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in title, tags, annotations or urlNivolumab for previously treated unresectable metastatic anal cancer (NCI9673): a multicentre, single-arm, phase 2 study - 0 views
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Patients received a median of six doses of nivolumab
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four of the first 12 patients had partial responses
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Nine (24% [95% CI 15–33]) of 37 patients achieved a response (seven partial responses and two complete responses
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Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal - 0 views
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Hydroxyl radicals cause oxidative damage to cells because they unspecifically attack biomolecules [22] located less than a few nanometres from its site of generation and are involved in cellular disorders such as neurodegeneration [23, 24], cardiovascular disease [25], and cancer [26, 27].
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It is generally assumed that in biological systems is formed through redox cycling by Fenton reaction, where free iron (Fe2+) reacts with hydrogen peroxide (H2O2) and the Haber-Weiss reaction that results in the production of Fe2+ when superoxide reacts with ferric iron (Fe3+)
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other transition-metal including Cu, Ni, Co, and V can be responsible for formation in living cells
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Induction of metastasis, cancer stem cell phenotype, and oncogenic metabolism in cancer cells by ionizing radiation - 0 views
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More than half of cancer patients are treated with IR at some point during their treatment
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fractionation schedule is the delivery of 1.8–2.0 Gy per day, five days per week
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Nuclear DNA is the primary target of IR; it causes DNA damage (genotoxic stress) by direct DNA ionization
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