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Dr. Goodyear

Dr. Goodyear is passionate about all things wellness. In particular, Dr. Goodyear is the Medical Director at Brio-Medical in Arizona to take on one of the greatest obstacles to long-term wellness in the Western hemisphere--cancer. In addition, Dr. Goodyear is the Chairman of the Scientific Medical Advisory Board of the Vitamin C International Consortium Institute (VCICI)

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5alpha-androstane-3alpha,17beta-diol selectively activates the canonical PI3K/AKT pathw... - 0 views

www.researchgate.net/...ctivated_cytoplasmic_signaling

3 alpha-androstanediol prostate cancer

shared by Nathan Goodyear on 27 Jan 14 - No Cached

Nathan Goodyear on 27 Jan 14

3-alpha androstanediol known to stimulate prostate cancer cell proliferation via ER alpha with little no affinity for AR. This study finds cell signaling via AR independent mechanism--AKT pathway.

<div class="cArrow"> </div><div class="cContentInner">3-alpha androstanediol known to stimulate prostate cancer cell proliferation via ER alpha with little no affinity for AR. This study finds cell signaling via AR independent mechanism--AKT pathway.</div>

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Association of Preoperative Testosterone Levels with Biochemical Failure in Men Undergo... - 0 views

online.liebertpub.com/...jomh.2013.0016

Testosterone low T prostate cancer male men hormone hormones

shared by Nathan Goodyear on 25 Jan 14 - No Cached

Nathan Goodyear on 25 Jan 14

Low Testosterone as defined via serum levels found to correlate with poor outcome in prostate cancer: positive margins, seminal vesicle invasion, and biochemical failure (ADR).

<div class="cArrow"> </div><div class="cContentInner">Low Testosterone as defined via serum levels found to correlate with poor outcome in prostate cancer: positive margins, seminal vesicle invasion, and biochemical failure (ADR).</div>

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http://ar.iiarjournals.org/content/28/4B/2129.full.pdf - 0 views

ar.iiarjournals.org/...2129.full.pdf

breast cancer progesterone metabolite metabolites 4-pregnene aromatase

shared by Nathan Goodyear on 23 Jan 14 - No Cached

Nathan Goodyear on 23 Jan 14

20alpha dihydroprogesterone, a 4 pregnene, has been shown to inhibit breast cancer cell proliferation, decrease mets through increased cell adhesion, and increased apoptosis. Here, it has been shown to inhibit aromatase activity. No longer are hormone metabolites to be viewed as waste. They are biological as active if not more so in many cases.

<div class="cArrow"> </div><div class="cContentInner">20alpha dihydroprogesterone, a 4 pregnene, has been shown to inhibit breast cancer cell proliferation, decrease mets through increased cell adhesion, and increased apoptosis. Here, it has been shown to inhibit aromatase activity. No longer are hormone metabolites to be viewed as waste. They are biological as active if not more so in many cases.</div>

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Breast Cancer Research | Full text | Progesterone metabolites regulate induction, growt... - 0 views

breast-cancer-research.com/...R38

breast cancer progesterone metabolite metabolites 5-alpha-pregnanediol 4-pregnene

shared by Nathan Goodyear on 23 Jan 14 - No Cached

Nathan Goodyear on 23 Jan 14

5alpha pregnanes and 4 pregnanes stimulate ER and PR negative breast cancer cells. Progesterone metabolites stimulate or inhibit cancer potential independent of receptor status. Though we know that progesterone metabolite balance can increase receptor binding.

<div class="cArrow"> </div><div class="cContentInner">5alpha pregnanes and 4 pregnanes stimulate ER and PR negative breast cancer cells. Progesterone metabolites stimulate or inhibit cancer potential independent of receptor status. Though we know that progesterone metabolite balance can increase receptor binding.</div>

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Activity and expression of progesterone metabolizing 5α-reductase, 20α-hydrox... - 0 views

www.researchgate.net/...10A)_human_breast_cancer_cells

progesterone metabolites breast cancer 5-alpha-pregnanediol 4-pregnenediol

shared by Nathan Goodyear on 23 Jan 14 - No Cached

Nathan Goodyear on 23 Jan 14

Intra mammary progesterone metabolism and its associated metabolites found to be associated with tumorigenic activity in cell lines. This was independent from ER PR status. 5 alpha-pregnanes were found to be pro-tumor and 4-pregnanes were anti-tumor.

<div class="cArrow"> </div><div class="cContentInner">Intra mammary progesterone metabolism and its associated metabolites found to be associated with tumorigenic activity in cell lines. This was independent from ER PR status. 5 alpha-pregnanes were found to be pro-tumor and 4-pregnanes were anti-tumor.</div>

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5alpha-androstane-3alpha,17beta-diol supports... [J Cell Biochem. 2008] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...18320593

5-alpha androstanediol 3-alpha androstanediol DHT metabolite prostate cancer hormone hormones metabolites androgen receptors AR estrogen ER

shared by Nathan Goodyear on 23 Jan 14 - No Cached

Nathan Goodyear on 23 Jan 14

5 alpha androstanediol promotes prostate cancer growth and survival independent of androgen receptors. This study didn't clarify the mechanism. We no know that this occurs via estrogen receptor alpha. Thus a Testosterone metabolite signals through an estrogen receptor.

<div class="cArrow"> </div><div class="cContentInner">5 alpha androstanediol promotes prostate cancer growth and survival independent of androgen receptors. This study didn't clarify the mechanism. We no know that this occurs via estrogen receptor alpha. Thus a Testosterone metabolite signals through an estrogen receptor.</div>

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Scleroderma - 8 - Fibroblasts, Systemic Sclerosis, Calcitriol - Life Extension Health C... - 0 views

www.lef.org/...scleroderma_08.htm

scleroderma natural therapy treatment

shared by Nathan Goodyear on 22 Jan 14 - No Cached

Nathan Goodyear on 22 Jan 14

nice review of natural therapies for scleroderma. Life extensions always does a great job of supporting natural therapies with science.

<div class="cArrow"> </div><div class="cContentInner">nice review of natural therapies for scleroderma. Life extensions always does a great job of supporting natural therapies with science.</div>

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JAMA Network | JAMA Dermatology | Oral Calcitriol as a New Therapeutic Modality for Gen... - 0 views

archderm.jamanetwork.com/article.aspx

vitamin D vitamin D morphea autoimmune disease inflammation scleroderma

shared by Nathan Goodyear on 22 Jan 14 - No Cached

Nathan Goodyear on 22 Jan 14

vitamin D therapy in small study of children with morphea found significant improvement with skin and joint mobility. The dosing was small and duration of therapy was only up to 7 months. The benefits was found to extend to up to 2 years.

<div class="cArrow"> </div><div class="cContentInner">vitamin D therapy in small study of children with morphea found significant improvement with skin and joint mobility. The dosing was small and duration of therapy was only up to 7 months. The benefits was found to extend to up to 2 years.</div>

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Treatment of linear scleroderma wit... [Pediatr Dermatol. 1999 Jan-Feb] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...10028002

scleroderma vitamin D vitamin D autoimmune disease

shared by Nathan Goodyear on 22 Jan 14 - No Cached

Nathan Goodyear on 22 Jan 14

Very small study finds benefit, described as good to excellent, of vitamin D therapy in 5 of 7 children with linear, cutaneous scleroderma. Only the abstract is available, but one wonders if they were using sub-therapeutic therapy as most do.

<div class="cArrow"> </div><div class="cContentInner">Very small study finds benefit, described as good to excellent, of vitamin D therapy in 5 of 7 children with linear, cutaneous scleroderma. Only the abstract is available, but one wonders if they were using sub-therapeutic therapy as most do.</div>

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Curcumin-induced Apoptosis of Human Colon Cancer Colo 205 Cells through the Production ... - 0 views

ar.iiarjournals.org/...4379.short

colon colon cancer cancer curcumin tumeric

shared by Nathan Goodyear on 22 Jan 14 - No Cached

Nathan Goodyear on 22 Jan 14

Curcumin found to induce apoptosis, cell death, of colon cancer cells.

<div class="cArrow"> </div><div class="cContentInner">Curcumin found to induce apoptosis, cell death, of colon cancer cells.</div>

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http://www.curcumin.co.nz/pdf/Curcumin_Getting_Back_To_The_Roots.pdf - 0 views

www.curcumin.co.nz/..._Getting_Back_To_The_Roots.pdf

curcumin turmeric disease natural therapy treatment

shared by Nathan Goodyear on 22 Jan 14 - No Cached

Nathan Goodyear on 22 Jan 14

Great, exhaustive review of turmeric and disease.

<div class="cArrow"> </div><div class="cContentInner">Great, exhaustive review of turmeric and disease.</div>

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Curcumin-induced apoptosis in scleroderma lung fibroblasts - Role of protein kinase Cep... - 0 views

eurekamag.com/...of-protein-kinase-cepsilon.php

curcumin tumeric autoimmune disease scleroderma fibrosis

shared by Nathan Goodyear on 22 Jan 14 - No Cached

Nathan Goodyear on 22 Jan 14

Curcumin found to cause apoptosis of fibrotic pulmonary cells versus no effect on healthy pulmonary cells.

<div class="cArrow"> </div><div class="cContentInner">Curcumin found to cause apoptosis of fibrotic pulmonary cells versus no effect on healthy pulmonary cells.</div>

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Curcumin suppresses TGF-β signaling by inhibition of TGIF degradation in scle... - 0 views

www.sciencedirect.com/...S0006291X11012630

curcumin tumeric scleroderma autoimmune disease TGF-beta inflammation

shared by Nathan Goodyear on 22 Jan 14 - No Cached

Nathan Goodyear on 22 Jan 14

Curcumin reduces fibrosis in scleroderma via TGF-beta inhibition. TGF-beta plays an important role in the fibrosis in scleroderma.

<div class="cArrow"> </div><div class="cContentInner">Curcumin reduces fibrosis in scleroderma via TGF-beta inhibition. TGF-beta plays an important role in the fibrosis in scleroderma.</div>

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[Madecassol treatment of systemic and localized scl... [Ter Arkh. 1998] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...9644746

Gotu kola scleroderma inflammation autoimmune disease Centella asiatica

shared by Nathan Goodyear on 22 Jan 14 - No Cached

Nathan Goodyear on 22 Jan 14

Gotu kola found to benefit the fibrosis in scleroderma both via oral and topical dosing.

<div class="cArrow"> </div><div class="cContentInner">Gotu kola found to benefit the fibrosis in scleroderma both via oral and topical dosing.</div>

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Effect of melatonin on normal and... [Clin Exp Rheumatol. 1996 Sep-Oct] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...8913650

melatonin fibrosis scleroderma autoimmune disease

shared by Nathan Goodyear on 22 Jan 14 - No Cached

Nathan Goodyear on 22 Jan 14

Melatonin inhibits fibrosis.

<div class="cArrow"> </div><div class="cContentInner">Melatonin inhibits fibrosis.</div>

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Effectiveness of a treatment based on mela... [Am J Ther. 2006 Jan-Feb] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...16428927

melatonin vitamin E vitamin E scleroderma autoimmune disease

shared by Nathan Goodyear on 22 Jan 14 - No Cached

Nathan Goodyear on 22 Jan 14

Very small study, 5 patients, found that melatonin + vitamin E provided stabilization of scleroderma at 2 months of therapy.

<div class="cArrow"> </div><div class="cContentInner">Very small study, 5 patients, found that melatonin + vitamin E provided stabilization of scleroderma at 2 months of therapy.</div>

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Effects of potassium para-aminobenzoate on... [J Invest Dermatol. 1979] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...155125

scleroderma fibrosis PABA autoimmune disease

shared by Nathan Goodyear on 22 Jan 14 - No Cached

Nathan Goodyear on 22 Jan 14

PABA at high doses shown to reduce fibrosis in those with scleroderma.

<div class="cArrow"> </div><div class="cContentInner">PABA at high doses shown to reduce fibrosis in those with scleroderma.</div>

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Epigallocatechin-3-gallate ameliorates experimental autoimmune encephalomyelitis by alt... - 0 views

www.researchgate.net/...lance_among_CD4_T-cell_subsets

EGCG epigallocatechin-3-gallate autoimmune disease MS cytokine cytokines inflammation

shared by Nathan Goodyear on 22 Jan 14 - No Cached

Nathan Goodyear on 22 Jan 14

EGCG found to reduce cytokine production in animal model of MS, experimental autoimmune encephalomyelitis. Specifically, EGCG reduced interferon gamma, IL017, IL-6, IL-1beta, TNF-alpha and decreased Th1 and Th17 cells with an increase in Treg cells.

<div class="cArrow"> </div><div class="cContentInner">EGCG found to reduce cytokine production in animal model of MS, experimental autoimmune encephalomyelitis. Specifically, EGCG reduced interferon gamma, IL017, IL-6, IL-1beta, TNF-alpha and decreased Th1 and Th17 cells with an increase in Treg cells.</div>

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http://www.expert-reviews.com/doi/pdf/10.1586/eci.11.67 - 0 views

www.expert-reviews.com/...eci.11.67

EGCG autoimmune disease inflammation

shared by Nathan Goodyear on 22 Jan 14 - No Cached

Nathan Goodyear on 22 Jan 14

Review finds EGCG benefits autoimmune disease. Evidence primarily is animal due to human studies lacking. EGCG is a suppresses T-cell production and inhibits NF-kappa B and thus inflammation.

<div class="cArrow"> </div><div class="cContentInner">Review finds EGCG benefits autoimmune disease. Evidence primarily is animal due to human studies lacking. EGCG is a suppresses T-cell production and inhibits NF-kappa B and thus inflammation.</div>

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Journal of Investigative Dermatology - Abstract of article: Green Tea Polyphenol Epigal... - 0 views

www.nature.com/...jid2008103a.html

EGCG keloid green tea epigallocatechin-3-gallate

shared by Nathan Goodyear on 22 Jan 14 - No Cached

Nathan Goodyear on 22 Jan 14

EGCG suppressed collagen production in keloid formation in this study.

<div class="cArrow"> </div><div class="cContentInner">EGCG suppressed collagen production in keloid formation in this study.</div>

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