Melanoma growth is reduced in fat-1 transgenic mice: impact of omega-6/omega-3 essential fatty acids.
Xia S, Lu Y, Wang J, He C, Hong S, Serhan CN, Kang JX.
Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12499-504. Epub 2006 Aug 3.
PMID: 16888035
doi: 10.1073/pnas.0605394103
In vitro experiments showed that addition of the n-3 fatty acid eicosapentaenoic acid or PGE(3) inhibited the growth of B16 cell line and increased the expression of PTEN, which could be partially attenuated by inhibition of PGE(3) production, suggesting that PGE(3) may act as an antitumor mediator. These data demonstrate an anticancer (antimelanoma) effect of n-3 fatty acids through, at least in part, activation of PTEN pathway mediated by PGE(3).
Opposing effects of n-6 and n-3 polyunsaturated fatty acids on
pancreatic cancer growth.
Funahashi H, Satake M, Hasan S, Sawai H, Newman RA, Reber HA,
Hines OJ, Eibl G.
Pancreas. 2008 May;36(4):353-62.
PMID: 18437081
doi: 10.1097/MPA.0b013e31815ccc44
Identification of endogenous resolvin E1 and other lipid mediators
derived from eicosapentaenoic acid via electrospray low-energy tandem
mass spectrometry: spectra and fragmentation mechanisms.
Lu Y, Hong S, Yang R, Uddin J, Gotlinger KH, Petasis NA, Serhan CN.
Rapid Commun Mass Spectrom. 2007;21(1):7-22.
PMID: 17131464
Group items tagged 
