Advanced eLearning Authoring Tools have made eLearning Development Easy The rapid and extensive advances in technology have brought on incredible innovation in all fields of human interest. The impact of the same can be seen in the e-learning space, and these days, this specialized segment is breaking new ground continuously.
Those of all ages whose physical disabilities restrict their movement, affect their ability to earn a living or become valued members of society. Specially designed tricycles provide a mode of transport for the physically disabled allowing them much sought after independence and an opportunity for self support. The tricycles will enable freedom of movement and less dependency on others. Most of the people who depend on these tricycles are daily wage workers who have to travel long distances every day. The regular tricycles have no suspension and the riders are prone to spinal injuries. Most of them also cannot afford good medical care, and driving these tricycles for a long time affects. To deal with the problem, come up with a model tricycle that can be very useful to people who have a disability in their lower limbs, but a strong torso.
The Handy tricycle to provide the ideal cycling experience for users advancement of upper body strength and toning for athletic events. Especially valuable to triathletes and challenged, it provides the perfect way to get in shape and stay that way. The tricycle achieves the true convenience of transportation while providing easy-to-use pedaling, steering and breaking controls. These are amongst the top selling handcycles on the market today. Handy is available in upright and recumbent versions. Hand powered front wheel drive. An internal hub-based gear shifting system is built into the front wheel.This provides ultra smooth shifting and is virtually maintenance-free. The entire front frame section is removable and connects easily, quickly and securely using a bolt-on system. The seat can be repositioned quickly and easily to allow the rider to achieve an optimally efficient distance between seat and handlebars.The rear wheels are removed using a single finger push system, allowing the bike to be broken down very quickly. Defined by two ways:
Fork steer:
It represent the majority of handcycles. They work well for both low
Power mobility allows people to move within their home and community and it can help maximize independence for those with limited mobility. The two main types of power mobility available are in the form of electric scooters or power wheelchairs. The choice to use either an electric scooter versus an electric wheelchair depends on the users' needs and abilities. Knowing some of the benefits of power wheelchairs can help in making the right decision. Power wheelchairs also can be classified on the basis of the location of the drive wheels. There are three types of power wheelchairs: front-wheel drive, mid- or centre-wheel drive, and rear-wheel drive. Traditionally, rear-wheel drive powerwheelchairs were preferred because of their similarity to manual wheelchairs in design and maneuverability. However, centre-wheel drive wheelchairs have gained popularity because they provide increased maneuverability.
Variety of Power Wheelchairs:
Karma KP 10-2 Power Wheelchair
Karma KP 10-3 Power Wheelchair
Karma KP 80 Power Wheelchair
GM Lite Power Wheelchair
Bronco Wheelchair
Angel Wheelchair
Karma KP 10.3 S Power Wheelchair
Ergonomic seat system provides comfortable seating
Tool-free disassembled into 3 parts for traveling and transportation
Quick-release battery pack
Washable upholstery
Height adjustable and flip back armrest
2-level adjustable back angle
KARMA KP 80 POWER WHEELCHAIR are propelled by a motor and battery. They are very sophisticated. They are operated with a joy stick or push buttons. Some power wheelchairs use advanced technology and can climb up stairs, move across gravel and even raise up to give access to high shelves. Power wheelchairs need strong frames to support the motor and battery so they are very heavy and also quite expensive.
KARMA KP 80 POWER WHEELCHAIR
Karma KP 80 POWER STANDING WHEELCHAIR
Karma latest power standing wheelchair is now available in India. Power Standing wheelchair - Increase your freedom Stand up ag
Large Electric Scooters LY-EW415
Large Electric Scooters LY-EW415 with CTS Suspension offers a smooth ride with performance to match. Comfort-Trac Suspension (CTS) is the next generation in mobility scooter ride comfort. Large Electric Scooters LY-EW415 first technology incorporates advanced suspension components for improved absorption over rough surfaces, and a more comfortable ride experience over various terrains.
Large Electric Scooters LY-EW415 Features
Comfort-Trac front and rear suspension.
Feather-touch disassembly permits simple frame separation with only one hand.
Delta tiller with wraparound handles.
Crush Proof Front Basket.
Black, non-scuffing tires.
Back-lit battery gauge.
Full LED lighting package that includes curb and rear lights, directional signals and courtesy light under tiller.
Auto connecting front to rear harness.
Easy Grip Tiller adjustment knob.
Easy access tiller-mounted charger port.
Storage compartment below tiller.
Enhanced flush-mounted horn buttons.
Large Electric Scooters LY-EW415 Specifications
Large medium scooter
450W motor(Optional 550W/750W)?
50AH battery
Max speed: 12 km/h
Max loading: 150 kg
Suspension in front and rear wheels
Are you looking to shape up your body? Do you want to look fit instead of looking fat? Then get yourself toned and get an attractive body shape with vaser liposuction in Manchester which is an advanced body contouring procedure.
Wrist and forearm splints may be suggested for people with weak wrists or for those that have been previously injured, for tendonitis wrist support and even as a preventative for those who awaken in the morning with pain or numbness after sleeping on their hands at night. The best orthopedic wrist braces for carpal tunnel syndrome, occupational stabilization and relief from the pain of wrist strains and sprains. This Right hand wrist and forearm splint from tynor is meant to be used among patients suffering from any injury or sprain in these regions. The splint is meant to provide controlled compression in various orthopaedic conditions. The splint immobilizes the area that helps in a speedier recovery. It has anatomical thumb opening that allows free movement of the thumb. It provides a lot of comfort and is easily breathable.
Forearm splint is the term used to describe the forearm pain similarly the pain of lower leg over the shin is known as shin splints. Forearm splint describes the painful disease of elbow or wrist joint. Continuous pain in forearm is often caused by tendonitis, joint injury or hairline fracture of forearm bones (proximal radius or ulna near elbow joint). Overstretching of the elbow joint often causes forearm injury. Symptoms consist of a dull pain in the forearm. Pain is minor initially but increases as activity continues. Often pin-pointed to the dorsal or back of the hand side of the forearm, mid-way between the wrist and elbow. The patient may experience weakness in the wrist extensor muscles and tenderness deep in the forearm. Pain may be reproduced by attempting to bend the wrist backwards against resistance.
They provided wrist splints are used in different medical institutions and hospitals for management of hand fractures. Our offered wrist splints are manufactured by skilled professionals using optimum quality basic material and advanced technology as per the set norms of market. As well, these wrist splints can be availed in v
Cervical orthosis Ethafoam is an advanced collar with scientific design which ensures complete immobilization on one hand and perfect comfort on the other. It is called as a gold standard in cervical immobilization.
Ultimate comfort.
Perfect immobilization.
Anatomically moulded.
Minimal contact surface.
Hypoallergenic.
Cervical Orthosis (Philadelphia) Ethafoam Features
Pre-formed chin
Provides rest to the chin, ensures comfort, improves immobilization.
Anatomical and balloon design
Offers perfect immobilization, minimal contact of the neck, allows use in burn or trauma patients.
Hypoallergenic materials
Ensures no rash or allergy even on prolonged use, compatible to geriatrics, better patient compliance .
Tracheotomy opening
Compatible to use of endotracheal tube, improves air ventilation, improves patient comfort and compliance.
Two piece design
Easy application, firm occipital support, option for varying rigidity.
Ethafoam
Light weight, better patient compliance, non absorbent ensures easy cleaning and maintenance.
Tynor Cervical Orthosis Plastazote
Cervical orthosis plastazote is an advanced collar with scientific design which ensures complete immobilization on one hand and perfect comfort on the other, It is called as a gold standard in cervical immobilization.
Ultimate comfort.
Perfect immobilisation.
Anatomically moulded.
Minimal contact surface.
Hypoallergenic.
Tynor Cervical Orthosis (Philadlphia) Plastazote Features
Pre-formed chin
Provides rest to the chin, ensures comfort, improves immobilization.
Anatomical and balloon design
Offers perfect immobilization, minimal contact of the neck, allows use in burn or trauma patients.
Plastazote
Light weight, better patient compliance.
Non absorbent ensures easy cleaning and maintenance
Hypoallergenic, Ensures no rash or allergy even to old age patients
Eco friendly manufacturing process
Better patient compliance
Tracheotomy opening
Compatible to use of endo tracheal tube, improves air ventilation.
Improves patient comfort and compliance.
Two piece design
Easy application, firm occipital support, option for varying rigidity.
Better immobilization
Tynor Cervical Orthosis (Philadlphia) Plastazote Measurements
Measure distance between edge of sternum and lower jaw with neck in extension position.
Cisplatin and 5-FU or CAP (cisplatin, doxorubicin, and cyclophosphamide) regimens can be used for combination chemotherapy
patients with advanced salivary gland malignancy treated with the CAP regimen achieved partial response (PR) or stable disease (SD) rates of 67% (8 out of 12 patients)
Agents commonly given as monotherapy for treating ACC are cisplatin, mitoxantrone, epirubicin, vinorelbine, paclitaxel, and gemcitabine. However, few of these agents have shown efficacy
single agent mitoxantrone or vinorelbine were recommended as reasonable choices
ACC is subdivided into 3 histological groups based on solid components of the tumor including cribriform, tubular, and solid
Cribriform and tubular ACCs usually exhibit a more indolent course, whereas the solid subtype is associated with worse prognosis
ACC consists of two different cell types: inner luminal epithelial cells and outer myoepithelial cells
epithelial cells express c-kit, cox-2 and Bcl-2
myoepithelial cells express EGFR and MYB
a balanced translocation of the v-myb avian myeloblastosis viral oncogene homolog-nuclear factor I/B (MYB-NFIB) is considered to be a signature molecular event of ACC oncogenesis
As a transcription factor, MYB is known to modulate multiple genetic downstream targets involved in oncogenesis, such as cox-2, c-kit, Bcl-2 and BclX
Various signaling cascades are essential for cancer cells to survive and grow. The PI3K/Akt/mTOR pathway is one of them
This pathway regulates cell survival and growth and is upregulated in many cancers
Mutations in genes associated with DNA repair are frequently found in familial cancer syndromes, such as hereditary breast-ovarian cancer syndrome (HBOC), hereditary non-polyposis colorectal cancer (HNPCC, also called Lynch syndrome) and Li-Fraumeni syndrome [30, 31]. These mutations were also reported in non-hereditary cancers
70% of ACC samples (58 of 84) were found to have genetic alterations in the MYB/MYC pathway, indicating that changes in this pathway are crucial in ACC pathogenesis
The second most frequently mutated pathway was involved in chromatin remodeling (epigenetic modification), a pathway that includes multiple histone related proteins, and was altered in 44% of samples
C-kit
VEGF, iNOS and NF-κB were noted to be highly expressed in ACC cells as compared to normal salivary gland cells
members of the SOX family, such as SOX 4 and SOX10, are overexpressed in ACC
FABP7 (Fatty acid binding protein 7) and AQP1 (Aquaporin 1) tend to be overexpressed in ACC cell lines
considerable variability in HER2 overexpression ranging from 0–58% in patients with ACC
the study with cetuximab and concurrent chemoradiation or chemotherapy showed the highest ORR (total 43%, 9.5% CR and 33% PR), but this regimen was only given to the EGFR positive patients
Cancer immunotherapy can be classified into 3 major groups. Active immunization using anti-tumor vaccines to induce and recruit T cells, passive immunization based on monoclonal antibodies, and adoptive cell transfer to expand tumor-reactive autologous T cells ex vivo and then reintroduce these cells into the same individual
LAK cells showed cytotoxicity against ACC cells
cytokine-induced cell apoptosis and the cytotoxic effect of the LAK cells contributed to tumor regression
molecular finding of the MYB-NFIB fusion gene has the greatest potential to target what appears to be a fundamental event in disease pathogenesis
Metformin prolongs survival in pancreatic cancer. Though, the evidence for prolonging survival decreased with advancing disease i.e. metastatic disease.
only abstract available here, but 20 mg melatonin plus 4 weeks of low-dose IL-2 found to provide partial response in 1 patient and stable disease in 7 other patients in 12 patients with untreatable, advanced hematologic cancers.
Study, again of advanced cancer, with previous failed chemotherapy found that melatonin plus low-dose IL-2 therapy stimulated lymphocyte production and provided a partial response and stable disease. No control group.
The serum level of LDH correlated with tumor burden and was thought to reflect the tumor’s growth and invasive potential
the majority of patients with advanced or metastatic disease could be detected to have extremely high serum level of LDH
strong evidence to support effective chemotherapy of full dose even in patients with high LDH level
LDH is a key enzyme in the process of energy production in cancer cells, it catalyzes the conversion of pyruvate to lactate in hypoxic conditions
its function in anaerobic metabolism, cancer cells grow even after their rapid proliferation that leads to low-oxygen conditions in the tumor microenvironment
LDH plays an important role in tumor progression and maintenance
inhibition of LDH inhibits tumor progression and has been considered for the therapeutic target of cancer energy metabolism
LDH levels are increased in response to tissue injury or during disease states
LDH could be a marker of tumor burden for advanced cancer patients
Patients with higher tumor markers are likely to have higher tumor burden, higher oxidative stress and, therefore, are more likely to have lower post IVC plasma levels.
Our data also showed that cancer patients with metastasis tend to have lower post-IVC vitamin C levels than those without metastasis
Lower peak plasma concentrations are obtained in cancer patients than in healthy subjects. Cancer patients who are deficient in vitamin C prior to therapy tend to achieve lower plasma levels post infusion.
Patients with higher inflammation or tumor burdens, as measured by CRP levels or tumor antigen levels, tend to show lower peak plasma ascorbate levels after IVC.
Patients with metastatic tumors tend to achieve lower post infusion plasma ascorbate levels than those with localized tumors.
Meta-analyses of clinical studies involving cancer and vitamins also conclude that antioxidant supplementation does not interfere with the efficacy of chemotherapeutic regiments
Most of the prostate cancer patients studied, 75±19% (95% confidence), showed reductions in PSA levels during the course of their IVC therapy
Laboratory studies suggest that, at high concentrations, ascorbate does not interfere with chemotherapy or irradiation and may enhance efficacy in some situations
Cameron and Pauling observed fourfold survival times in terminal cancer patients treated with intravenous ascorbate infusions followed by oral supplementation
The inflammatory microenvironment of cancer cells leads to increasing oxidative stress, which apparently depletes vitamin C, resulting in lower plasma ascorbate concentrations in blood samples post IVC infusion. Another explanation for this finding may be that cancers are themselves more metabolically active in their uptake of vitamin C, causing subjects to absorb more of the vitamin, and as a results show lower plasma ascorbate concentrations in blood post IVC infusion.
patients with severely elevated CRP levels attain plasma ascorbate concentrations after IVC infusions that are only 65% of those attained for subjects with normal CRP levels
The finding of decreased plasma ascorbate levels in cancer patients may relate to the molecular structure of ascorbic acid; in particular, the similarity of its oxidized form, dihydroascorbic acid, to glucose
Since tumor have increased requirement for glucose [67], transport of dehydroascorbate into the cancer cells via glucose transport molecules and ascorbate through sodium-dependent transporter may be elevated
Increased accumulation of ascorbic acid in the tumor site was supported by measurements of the level of ascorbic acid in tumors in animal experiments
patients with advanced malignancies may have lower level of ascorbic acid in tissue, creating a higher demand for the vitamin C
IVC therapy appears to reduce CRP levels in cancer patients.
CRP concentrations directly correlate with disease activity in many cases and can contribute to disease progression through a range of pro-inflammatory properties.
Being an exquisitely sensitive marker of systemic inflammation and tissue damage, CRP is very useful in screening for organic disease and monitoring treatment responses
ncreases in CRP concentrations have been associated with poorer prognosis of survival in cancer patients, particularly with advance disease independent of tumor stage
Regarding inflammation, 73±13% of subjects (95% confidence) showed a reduction in CRP levels during therapy. This was an even more dramatic 86±13% (95% confidence) in subjects who started therapy with CRP levels above 10 mg/L
patients treated by IVC with follow-up several year showed that suppression of inflammation in cancer patients by high-dose IVC is feasible and potentially beneficial
Inflammation is a marker of high cancer risk, and poor treatment outcome
The subjects with highly elevated CRP concentrations have a three-fold elevation “all-cause” mortality risk and a twenty-eight fold increase in cancer mortality risk
cancer patients may need higher doses to achieve a given plasma concentration.
patients with lower vitamin C levels may see more distribution of intravenously administered ascorbate into tissues and thus attain less in plasma.
When treating patients with IVC, the first treatment likely serves to replenish depleted tissue stores, if those subjects were vitamin C deficient at the beginning of the treatment. Then, in subsequent treatments, with increasing doses, higher plasma concentrations can be attained. On-going treatments serve to progressively reduce oxidative stress in cancer patients.
large doses given intravenously may result in maximum plasma concentrations of roughly 30 mM, a level that has been shown to be sufficient for preferential cytotoxicity against cancer cells
oral intake of vitamin C exceeded 200 mg administered once daily, it was difficult to increase plasma and tissue concentrations above roughly 200 μM.
Great review on the use of IV vitamin C in cancer and to reduce inflammation. The article does a great job of discussing the mechanism of vitamin C therapy in cancer as well as the proposed reasons for low vitamin C in cancer patients. The study also highlights the obstacles to rise in vitamin C levels post IV vitamin C in cancer patients.