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Katelyn Madigan

'Quadruple helix' DNA discovered in human cells - 0 views

www.sciencedaily.com/...130120150033.htm

DNA quadruple helix

shared by Katelyn Madigan on 07 Feb 13 - No Cached
  • our-stranded 'quadruple helix' DNA structures -- known as G-quadruplexes
  • rich in the building block guanine
  • over 10 years investigation by scientists to show these complex structures in vivo -- in living human cells
  • ...2 more annotations...
  • quadruplexes are more likely to occur in genes of cells that are rapidly dividing, such as cancer cells.
  • quadruplex DNA is found fairly consistently throughout the genome of human cells and their division cycles
  • Katelyn Madigan on 07 Feb 13
     
    A better understanding of DNA structure, as well as other factors at the molecular level, have tremendous clinical implications. A personalized inhibitory mechanism for proliferating cancer cells looks like a promising approach for cancer treatments.
Casey Finnerty

A DNA Lesson, From the Expert's Pen - NYTimes.com - 1 views

www.nytimes.com/...-the-pen-of-francis-crick.html

microbiology molecular biology dna

shared by Casey Finnerty on 27 Feb 13 - No Cached
  • The final piece in solving the puzzle of DNA was achieved on the morning of Feb. 28, 60 years ago this week, when Dr. Watson saw how the bases of DNA paired up.
Megan Goldman

Hyperstability and Substrate Promiscuity in Laboratory Resurrections of Preca... - 0 views

pubs.acs.org/...ja311630a

shared by Megan Goldman on 30 Apr 13 - No Cached
  • Megan Goldman on 30 Apr 13
     
    This is the article of my last post, I obviously understand the two last posts count as one as they are the same topic. I simply wanted supplementary information for both since you cannot see this full text and the previous post was from .net.
Megan Goldman

BMC Microbiology | Full text | Molecular characterization of multiresistant E... - 0 views

www.biomedcentral.com/...84

shared by Megan Goldman on 30 Apr 13 - No Cached
  • Megan Goldman on 30 Apr 13
     
    The prevalence and type of plasmids, resistance genes and integrons carried by two collections of multiresistant E. coli producing or not extended-spectrum β-lactamases have been compared. Rep-PCR was used to determine the clonal relationship of the organisms. Plasmids were classified according to their incompatibility.
Alletia DeMartino

Activity of cancer inducing genes can be controlled by the cell's skeleton - 0 views

www.sciencedaily.com/...130506095103.htm

shared by Alletia DeMartino on 07 May 13 - No Cached
  • n the latest issue of the journal Oncogene, Florence Janody and her team at the Instituto Gulbenkian de Ciência (IGC, Portugal), identified a novel mechanism by which the activity of Src is limited by the cell's skeleton (cytoskeleton) limiting the development of tumours.
  • ble to stop the tumour development induced by the high activity of Src through the genetic manipulation of the cytoskeleton in fly tissues
  • showed that the development of tumours is stopped in the presence of high levels of the actin Capping Protein.
  • ...2 more annotations...
  • Although the precise molecular mechanism is still unknown, the hypothesis raised by these scientists is that the "tuner" creates a tension in the cables of the cytoskeleton that impedes the action of these proteins
  • The cytoskeleton works as a "barbwire" network.
  • Alletia DeMartino on 07 May 13
     
    WOW! random discoveries are being made every day. Makes you wonder when the cure will come!
Casey Finnerty

Flawed herpes testing leads to false positives, and needless suffering - 0 views

www.statnews.com/...herpes-testing-false-positives

molecular diagnostics herpesvirus

shared by Casey Finnerty on 08 Feb 17 - No Cached
  • Up to 1 in 2 positive tests could be false, according to the USPSTF’s most recent guidelines.
Casey Finnerty

In a First, Test of DNA Finds Root of Illness - NYTimes.com - 0 views

www.nytimes.com/...-diagnoses-a-boys-illness.html

genomics molecular diagnostics

shared by Casey Finnerty on 10 Jun 14 - No Cached
  • But in the first procedure of its kind, researchers at the University of California, San Francisco, managed to pinpoint the cause of Joshua’s problem — within 48 hours. He had been infected with an obscure species of bacteria. Once identified, it was eradicated within days.
Casey Finnerty

Will polymerase chain reaction (PCR)-based diagnostics improve outcome in septic patien... - 0 views

link.springer.com/...fulltext.html

molecular diagnostics

shared by Casey Finnerty on 13 Jun 14 - No Cached
  • if the primary aim of PCR diagnostics is to decrease inappropriate empirical treatment and improve patient outcome, detection should focus on those pathogens or resistance determinants that are not covered by guideline-recommended treatment regimens and that have been identified as the major cause of inappropriate treatment according to current studies
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