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Proposed study is designed to evaluate patients at particular risk for preterm delivery; those with advanced cervical exam. In this randomized prospective controlled study, we intend to examine the influence of adjunctive antibiotic use in preterm labor complicated by a cervical exam of 4 cm or greater. Comparison will be made between a study group receiving broad-spectrum antibiotics with a control group that will not receive antibiotics for pregnancy prolongation

Study to evaluate the effects of pre-operative gait analysis testing on surgical outcomes in children with cerebral palsy who have problems walking.

Ongoing clinical trial sponsored by the University of Texas Southwestern Medical Center to Evaluate the Effects of a Single Dose of Intravenous Premarin for the Treatment of Severe Traumatic Brain Injury

Study is to examine the role of ShuntCheck and MR Imaging in evaluating the presence or absence of Shunt Obstruction in the patients of Hydrocephalus or Idiopathic Intracranial Hypertension (IIH) undergoing radionuclide test for suspected shunt obstruction. This is an exploratory study to determine how a non-invasive device can assist in detection of presence of flow in these patients.

CBER is the Center within FDA that regulates biological products for human use under applicable federal laws, including the Public Health Service Act and the Federal Food, Drug and Cosmetic Act. CBER protects and advances the public health by ensuring that biological products are safe and effective and available to those who need them. CBER also provides the public with information to promote the safe and appropriate use of biological products.

Idiopathic juvenile thoracic scoliosis is a tridimensional deformation of the spine which may impact on the intrathoracic organs. Bracing is one of the oldest treatments of spinal deformities. It relies on the indirect manipulation of spinal curvatures in order to prevent curve progression, which may affect respiratory function.The acoustic reflection method is based on the analysis of the reflection of a single transient planar wave giving the longitudinal cross-sectional area profile of the examined cavity. It is noninvasive and harmless.The EOS™ device allows a double incidence, full body, and low-dose X-ray acquisition with thoracic 3D reconstruction.The aim of the study is to evaluate the impact of bracing on the upper airways patency (by means of the acoustic method), on the breathing pattern (noninvasive respiratory muscles assessment), and on the thoracic penetration index (by means of the EOS™)

New England Journal of Medicine abstract of study to evaluate the effects of induction of moderate hypothermia in infants who had perinatal asphyxia. Study concluded that Induction of moderate hypothermia for 72 hours in infants who had perinatal asphyxia did not significantly reduce the combined rate of death or severe disability but resulted in improved neurologic outcomes in survivors. (Current Controlled Trials number, ISRCTN89547571 [controlled-trials.com] .)

To evaluate the safety and efficacy of magnesium sulfate for preterm suspected abruption

The purpose of this Winthrop-University Hospital, NY study was to evaluate whether computerized analysis of fetal heart rate variation may improve fetal surveillance in post term pregnancy. The study concluded that a computerized numeric analysis of fetal heart rate variation may improve fetal surveillance in post term pregnancy.

Completed study classified types of Hypertonia in patients with Cerebral Palsy and determine if the classifications are reasonable in relation to the functional task of walking. Hypertonia is an abnormal increase in muscle tension. It is a common symptom of Cerebral Palsy that can lead to loss of function and deformity. This study may help scientists improve evaluation criteria for hypertonia and, ultimately, treatment results.

NIH PubMed Abstract of study assessing sucking behavior of preterm neonates as a predictor of developmental outcomes.The relationship between the pattern of sucking behavior of preterm infants during the early weeks of life and neurodevelopmental outcomes during the first year of life was evaluated

PubMed Abstract of study to evaluate the effect of Selective Dorsal Rhizotomy (SRD) Surgery on functional abilities in a well-defined group of ambulatory children with Spastic Diplegia

PubMed Abstract of study to evaluate the role of the neonatal muscle hypotonia as an early indicative symptom of Cerebral Palsy (CP).

Informational clearinghouse for use by those concerned with finding and evaluating methodologies and treatment for brain-injured children. It is based on the belief that the brain along with the body as a whole is an ever-changing, dynamic, active organ striving for adaptation and capable of healing.

Federation of individuals and organizations working together to build a better world for people affected by rare diseases. given a top (4-star) rating by a leading independent evaluator of nonprofit organizations

Information on ongoing study being sponsored by Shriners Hospitals for Children. Study is currently recruiting participants to develop an analysis method for the use of Wavelet Analysis of Electromyography (EMG) in Cerebral Palsy to evaluate motor function in children with cerebral palsy

National Institutes of Halth Clinic Center study to: 1) characterize and compare lower extremity motor coordination in children with cerebral palsy (CP) across mobility levels and to children without CP; and 2) evaluate the effects of two home-based exercise programs on motor coordination, as well as other physical, functional and neurological outcomes in children with CP

Clinical trial being sponsored by the Eunice Kennedy Shriver National Institute of Child Health and Human Development NICHD to evaluate whether induced whole-body hypothermia initiated between 6-24 hours of age and continued for 96 hours in infants ≥ 36 weeks gestational age with hypoxic-ischemic encephalopathy will reduce the incidence of death or disability at 18-24 months of age.

Pilot study to evaluate the efficacy and tolerability of the modified Atkins diet in infantile spasms refractory to conventional treatment (ACTH, vigabatrin, and anti-epileptic drugs).

Planned study to evaluated how children with Cerebral Palsy move their legs differently from children without CP. Additional objective to determine if an exercise program can improve leg coordination in children with CP