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Nathan Goodyear

Curcumin inhibits angiogenesis and improves defective hematopoiesis induced by tumor-derived VEGF in tumor model through modulating VEGF-VEGFR2 signaling pathway - 0 views

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    Curcumin inhibits VEGF to inhibit angiogenesis.
Nathan Goodyear

Immunosuppressive Myeloid Cells Induced by Chemotherapy Attenuate Antitumor CD4+ T-Cell Responses through the PD-1-PD-L1 Axis | Cancer Research - 0 views

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    This study points to the increase in immunosuppression as a result of chemotherapy induced increase in MDSCs and T reg. This effect is dose dependent.
Nathan Goodyear

Thymosin alpha-1 blocks the accumulation of myeloid suppressor cells in NSCLC by inhibiting VEGF production - PubMed - 0 views

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    TA-1 alters tumor microenvironment via VEGF induced decrease in MDSC.
Nathan Goodyear

Molecular Targeting of H/MDM-2 Oncoprotein in Human Colon Cancer Cells and Stem-like Colonic Epithelial-derived Progenitor Cells - PubMed - 0 views

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    PNC-27 selectively kills colon cancer stem cells by binding to membrane H/MDM-2. This was an in vivo study. As with other studies, the result was tumor cell necrosis and associated high LDH release.
Nathan Goodyear

Methionine enkephalin (MENK) improved the functions of bone marrow-derived dendritic cells (BMDCs) loaded with antigen - 0 views

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    MET-enkephalin acts as an immunomodulator via dendritic cell and CD8 activity
Nathan Goodyear

MicroRNAs Derived from Extracellular Vesicles: Keys to Understanding SARS-CoV-2 Vaccination Response in Cancer Patients? - Abstract - Europe PMC - 0 views

  • the clinical trials for COVID-19 vaccines did not include cancer patients, leaving a knowledge gap about how vaccination affects this vulnerable population
Nathan Goodyear

Frontiers | Antitumor Effects of Cannabinoids in Human Pancreatic Ductal Adenocarcinoma Cell Line (Capan-2)-Derived Xenograft Mouse Model - 0 views

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    dose-dependent trigger of pancreatic cancer apoptosis in mouse model. They dosed up to 10 mg/kg at a ratio of THC:CBD of 1:6.
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