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Matti Narkia

Vitamin D replacement in Asians with diabetes may increase insulin resistance. - 0 views

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    Vitamin D replacement in Asians with diabetes may increase insulin resistance.
    Taylor AV, Wise PH.
    Postgrad Med J. 1998 Jun;74(872):365-6.
    PMID: 9799895

    We report three cases of vitamin D replacement in British Asians with vitamin D deficiency and non-insulin-dependent diabetes mellitus. In all cases, replacement resulted in an increase in insulin resistance and a deterioration of glycaemic control
Matti Narkia

25-Hydroxyvitamin D, IGF-1, and Metabolic Syndrome at 45 Years of Age - Diabetes - 0 views

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    25-hydroxyvitamin D, IGF-1, and metabolic syndrome at 45 years of age: a cross-sectional study in the 1958 British Birth Cohort.
    Hyppönen E, Boucher BJ, Berry DJ, Power C.
    Diabetes. 2008 Feb;57(2):298-305. Epub 2007 Nov 14.
    PMID: 18003755
    doi: 10.2337/db07-1122

    CONCLUSIONS-Serum 25(OH)D is inversely associated with metabolic syndrome, whereas the inverse association with IGF-1 was found only among those without hypovitaminosis D. These results suggest that metabolic syndrome prevalence is the lowest when both 25(OH)D and IGF-1 are high.
Matti Narkia

Vitamin D Status and Glucose Homeostasis in the 1958 British Birth Cohort - Diabetes Care - 0 views

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    Vitamin D status and glucose homeostasis in the 1958 British birth cohort: the role of obesity.
    Hyppönen E, Power C.
    Diabetes Care. 2006 Oct;29(10):2244-6.
    PMID: 17003300
    doi: 10.2337/dc06-0946

    CONCLUSIONS-Body size was a strong determinant for 25(OH)D, with concentrations being suboptimal in most obese participants. Randomized controlled trials [using dosages sufficient to improve 25(OH)D also for the obese] are required to determine whether clinically relevant improvements in glucose metabolism can be obtained by vitamin D supplementation.
Matti Narkia

Hypovitaminosis D in British adults at age 45 y: nationwide cohort study of d... - 0 views

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    Hypovitaminosis D in British adults at age 45 y: nationwide cohort study of dietary and lifestyle predictors.
    Hyppönen E, Power C.
    Am J Clin Nutr. 2007 Mar;85(3):860-8.
    PMID: 17344510

    Conclusion: Prevalence of hypovitaminosis D in the general population was alarmingly high during the winter and spring, which warrants action at a population level rather than at a risk group level.

    Data from the 1958 birth cohort suggest that, at different cutoffs for hypovitaminosis D, a substantial public health problem exists in British whites. Obese participants and those living in Scotland were at the highest risk of hypovitaminosis D. However, the prevalence in the general population was very high during the winter and spring, which suggests that, to improve the situation, action is required at a population level rather than at a risk-group level. In the United States, calls have gone out for an increase in vitamin D fortification of foods (11), and the data from the current study suggest that such action is also warranted in the United Kingdom. Vitamin D is currently available without prescription as a dietary supplement only as part of cod liver oil or multivitamin products; hence, a need clearly exists to consider increased availability of over-the-counter supplements. Hypovitaminosis D has been implicated in the development of serious conditions, including diabetes, various types of cancer, and cardiovascular diseases, in addition to its essential role in maintaining bone health (1, 2). The high rates of hypovitaminosis D reported in this study suggest that immediate action is needed to improve the vitamin D status of the British population.
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