI BE guidance, it is desirable that current in vitro testing for DPIs be more reflective of in vivo performance.  Computational fluid dynamics (CFD) and discrete element modeling (DEM) have been used to predict dry powder aerosol behavior, including the effects of agglomeration and deagglomeration.  The purpose of the study will be to develop a CFD-DEM model which can be used to evaluate the impact of various physicochemical properties and device performance properties on regional deposition, to identify potentially biorelevant ranges for these properties that may be useful for future BE recommendations.   

MiamiOH OARS

Fiscal Year 2019 Defense University Research Instrumentation Program (DURIP) - ARMY SUB... - 0 views

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    The Department of Defense (DoD) announces the Fiscal Year 2019 Defense University Research Instrumentation Program (DURIP). DURIP is designed to improve the capabilities of accredited United States (U.S.) institutions of higher education to conduct research and to educate scientists and engineers in areas important to national defense, by providing funds for the acquisition of research equipment or instrumentation. For-profit organizations are not eligible for DURIP funding. We refer to eligible institutions of higher education as universities in the rest of this announcement. DURIP is part of the University Research Initiative (URI).
MiamiOH OARS

Fiscal Year 2019 Defense University Research Instrumentation Program (DURIP) - 0 views

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    The Department of Defense (DoD) announces the Fiscal Year 2019 Defense University Research Instrumentation Program (DURIP).DURIP is designed to improve the capabilities of accredited United States (U.S.) institutions of higher education to conduct research and to educate scientists and engineers in areas important to national defense, by providing funds for the acquisition of research equipment or instrumentation. For-profit organizations are not eligible for DURIP funding. We refer to eligible institutions of higher education as universities in the rest of this announcement. DURIP is part of the University Research Initiative (URI).
MiamiOH OARS

RFA-FD-18-010: Bioequivalence of Topical Products: Elucidating the Thermodynamic and Fu... - 0 views

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    The purpose of this funding opportunity is to support the research necessary to elucidate how systematic alterations to the qualitative (Q1) and/or quantitative (Q2) composition of topical formulations impacts their physical, structural, and functional properties. A key aspect of the research relates to understanding how the thermodynamic properties of a topical dosage form change as it undergoes metamorphosis during dose application and drying on the skin, how the drug's thermodynamic activity profile during the metamorphosis of the dosage form may compare between compositionally different (non-Q1 and/or non-Q2) topical formulations, and how these and other forces may modulate the rate and extent to which topically applied drugs may become available at or near their site(s) of action in the skin. Another key aspect of the research relates to identifying and understanding other potential failure modes for bioequivalence (BE) and/or therapeutic equivalence (TE) (e.g., differences in irritation potential) that may arise between compositionally different (non-Q1 and/or non-Q2) topical formulations.
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