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Study to determine if Antenatal Allopurinol Administration Reduce Post-Hypoxic-Ischemic Reperfusion Damage During Fetal Hypoxia in the Newborn

University of Weatern Ontario, Canada study to estimate to what extent computerized fetal heart rate (FHR) parameters are affected by labor and to estimate the relationship between FHR parameters and the degree of fetal metabolic acidosis in laboring patients at term. Study concluded that in term pregnant women with reassuring FHR tracing, labor causes an increase in both short- and long-term FHR variation, which was abolished in the presence of nonreassuring FHR tracing. Computer-derived FHR parameters studied during the last hour of labor were not correlated with the degree of metabolic acidosis as measured in the umbilical artery at birth.

Study to demonstrate beneficial effects of parenteral carnitine supplementation in premature neonates for liver, heart and muscle metabolism and functions.

In large, multicenter clinical studies, a therapy has been shown to significantly lower the risk of lung and brain damage in some very low birthweight premature infants. Results from two randomized clinical trials demonstrate that when given within the first few weeks of life, inhaled nitric oxide helps prevent chronic lung disease in some low birthweight premature infants. In addition, when used within 48 hours after birth, treatment appears to protect some premature newborns from brain injury.

Children's Hospital Boston is a 396-bed comprehensive center for pediatric health care. As one of the largest pediatric medical centers in the United States, Children's offers a complete range of health care services for children from birth through 21 years of age. (Our Advanced Fetal Care Center can begin interventions at 15 weeks gestation, and in some situations, we treat adults.)

U.S. Department of Education - The Individuals with Disabilities Education Act (IDEA) is a law ensuring services to children with disabilities throughout the nation. IDEA governs how states and public agencies provide early intervention, special education and related services to more than 6.5 million eligible infants, toddlers, children and youth with disabilities. Infants and toddlers with disabilities (birth-2) and their families receive early intervention services under IDEA Part C. Children and youth (ages 3-21) receive special education and related services under IDEA Part B.

PEDIATRICS Journal Abstract of study to determine whether serial head circumference measurements and decreased rate of head growth in asphyxiated full-term newborns during the first few months of life may predict the development of eventual microcephaly.

PubMed Abstract - Early diagnosis of perinatal asphyxia by nucleated red blood cell count: a case-control study

PubMed Abstract: Perinatal asphyxia: current status and approaches towards neuroprotective strategies, with focus on sentinel proteins

Psychiatric Times Article - Neurological Complications of Perinatal Asphyxia

Cerebral Palsy International Research Foundation CPI - Injury to the Preterm Brain and Cerebral Palsy - Part 1: Clinical Aspects of Injury to the Preterm Brain

NIH, and Eunice Kennedy Shriver National Institute of Child Health and Human Development - Review and trial to determine whether magnesium sulfate administered to women at risk of preterm delivery may reduce the risk of cerebral palsy in their children

The Global Library of Women's Medicine - Expert clinical resources for women's healthcare . Women's Medicine, 442 peer and expert reviewed chapters - Safer Motherhood, Extensive clinical guidance - Visual Medicine - Lab Tests and more

PubMed Abstract of study to determine the association of hypotonia and depression in neonates at or near term with metabolic acidemia at birth (umbilical arterial pH<-12 mM).

NICHD National Institute of Health Eunice Kennedy Shriver National Institute of Child Health & Human Development - Center for Research for Mothers & Children CRMC - CRMC serves as a principal source of NIH support for research and research training in maternal and child health. Supported scientists are advancing fundamental and clinical knowledge concerning maternal health and child development problems, such as gestational diabetes, antecedents of adult diseases, obesity and overweight, specific learning disabilities, mechanisms of cognition and learning, growth retardation, HIV/AIDS, and other congenital infections and diseases. The Center also houses the primary federal research entity for research to understand the effects and effectiveness of pharmaceuticals on maternal and child health, as well as a large portfolio on the unique aspects of HIV/AIDS in women and mothers.

Preconception Care at Eunice Kennedy Shriver National Institute of Child Health & Human Development - What is prenatal care and preconception care?

University of California, UCSF Medical Center - Medical Tests - Fetal Heart Monitoring - Definition - Types - Information

Intrapartum Fetal Heart Rate Monitoring at perinatology.com

FDA.gov - Device Approvals and Clearances - STAN S31 Fetal Heart Monitor. STAN® S31 Fetal Heart Monitor is new type of fetal monitor that uses the fetal electrocardiogram (ECG) obtained through a fetal scalp electrode during labor to help the doctor or midwife decide whether to allow the mother to continue to labor or to intervene and deliver the baby.

PEDIATRICS - Official Journal of the American Academy of Pediatrics - Declining Diagnosis of BirthAsphyxia in California: 1991-2000 PEDIATRICS Vol. 114 No. 6 Dec 2004