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Contents contributed and discussions participated by jpolanco10

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jpolanco10

Rabies Virus Hijacks and Accelerates the p75NTR Retrograde Axonal Transport Machinery - 2 views

www.ncbi.nlm.nih.gov/...PMC4148448

shared by jpolanco10 on 07 Nov 14 - No Cached
  • the RABV phosphoprotein P directly interacts with a dynein light chain [11], [12], suggesting a mechanism whereby this interaction is key to RABV's retrograde trafficking. However, studies on the retrograde transport of RABV enveloped virions [14] and infection of the CNS from the periphery with dynein light chain binding defective virus mutants [13] already showed that such an interaction is not essential for retrograde axonal transport of the virus
    • jpolanco10
      jpolanco10 on 07 Nov 14
       
      It says that this mechanism is key, yet the mutations with the defect show this is not essential. Is something else that is facilitating the trafficking with the phosphoprotein P?
jpolanco10

Virus-Mediated Compartmentalization of the Host Translational Machinery - 22 views

mbio.asm.org/...e01463-14.full

shared by jpolanco10 on 27 Oct 14 - No Cached
  • jpolanco10 on 28 Oct 14
     
    Focus paper for friday
jpolanco10

Norovirus Translation Requires an Interaction between the C Terminus of the Genome-link... - 75 views

www.jbc.org/...21738.long

shared by jpolanco10 on 12 Sep 14 - No Cached
  • It is important to note that in both these approaches low levels of eIF4E remained (Fig. 8C) and 4E-BP1 expression in the MNV permissive cells did not completely block the eIF4E-4G interaction. Therefore, further studies on the role of eIF4E during the norovirus life cycle are clearly warranted, but it is worth noting that in addition to a direct role in cap binding for translation initiation, eIF4E plays numerous roles in the regulation of gene expression.
    • jpolanco10
      jpolanco10 on 19 Sep 14
       
      Why did this not block the eIF4E-4G interaction? Is there a really high affinity or was it able to recruit other proteins to aide it? It seems that the low level of eIF4E was still able to do its job, mainly regulation of the genes
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