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Matti Narkia

Why Low Vitamin D Raises Heart Disease Risks In Diabetics - 0 views

    ScienceDaily (Aug. 25, 2009) - Low levels of vitamin D are known to nearly double the risk of cardiovascular disease in patients with diabetes, and researchers at Washington University School of Medicine in St. Louis now think they know why.

    They have found that diabetics deficient in vitamin D can't process cholesterol normally, so it builds up in their blood vessels, increasing the risk of heart attack and stroke. The new research has identified a mechanism linking low vitamin D levels to heart disease risk and may lead to ways to fix the problem, simply by increasing levels of vitamin D.
Matti Narkia

Vitamin D toxicity redefined: Vitamin K and the molecular mechanism - 0 views

    Vitamin D toxicity redefined: vitamin K and the molecular mechanism.
    Masterjohn C.
    Med Hypotheses. 2007;68(5):1026-34. Epub 2006 Dec 4.
    PMID: 17145139
Matti Narkia

Effects of Atorvastatin on Vitamin D Levels in Patients With Acute Ischemic Heart Disease - 0 views

    Effects of Atorvastatin on vitamin D levels in patients with acute ischemic heart disease.
    Pérez-Castrillón JL, Vega G, Abad L, Sanz A, Chaves J, Hernandez G, Dueñas A.
    Am J Cardiol. 2007 Apr 1;99(7):903-5. Epub 2007 Feb 8.
    PMID: 17398180

    In conclusion, atorvastatin increases vitamin D levels. This increase could explain some of the beneficial effects of atorvastatin at the cardiovascular level that are unrelated to cholesterol levels.

    The mechanism by which atorvastatin increases vitamin D levels is related to inhibition of 3-hydroxy-3 methylglutaryl coenzyme A (HMG-CoA) reductase. Cholesterol is synthesized from 7-dehydrocholesterol, which is also a precursor of vitamin D3. For this reason, we initially observed a statistically significant relation between total cholesterol and vitamin D. HMG-CoA enzyme reductase is key to the synthesis of cholesterol, whereas ultraviolet radiation causes the formation of 25-hydroxyvitamin D. Inhibition of the enzyme may increase levels of 7-dehydrocholesterol and increase the synthesis of 25-hydroxycholecalciferol, thereby increasing vitamin D levels,10 although we observed no relation between lower cholesterol and increased vitamin D. In addition, 25-hydroxyvitamin D has been shown to inhibit HMG-CoA enzyme reductase activity in in vitro studies.11 A greater concentration of vitamin D could increase enzymatic inhibition, acting in synergy with the statin in decreasing total cholesterol.
Matti Narkia

YouTube - Vitamin D and Cancer Prevention - 0 views

    YouTube - Vitamin D and Cancer Prevention. A presentation by Dr. Cedric Garland.
Matti Narkia

Vitamin D and multiple sclerosis. - Wiley InterScience - J Cell Biochem. 2008 Oct 1 - 0 views

    Vitamin D and multiple sclerosis.
    Raghuwanshi A, Joshi SS, Christakos S.
    J Cell Biochem. 2008 Oct 1;105(2):338-43. Review.
    PMID: 18655192
Matti Narkia

Vitamin D and Intervention Trials in Prostate Cancer: From Theory to Therapy - 0 views

    Vitamin D and intervention trials in prostate cancer: from theory to therapy.
    Schwartz GG.
    Ann Epidemiol. 2009 Feb;19(2):96-102. Epub 2008 Jul 10.
    PMID: 18619854

    This suggests that whereas vitamin D (e.g., cholecalciferol) might prevent prostate cancer, existing prostate tumors likely would require treatment with 1,25(OH)(2)D and/or its analogs. The major obstacle to the use of 1,25(OH)(2)D in patients therapeutically is the risk of hypercalcemia. Several maneuvers to reduce this risk, including pulse dosing and the use of less calcemic 1,25(OH)(2)D analogs, have been explored in Phase I-III clinical trials. Once merely a promise, vitamin D-based therapies for prostate cancer may soon be medical practice.
Matti Narkia

Vitamin D and cancer Ali MM, Vaidya V - J Can Res Ther 2007 Oct-Dec - 0 views

    Vitamin D and cancer.
    Ali MM, Vaidya V.
    J Cancer Res Ther. 2007 Oct-Dec;3(4):225-30. Review.
    PMID: 18270398
    DOI: 10.4103/0973-1482.38998
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