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laceemarie

Airborne Transmission of Influenza A/H5N1 Virus Between Ferrets - 12 views

www.sciencemag.org/...1534.full

shared by laceemarie on 04 Dec 12 - No Cached
  • The MBCS in HA can be cleaved by ubiquitously expressed host proteases; this cleavage facilitates systemic virus replication and results in mortality of up to 100% in poultry (9, 10).
  • Although limited A/H5N1 virus transmission between persons in close contact has been reported, sustained human-to-human transmission of HPAI A/H5N1 virus has not been detected (13–15).
    • Casey Finnerty
      Casey Finnerty on 05 Sep 14
       
      Could this not be happening?
  • The viruses that caused the major pandemics of the past century emerged upon reassortment (that is, genetic mixing) of animal and human influenza viruses (22).
    • Casey Finnerty
      Casey Finnerty on 05 Sep 14
       
      How many pandemics are they talking about? Put another way, for how many pandemics in human history, do we have the virus on hand to analyze?
  • ...2 more annotations...
  • Influenza A viruses show pronounced genetic variation of the surface glycoproteins HA and NA
    • slgoogin8981
      slgoogin8981 on 05 Sep 14
       
      Why is this an important site for variation?
    • laceemarie
      laceemarie on 08 Sep 14
       
      To be able to bind to a variety of different cells?
  • the factors that determine airborne transmission of influenza viruses among mammals, a trait necessary for a virus to become pandemic, have remained largely unknown (18–21)
  • Casey Finnerty on 04 Sep 14
     
    This is the H5N1 mammal transmissibility paper from the Fouchier group.
Casey Finnerty

mBio - September/October 2012, 3 (5) - 0 views

mbio.asm.org/5.toc

virology influenza H5N1

shared by Casey Finnerty on 04 Dec 12 - No Cached
  • Casey Finnerty on 04 Dec 12
     
    This issue of mBio has several updates and opinion pieces on the H5N1 research moratorium.
Casey Finnerty

Experimental adaptation of an influenza H5 HA confers respiratory droplet transmission ... - 5 views

www.nature.com/...nature10831.html

virology influenza H5N1

shared by Casey Finnerty on 04 Dec 12 - No Cached
  • Casey Finnerty on 04 Sep 14
     
    This paper by the Kawaoka group is the first report of an H5N1 virus that is transmissible by aerosol between mammals.
Casey Finnerty

For Young Scientists, A Wild Ride - 0 views

www.sciencemag.org/...1495.full

virology microbiology Influenza

shared by Casey Finnerty on 02 Oct 12 - No Cached
  • Casey Finnerty on 02 Oct 12
     
    This article discusses the drama behind the scenes of the debate over publication of the H5N1 transmissibility studies and the effect it had on young scientists carrying out the work.
Sarah Muncy

PLOS ONE: Safety and Immunogenicity of H5N1 Influenza Vaccine Based on Baculovirus Surf... - 0 views

www.plosone.org/...5E58993766A3A1256696729D429B79

shared by Sarah Muncy on 26 Sep 12 - No Cached
  • Sarah Muncy on 26 Sep 12
     
    This paper gives a descriptive about how they were able to make a candidate vaccine for influenza that is really cheap/safe and very effective using Bombyx mori caterpillars as bioreactors to get needed proteins.
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