Best content in Dr. Goodyear

Aromatase activity in the rat brain: Hormonal regulation and sex differences - 0 views

www.sciencedirect.com/...096007609390254T

DHT estradiol Testosterone aromatase

shared by Nathan Goodyear on 27 Jan 14 - No Cached

Nathan Goodyear on 27 Jan 14

Rat study finds balance of DHT and estradiol play important role. The production of DHT removes Testosterone from the pool to make estradiol through aromatase activity.

<div class="cArrow"> </div><div class="cContentInner">Rat study finds balance of DHT and estradiol play important role. The production of DHT removes Testosterone from the pool to make estradiol through aromatase activity.</div>

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The Androgen Derivative 5α-Androstane-3β,17β-Diol Inhibits Prostate Cancer Ce... - 0 views

cancerres.aacrjournals.org/...5445.full

prostate cancer 3-beta androstanediol DHT metabolite E-cadherin ER beta ER-beta male hormone hormones men

shared by Nathan Goodyear on 27 Jan 14 - No Cached

In the early stages, prostate cancer growth is dependent on circulating androgens
- Nathan Goodyear on 27 Jan 14
  
  This is in contrast to studies that show poor prognosis with Lower T at time of diagnosis of prostate cancer
  
  <div class="cArrow"> </div><div class="cContentInner">This is in contrast to studies that show poor prognosis with Lower T at time of diagnosis of prostate cancer</div>
  
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5α-reductase not only provides a potent amplification of the androgenic signal ( 4– 6), but it also prevents estrogen formation by subtracting testosterone from the action of aromatase ( 7, 8), thus blocking activation of the estrogen receptor subtypes (ERα and ERβ; refs. 9, 10)
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ERβ is the prevailing subtype ( 11), and a growing body of evidence points to the protective role of this receptor in prostate cancer
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It has been shown that the transformation of the dihydrotestosterone to 5α-androstane-3α,17β-diol (3α-diol) and 5α-androstane-3β,17β-diol (3β-Adiol), generates two metabolites unable to bind the androgen receptor, but possessing a very high affinity for the estrogen receptors
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the effects of testosterone may result from the balance between the androgenic and the estrogenic molecules originating from its catabolism.
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Recent data have been published postulating a direct estrogenic role of the 3β-hydroxylated derivatives of dihydrotestosterone in the prostate development and homeostasis
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Nathan Goodyear on 27 Jan 14

Here is the full article.

<div class="cArrow"> </div><div class="cContentInner">Here is the full article.</div>

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The Androgen Derivative 5α-Androstane-3β,17β-Diol Inhibits Prostate Cancer Ce... - 0 views

cancerres.aacrjournals.org/...5445.short

prostate cancer DHT metabolite 3-alpha androstanediol ER beta ER-beta E-cadherin male hormone hormones men

shared by Nathan Goodyear on 27 Jan 14 - No Cached

the dihydrotestosterone metabolite 5α-androstane-3β,17β-diol (3β-Adiol), a steroid which does not bind androgen receptors, but efficiently binds the estrogen receptor β (ERβ), exerts a potent inhibition of prostate cancer cell migration through the activation of the ERβ signaling
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estradiol is not active
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3β-Adiol, through ERβ, induces the expression of E-cadherin, a protein known to be capable of blocking metastasis formation in breast and prostate cancer cells
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Nathan Goodyear on 27 Jan 14

DHT metabolite 3-beta androstanediol inhibits prostate cancer via its interaction with ER beta not AR. This study finds increased E-cadherin transcription to reduce metastasis. Estrogen was not active, according to this study. This implies that estrogen in early disease may have a different signal than late.

<div class="cArrow"> </div><div class="cContentInner">DHT metabolite 3-beta androstanediol inhibits prostate cancer via its interaction with ER beta not AR. This study finds increased E-cadherin transcription to reduce metastasis. Estrogen was not active, according to this study. This implies that estrogen in early disease may have a different signal than late.</div>

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5alpha-androstane-3alpha,17beta-diol selectively activates the canonical PI3K/AKT pathw... - 0 views

www.researchgate.net/...ctivated_cytoplasmic_signaling

3 alpha-androstanediol prostate cancer

shared by Nathan Goodyear on 27 Jan 14 - No Cached

Nathan Goodyear on 27 Jan 14

3-alpha androstanediol known to stimulate prostate cancer cell proliferation via ER alpha with little no affinity for AR. This study finds cell signaling via AR independent mechanism--AKT pathway.

<div class="cArrow"> </div><div class="cContentInner">3-alpha androstanediol known to stimulate prostate cancer cell proliferation via ER alpha with little no affinity for AR. This study finds cell signaling via AR independent mechanism--AKT pathway.</div>

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Association of Preoperative Testosterone Levels with Biochemical Failure in Men Undergo... - 0 views

online.liebertpub.com/...jomh.2013.0016

Testosterone low T prostate cancer male men hormone hormones

shared by Nathan Goodyear on 25 Jan 14 - No Cached

Nathan Goodyear on 25 Jan 14

Low Testosterone as defined via serum levels found to correlate with poor outcome in prostate cancer: positive margins, seminal vesicle invasion, and biochemical failure (ADR).

<div class="cArrow"> </div><div class="cContentInner">Low Testosterone as defined via serum levels found to correlate with poor outcome in prostate cancer: positive margins, seminal vesicle invasion, and biochemical failure (ADR).</div>

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http://ar.iiarjournals.org/content/28/4B/2129.full.pdf - 0 views

ar.iiarjournals.org/...2129.full.pdf

breast cancer progesterone metabolite metabolites 4-pregnene aromatase

shared by Nathan Goodyear on 23 Jan 14 - No Cached

Nathan Goodyear on 23 Jan 14

20alpha dihydroprogesterone, a 4 pregnene, has been shown to inhibit breast cancer cell proliferation, decrease mets through increased cell adhesion, and increased apoptosis. Here, it has been shown to inhibit aromatase activity. No longer are hormone metabolites to be viewed as waste. They are biological as active if not more so in many cases.

<div class="cArrow"> </div><div class="cContentInner">20alpha dihydroprogesterone, a 4 pregnene, has been shown to inhibit breast cancer cell proliferation, decrease mets through increased cell adhesion, and increased apoptosis. Here, it has been shown to inhibit aromatase activity. No longer are hormone metabolites to be viewed as waste. They are biological as active if not more so in many cases.</div>

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Breast Cancer Research | Full text | Progesterone metabolites regulate induction, growt... - 0 views

breast-cancer-research.com/...R38

breast cancer progesterone metabolite metabolites 5-alpha-pregnanediol 4-pregnene

shared by Nathan Goodyear on 23 Jan 14 - No Cached

Nathan Goodyear on 23 Jan 14

5alpha pregnanes and 4 pregnanes stimulate ER and PR negative breast cancer cells. Progesterone metabolites stimulate or inhibit cancer potential independent of receptor status. Though we know that progesterone metabolite balance can increase receptor binding.

<div class="cArrow"> </div><div class="cContentInner">5alpha pregnanes and 4 pregnanes stimulate ER and PR negative breast cancer cells. Progesterone metabolites stimulate or inhibit cancer potential independent of receptor status. Though we know that progesterone metabolite balance can increase receptor binding.</div>

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Activity and expression of progesterone metabolizing 5α-reductase, 20α-hydrox... - 0 views

www.researchgate.net/...10A)_human_breast_cancer_cells

progesterone metabolites breast cancer 5-alpha-pregnanediol 4-pregnenediol

shared by Nathan Goodyear on 23 Jan 14 - No Cached

Nathan Goodyear on 23 Jan 14

Intra mammary progesterone metabolism and its associated metabolites found to be associated with tumorigenic activity in cell lines. This was independent from ER PR status. 5 alpha-pregnanes were found to be pro-tumor and 4-pregnanes were anti-tumor.

<div class="cArrow"> </div><div class="cContentInner">Intra mammary progesterone metabolism and its associated metabolites found to be associated with tumorigenic activity in cell lines. This was independent from ER PR status. 5 alpha-pregnanes were found to be pro-tumor and 4-pregnanes were anti-tumor.</div>

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5alpha-androstane-3alpha,17beta-diol supports... [J Cell Biochem. 2008] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...18320593

5-alpha androstanediol 3-alpha androstanediol DHT metabolite prostate cancer hormone hormones metabolites androgen receptors AR estrogen ER

shared by Nathan Goodyear on 23 Jan 14 - No Cached

Nathan Goodyear on 23 Jan 14

5 alpha androstanediol promotes prostate cancer growth and survival independent of androgen receptors. This study didn't clarify the mechanism. We no know that this occurs via estrogen receptor alpha. Thus a Testosterone metabolite signals through an estrogen receptor.

<div class="cArrow"> </div><div class="cContentInner">5 alpha androstanediol promotes prostate cancer growth and survival independent of androgen receptors. This study didn't clarify the mechanism. We no know that this occurs via estrogen receptor alpha. Thus a Testosterone metabolite signals through an estrogen receptor.</div>

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