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Matti Narkia

Serum 25-Hydroxyvitamin D Levels and the Prevalence of Peripheral Arterial Disease: Res... - 0 views

atvb.ahajournals.org/...1179

2008 June study research epidemiological humans vitamin_D status 25ohd Peripheral Arterial Disease: PAD prevalence CVD phosphate PTH nutrition medline

shared by Matti Narkia on 02 Sep 09 - Cached
  • Matti Narkia on 02 Sep 09
     
    Serum 25-hydroxyvitamin D levels and the prevalence of peripheral arterial disease: results from NHANES 2001 to 2004. Melamed ML, Muntner P, Michos ED, Uribarri J, Weber C, Sharma J, Raggi P. Arterioscler Thromb Vasc Biol. 2008 Jun;28(6):1179-85. Epub 2008 Apr 16. PMID: 18417640 doi: 10.1161/ATVBAHA.108.165886 Conclusions- Low serum 25(OH)D levels are associated with a higher prevalence of PAD. Several mechanisms have been invoked in the literature to support a potential antiatherosclerotic activity of vitamin D. Prospective cohort and mechanistic studies should be designed to confirm this association. Vitamin D is an inhibitor of the renin-angiotensin system and has antiinflammatory and anticoagulant properties. Among 4839 NHANES 2001 to 2004 participants, low 25(OH)D levels were associated with a higher prevalence of PAD, after multivariate adjustment. To confirm this association, longitudinal cohort and mechanistic studies are needed.
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