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Drug companies have a problem: they are finding it ever harder to get painkillers through clinical trials. But this isn't necessarily because the drugs are getting worse. An extensive analysis of trial data1 has found that responses to sham treatments have become stronger over time, making it harder to prove a drug’s advantage over placebo. The change in reponse to placebo treatments for pain, discovered by researchers in Canada, holds true only for US clinical trials. "We were absolutely floored when we found out," says Jeffrey Mogil, who directs the pain-genetics lab at McGill University in Montreal and led the analysis. Simply being in a US trial and receiving sham treatment now seems to relieve pain almost as effectively as many promising new drugs. Mogil thinks that as US trials get longer, larger and more expensive, they may be enhancing participants’ expectations of their effectiveness.

As the unofficial spokespeople for our organic-eating, Food Network-watching ways, when chefs talk, Americans tend to listen. And Dan Barber — the farm-to-table icon behind restaurants Blue Hill in New York City and Blue Hill Stone Barns in Tarrytown — isn’t wasting his platform.Barber has given a wildly popular TED talk, been counted among TIME’s 100 most influential people, been appointed to the President’s Council on Fitness, Sports & Nutrition and, as of last week, authored a nearly 500-page book laying out a radical new vision for the future of food.So when Barber came out last weekend with a New York Times op-ed detailing the shortcomings of the farm-to-table movement he had previously helped promote, people paid attention. While we like to pat ourselves on the back for eating seasonally and locally, Barber’s contentious argument went, the foodie fad that grew to become the face of sustainable eating has failed to bring about the promised revolution. Industrial agriculture still rules, Barber argued. And as it keeps growing, more and more small farms and native prairie disappear under Big Ag’s plow.If we really care about changing our food system (as anyone who hopes to feed our growing world should), Barber believes we’re going to need a true revolution. And “The Third Plate“ is his thesis, over a decade in the works, for what that change must look like.Among other things, change means thinking holistically, embracing diversity in ingredient choice and cuisine, and shifting meat over from its vaulted place at the center of the dinner plate. But while the solutions Barber describes are frighteningly extensive, they also, in his telling, sound delicious. That, more than any warning about the consequences of continuing along with the status quo, could be thing that ends up making a difference.

The discovery by the French state-owned railway company SNCF that 2,000 new trains are too wide for many station platforms is embarrassing, but far from the first time a small mis-measurement or miscalculation has had serious repercussions.

“Non-overlapping magisteria” has a nice ring to it. The problem is that there are many religious claims that not only “overlap” with empirical data but are incompatible with it. As a scientist who also spends a fair amount of time in the public arena, if I am asked if our understanding of the Big Bang conflicts with the idea of a six-thousand-year-old universe, I face a choice: I can betray my scientific values, or encourage that person to doubt his or her own beliefs. More often than you might think, teaching science is inseparable from teaching doubt.

"Metaphorical thinking—our instinct not just for describing but for comprehending one thing in terms of another—shapes our view of the world, and is essential to how we communicate, learn, discover and invent. ... Our understanding of metaphor is in the midst of a metamorphosis. For centuries, metaphor has been seen as a kind of cognitive frill, a pleasant but essentially useless embellishment to 'normal' thought. Now, the frill is gone. New research in the social and cognitive sciences makes it increasingly plain that metaphorical thinking influences our attitudes, beliefs, and actions in surprising, hidden, and often oddball ways." Geary further unpacks metaphor's influence in his foreword: "Metaphor conditions our interpretations of the stock market and, through advertising, it surreptitiously infiltrates our purchasing decisions. In the mouths of politicians, metaphor subtly nudges public opinion; in the minds of businesspeople, it spurs creativity and innovation. In science, metaphor is the preferred nomenclature for new theories and new discoveries; in psychology, it is the natural language of human relationships and emotions."

The upshot of the boom in metaphor studies, Geary makes clear, is the overturning of that presumption toward literalism: Nowadays, it's believers in a literalism that goes all the way down (so to speak) who are on the defensive in intellectual life, and explorers of metaphor who are on the ascendant. As a result, Geary hardly feels a need to address literalism, devoting most of his book to how metaphor connects to etymology, money, mind, politics, pleasure, science, children, the brain, the body, and such literary forms as the proverb and aphorism.

There is a common narrative in science of the tragic genius who suffers for a great reward, and the tale of Curie, who died from exposure to radiation as a result of her pioneering work, is one of the most famous. There is a sense of grandeur in the idea that paying heavily is a means of advancing knowledge. But in truth, you can’t control what it is that you find — whether you’ve sacrificed your health for it, or simply years of your time.

A chimpanzee is not entitled to the same rights as people and does not have be freed from captivity by its owner, a US court has ruled. The appeals court in New York state said caged chimpanzee Tommy could not be recognised as a "legal person" as it "cannot bear any legal duties". The Nonhuman Rights Project had argued that chimps who had such similar characteristics to the humans deserved basic rights, including freedom. The rights group said it would appeal. Owner pleased In its ruling, the judges wrote: "So far as legal theory is concerned, a person is any being whom the law regards as capable of rights and duties. "Needless to say, unlike human beings, chimpanzees cannot bear any legal duties, submit to societal responsibilities or be held legally accountable for their actions.'' The court added that there was no precedent for treating animals as persons and no legal basis.

Many concert-goers are often frustrated by the sound of people coughing during classical music performances. These coughers have now become the subject of an academic paper concerning "the economics of concert etiquette", which analyses a stark fact: people appear to cough more in concerts than in they do in normal life. The German economist Andreas Wagener told the Today programme: "The statistics indicate people cough during concerts twice as much as they do in normal life." Concert pianist Susan Tomes said: "I certainly do notice it, but I think it has something to do with the fact that people have gotten so used to hearing music amplified. "Many types of music are so loud, but classical music is not, and when you go to a classical concert, you forget how quiet acoustic instruments are." First broadcast on BBC Radio 4's Today Programme on Monday 28 January 2012.

Richard Serra’s new sculpture, “East-West/West-East,” is a set of four standing steel plates rolled in Germany, shipped via Antwerp, and offloaded, trucked, and craned into place in the middle of the western Qatari desert. It’s his second public commission in Qatar—the first, a towering sculpture titled “7,” is his tallest ever—and it is being unveiled, together with a new work, at the Al Riwaq exhibition space, in Doha. “East-West/West-East,” which spans the greatest area of any of Serra’s creations, is yet another grand piece of public art purchased by the Gulf nation. The Qatar Museums Authority is estimated to spend about a billion dollars per year on art. At its head is the young Sheikha al-Mayassa Hamad bin Khalifa al-Thani, a sister of the Emir of Qatar and a Duke University graduate, who was recently named the most powerful person in the art world by ArtReview.

Last week, Marvel launched a new Avengers movie, “Age of Ultron,” and this month it’s launching a new comic book, “A-Force.” Ultron is a robot with artificial intelligence who believes that the only way to achieve peace on earth is to exterminate the human race. The A-Force is a race of lady Avengers, led by She-Hulk, who come from a “feminist paradise,” but I don’t know what that could possibly mean, because they all look like porn stars.

It’s an intuitive claim, but also a profound one. It asserts that the benefits of bilingualism extend well beyond the realm of language, and into skills that we use in every aspect of our lives. This view is now widespread, heralded by a large community of scientists, promoted in books and magazines, and pushed by advocacy organizations.

A landmark 2015 report that cast doubt on the results of dozens of published psychology studies has exposed deep divisions in the field, serving as a reality check for many working researchers but as an affront to others who continue to insist the original research was sound. On Thursday, a group of four researchers publicly challenged the report, arguing that it was statistically flawed and, as a result, wrong.The 2015 report, called the Reproducibility Project, found that less than 40 studies in a sample of 100 psychology papers in leading journals held up when retested by an independent team. The new critique by the four researchers countered that when that team’s statistical methodology was adjusted, the rate was closer to 100 percent.

One of the few Palestinians who has tried to teach the Holocaust, Muhammad S. Dajani Daoudi, included it in a course at Al Quds University, in Jerusalem, and took twenty-seven Palestinian students to visit Auschwitz last year. He was vilified and hounded into resigning.

The idea that poverty can change the brain has gotten significant attention recently, and not just from those lay readers (a minority, according to recent research) who spend a lot of time thinking about neuroscience. Policy makers and others have begun to apply neuroscientific principles to their thinking about poverty — and some say this could end up harming poor people rather than helping. At The Conversation, the sociologist Susan Sered takes issue with “news reports with headlines like this one: ‘Can Brain Science Help Lift People Out Of Poverty?’” She’s referring to a June story by Rachel Zimmerman at WBUR, about a nonprofit called Crittenton Women’s Union that aims to use neuroscience to help get people out of poverty. Elisabeth Babcock, Crittenton’s chief executive, tells Ms. Zimmerman: “What the new brain science says is that the stresses created by living in poverty often work against us, make it harder for our brains to find the best solutions to our problems. This is a part of the reason why poverty is so ‘sticky.’”

Using data from more than 330,000 doctors and 12 pharmaceutical firms, it identified 58% as having received payments. It found that payments were unlikely to represent significant opportunities to educate doctors about new drugs, and that financial gain appears to be an important motive for doctors. Daniel Carlat, director of the prescription project at the non-profit group Pew Trusts, says research to date shows that doctors who have dealings with drugs reps "tend to prescribe differently". "They prescribe more drugs, more expensive drugs, more brand-name drugs, and they're less likely to follow evidence-based practice guidelines in prescribing drugs.

women” in 2013, Park Yu-ha wrote that she felt “a bit fearful” of how it might be received. After all, she said, it challenged “the common knowledge” about the wartime sex slaves.But even she was not prepared for the severity of the backlash.In February, a South Korean court ordered Ms. Park’s book, “Comfort Women of the Empire,” redacted in 34 sections where it found her guilty of defaming former comfort women with false facts. Ms. Park is also on trial on the criminal charge of defaming the aging women, widely accepted here as an inviolable symbol of Korea’s suffering under colonial rule by Japan and its need for historical justice, and she is being sued for defamation by some of the women themselves.