A recent study using high-dose rhEpo (3000 U rhEpo/kg body weight at birth) for neuroprotection in very preterm infants revealed that no signs of adverse effects of early high-dose rhEpo treatment in very preterm infants were identified. Contrary to this, a recent study in PVL of a
rat model revealed that using a low dose rhEpo (50-100 U/kg) was effective in the treatment of brain damage induced by hypoxia-ischemia and did not affect normal oligodendrocyte maturity. On this basis, the researchers intent to investigate (1) whether low-dose rhEpo (100 U/kg) or high-dose rhEpo (3,000 U/kg) given to very preterm infants (gestation age < 32 weeks) immediately after birth and subsequently during the first 2 days is safe and possesses neuroprotective properties;(2) whether there are gender differences in response to the hypoxia-ischemic insult and EPO treatment; (3)the pharmacokinetics of low dose and high dose rhEPO.
NCBI NIH PubMed.gov Abstract of Finland study investigating reproductive maternal risk factors of intrapartum fetal asphyxia. The study concluded that the incidence of intrapartum fetal asphyxia was 2.5%. Placental abruption, primiparity, alcohol use during pregnancy, low birth weight, preeclampsia, male fetuses, and small-for-gestational age births were independent risk factors of intrapartum asphyxia, with adjusted relative risks of 3.74, 3.10, 1.75, 1.57, 1.49, 1.48 and 1.33, respectively. Most cases of intrapartum fetal asphyxia occur in low-risk pregnancies and, therefore, risk screening in antenatal care cannot accurately predict which women will eventually need emergency care for fetal asphyxia.
The Clinical and Translational Science Center (CTSC) addresses the necessity of an integrated, comprehensive research support system that includes education, training and mentoring for clinical research investigators, coordinators and staff. Our mission is to support, advance, and promote clinical and translational research enterprises at WCMC
The Neuromuscular Biomechanics Lab at Stanford University combines experimental and computational approaches to study movement. We investigate the form and function of
biomechanical systems ranging from molecular motors to persons with movement disorders. We seek fundamental understanding of the mechanisms involved in the
production of movement, and are motivated by opportunities to improve treatments for individuals with cerebral palsy, stroke, osteoarthritis, and Parkinson's disease.
Pub Med Article Abstract presents a short clinical review of metabolic diseases associated with metabolic acidosis in the newborn and discusses appropriate investigations and
differential diagnoses. It is important to remember the possibility of metabolic diseases as the cause of metabolic acidosis in the newborn period.
PubMed Abstract - Sensory and motor deficits in children with cerebral palsy born preterm correlate with diffusion tensor imagine abnormalities in thalamocortical pathways. Cerebral palsy (CP) is frequently linked to white matter injury in children born preterm. Diffusion tensor imaging (DTI) is a powerful technique providing precise identification of white matter microstructure. We investigated the relationship between DTI-observed thalamocortical (posterior thalamic radiation) injury, motor (corticospinal tract) injury, and sensorimotor function.
Long-term evaluation of granulocyte-colony stimulating factor on hypoxic-ischemic brain damage in infant rats. Hypoxia-ischemia (HI), as a major cause of fetal brain damage, has long-lasting neurological implications. Therefore, therapeutic interventions that attenuate
the neuropathological out come of HI while also improving the neurofunctional outcome are of paramount clinical importance. The aim of this study was to investigate the long-term functional and protective actions of granulocyte-colony stimulating factor (G-CSF) treatment in an experimental model of cerebral. RESULTS: Granulocyte-colony stimulation promoted somatic growth and prevented brain atrophy and underdevelopment of the heart in infant rats.
Information on completed clinical trial and study investigating the change in muscle activity during gait with the use of ankle foot orthoses in children diagnosed with hemiplegic cerebral palsy
Study to improve understanding of the pathophysiology of movement disorders by performing small behavioral, electrophysiological and neuroimaging substudies. This will allow identifying dysfunction of the central nervous system that causes behavioral abnormalities seen in movement disorder patients.
Completed study sponsored by NINDS designed to use positron emission tomography to measure brain energy use. Positron Emission Tomography (PET) is a technique used to investigate the functional activity of the brain. The PET technique allows doctors to study the normal processes of the brain (central nervous system) of normal individuals and patients with neurologic illnesses without physical / structural damage to the brain.
Study to improve the investigators' current Selective Dorsal Rhizotomy (SDR) analgesia protocol by eliminating or minimizing the use of fentanyl in the post-operative period.
Information on planned study to improve investigators' current Selective Dorsal Rhizotomy (SDR) analgesia protocol by eliminating or minimizing the use of fentanyl in post-operative period.
Mayo research study to determine if there are enough patients with hard to treat epilepsy that might qualify for a future study of a medical device that is being developed to treat epilepsy. Participants will not be testing the device during this study. The study doctor will be assessing seizure type(s) and determine how frequently they occur, and to verify if antiseizure medications can be held constant for a period of 12 weeks.
Mayo Clinic researchers are looking at a new procedure that involves surgically placing a Responsive Neurostimulator (RNS) in the brain that may be able to suppress seizures in patients with epilepsy
Objective of study is to investigate the safety and efficacy of Transoral Incisionless Fundoplication (TIF) among a broad range of GERD patients treated in routine clinical
practice"
Planned future study investigating the protein composition of nutrition may affect the rate of gastric emptying and gastric pysiology. This is espesially important in children with neurologic impariment, who commonly rely on tube feedings, have feeding proThe intent is to find out whether 4 different protein sources affect the rate of gastric emptying and electrofysiology in this group of children
AHRQ Research and Quality Evidence Report and Technology Assessment: Number 72 - Failure to Thrive - Criteria for Determining disability in Infants and Children summary.The Social Security Administration (SSA) requested that the Agency for Healthcare Research and Quality (AHRQ), through its Evidence-based Practice Center (EPC) program, provide a systematic review of the scientific evidence on whether children, defined by investigators as failing to thrive or grow adequately, have a concurrent disability, or will have one within 6 months. The population of interest includes children age 18 years or younger, both male and female, of all racial, ethnic, and socioeconomic groupings. The evidence report was prepared to assist SSA in updating its Listing of Impairments and revising its disability policy, as may be appropriate.
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