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Mayo study to evaluate a potential new treatment for epilepsy. Researchers want to learn if the investigational drug called perampanel is safe and can help people with partial seizures who are already taking seizure medications and the current seizure medications are not enough to control those seizures. Perampanel is being tested as a possible add-on drug for people with seizures who are taking other seizure medications.

NINDS sponsored study will examine the safety and effectiveness of infusing a chemical called muscimol into the brain to control seizures in patients with intractable epilepsy (frequent seizures that persist despite therapy). Muscimol, which is similar to a naturally occurring brain chemical called GABA, has been shown to reduce seizures in rats.

The first comprehensive comparative effectiveness clinical trial of three widely used anti-seizure drugs for childhood absence epilepsy - the most common form of epilepsy in kids - has established an evidence-based approach for initial drug therapy. Published March 4 in the New England Journal of Medicine*, data from the double-blind, randomized, comparative clinical trial fill a large information gap in the treatment of childhood absence epilepsy, also known as "petit mal" epilepsy. The research, which identifies important differences between drugs in seizure control and side effects, is expected to impact how physicians select and monitor initial therapy for children with the disorder and ultimately lead to improved outcomes.

Safety and Efficacy of Vanquix™ Auto-Injector (Diazepam Injection) for the Management of Selected, Refractory Patients With Epilepsy Who Require Intermittent Medical Intervention to Control Episodes of Acute Repetitive Seizures

Duke University Clinical trial and study to evaluate the safety, tolerability, and pharmacokinetics of the study drug Pregabalin in pediatric patients with partial onset seizures in addition to measuring how much pregabalin is in your child's blood and urine after he/she takes the study drug

Study being conducted to learn about the effects (both good and bad) of a brain stimulating device known as the External Responsive Neurostimulating System. This is an investigational device that was designed to detect seizure activity and give an electrical stimulation to the brain to try to stop it

Duke University and Multicenter, Open-label Study to Investigate the Safety, Tolerability and Pharmacokinetics of Lacosamine (LCM) Oral Solution (syrup) as Adjunctive Therapy in Children with Partial Onset Seizures. This study is being done to test the safety of the study drug Lacosamide (LCM) syrup and how the body processes it.

Study is designed to provide short term efficacy and safety data of TRI476 in children with inadequately-controlled partial seizures. The purpose of study is to confirm that TRI476 as adjunctive therapy is effective and safe.

Mayo Clinic researchers are looking at a new procedure that involves surgically placing a Responsive Neurostimulator (RNS) in the brain that may be able to suppress seizures in patients with epilepsy

Information on completed study to assess if the classic ketogenic diet is effective in reducing seizure frequency, and medication toxicity

Mayo research study to determine if there are enough patients with hard to treat epilepsy that might qualify for a future study of a medical device that is being developed to treat epilepsy. Participants will not be testing the device during this study. The study doctor will be assessing seizure type(s) and determine how frequently they occur, and to verify if antiseizure medications can be held constant for a period of 12 weeks.

Study sponsored by the university of Chicago to demonstrate the efficacy and safety of Vanquix for the management of acute repetitive seizures (ARS). Study will provide clinical evidence for the effective and safe use of a diazepam auto-injector, Vanquix, to provide patients and their caregivers with an alternative to rectal administration.

NINDS - a Brain-Recording Device that Melts into Place - The technology could pave the way for better devices to monitor and control seizures, and to transmit signals from the brain past damaged parts of the spinal cord. "These implants have the potential to maximize the contact between electrodes and brain tissue, while minimizing damage to the brain. They could provide a platform for a range of devices with applications in epilepsy, spinal cord injuries and other neurological disorders," said Walter Koroshetz, M.D., deputy director of the National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health.

A Randomized, Multicenter, Double-blind, Placebo-controlled, Parallel-group Phase 3 Study to Evaluate the Efficacy and Safety of USL255 as Adjunctive Therapy in Patients With Refractory Partial-Onset Seizures

Completed study that evaluated the efficacy of surgical resection of an identifiable zone of cortical abnormality versus multiple drug therapy in children with infantile spasms refractory to standard therapy: II. Assess how infantile spasms interfere with development and whether this is partially reversible. III. Determine the predictors of good surgical outcome and whether surgery permanently controls seizures and improves development.

Korean study comparing the effect of anti-epileptic drugs' (AEDs) long-term treatment on cognitive function. This study is an open-label, randomized, multicenter comparative trial of lamotrigine versus carbamazepine"

Mayo study to look for genes that are the cause of epilepsy and to look for genes that have an impact on the effectiveness of over the counter and prescription medicines used to treat epilepsy.

Multicenter, randomized, controlled trial to compare the anti-seizure effect of parenteral MgSO4 versus oral labetalol in hypertensive pregnant women who are eligible for MgSO4 therapy. The primary outcome measure is eclampsia, and the secondary outcome measures include blood pressure control, and relevant antenatal, intrapartum, and postnatal maternal and fetal/neonatal parameters including adverse effects and complications.

Wikipedia - Ketogenic diet Definition

NG "NG-tube feedings" nasogastric "nasogastric tube feedings" "nasogastric tube feeding definition"

Study to compare Short-term ketogenic diet with conventional long-term trial in refractory infantile spasms.