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Casey Finnerty

Yeast Infection Led to Removal of Transplanted Uterus - The New York Times - 0 views

www.nytimes.com/...al-of-transplanted-uterus.html

shared by Casey Finnerty on 11 Apr 16 - No Cached
  • The infection was caused by a fungus, a type of yeast called Candida albicans
  • It is normally found in the vagina, living in balance with bacteria and other microbes. But illness or some medications can disrupt the balance, allowing for a problematic overgrowth of the yeasts.
  • The surgeons said that since yeasts normally inhabit the genital tract, they could have come from either the donor or the recipient.
  • ...11 more annotations...
  • But in transplant recipients, yeast infections can be hard to control, because the drugs that prevent rejection also prevent the immune system from fighting the infection. If a yeast infection spreads into the bloodstream, it can be extremely difficult to treat, and can be fatal.
  • Doctors rushed Ms. McFarland into surgery and discovered that an infection — they did not know then what kind — had extended into an artery they had connected to provide blood flow to the uterus. It had damaged the vessel and caused clots. The transplant had to be removed immediately. A week later, Ms. McFarland needed another operation, to treat more bleeding.
  • Once the cause of the infection was identified, she was treated with antifungal medicines. With the transplant removed, she was able to stop taking antirejection drugs and give her immune system a chance to recover and help control the infection.
  • She spent about five weeks in the hospital. Dr. Tzakis said she was still taking antifungal medicine, but was well.
  • The goal of the surgery is to make pregnancy and childbirth possible for women who were born without a uterus or lack one because of illness or injury.
  • They said they were considering various options, like using antifungal medicines preventively and washing the tissues of both the donor and recipient to reduce the risk of infection.
  • The only successful uterus transplants have been performed in Sweden, at the University of Gothenburg. Nine women have had the transplants there, and five have given birth.
  • Two of the nine transplants failed during the first year after the surgery and had to be removed
  • the other because of a bacterial infection.
  • Unlike the Cleveland team, doctors in Sweden used live uterus donors rather than cadavers for the transplants.
  • He also said that the Baylor team had adjusted its screening procedures to take into account possible exposure to the Zika virus
Nate Scheibe

CDC: Man died of rabies from kidney transplant - CNN.com - 0 views

www.cnn.com/...index.html

rabies virus transplant

shared by Nate Scheibe on 15 Mar 13 - No Cached
  • Doctors knew the donor had encephalitis, an inflammation of the brain, when they harvested the organs. However, they didn't know rabies was the cause.
  • In this most recent case, the donor was experiencing "changes in mental status" before he died, according to Dr. Matthew Kuehnert, director of the CDC's Office of Blood, Organ, and Other Tissue Safety. He said doctors in Florida tested the donor for various causes of encephalitis, including West Nile Virus and herpes, but did not test for rabies.
  • Hospitals do test for other causes of encephalitis, and if no cause is found, the organs are donated.
  • Nate Scheibe on 15 Mar 13
     
    The part that is most concerning is that the doctors knew the patient had encephalitis (granted not all causes of encephalitis are infectious in nature) and decided to donate the organs anyway.
Katelyn Madigan

First documented case of child cured of HIV - 0 views

www.sciencedaily.com/...130303172640.htm

microbiology immune HIV child

shared by Katelyn Madigan on 04 Mar 13 - No Cached
  • i diagnosed with HIV at birth and immediately put on antiretroviral therapy.
  • brought back into care at 23 months, despite being off treatment for five months, the child was found to have an undetectable viral load
  • d today no signs of HIV infection in the child can be detected by the most sensitive means available.
  • ...2 more annotations...
  • physician was able to treat his leukemia with a stem-cell transplant from a person who was born with a genetic mutation causing immunity to HIV infection. Following the transplant, Mr. Brown was able to stop HIV treatment without experiencing a return of his HIV disease
  • achieved by antiretroviral therapy alone
Whitney Hopfauf

First documented case of child cured of HIV - 0 views

www.sciencedaily.com/...130303172640.htm

virus

shared by Whitney Hopfauf on 04 Mar 13 - No Cached
  • Whitney Hopfauf on 04 Mar 13
     
    Exciting when AIDS research takes a step forward. However, is it true that although they cannot detect the virus, it may lie dormant? How sensitive are those tests? There was a case of a man who had HIV and leukemia and so they treated him with a bone marrow transplant from someone who was resistant to HIV. The man was said to be cured but there were later debates on the validity. 
Alletia DeMartino

Human brain cells developed in lab, grow in mice - 0 views

www.sciencedaily.com/...130503230313.htm

shared by Alletia DeMartino on 07 May 13 - No Cached
  • The researchers generated and transplanted a type of human nerve-cell progenitor called the medial ganglionic eminence (MGE) cell, in experiments describe
  • The researchers generated and transplanted a type of human nerve-cell progenitor called the medial ganglionic eminence (MGE) cel
  • Kriegstein sees MGE cells as a potential treatment to better control nerve circuits that become overactive in certain neurological disorders.
  • ...13 more annotations...
  • Kriegstein sees MGE cells as a potential treatment to better control nerve circuits that become overactive in certain neurological disorders.
  • , the human MGE-like cells survived within the rodent forebrain, integrated into the brain by forming connections with rodent nerve cells, and matured into specialized subtypes of interneurons.
  • To generate MGE cells in the lab, the researchers reliably directed the differentiation of human pluripotent stem cells -- either human embryonic stem cells or induced pluripotent stem cells derived from human skin
  • unlimited potential to become any human cell type.
  • To generate MGE cells in the lab, the researchers reliably directed the differentiation of human pluripotent stem cells -- either human embryonic stem cells or induced pluripotent stem cells derived from human skin.
  • These findings may serve as a model to study human diseases in which mature interneurons malfunction,
  • These findings may serve as a model to study human diseases in which
  • mature interneurons malfunction,
  • Nicholas utilized key growth factors and other molecules to direct the derivation and maturation of the human MGE-like interneurons
  • Nicholas utilized key growth factors and other molecules to direct the derivation and maturation of the human MGE-like interneurons. He timed the delivery of these fa
  • "The hope is that we can deliver these cells to various places within the nervous system that have been overactive and that they will functionally integrate and provide regulated inhibition," Nicholas said.
  • The researchers also plan to develop MGE cells from induced pluripotent stem cells derived from skin cells of individuals with autism, epilepsy, schizophrenia and Alzheimer's disease, in order to investigate how the development and function of interneurons might become abnormal -- creating a lab-dish model of disease.
  • One mystery and challenge to both the clinical and pre-clinical study of human MGE cells is that they develop at a slower, human pace, reflecting an "intrinsic clock." In fast-developing mice, the human MGE-like cells still took seven to nine months to form interneuron subtypes that normally are present near birth.
  • Alletia DeMartino on 07 May 13
     
    pretty interesting that there wasnt rejection from the mice immune system. very cool for furthering research 
Casey Finnerty

Fecal Treatment Gains Favor for Some Illnesses - NYTimes.com - 3 views

www.nytimes.com/...eatment-works-study-finds.html

microbiology

shared by Casey Finnerty on 17 Jan 13 - No Cached
  • A new study finds that such transplants cured 15 of 16 people who had recurring infections with Clostridium difficile bacteria, whereas antibiotics cured only 3 of 13 and 4 of 13 patients in two comparison groups.
  • anonymous on 17 Jan 13
     
    I didn't know this was even possible. I wonder how they convinced people to donate. "The donors were tested for an array of diseases to make sure they did not infect the patients." I wonder how extensive that panel was and what they tested for.
  • Casey Finnerty on 17 Jan 13
     
    Isn't this neat? I have met people who are hoping to get this treatment. Re: the screening, I think it is probably just for the absence of pathogens. As the article states, we really don't know what the "good" bacteria are that help these patients.
  • anonymous on 18 Jan 13
     
    RE: I would hope that they would check for things like HIV and other blood to blood transmitted diseases. If there was a bleed in the GI tract of both the donor and the patient, I could imagine it would be a problem.
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