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Nate Scheibe

CDC Features - Pneumonia Can Be Prevented - Vaccines Can Help - 0 views

www.cdc.gov/Pneumonia

pneumonia cdc

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Nate Scheibe

Tigecycline Versus Levofloxacin in Hospitalized Patients With Community-Acquired Pneumo... - 0 views

www.ncbi.nlm.nih.gov/...PMC3601338

pneumonia

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Nate Scheibe

Efficacy and safety of tigecycline versus levofloxacin for community-acquired pneumonia - 0 views

www.ncbi.nlm.nih.gov/...PMC2753558

pneumonia

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Alletia DeMartino

Pseudomonas aeruginosa Turns Protein Into a Virulence Factor in One Easy Step - 0 views

www.infectioncontroltoday.com/...e-factor-in-one-easy-step.aspx

shared by Alletia DeMartino on 09 May 13 - No Cached
  • To infect its host, the respiratory pathogen Pseudomonas aeruginosa takes an ordinary protein usually involved in making other proteins and adds three small molecules to turn it into a key for gaining access to human cells.
  • P. aeruginosa, one of the most common causes of hospital-acquired pneumonia.
  • P. aeruginosa mostly uses this protein called elongation factor-Tu (EF-Tu) inside the cel
  • ...10 more annotations...
  • but she and her collaborators have learned that as a virulence factor, it could represent a vulnerability for the bacterium
  • EF-Tu is presumed to be an essential protein, and it's performing these moonlighting functions as well. If we figured out how it was doing that, we could devise strategies to inhibit it," says Goldberg.
  • acquired pneumonia and is the leading cause of death among critically ill patients whose airways have been damaged by ventilation, trauma, or other infections.
  • P. aeruginosa takes
  • the protein EF-Tu, which was generally thought to exist only inside the cell, and decorates the exterior of the cell with it, but in a modified form.
  • EF-Tu is modified somehow to mimic ChoP, allowing P. aeruginosa to enjoy the benefits of ChoP.
  • , ChoP carries out a crucial step for setting up an infection for a number of different types of respiratory pathogens.
  • Using a host of techniques, including mass spectrometry, site directed mutagenesis of key residues in the protein, and genetic loss of function/gain of function studies, they found that P. aeruginosa only makes small changes to EF-Tu to get it to mimic this powerful ligand. P. aeruginosa transfers three methyl groups to a lysine on EF-Tu, giving it a structure similar to ChoP and allowing it to fit in the PAFR receptor in the way ChoP does.
  • "It allows [P. aeruginosa] to adhere to the cells and invade,"
  • "Its interaction with humans is accidental. It's an opportunist. The fact that it has this novel modification on this protein that is inherent in the bacterium that enables it to attach and persist and cause disease is exciting,"
  • Alletia DeMartino on 09 May 13
     
    Interesting!! however, very scary. It just keeps modifying itself and being more virulent. what's next?!
Casey Finnerty

How Scientists Stopped Klebsiella Pneumoniae: Deadly Superbug Killed 6 At NIH Clinical ... - 1 views

www.huffingtonpost.com/...l-center-deadly_n_1822695.html

microbiology antibiotic resistance

shared by Casey Finnerty on 29 Jan 13 - No Cached
  • 18 people harbored the dangerous germ, and six died of bloodstream infections from it. Another five made it through the outbreak only to die from the diseases that brought them to NIH's world-famous campus in the first place.
  • Infections at health care facilities are one of the nation's leading causes of preventable death, claiming an estimated 99,000 lives a year.
  • KPC has emerged over the past decade to become a fast-growing threat in intensive care units, spreading easily between very ill people and killing half of those it sickens.
  • ...3 more annotations...
  • KPC was transmitted three separate times from Patient No. 1, and then spread more widely.
  • Test after test never found the bug on hospital workers' hands.
  • "There's better technology becoming available for your hospital to prevent these bacteria from spreading, and this is what you should expect from your hospital," he said.
  • Katelyn Madigan on 29 Jan 13
     
    I agree that it is wise to broaden the scope of infection control to custodial workers, since they would often be in contact with several of the inanimate objects in the room. This is really shown when they were unable to find the superbug on the "hospital workers' hands." Did they test everyone?
Nate Scheibe

Etiology and factors contributing to the severity... [Intern Med. 2013] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...23370738

pneumonia microbiology

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Nate Scheibe

Diagnostic tests for agents of community-acq... [Clin Infect Dis. 2011] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...21460288

pneumonia microbiology

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Nate Scheibe

Vaccines: VPD-VAC/Pneumo/main page - 0 views

www.cdc.gov/...default.htm

pneumonia vaccines

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Amy Jorgenson

Pathogen turns protein into a virulence factor in one easy step - 0 views

phys.org/...ein-virulence-factor-easy.html

shared by Amy Jorgenson on 08 May 13 - No Cached
  • Amy Jorgenson on 08 May 13
     
    This is more of a blurb (rather than an article) about P. aeruginosa making three small changes to the EF-Tu protein in order to gain entry into human cells. Understanding these changes appears to be a great link to understanding/studying hospital-acquired pneumonia. Not sure how I feel about the comment comparing proteins to a spork in a takeout meal....
Abdirizak Abdi

Researchers Find Immunity Protein That Ramps Up Inflammation, and Agents That Can Block It - 0 views

www.sciencedaily.com/...130331165601.htm

shared by Abdirizak Abdi on 01 Apr 13 - No Cached
  • Abdirizak Abdi on 01 Apr 13
     
    Scientist have a found innate protein that increases inflammation and,agents that block it, resulting in increased in survival and improved lung function in animal models pneumonia. "The F-box protein Fbxo3, and other related proteins, represent ideal targets for treatment of acute lung injury, because it controls the innate immune response, is upstream of important inflammatory signaling pathways, and is more selective than traditional drugs that regulate protein turnover" noted Mark T Gladwin M.D., chief of the Division of Pulmonary, Allergy and Critical Care Medicine, Pitt School of Medicine.
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