Group items matching

in title, tags, annotations or url

EPIDEMICS' TIMING DETERMINED BY LATITUDEGoINg back to 1945, Hope-Simpson discovered that INfluenza epidemics above 30 degrees latitude IN both hemispheres occurred durINg the six months of least solar radiation and that outbreaks IN the tropics almost always occured durINg the raINy season. He thus concluded, "Latitude alone broadly determINes the timINg of the epidemics IN the annual cycle, a relationship that suggests a rather direct effect of some component of solar radiation actINg positively or negatively upon the virus, the human host, or their INteraction." That is, somethINg may be regularly reducINg our immunity every fall and wINter. IN 2003 researchers confirmed that INfluenza epidemics IN the tropics occur, with few exceptions, durINg the raINy season, when vitamIN D levels should be fallINg

(NaturalNews) 30 years ago the famous Nobel laureate Linus Pauling said that vitamin C supplements can prevent cancer, a highly controversial statement at the time. Now a team of Johns Hopkins scientists have shown that vitamin C stops the growth of some tumors in mice. The Study The study was lead by Chi Dang, M.D., Ph.D., professor of medicine and oncology and Johns Hopkins Family Professor in Oncology Research. Their work is detailed in Cancer Cell, Volume 12, Issue 3, 230-238, 11 September, 2007. They found that the antioxidants' actual role may be to destabilize a tumor's ability to grow under conditions where there isn't enough oxygen to feed it. The conventional belief is that vitamin C helps prevent cancer growth by grabbing up volatile oxygen free radical molecules and preventing the damage they do to our DNA. "The potential anticancer benefits of antioxidants have been the driving force for many clinical and preclinical studies," Says Dang. "By uncovering the mechanism behind antioxidants, we are now better suited to maximize their therapeutic use."

ScienceDaily (May 12, 2009) - A research project at the University of Gothenburg has been testing large groups of 13-year-olds in Sweden since the early 1960s using the same intelligence test. The tests have taken place at approximately five year intervals and consist of an inductive-logic test, a verbal test and a spatial test. Crucial factor The most recent study, which was reported in the new issue of Journal of Swedish Educational Research, shows that today's teenagers are achieving demonstrably better results in the logic test than was the case fifty years ago. This is positive as logic is a crucial factor for achievement in mathematics. "With regard to pupils chances of assimilating maths teaching, there is thus nothing to indicate that the preconditions have deteriorated in recent decades," says Professor Allan Svensson at the Department of Education.

Scientists in Canada reviewing the research so far on links between different diets and heart disease found strong evidence that diets high in vegetables and nuts, and those that follow a Mediterranean pattern rich in fruit, vegetables and fish were strongly associated with lower heart disease risk than those that rely on food with a high glycemic index or high in trans-fatty acids. High glycemic index food includes rice, pasta and refined carbohydrates like white bread, and foods high in trans-fatty acids include fried foods, baked goods and snacks.

Th1/Th2 balance: the hypothesis, its limitations, and implications for health and disease. Kidd P. Altern Med Rev. 2003 Aug;8(3):223-46. Review. PMID: 12946237 Th1 pathways typically produce activation of cytotoxic T lymphocytes (Tc), NK cells, macrophages, and monocytes, all of which can attack cancer cells and generally defend against tumors. 55 IFN-gamma and other Th1 cytokines are typically lower in advanced cancer patients, while the Th2 marker IL-4 can be higher or unchanged.56 Nodules of non-small cell lung cancer freshly removed from patients expressed a marked imbalance toward Th2, as did biopsy samples from basal cell carcinoma.57 in prostate cancer patients IL-2 was low (Th1) and IL-10 high.58 IL-10 is a confirmed Th1-suppressive cytokine, and heightened IL-10 is a common factor in cancer.55 IL-10 has a variety of suppressive effects that include inhibiting Th1 cytokine production, down-regulating APC and NK cell function, and lowering overall T-cell proliferation.57 Especially under the influence of IL-4 (Th2), tumor cells apparently up-regulate IL-10 that suppresses nearby killer cells. Tumor-derived IL-10 has been documented in lymphoma, ovarian carcinoma, melanoma, neuroblastoma, and renal cell and colon carcinoma.57 IL-12 is another cytokine that can be up-regulated by Th1 activity and inhibited by Th2.59 A low IL-12/IL-10 ratio was found in cervical cancer patients.55 Recent clinical studies suggest elevated IL-10 is predictive of a poor prognosis. 57 With both IL-4 and IL-10 being proven inhibitors of Th1 and promoters of Th2 activity, the recognized capability of cancerous tissue to suppress immunity is readily rationalized.

Floyd Chilton and colleagues wanted to examine whether theses fatty acids might have other effects, and developed a dietary intervention strategy in which 27 healthy humans were fed a controlled diet mimicking the w6/w3 ratios of early humans over 5 weeks. They then looked at the gene levels of immune signals and cytokines (protein immune messengers), that impact autoimmunity and allergy in blood cells and found that many key signaling genes that promote inflammation were markedly reduced compared to a normal diet, including a signaling gene for a protein called PI3K, a critical early step in autoimmune and allergic inflammation responses. This study demonstrates, for the first time in humans, that large changes in gene expression are likely an important mechanism by which these omega fatty acids exert their potent clinical effects

Derived from the bulb or clove of the plant. Garlic is used as a spice and to treat hyperlipidemia, hypertension, atherosclerosis, cancer, and infections. Processing can have a substantial effect on the chemical content in garlic; the volatile oil components are sensitive to heat and certain enzymes are acid-labile. Several oral garlic formulations are available, and clinical studies have addressed a variety of the proposed claims. Placebo-controlled trials on the cholesterol lowering effect of garlic yielded mixed results (16) (17) (18) (21) (22) (26). Studies evaluating the antithrombotic effects repeatedly have shown modest reduction in platelet aggregation, but varying levels of fibrinolytic activity. Research shows mixed effects with regard to reductions in blood glucose, blood pressure, or risk of cardiovascular disease (23). Frequently reported adverse events include bad breath, headache, fatigue, GI upset, diarrhea, sweating, and possible hypoglycemia (9). Because garlic is known to decrease platelet aggregation and potentially elevate the inR, it should not be used with anticoagulants or in patients with platelet dysfunction (15). Garlic appears to induce cytochrome p450 3A4 and may enhance metabolism of many medications (e.g. cyclosporin and saquinavir) (12). An analysis of several case-control studies in Europe suggests an inverse association between garlic consumption and risk of common cancers (25).

A heat-stable extract of white button mushrooms (Agaricus bisporus) with potential chemopreventive and immunomodulating activities. Phytochemicals, such as polysaccharides and especially beta-D-glucans found in the white button mushroom extract, bind to and inhibit the activity of aromatase, an enzyme responsible for the conversion of androgens to estrogens and which is often upregulated in breast cancer cells. The consequent decrease in estrogen production may result in the suppression of estrogen-dependent cellular proliferation. in addition, this extract may promote dendritic cell (DC) maturation, increase interferon gamma (IFN-gamma) and tumor necrosis factor alpha (TNF-alpha) production, and may enhance natural killer (NK) cell activity, thus amplifying both innate and T cell-mediated immune responses against cancer cells. Check for active clinical trials or closed clinical trials using this agent.

Edible mushrooms are a versatile functional food and have been touted as a way to preserve youth, longevity and overall health for centuries. Now nutrition researchers from Arizona State University and Pennsylvania State University are finding that they may even help boost the immune system and reduce inflammation, especially in the colon. Keith R. Martin, ASU assistant professor in nutrition, along with his Penn State colleagues, experimented with various types of mushrooms, from the more common white button to the exotic like shiitake and oyster, to see what sort of effect they had on the immune system. Their paper was published in late February in BMC Immunology, a peer reviewed online journal. "We found that the white button mushroom seemed to be the most effective in boosting the immune system, which is good because they are the most affordable," said Martin.

Mice injected with cancer cells experienced significantly elevated levels of C-reactive protein, white blood cells, and lipid peroxidation compared with control mice. These levels were reduced in animals that received cisplatin and/or DHA. While treatment with 125 mg/kg DHA inhibited tumor growth by 38 percent compared to untreated animals, 250 mg/kg suppressed tumor growth by 79 percent, which was a greater effect than that of cisplatin alone (which was associated with a 55 percent reduction). The combination of DHA and cisplatin resulted in an 81 percent inhibition of growth, while reducing elevated white blood cell levels (leukocytosis) to normal levels. Treatment with the higher dose of DHA alone was associated with a similar reduction in white blood cells, which, when elevated, are associated with tumor growth. A strong relationship was observed between tumor growth and white blood cell levels as well as C-reactive protein levels. in another experiment with rats treated with cisplatin, the addition of 250 mg/kg DHA prevented lethal kidney toxicity in 88 percent of the animals that received it, while none of the rats that received cisplatin alone survived.

In the July 2005 FASEB Journal, Adrian F. Gombart of the University of California, Los Angeles (UCLA) and his colleagues reported that vitamIn D boosts production In white blood cells of one of the antimicrobial compounds that defends the body agaInst germs.\n\nImmediately, Cannell says, the proverbial lightbulb went on In his head: Maybe the high doses of vitamIn D that he had been prescribIng to virtually all the men on his ward had boosted their natural arsenal of the antimicrobial, called cathelicidIn, and protected them from flu. Cannell had been admInisterIng the vitamIn D because his patients, like many other people In the Industrial world, had shown a deficiency:

In vitro antiproliferative, apoptotic and antioxidant activities of punicalagIn, ellagic acid and a total pomegranate tannIn extract are enhanced In combInation with other polyphenols as found In pomegranate juice. Seeram NP, Adams LS, HennIng SM, Niu Y, Zhang Y, Nair MG, Heber D. J Nutr Biochem. 2005 Jun;16(6):360-7. PMID: 15936648

Pomegranate fruit extracts have been shown to block enzymes that contribute to cartilage degradation in osteoarthritis, a condition that currently has little perspective for treatment. The findings, although still at a preliminary stage not yet proven in humans, are likely to encourage further consumption of pomegranate juice in the UK, where sales have rocketed in the last year thanks to media coverage of its antioxidant content.

Increased Intakes of folic acid by mandatory fortification of graIn products to reduce neural tube defects may also reduce a baby's risk of severe congenital heart defects, says a new study. The Incidence of the heart problems was reduced by 6 per cent followIng mandatory fortification of graIn products, Introduced In Canada In 1998, researchers from McGill University and the University of Alberta report In the British Medical Journal.

For more similar articles reviewed, visit drjohndc.tumblr.com

The results of a year long clinical trial examining the effects of mushroom supplementation in patients with Human Papillomavirus (HPV) have recently been presented at congress. Dr. Jose Silva Couto and Dr. Daniel Pereira da Silva of the Cervical Pathology Unit of the Portuguese institute of Oncology in Coimbra, Portugal presented their findings at the 20th European Congress of Obstetrics and Gynaecology, in Lisbon Portugal. This study provides a promising set of results and demonstrates proof-of concept for the question as to whether immunonutrition supplements can be successfully used to improve HPV status in patients.

Serum tumor necrosis factor-alpha concentrations are negatively correlated with serum 25(OH)D concentrations in healthy women. Peterson CA, Heffernan ME. J inflamm (Lond). 2008 Jul 24;5:10. PMID: 18652680 doi:10.1186/1476-9255-5-10 Conclusion Serum 25(OH)D status is inversely related to TNF-α concentrations in healthy women, which may in part explain this vitamin's role in the prevention and treatment of inflammatory diseases. Results gleaned from this investigation also support the need to re-examine the biological basis for determining optimal vitamin D status.

Do you live in a big city or an area where you are sometimes forced to inhale car and truck exhaust? If so, you should strongly consider using a face mask, because exhaust causes arteries to lose their flexibility. Researchers writing in the journal Particle and Fibre Toxicology found that exposure to engine pollution resulted in arterial stiffness in a group of healthy volunteers.

Blind Girl Can See Thanks to Umbilical Cord-Based Adult Stem Cell Treatment London, England (LifeNews.com) -- Born two years ago with severe eye problems, Dakota Clarke could not even see well enough to recognize her own mother and father. But now the parents of the little girl, who is registered blind, say she can make out their faces for the first time after pioneering stem cell treatment. The couple gave up work to raise well over $40,000 to fly their daughter to China for the treatment, which remains at the experimental level in Britain -- because the nation has been too preoccupied with embryonic stem cells and human cloning. They returned home this week convinced that Dakota can now see colors, lights and objects around her as a result. They hope further therapy will give her a lifetime of sight. "It's nothing short of a miracle for us," said Mr Clarke, a former engineer. "She can see the world for the first time." in Dakota's case, cells were administered intravenously through her hairline and reportedly traveled towards her optic nerve, repairing the damaged area. The stem cells came from umbilical cords donated by Chinese mothers. Despite the obvious success, some doctors are talking down the results simply because the treatments aren't approved in England. Pro-life advocates say the results are yet another showing of how adult stem cells outpace their embryonic cousins both ethically and when used in treatments.

If wheat is so bad, what about all the other grains? First of all, I demonize wheat because of its top-of-the-list role in triggering: --Appetite--Wheat increases hunger dramatically --insulin --Blood sugar--Wheat is worse than table sugar in triggering a rapid, large rise in blood sugar --Triglycerides --Small LDL particles--the number one cause for heart disease in the U.S. --Reduced HDL --Diabetes --Autoimmune diseases--Most notably celiac disease and thyroiditis. Most other "healthy, whole grains" aren't quite as bad. It's a matter of degree.

Chatfield SM, Brand C, Ebeling PR, Russell DM. Vitamin D deficiency in general medical inpatients in summer and winter. intern Med J. 2007 Jun;37(6):377-82. PMID: 17535381 [PubMed - in process]