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Nathan Goodyear

Thyroid hormone action in mitochondria -- Wrutniak-Cabello et al. 26 (1): 67 -- Journal of Molecular Endocrinology - 0 views

jme.endocrinology-journals.org/...67

T3 T4 mitochondria energy fatigue

shared by Nathan Goodyear on 20 Dec 10 - No Cached
  • Triiodothyronine (T3) is considered a major regulator of mitochondrial activity
  • Nathan Goodyear on 20 Dec 10
     
    T3 is major regulator of mitochondrial activity; not T4
Nathan Goodyear

Safety and hemodynamic effects of intravenous trii... [Am J Cardiol. 1998] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...9485134

T3 hypothyroidism hypothyroid heart failure

shared by Nathan Goodyear on 01 Feb 11 - No Cached
  • Acute intravenous administration of triiodothyronine is well tolerated in patients with advanced heart failure
  • Nathan Goodyear on 01 Feb 11
     
    T3 beneficial in those with acute heart failure
Nathan Goodyear

Acute Effects of Triiodothyronine (T3) Replacement Therapy in Patients with Chronic Heart Failure and Low-T3 Syndrome: A Randomized, Placebo-Controlled Study -- Pingitore et al. 93 (4): 1351 -- Journal of Clinical Endocrinology & Metabolism - 0 views

jcem.endojournals.org/...1351

T3 hypothyroid hypothyroidism cardiac disease

shared by Nathan Goodyear on 01 Feb 11 - No Cached
  • In DC patients, short-term synthetic L-T3 replacement therapy significantly improved neuroendocrine profile and ventricular performance
  • Nathan Goodyear on 01 Feb 11
     
    T3 provides significant improvement in cardiac function in those with dilated cardiomyopathy
Nathan Goodyear

Only the combined treatment with thyroxine and triiodothyronine ensures euthyroidism in all tissues of the thyroidectomized rat -- Escobar-Morreale et al. 137 (6): 2490 -- Endocrinology - 0 views

endo.endojournals.org/...2490

hypothyroid hypothyroidism T4 T3

shared by Nathan Goodyear on 08 Mar 11 - No Cached
  • Combined replacement therapy with T4 and T3 (in proportions similar to those secreted by the normal rat thyroid) completely restored euthyroidism in thyroidectomized rats at much lower doses of T4 than those needed to normalize T3 in most tissues when T4 alone was used
  • Nathan Goodyear on 08 Mar 11
     
    combined T4/T3 therapy the best approach in hypothyroidism
Nathan Goodyear

Elsevier: Article Locator - 0 views

linkinghub.elsevier.com/...S0140673674920704

low T3 hypothyroid hypothyroidism

shared by Nathan Goodyear on 08 Mar 11 - No Cached
  • The most striking abnormality detected in 75 sick euthyroid patients was a highly significant reduction in the mean total serum-triiodothyronine (T3) levels, with most patients having total T3 levels in the hypothyroid range. The severity of the illness correlated well with the reduction in total serum-T3 levels.
  • Nathan Goodyear on 08 Mar 11
     
    low T3 in sick euthyroid clients; severity correlated with decreasing T3
Nathan Goodyear

A Radioimmunoassay for 3,3',5'-L-Triiodothyronine (Reverse T3): Assessment of Thyroid Gland Content and Serum Measurements in Conditions of Normal and Altered Thyroidal Economy and Following Administration of Thyrotropin Releasing Hormone (TRH) and Thyrot - 0 views

jcem.endojournals.org/...660

reverse T3 estrogen pregnancy hypothyroid hypothyroidism

shared by Nathan Goodyear on 08 Mar 11 - No Cached
  • Both pregnancy and estrogen administration were associated with increases in serum reverse T3 concentrations presumably because of their ability to augment thyroxine binding globulin synthesis.
  • Nathan Goodyear on 08 Mar 11
     
    oral estrogen supplementation increase reverse T3 and lowers metabolism and leads to weight gain
Nathan Goodyear

Thyroid Hormones (T3 and T4): Dual Effect on Human Cancer Cell Proliferation - 0 views

ar.iiarjournals.org/...89.long

triiodothyronine thyroid hormones hormone cancer

shared by Nathan Goodyear on 13 Aug 14 - No Cached
  • Nathan Goodyear on 13 Aug 14
     
    The effects of T3 on cancer cell lines varies.  All cell lines came from the same tissue. It doesn't appear that simply stating T3 promotes cellular metabolism and thus provides an increase in cancer progression risk.  Some cell lines studies actually had an inhibition of cell growth, whereas others saw an increase.  
Nathan Goodyear

Implication from thyroid function decreasing during chemotherapy in breast cancer patients: chemosensitization role of triiodothyronine - 0 views

www.ncbi.nlm.nih.gov/...PMC3717040

Thyroid T3 cancer chemotherapy

shared by Nathan Goodyear on 07 Nov 18 - No Cached
  • Nathan Goodyear on 07 Nov 18
     
    chemotherapy decreases thyroid hormone levels; T3 therapy improves chemosensitization via increase S phase from G0 and G1 phases of growth
Nathan Goodyear

Incidence of low-triiodothyronine syndrome in patients with septic shock - 0 views

www.ncbi.nlm.nih.gov/...PMC7853677

T4 TSH non-thyroidal illness syndrome septic shock sepsis T3

shared by Nathan Goodyear on 13 Apr 21 - No Cached
  • In the course of different disease states, the levels of T3, T4, and TSH decrease
  • euthyroid sick syndrome
  • low T3 can contribute to associated organ dysfunction
  • ...5 more annotations...
  • proportionally associated with disease severity and survival
  • nonthyroidal illness syndrome
  • Patients with persistent deterioration of hormone levels (T3, T4) during the study period had higher mortality than those who normalized the function of the thyroid axis
  • LT3S in patients with septic shock is part of the pathophysiology of this disease and/or an associated organ (endocrine-metabolic) failure and not just an adaptive phenomenon
  • substitution treatment with synthetic thyroid hormones could modify the hemodynamic symptoms of septic patients, contributing in part to the decrease in their morbidity and mortality
    • Nathan Goodyear
      Nathan Goodyear on 13 Apr 21
       
      Important statement
  • Nathan Goodyear on 13 Apr 21
     
    Septic shock and low T3
Nathan Goodyear

Low triiodothyronine syndrome as a predictor of poor outcomes in patients undergoing brain tumor surgery: A pilot study | Request PDF - 0 views

www.researchgate.net/...in_tumor_surgery_A_pilot_study

T3 non-thyroidal illness syndrome euthyroid sick syndrome brain tumor cancer surgery

shared by Nathan Goodyear on 15 Mar 21 - No Cached
  • Nathan Goodyear on 15 Mar 21
     
    Low T3 poor predictor pre-surgery for those with brain tumor.
Nathan Goodyear

["Low triiodothyronine (T3) syndrome": "thyroxine (T4) euthyroidism" evidence (author's transl)] - PubMed - 0 views

pubmed.ncbi.nlm.nih.gov/554102

thyroid hormones low T3 syndrome

shared by Nathan Goodyear on 31 Jul 21 - No Cached
  • Nathan Goodyear on 31 Jul 21
     
    Only abstract available here.
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