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Contents contributed and discussions participated by alexridesducati

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alexridesducati

Targeting therapeutics to an exposed and conserved binding element of the HIV-1 fusion ... - 10 views

www.ncbi.nlm.nih.gov/...PMC154290

shared by alexridesducati on 18 Nov 14 - No Cached
  • alexridesducati on 18 Nov 14
     
    Focus paper for wednesday
alexridesducati

Rabies Virus Hijacks and Accelerates the p75NTR Retrograde Axonal Transport Machinery - 14 views

www.ncbi.nlm.nih.gov/...PMC4148448

shared by alexridesducati on 03 Nov 14 - No Cached
  • Rabies virus (RABV) is a neurotropic virus that depends on long distance axonal transport in order to reach the central nervous system (CNS).
    • alexridesducati
      alexridesducati on 07 Nov 14
       
      This research shows that RABV doesnt need to be transported via p75NTR, but when it is, it is done with acidic compartments and reaches the target area faster. Also, it was mentioned that the acididty of the compartment induced a conformational change of the virus for membrane fusion. Is there any sort of correlation between speed and compartment acidity, or are there significant structural changes due to acidity that may allow for the virus to reach its destination sooner than if it were p75NTR independent?
alexridesducati

Virus-Mediated Compartmentalization of the Host Translational Machinery - 22 views

mbio.asm.org/...e01463-14.full

shared by alexridesducati on 27 Oct 14 - No Cached
  • Within the VF, viral core particles transcribe and release viral mRNAs that possess a dimethylated cap 1 structure at the 5′ terminus but lack a poly(A) tail (19).
    • alexridesducati
      alexridesducati on 31 Oct 14
       
      It seems that Reovirus recruits host proteins in order to replicate, and in this sentence we see that the viral mRNAs use a dimethlyated cap vs. the traditional host methylguanosine cap. Does this have any sort of impact on initiation factors associated with the ribosome? The viral mRNA also seems to be lacking in a poly-A tail. Is it because the mRNAs are created in a VF that they dont need to worry about having one?
alexridesducati

HSV carrying WT REST establishes latency but reactivates only if the synthesis of REST ... - 7 views

www.pnas.org/...E498.long

shared by alexridesducati on 15 Oct 14 - No Cached
  • Finally, in contrast to the events following entry of virus after retrograde transport from the periphery, the data suggest that reactivation does not trigger a stress response that leads to activation of REST
    • alexridesducati
      alexridesducati on 17 Oct 14
       
      Has anyone been able to pinpoint the exact step in infection that activates REST so that it can be studied? If so, perhaps it is possible to manipulate the effects of that step in order to induce an artificial response to the reactivation of HSV1 from its latency period in order to retrigger the stress response that leads to REST activation.
alexridesducati

4 more kids with neurologic illness - 1 views

www.cnn.com/...index.html

shared by alexridesducati on 02 Oct 14 - No Cached
  • alexridesducati on 02 Oct 14
     
    "Doctors in Colorado spotted it first -- a group of 10 children hospitalized with signs of a neurologic illness: limb weakness, cranial nerve dysfunction and abnormalities in their spinal gray matter..... Tests of the Colorado children's cerebrospinal fluid came back negative for enteroviruses and West Nile virus. But a test of their nasal passages found enterovirus in six out of eight patients who were tested."
  • alexridesducati on 02 Oct 14
     
    Dr. Finnerty asked if I could link this here on Diigo.
alexridesducati

Norovirus Translation Requires an Interaction between the C Terminus of the Genome-link... - 75 views

www.jbc.org/...21738.long

shared by alexridesducati on 12 Sep 14 - No Cached
    • alexridesducati
      alexridesducati on 19 Sep 14
       
      It seems in order for this virus to replicate effectively, it has to bind several different ways, at least, just to initiate protein synthesis. Is there any way to synthesize a molecule that can target any of these proteins for degradation or at least something that can inhibit the binding site (similar to a neutralizing antibody :) . It seems that if you nip this right at the bud, that its possible to shut this virus down for the most part, except for the fact that in vitro, elF4E can be dispensed for translation initiation. Makes me wonder what the key differences are between an in vitro and in vivo environment that allows this to happen.
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