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Reports that vitamins C and E may blunt the positive effects of exercise are misleading, according to an antioxidant expert. German researchers have reported that antioxidant vitamins C and E may blunt the positive effects of exercise, with respect to insulin sensitivity. Findings were published in the Proceedings of the National Academy of Sciences. Reacting to the study , Alexander Schauss, PhD, from AIBMR Life Sciences, a nutraceutical products consultancy, told NutraIngredients.com that the title of the study (Antioxidants prevent health-promoting effects of physical exercise in humans) was misleading. "The primary objective of this study was to study the effect of a 4-week intensive 5-days a week exercise program on insulin sensitivity. Yet the title of the paper leads one to believe otherwise," he said. "This is a small gender-biased study of 40 male subjects, 25 to 35 years of age. When I read through the study for the first time I had to wonder how could the authors have come up with such a title for their paper?" he asked.

Supplements of antioxidant vitamins after exercise may decrease the benefits of the workout by blocking the positive effects of reactive oxygen, says a new study. Researchers from Germany and the US report in the Proceedings of the National Academy of Sciences that a combination of 1,000 mg per day of vitamin C and 400 IU per day of vitamin E adversely affected insulin sensitivity, and thereby increase the risk of type 2 diabetes. Participants, both trained and untrained, underwent 85 minutes of exercise five days per week for four weeks.

Published March 30th, 2009 in General Interest, Health, Health News, Health and Wellness, Life, Medical News, Nutrition, Parents, Popular Scientists studying a mysterious neurological affliction in pregnant cats that have been fed irradiated food have discovered a surprising ability of the central nervous system to repair itself and restore function when placed back on a normal diet. In a study published today (March 30, 2009) in the Proceedings of the National Academy of Sciences, a team of researchers from the University of Wisconsin-Madison reports that the restoration in cats of myelin - a fatty insulator of nerve fibers that degrades in a host of human central nervous system disorders, the most common of which is multiple sclerosis - can lead to functional recovery

Science Journal: Biological, Physical, Medical, Nutrition and Social Sciences.

"Ann Arbor, MI - New laboratory research suggests that the COX-2 inhibitor celecoxib (Celebrex, Pfizer), might impede the action of "baby" aspirin [1]. Dr Gilad Rimon (University of Michigan, Ann Arbor) and colleagues found evidence that this was the case in a dog model and say that "it will be important to determine" whether the same is true in humans. The report was published online December 1, 2009 in the Proceedings of the National Academy of Medicine. Celecoxib is the only COX-2 inhibitor to have remained on the market in the US, and doctors who recommend this painkiller often coprescribe a daily low dose of 81 mg of aspirin (known as a "baby" dose) to counteract any possible prothrombotic effects of the coxib, while minimizing potential gastrointestinal toxicity of the aspirin. Senior author of the new work, Dr William L Smith (University of Michigan, Ann Arbor), explained to heartwire that previous studies in humans have shown that celecoxib does not interfere with the effect of a standard dose of aspirin (325 mg), but any potential interaction of celecoxib with the lower dose has not been examined. Stagger dosing to avoid any potential problems First, Smith explained that he and his colleagues looked in vitro at celecoxib and found that it binds to one of two available sites on the COX-1 enzyme. "This surprised us," he commented. "It appears to interfere with the ability of some other drugs to affect COX-1, most notably aspirin." Second, in beagles, they administered the dog-equivalent of a baby dose of aspirin in humans and then gave some of the animals the equivalent of 100 mg of celecoxib twice daily in addition. "Celecoxib plus aspirin interfered with the normal effect of low-dose aspirin on platelets," he notes. Smith says this observation obviously requires confirmation in humans, but in the meantime he suggests "getting around the problem" by patients taking the low-dose aspirin at least 15 to 30 minutes before the celecoxib is taken, "because

Coenzyme Q10. Bonakdar RA, Guarneri E. Am Fam Physician. 2005 Sep 15;72(6):1065-70. Review. PMID: 16190504 Coenzyme Q10 is a vitamin-like substance used in the treatment of a variety of disorders primarily related to suboptimal cellular energy metabolism and oxidative injury. Studies supporting the efficacy of coenzyme Q10 appear most promising for neurodegenerative disorders such as Parkinson's disease and certain encephalomyopathies for which coenzyme Q10 has gained orphan drug status. Results in other areas of research, including treatment of congestive heart failure and diabetes, appear to be contradictory or need further clarification before proceeding with recommendations. Coenzyme Q10 appears to be a safe supplement with minimal side effects and low drug interaction potential.

High prevalence of vitamin D inadequacy and implications for health.\nHolick MF.\nMayo Clin Proc. 2006 Mar;81(3):353-73. Review.\nPMID: 16529140 \ndoi: 10.4065/​81.3.353\n

Ames BN. Low micronutrient intake may accelerate the degenerative diseases of aging through allocation of scarce micronutrients by triage. Proc Natl Acad Sci U S A. 2006 Nov 21;103(47):17589-94. Epub 2006 Nov 13. PMID: 17101959 [PubMed - in process]

Nutrion Journal by the Nutrition Society, UK

M. F. Holick Vitamin D Deficiency: What a Pain It Is Mayo Clin. Proc., December 1, 2003; 78(12): 1457 - 1459.