Skip to main content

Home/ Dr. Goodyear/ Group items matching "Cd" in title, tags, annotations or url

Group items matching
in title, tags, annotations or url

Sort By: Relevance | Date Filter: All | Bookmarks | Topics Simple Middle
Nathan Goodyear

http://cancerdiscovery.aacrjournals.org/content/early/2016/05/28/2159-8290.CD-15-1177.full.pdf - 0 views

cancerdiscovery.aacrjournals.org/...2159-8290.CD-15-1177.full.pdf

cancer obesity inflammation

shared by Nathan Goodyear on 11 Jul 16 - No Cached
  • Nathan Goodyear on 11 Jul 16
     
    No surprise here, obesity favors cancer.
Nathan Goodyear

http://www.update-software.com/BCP/WileyPDF/EN/CD007365.pdf - 0 views

www.update-software.com/...CD007365.pdf

huperzine huperzine-A huperzine A dementia Alzheimer's alzheimer's disease Alzheimers

shared by Nathan Goodyear on 10 Apr 14 - No Cached
  • Nathan Goodyear on 10 Apr 14
     
    meta-analysis found no high level of evidence to support Huperzine A in the treatment of vascular dementia.  The conclusion sounds scientifically sound, but when you look at the studies included: this is a meta-analysis of 1 of Huperzine A and vascular dementia.  This one study was of 14 participants only and they found improvement in daily functioning.   There are a lot of animal studies that point out benefits of huperzine A and even the mechanisms of action,  but human studies are lacking.  That is a better conclusion.  
Nathan Goodyear

Exposure to Bisphenol A Prenatally or in Adulthood Promotes TH2 Cytokine Production Associated with Reduction of CD4+CD25+ Regulatory T Cells - 0 views

www.ncbi.nlm.nih.gov/...PMC2290985

BPA plastics endocrine disruptor immune T reg cells

shared by Nathan Goodyear on 01 Jul 11 - No Cached
  • BPA promotes the development of TH2 cells in adulthood and both TH1 and TH2 cells in prenatal stages by reducing the number of regulatory T cells.
  • Bisphenol A (BPA), an estrogenic endocrine-disrupting chemical (EDC
  • BPA is one of the most widespread EDCs.
  • ...12 more annotations...
  • BPA antagonizes the actions of thyroid hormone
  • Prenatal exposure to BPA has been shown to alter a variety of reproductive endocrine parameters, such as testosterone and luteinizing hormone levels
  • arly onset of sexual maturation of female mice
  • imbalanced T-helper (TH)1/TH2 immune responses have been demonstrated on exposure to BPA
  • indicating that BPA exerted its effects by reducing the number of Treg cells.
  • Exposure to BPA by subcutaneous injection in adulthood significantly promoted antigen-stimulated production of IL-4, IL-10, and IL-13 in TH2-skewed
  • BPA can leak from the placenta and accumulate in the fetus
  • We showed that prenatal exposure to BPA increased the production of a TH1 cytokine, IFN-γ, and a TH2 cytokine, IL-4, after the offspring developed, suggesting that prenatal exposure to BPA can induce persistent immunologic effects lasting into adulthood.
  • These results are consistent with a previous report that fetal exposure to BPA augmented TH1 and TH2 immune responses
  • our results clearly demonstrate that the production of TH2 cytokines is promoted by BPA in adult mice and in offspring during developmental exposure.
  • The decrease of Treg cells would predispose to immune dysfunction in aged individuals, explaining their higher risk of immune-mediated diseases, cancer, and infections.
  • BPA might cause these diseases. Thus, avoiding exposure to or promoting the excretion of BPA and other EDCs would help in preventing diseases and adverse health effects.
  • Nathan Goodyear on 01 Jul 11
     
    BPA as endocrine disruptor and as immune disruptor
Nathan Goodyear

Safety and immunologic effects of high- vs low-dose cholecalciferol in multiple sclerosis - 0 views

www.neurology.org/...382

vitamin D MS multiple Sclerosis inflammation IL-17

shared by Nathan Goodyear on 25 Feb 16 - No Cached
  • Nathan Goodyear on 25 Feb 16
     
    High dose vitamin D (10,400 IU) found to reduce IL-17, CD161 and effector memory cells; in contrast low dose vitamin D (800 IU)  did not.  The study also called into question the traditional target range of vitamin D.  The authors here proposed 40-60
Nathan Goodyear

http://www.medsci.org/v12p0042.pdf - 0 views

www.medsci.org/v12p0042.pdf

mistletoe NK cells endometriosis

shared by Nathan Goodyear on 06 Jul 18 - No Cached
  • Nathan Goodyear on 06 Jul 18
     
    Study shows mistletoe to increase NK cell activation through upregulation of CD107a.
Nathan Goodyear

American Journal of Obstetrics & Gynecology Home Page - 0 views

www.ajog.org/...fulltext

"Vaginal mesh" immune system

shared by Nathan Goodyear on 31 Aug 18 - No Cached
  • M1 macrophages are characterized by the secretion of reactive oxygen species and proinflammatory cytokines and chemokines and can be identified via the cell surface marker CD86
  • M2 macrophages secrete growth factors and antiinflammatory immune modulators and can be identified by the cell surface marker CD206
  • an overzealous M2 response can also lead to excess tissue deposition and fibrosis
  • ...14 more annotations...
  • Studies of similar meshes that are used in hernia repair have demonstrated that all polypropylene meshes induce a prolonged inflammatory response at the site of implantation
  • the long-term presence of activated inflammatory cells, such as macrophages at the mesh tissue interface, can impact negatively the ability of the mesh to function as intended.
  • All M1 proinflammatory and M2 proremodeling cytokines and chemokines were increased in mesh explants as compared with nonmesh tissue (Table 3Table 3), which indicated a robust, active, and ongoing host response to polypropylene long after implantation
  • Comparison of the ratio of the M2 proremodeling cytokines (IL-10+IL-4) with the M1 proinflammatory cytokines (TNF-α+IL-12p70) revealed a decrease in mesh explants as compared with controls (P = .003), which indicated a shift towards a proinflammatory profile.
  • Mesh explants contained a higher number of total cells/×200 field when compared with controls (682.46 ± 142.61 cells vs 441.63 ± 126.13 cells; P < .001) and a lower ratio of M2:M1 macrophages (0.260 ± 0.161 cells vs 1.772 ± 1.919; P = .001), which supported an ongoing proinflammatory response.
  • the host response was proportional to the amount of material in contact with the host
  • A persistent foreign body response was observed in mesh-tissue complexes that were excised from women who required surgical excision of mesh months to years after mesh implantation
  • The host response was characterized by a predominance of macrophages with an increase in both proinflammatory and proremodeling cytokines/chemokines along with increased tissue degradation, as evidenced by increased MMP-2 and -9
  • Mesh-tissue complexes removed for mesh exposure had increased pro–MMP-9 that indicated a proinflammatory and tissue destruction–type response
  • The presence of macrophages, elevated cytokines, chemokines, and MMPs in tissue-mesh complexes that were excised from patients with exposure or pain suggests that polypropylene mesh elicits an ongoing host inflammatory response
  • In the presence of a permanent foreign body, the implant is surrounded with a fibrotic capsule because it cannot be degraded
  • For hernia meshes, if the fibers are too close (<1 mm), the fibrotic response to neighboring fibers overlaps, or “bridges,” and results in “bridging fibrosis” or encapsulation of the mesh
  • Gynemesh PS has a highly unstable geometry when loaded that resulted in pore collapse and increasing stiffness of the product
  • mesh shrinkage (50-70%) has been described to occur after transvaginal insertion of prolapse meshes
  • Nathan Goodyear on 31 Aug 18
     
    Mesh and the abnormal immune response.
Nathan Goodyear

Update on Programmed Death-1 and Programmed Death-Ligand 1 Inhibition in the Treatment of Advanced or Metastatic Non-Small Cell Lung Cancer - 0 views

www.ncbi.nlm.nih.gov/...PMC5382272

cancer PD-1 immunotherapy programmed death-1

shared by Nathan Goodyear on 20 Apr 18 - No Cached
  • Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), the first immune checkpoint receptor to be clinically targeted, is exclusively expressed on the surface of CD4+ and CD8+ T cells in lymphatic tissue and is involved in T-cell regulation, proliferation, and tolerance
  • programmed death-1 (PD-1) immune checkpoint inhibitor antibodies, which restores T-cell effector function and augments the host anti-tumor response by blocking the binding of either programmed death-ligand 1 (PD-L1) and/or PD-L2 to PD-1 receptors
  • lung cancer is the first and second cause of cancer mortality in men and women
  • ...1 more annotation...
  • Eighty-five percent of lung cancers are non-small-cell lung cancer (NSCLC)
  • Nathan Goodyear on 20 Apr 18
     
    To read update article on PD-1 and immunotherapy.
Nathan Goodyear

Eczema in early life: Genetics, the skin barrier, and lessons learned from birth cohort studies - 0 views

www.ncbi.nlm.nih.gov/...PMC2957505

LPS lipopolysaccharides eczema

shared by Nathan Goodyear on 28 Nov 17 - No Cached
  • Nathan Goodyear on 28 Nov 17
     
    LPS implicated, through CD14, in eczema.  This was linked to those with high genetic prediposition.  This review article also discusses the heterogeneous disease eczema is.
Nathan Goodyear

Intratumoral T Cells, Recurrence, and Survival in Epithelial Ovarian Cancer | NEJM - 0 views

www.nejm.org/...NEJMoa020177

T cells cancer

shared by Nathan Goodyear on 25 May 21 - No Cached
  • Nathan Goodyear on 25 May 21
     
    Intra-tumoral CD3+ T cells correlates with positive outcomes.
Nathan Goodyear

Artesunate promotes Th1 differentiation from CD4+ T cells to enhance cell apoptosis in ovarian cancer via miR-142 - 0 views

www.ncbi.nlm.nih.gov/...PMC6489539

ovarian cancer cancer apoptosis T cells artesunate

shared by Nathan Goodyear on 23 May 19 - No Cached
  • Nathan Goodyear on 23 May 19
     
    Artesunate found to promote T cell differentiation to increase apoptosis of ovarian cancer cells in a murine model.
Nathan Goodyear

Methionine enkephalin (MENK) improved the functions of bone marrow-derived dendritic cells (BMDCs) loaded with antigen - 0 views

www.ncbi.nlm.nih.gov/...PMC3579904

cancer MET-enkephalin MET-5

shared by Nathan Goodyear on 15 Aug 21 - No Cached
  • Nathan Goodyear on 15 Aug 21
     
    MET-enkephalin acts as an immunomodulator via dendritic cell and CD8 activity
« First ‹ Previous 41 - 60 of 102 Next › Last »
Showing 20▼ items per page