Later this year the U.S. Food and Drug Administration is expected to approve a new pill that can cure hepatitis C
Updated CDC Guidance Expands PCR-based Zika Testing for Pregnant Women | GenomeWeb - 1 views
We Now Have the Cure for Hepatitis C, but Can We Afford It? - Scientific American - 13 views
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It will contain two drugs, one of which is already available at $1,000 per dose, or $84,000 for a complete 12-week course. The dual-drug combination will likely cost even more
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They also determined that the virus's genes mutate very fast—a process that has generated several equally successful varieties, called genotypes, and rendered an effective vaccine impossible to create so far.
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West Nile Update: Cases Rise, U.S. on Track for Worst Outbreak Ever | Healthland | TIME... - 0 views
Oncolytic Virus-Mediated Manipulation of DNA Damage Responses: Synergy With Chemotherap... - 0 views
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There is a new scientific discovery about the "oncolytic virus" which means attack a tumor. That discovery said that RSV-respiratory syncytial virus- is an oncolytic virus which can attack cancer tumor selectively. But, that paper has not published yet, so i find a paper about the oncolytic virus.
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http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0002917 is also Oncolytic Virus. Title : Systemic Therapy for Cervical Cancer with Potentially Regulatable Oncolytic Adenoviruses
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It's really cool to think that we're spending all this time and money on nanotechnology in the medical field, when we already have biological nanotechnology at our fingertips-- if we can learn to use them (viruses) anyway. Perhaps in 100 years a virion will refer to a virus that can heal a cell vs. infect it.
Norovirus Translation Requires an Interaction between the C Terminus of the Genome-link... - 75 views
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Importantly, however, despite the interaction between the norovirus VPg protein and eIF4E, it appears to be dispensable for MNV translation initiation, at least in vitro
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Mass spectrometry was used to identify proteins present within the samples with a minimum of 2 unique peptides and >90% identification probability
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I'm confused as to how exactly mass spectrometry was used in this experiment. If the proteins are already separated by molecular weight after the SDS-PAGE, what precisely are they looking for when running a mass spec? It article says, ".... a minimum of 2 unique peptides and >90% identification probability," but this doesn't mean much to me. I understand the identification part because based on the way the molecule splits after being shot with ions, you can get a basic idea of the structure of the molecule. My question with the 2 unique peptides is that each amino acid has a different molecular weight right? So if the proteins were all the same except at the 2 unique peptides, the mass spec would show a different mass to charge ratio for each protein with the varying peptides correct? Would the charge of the amino acids in the peptide have anything to do with the charge portion of the mass to charge ratio? I hope this question came out okay.
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I also found this confusing. I understand what your saying and it makes your question makes sense to me. I think that the charge of the amino acids in the peptide would have something to do with the charge portion of the mass to charge ration.
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I'll address this in class. In the meantime, check out http://en.wikipedia.org/wiki/Peptide_mass_fingerprinting
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inability to culture many members of the virus family in immortalized cells.
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The Major Genetic Determinants of HIV-1 Control Affect HLA Class I Peptide Presentation - 11 views
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Yet a small number of people demonstrate sustained ability to control HIV replication without therapy. Such individuals, referred to as HIV controllers, typically maintain stable CD4+ cell counts, do not develop clinical disease, and are less likely to transmit HIV to others (2).
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This is really cool! I have not heard of this until now. Have these people been studied to find out why this occurs? Is it because of the genetics of the person or a certain mutation in the virus? And the key words here are "less likely." That's a pretty broad statement - "less likely" meaning how likely?
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It is interesting to see that there are 3 allelic variants that correlate with disease prognosis, but how does this information benefit society? We can't change peoples genetic so to alter their prognosis. Is this just a benefit to know what medications would be most beneficial with the least amount of side effects?
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Abstract
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