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Nathan Goodyear

L-theanine Administration Results in Neuroprot... [Phytother Res. 2013] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...23097345

l-theanine CVA stroke neurology

shared by Nathan Goodyear on 15 Oct 13 - No Cached
  • Nathan Goodyear on 15 Oct 13
     
    l-Theanine is neuroprotective in rat mode simulating CVA.
Nathan Goodyear

Elderly men over 65 years of age with late-onset hypogonadism benefit as much from test... - 0 views

www.ncbi.nlm.nih.gov/...PMC4392031

low T low Testosterone Testosterone men male hormone hormones late onset hypogonadism hypogonadism

shared by Nathan Goodyear on 21 May 15 - No Cached
  • The benefits of restoring serum testosterone in men with LOH were not significantly different between men older than 65 years of age and younger men. There were no indications that side effects were more severe in elderly men. The effects on prostate and urinary function and hematocrit were within safe margins.
  • obesity, but also impaired general health, are the more common causes of low testosterone in aging men
  • Severe LOH is associated with substantially higher risks of all-cause and cardiovascular mortality,
  • ...30 more annotations...
  • advanced age, obesity, a diagnosis of metabolic syndrome, and poor general health status were predictors of LOH
  • Diabetes mellitus was correlated with hypogonadism in most studies
  • coronary heart disease, hypertension, stroke, and peripheral arterial disease did not predict hypogonadism, they did correlate with the incidence of low testosterone
  • LOH can be defined by the presence of at least three sexual symptoms associated with a total testosterone level of less than 11 nmol/L (3.2 ng/mL) and a free testosterone level of less than 220 pmol/L (64 pg/mL)
    • Nathan Goodyear
      Nathan Goodyear on 27 May 15
       
      the European Male Aging study defined low T as total < 320 ng/dl and free < 64 pg/ml.  
  • Mean weight decreased
  • Waist circumference decreased
  • Total cholesterol decreased
  • Low-density lipoprotein decreased
  • Triglycerides decreased
  • High-density lipoprotein (HDL) increased
  • ratio of total cholesterol to HDL improved
  • Prostate volume increased
  • PSA increased
  • The benefits for men older than 65 years of age were compared with those of younger men, and the improvements in body weight, metabolic factors, psychological functioning, and sexual functioning were of the same magnitude in both age groups
  • weight loss was progressive over the 6-year period, effects of testosterone on lipids and on psychological and sexual functioning reached a plateau after approximately 3 years and these effects were sustained
  • Effects of testosterone on hematopoiesis, on the prostate, and on bladder function were not more severe in older men than in younger men
  • observe a mild increase in prostate volume and serum PSA over time, which is a normal finding in aging men. Maybe somewhat surprising, postvoiding residue and the IPSS did not deteriorate with aging but showed a degree of improvement
  • the severity of the metabolic syndrome is associated with the severity of lower urinary tract symptoms
  • The symptoms of the metabolic syndrome improve upon testosterone treatment and testosterone may thus have a favorable effect on lower urinary tract symptoms
  • it seems reasonable to conclude that the risks of testosterone administration to elderly men are not disproportionately higher in elderly men than in younger men.
  • Despite evidence to the contrary, physicians still harbor a wrongful association between testosterone and the development of prostate pathology (prostate cancer and benign prostate hyperplasia)
  • Not surprisingly, the incidence of prostate cancer was higher in older men; however, it was lower than expected in both groups
  • These observations suggest that the incidence of prostate cancer in patients receiving testosterone therapy, both in the younger and in the older group, was not greater than in the general population not receiving testosterone treatment
  • The historical fear that raising testosterone levels will result in more prostate cancer has been dispelled, particularly by the work of Abraham Morgentaler
  • Higher serum testosterone levels fail to show an increased risk of prostate cancer, and supraphysiological testosterone does not increase prostate volume or PSA in healthy men
  • This apparent paradox is explained by the "saturation model,"
  • Recent studies indicate no increased risk of prostate cancer among men with serum testosterone in the therapeutic range
  • In the present observational study, no cases of major adverse cardiovascular events occurred.
  • the benefits of testosterone therapy are fully achieved only by long-term treatment
  • To achieve maximal benefits, good patient adherence is a prerequisite
  • Nathan Goodyear on 21 May 15
     
    Study finds new difference in Testosterone benefits and/or side effects between men < 65 with low T and men > 65 with low T.
Nathan Goodyear

Effect of androgen replacement therapy... [Clin Endocrinol (Oxf). 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25280063

atherosclerosis carotid IMT carotid intima-media thickness low T low Testosterone idiopathic hypogonadotrophic hypogonadism men male hormone hormones CVD CAD

shared by Nathan Goodyear on 06 Oct 14 - No Cached
  • Nathan Goodyear on 06 Oct 14
     
    men with idiopathic hypogonadotropic hypogonadism have increased carotid IMT--atherosclerosis.  Testosterone therapy reduced carotid IMT.  
Nathan Goodyear

http://www.ccsenet.org/journal/index.php/cco/article/viewFile/26281/16499 - 0 views

www.ccsenet.org/...16499

TK-1 cancer thymidine kinase 1

shared by Nathan Goodyear on 28 Mar 15 - No Cached
  • Nathan Goodyear on 28 Mar 15
     
    another thumbs up for TK-1.  This finds serum and tumor TK-1 differentiate from normal, healthy tissue.
Nathan Goodyear

Low serum testosterone level was associated with extensive coronary artery calcificatio... - 0 views

www.ncbi.nlm.nih.gov/...25968306

low T low Testosterone CAD coronary artery disease men male hormone s

shared by Nathan Goodyear on 22 May 15 - No Cached
  • Nathan Goodyear on 22 May 15
     
    In men > 65, low Testosterone is associated with CAD.
Nathan Goodyear

Salivary testosterone: a reliable approach to the ... [Clin Endocrinol (Oxf). 2007] - P... - 0 views

www.ncbi.nlm.nih.gov/...17953627

testosterone salivary saliva testing bioidentical hormones hormone

shared by Nathan Goodyear on 22 Nov 10 - No Cached
  • Our data showed that Sal-T is a reliable marker of testosterone bioavailability. The results support the inclusion of this biomarker as a noninvasive approach in the diagnosis of male androgen deficiency.
  • A cut-off value of Sal-T &lt; or = 0.195 nm showed 100% sensibility and specificity to rule out hypogonadism.
  • Nathan Goodyear on 22 Nov 10
     
    Salivary testosterone: a reliable approach to the diagnosis of male hypogonadism.
Nathan Goodyear

Testosterone and obesity. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25982085

Testosterone obesity hormones hormone

shared by Nathan Goodyear on 22 May 15 - No Cached
  • Nathan Goodyear on 22 May 15
     
    Testosterone and obesity is bidirectional: thus Testosterone therapy in men with low T will improve metabolism
Nathan Goodyear

Clinical significance of therapy using branched-chain amino acid granules in patients w... - 0 views

onlinelibrary.wiley.com/...full

hepatitis C hepatitis BCAA amino acids liver disease cancer hepatocellular

shared by Nathan Goodyear on 20 May 15 - No Cached
  • Nathan Goodyear on 20 May 15
     
    BCAA reduces incidence of hepatocellular cancer in patients with HCV.
Nathan Goodyear

Oral supplementation with branched-chain amino acid granules prevents hepatocarcinogene... - 0 views

www.ncbi.nlm.nih.gov/...23607436

BCAA amino acids liver disease cancer HCV hepatitis C hepatocellular cirrhosis hepatitis

shared by Nathan Goodyear on 20 May 15 - No Cached
  • Nathan Goodyear on 20 May 15
     
    Study finds 12 g/day BCAA reduced the incidence of hepatocellular carcinoma in those patients with HCV.
Nathan Goodyear

The effect of long-term supplementation with branched-chain amino acid granules in pati... - 0 views

www.ncbi.nlm.nih.gov/...23090049

BCAA amino acids HCV hepatitis hepatitis C liver disease cancer hepatocellular

shared by Nathan Goodyear on 20 May 15 - No Cached
  • Nathan Goodyear on 20 May 15
     
    BCAA improve overall survival in HCV related liver cancer.
Nathan Goodyear

Glucose Fluctuations in Association With Oxidative Stress Among Children With T1DM: Com... - 0 views

press.endocrine.org/...jc.2014-2879

diabetes oxidative stress

shared by Nathan Goodyear on 20 May 15 - No Cached
  • Nathan Goodyear on 20 May 15
     
    glucose fluctuations in type I diabetic children associated with oxidative stress.
Nathan Goodyear

Inflammatory and Cardiometabolic Risk on Obesity: Role of Environmental Xenoestrogens: ... - 0 views

press.endocrine.org/...jc.2014-4136

xenoestrogen xenoestrogens obesity cardiovascular disease inflammation women obese hormones

shared by Nathan Goodyear on 20 May 15 - No Cached
  • Nathan Goodyear on 20 May 15
     
    Study finds heavy presence of xenoestrogens in obese Portuguese women, both pre menopause and post menopause.  This study only looked at obese women; it would be nice to have a control of thin women to contrast the plasma and adipose xenoestrogen levels.  The authors found the presence of xenoestrogens in plasma in pre menopause women to be a 10 year predictor of cardiovascular disease risk in these women.  The authors also found increased Xenoestrogen levels to be associated with metabolic dysfunction and inflammation.
Nathan Goodyear

Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis ... - 0 views

www.ncbi.nlm.nih.gov/...22797645

milk thistle hepatitis C hepatitis liver disease HCV

shared by Nathan Goodyear on 20 May 15 - No Cached
  • Nathan Goodyear on 20 May 15
     
    study finds milk thistle unsuccessful in lower ALT in HCV patients that had failed interferon therapy.  The dosing used in this study was low.
Nathan Goodyear

A conservative triple antioxidant approach to the treatment of hepatitis C. Combination... - 0 views

www.ncbi.nlm.nih.gov/...10554539

alpha lipoic acid milk thistle selenium hepatitis C liver disease

shared by Nathan Goodyear on 20 May 15 - No Cached
  • Nathan Goodyear on 20 May 15
     
    Alpha lipoic acid, milk thistle, and selenium found useful in 3 case studies with hepatitis C.  Only abstract available here.
Nathan Goodyear

Amino acid management of Parkinson's disease: a case study - 0 views

www.ncbi.nlm.nih.gov/...PMC3068871

Parkinson's disease Parkinson's disease amino acids natural

shared by Nathan Goodyear on 18 May 15 - No Cached
  • Nathan Goodyear on 18 May 15
     
    to be read
Nathan Goodyear

Seasonal variation of salivary testosterone in men, normally cycling women, and women u... - 0 views

www.ncbi.nlm.nih.gov/...PMC3494403

men male hormone hormones testing seasonal Testosterone saliva salivary hormones salivary hormone

shared by Nathan Goodyear on 18 May 15 - No Cached
  • Nathan Goodyear on 18 May 15
     
    study of 296 men with mean age at 22.7, have peak salivary Testosterone production in December and January. 
Nathan Goodyear

Testosterone modulates cardiac contraction and calcium homeostasis: cellular and molecu... - 0 views

www.ncbi.nlm.nih.gov/...PMC4411792

testosterone low Testosterone low T heart health calcium men male hormone hormones

shared by Nathan Goodyear on 18 May 15 - No Cached
  • Nathan Goodyear on 18 May 15
     
    low Testosterone is associated with calcium dysregulation in the heart.
Nathan Goodyear

[Testosterone replacement therapy and prostate cancer: the downfall of a paradigm?]. - ... - 0 views

www.ncbi.nlm.nih.gov/...25919660

Testosterone prostate cancer hormone hormones

shared by Nathan Goodyear on 18 May 15 - No Cached
  • Nathan Goodyear on 18 May 15
     
    In this time of evidence-based medicine, the prevailing therapy that Testosterone causes prostate cancer is devoid of evidence.
Nathan Goodyear

Global burden of cancer attributable to high body-mass index in 2012: a population-base... - 0 views

www.thelancet.com/...abstract

BMI cancer obesity

shared by Nathan Goodyear on 21 Jan 15 - No Cached
  • Nathan Goodyear on 21 Jan 15
     
    Worldwide increase in BMI is associated with increase in Cancer.  This article, abstract only available here, found that up to 6% of new cancer cases is associated with a high BMI.
Nathan Goodyear

Serum and Dietary Potassium and Risk of Incident Type 2 Diabetes: The Atherosclerosis R... - 0 views

www.ncbi.nlm.nih.gov/...PMC3469719

potassium diabetes

shared by Nathan Goodyear on 12 May 15 - No Cached
  • Nathan Goodyear on 12 May 15
     
    Potassium less than 4.5 associated with increased risk of type II Diabetes.  Even 4.5 to 5 was associated with increased risk.
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