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Nathan Goodyear

The Long-term Survival of a Patient With Pancreatic Cancer With Metastases to the Liver... - 0 views

journals.sagepub.com/...1534735405285901

alpha lipoic acid low dose naltrexone LDN pancreatic cancer ALA alpha

shared by Nathan Goodyear on 02 Jul 19 - No Cached
  • Nathan Goodyear on 02 Jul 19
     
    IV ALA + po LDN found to be effective in pancreatic cancer-case study.
Nathan Goodyear

Revisiting the ALA/N (a-Lipoic Acid/Low- Dose Naltrexone) Protocol for People With Meta... - 0 views

journals.sagepub.com/...1534735409352082

low dose naltrexone pancreatic cancer alpha lipoic acid ALA LDN

shared by Nathan Goodyear on 02 Jul 19 - No Cached
  • Nathan Goodyear on 02 Jul 19
     
    3 case studies of the use of ALA and LDN to treat pancreatic cancer.
Nathan Goodyear

PO-238 Dichloroacetate (DCA) treatment affects mitochondrial activity and ste... - 0 views

esmoopen.bmj.com/...A113.1

cancer" DCA CSC pancreatic cancer stem cells cancer dichloracetic acid dichloroacetate

shared by Nathan Goodyear on 27 Nov 18 - No Cached
  • Nathan Goodyear on 27 Nov 18
     
    DCA shown to decrease tumor size in mouse model of pancreatic cancer stem cells.
Nathan Goodyear

Revisiting the ALA/N (a-Lipoic Acid/Low- Dose Naltrexone) Protocol for People With Meta... - 0 views

low dose naltrexone LDN cancer pancreatic cancer alpha lipoic acid

shared by Nathan Goodyear on 01 Jul 19 - No Cached
  • Nathan Goodyear on 01 Jul 19
     
    3 case studies on the benefit of IV ALA and po LDN in the treatment of pancreatic cancer.
Nathan Goodyear

Effect of Small Interference RNA Targeting HIF-1α Mediated by rAAV Combined L... - 0 views

vitamin C HIF-1alpha pancreatic cancer cancer Hypoxia-inducible Factor 1 HIF-1 VEGF

shared by Nathan Goodyear on 01 Apr 21 - No Cached
  • Nathan Goodyear on 01 Apr 21
     
    Vitamin C "restrains" HIF-1 expression according to authors of this in vivo study of pancreatic cancer.
Nathan Goodyear

Treatment of pancreatic cancer with intravenous vitamin C: a... : Anti-Cancer Drugs - 0 views

journals.lww.com/...ancer_with_intravenous.10.aspx

metastasis High dose IV vitamin C high dose vitamin C vitamin C IV vitamin C cancer pancreatic cancer

shared by Nathan Goodyear on 09 Mar 21 - No Cached
  • Nathan Goodyear on 09 Mar 21
     
    High dose vitamin C found to be effective in partial regression of pancreatic cancer.
Nathan Goodyear

Hypereosinophilia Induced by High-Dose Intratumoral and Peritumoral Mistletoe Applicati... - 0 views

www.liebertpub.com/...10755530050120664

pancreatic cancer mistletoe eosinophils cancer

shared by Nathan Goodyear on 27 May 20 - No Cached
  • Nathan Goodyear on 27 May 20
     
    IV and Intratumoral mistletoe induced hypereosinophilia in pancreatic cancer case study.
Nathan Goodyear

Frontiers | Antitumor Effects of Cannabinoids in Human Pancreatic Ductal Adenocarcinoma... - 0 views

www.frontiersin.org/...full

cannabinoids medical marijuana medical cannabis pancreatic cancer THC CBD

shared by Nathan Goodyear on 28 Nov 22 - No Cached
  • Nathan Goodyear on 28 Nov 22
     
    dose-dependent trigger of pancreatic cancer apoptosis in mouse model. They dosed up to 10 mg/kg at a ratio of THC:CBD of 1:6.
Nathan Goodyear

Cannabinoids Inhibited Pancreatic Cancer via P-21 Activated Kinase 1 Mediated Pathway -... - 0 views

www.ncbi.nlm.nih.gov/...PMC7662796

pancreatic cancer CBD P-21 THC KRAS

shared by Nathan Goodyear on 30 Jan 24 - No Cached
  • Nathan Goodyear on 30 Jan 24
     
    THC:CBD target pancreatic cancer which expresses KRAS mutation appx 90% of time.
Nathan Goodyear

Mechanisms of Pancreatic β-Cell Death in Type 1 and Type 2 Diabetes - 0 views

diabetes.diabetesjournals.org/...S97.full

diabetes type II diabetes DM insulin pancreas inflammation cytokines metabolic endotoxemia

shared by Nathan Goodyear on 15 Jan 13 - No Cached
  • Nathan Goodyear on 15 Jan 13
     
    inflammation leads to death of pancreatic beta cells and result in diabetes.
Nathan Goodyear

Cytokines in the Progression of Pancreatic β-Cell Dysfunction - 0 views

www.hindawi.com/...515136

inflammation cytokines inflammatory pancreas DM diabetes type II diabetes metabolic endotoxemia

shared by Nathan Goodyear on 15 Jan 13 - No Cached
  • Nathan Goodyear on 15 Jan 13
     
    inflammatory cytokines lead to progressive pancreatic Beta islet cells dysfunction and resultant diabetes.
Nathan Goodyear

Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive ... - 0 views

www.pnas.org/...11105.full

IV vitamin C vitamin C ovarian cancer pancreatic cancer glioblastoma cancer

shared by Nathan Goodyear on 26 May 13 - Cached
  • Nathan Goodyear on 26 May 13
     
    high dose IV vitamin C shown to be treatment option in Cancer.  Granted in a mouse study, but high dose IV vitamin C shown to decrease growth rates of ovarian, pancreatic, and glioblastoma cancers.
Nathan Goodyear

The role of octreotide and somatostatin in acute a... [Digestion. 1999] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...10207228

octreotide pancreatitis

shared by Nathan Goodyear on 11 Sep 13 - No Cached
  • Nathan Goodyear on 11 Sep 13
     
    Octreotide useful in pancreatitis.
Nathan Goodyear

Interaction of gonadal status with syste... [Support Care Cancer. 2011] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...20221887

hormone hormones pancreatic cancer pancreas

shared by Nathan Goodyear on 17 Sep 13 - No Cached
  • Nathan Goodyear on 17 Sep 13
     
    pancreatic cancer survival risk is shorted by 2.43 with elevated estradiol in women.  This risk is linked to an increase in TNF alpha.  In contrast, men survival risk was worse by 1.96 odds ratio with low Testosterone.  Again, inflammation was the culprit.
Nathan Goodyear

Efficacy of liposomal curcumin in a human pan... [Anticancer Res. 2013] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24023285

curcumin tumeric pancreatic cancer

shared by Nathan Goodyear on 17 Sep 13 - No Cached
  • Nathan Goodyear on 17 Sep 13
     
    liposomal curcumin at 20 mg/kg reduced pancreatic tumor growth by 42% in in vitro and xenograft studies.  The curcumin, the most prevalent polyphenol in tumeric, was given intraperitoneal in this study.
Nathan Goodyear

Nuclear factor-kappaB and IkappaB kinase are constitu... [Cancer. 2004] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...15476283

pancreatic cancer curcumin turmeric NF-KappaB

shared by Nathan Goodyear on 17 Sep 13 - No Cached
  • Nathan Goodyear on 17 Sep 13
     
    curcumin down regulates NF-kappaB in pancreatic cancer.
Nathan Goodyear

Boswellic Acid Suppresses Growth and Metastasis of Human Pancreatic Tumors in an Orthot... - 0 views

www.ncbi.nlm.nih.gov/...PMC3204996

Frankincense acetyl-11-keto-beta-boswellic acid AKBA cancer

shared by Nathan Goodyear on 06 Jan 15 - No Cached
  • Nathan Goodyear on 06 Jan 15
     
    Study finds that acetyl-11-keto-Beta-boswellic acid (AKBA) reduced growth of pancreatic cancer and metastasis in mouse model.  AKBA also inhibits NF-kappaB and induced apoptosis.  AKBA is found in Frankinsense. 
Nathan Goodyear

Anticancer mechanisms of cannabinoids - 0 views

www.ncbi.nlm.nih.gov/...PMC4791144

THC cannabinoids cancer

shared by Nathan Goodyear on 18 Sep 18 - No Cached
  • modulating key cell signalling pathways involved in the control of cancer cell proliferation and survival
  • cannabinoids inhibit angiogenesis and decrease metastasis in various tumour types in laboratory animals
  • Cannabis sativa L. (marijuana)
  • ...41 more annotations...
  • of the approximately 108 cannabinoids produced by C. sativa, Δ9-tetrahydrocannabinol (thc) is the most relevant because of its high potency and abundance in plant preparations
  • Tetrahydrocannabinol exerts a wide variety of biologic effects by mimicking endogenous substances—the endocannabinoids anandamide3 and 2-arachidonoylglycerol4,5—that engage specific cell-surface cannabinoid receptors
  • the cb2 receptor was initially described to be present in the immune system6, but was more recently shown to also be expressed in cells from other origins
  • transient receptor potential cation channel subfamily V, member 1
  • orphan G protein–coupled receptor 55
  • Most of the effects produced by cannabinoids in the nervous system and in non-neural tissues rely on cb1 receptor activation
  • two major cannabinoid-specific receptors—cb1 and cb2
  • cardiovascular tone, energy metabolism, immunity, and reproduction
  • cannabinoids are well known to exert palliative effects in cancer patients
  • best-established use is the inhibition of chemotherapy-induced nausea and vomiting
  • thc and other cannabinoids exhibit antitumour effects in a wide array of animal models of cancer
  • cannabinoid receptors and their endogenous ligands are both generally upregulated in tumour tissue compared with non-tumour tissue
  • cb2 promotes her2 (human epidermal growth factor receptor 2) pro-oncogenic signalling in breast cancer
  • pharmacologic activation of cannabinoid receptors decreases tumour growth
  • endocannabinoid signalling can also have a tumour-suppressive role
  • pharmacologic stimulation of cb receptors is, in most cases, antitumourigenic. Nonetheless, a few reports have proposed a tumour-promoting effect of cannabinoids
  • most prevalent effect is the induction of cancer cell death by apoptosis and the inhibition of cancer cell proliferation
  • impair tumour angiogenesis and block invasion and metastasis
  • thc and other cannabinoids induce the apoptotic death of glioma cells by cb1- and cb2-dependent stimulation
  • Autophagy is primarily a cytoprotective mechanism, although its activation can also lead to cell death
  • autophagy is important for cannabinoid antineoplastic activity
  • autophagy is upstream of apoptosis in the mechanism of cannabinoid-induced cell death
  • the effect of cannabinoids in hormone- dependent tumours might rely, at least in part, on the ability to interfere with the activation of growth factor receptors
  • glioma cells), pharmacologic blockade of either cb1 or cb2 prevents cannabinoid-induced cell death with similar efficacy
  • other types of cancer cells (pancreatic48, breast24, or hepatic43 carcinoma cells, for example), antagonists of cb2 but not of cb1 inhibit cannabinoid antitumour actions
  • thc promotes cancer cell death in a cb1- or cb2-dependent manner (or both) at lower concentrations
  • cannabidiol (cbd), a phytocannabinoid with a low affinity for cannabinoid receptors15, and other marijuana-derived cannabinoids57 have also been proposed to promote the apoptotic death of cancer cells acting independently of the cb1 and cb2 receptors
  • In cancer cells, cannabinoids block the activation of the vascular endothelial growth factor (vegf) pathway, an inducer of angiogenesi
  • In vascular endothelial cells, cannabinoid receptor activation inhibits proliferation and migration, and induces apoptosis
  • cb1 or cb2 receptor agonists (or both) reduce the formation of distant tumour masses in animal models of both induced and spontaneous metastasis, and inhibit adhesion, migration, and invasiveness of glioma64, breast65,66, lung67,68, and cervical68 cancer cells in culture
  • the ceramide/p8–regulated pathway plays a general role in the antitumour activity of cannabinoids targeting cb1 and cb2
  • cbd, by acting independently of the cb1 and cb2 receptors, produces a remarkable anti-tumour effect—including reduction of invasiveness and metastasis
  • cannabinoids can also enhance immune system–mediated tumour surveillance in some contexts
  • ability of thc to reduce inflammation75,76, an effect that might prevent certain types of cancer
  • recent observations suggest that the combined administration of cannabinoids with other anticancer drugs acts synergistically to reduce tumour growth
  • combined administration of gemcitabine (the benchmark agent for the treatment of pancreatic cancer) and various cannabinoid agonists synergistically reduced the viability of pancreatic cancer cells
  • Other reports indicated that anandamide and HU-210 might also enhance the anticancer activity of paclitaxel89 and 5-fluorouracil90 respectively
  • Combined administration of thc and cbd enhances the anticancer activity of thc and reduces the dose of thc needed to induce its tumour growth-inhibiting activity
  • Preclinical animal models have yielded data indicating that systemic (oral or intraperitoneal) administration of cannabinoids effectively decreases tumour growth
  • Combinations of cannabinoids with classical chemotherapeutic drugs such as the alkylating agent temozolomide (the benchmark agent for the management of glioblastoma80,84) have been shown to produce a strong anticancer action in animal models
  • pharmacologic inhibition of egfr, erk83, or akt enhances the cell-death-promoting action of thc in glioma cultures (unpublished observations by the authors), which suggests that targeting egfr and the akt and erk pathways could enhance the antitumour effect of cannabinoids
  • Nathan Goodyear on 18 Sep 18
     
    Good review of the anticancer effects of cananbinoids.
Nathan Goodyear

ScienceDirect - 0 views

www.sciencedirect.com/...S2212492618300745

"pancreatic cancer" cancer metformin chloroquine berberine

shared by Nathan Goodyear on 27 Nov 18 - No Cached
  • Nathan Goodyear on 27 Nov 18
     
    metformin augments chemotherapy in the treatment of pancreatic cancer. It promotes the anti-proliferative effects of mTORC and inhibits the proliferative PI3k/mTOR. It also works synergistically with the known anti-tumor anti-malarial drugs chloroquine and with the herb berberine.
Nathan Goodyear

From the Cover: Pharmacologic doses of ascorbate act as a prooxidant and decrease growt... - 0 views

www.ncbi.nlm.nih.gov/...PMC2516281

cancer IV intravenous vitamin C IV vitamin C

shared by Nathan Goodyear on 18 Sep 13 - No Cached
  • An extensive panel of 43 tumor and 5 normal cell lines were exposed to ascorbate in vitro for ≤2 h to mimic clinical pharmacokinetics
  • effective concentration that decreased survival 50% (EC50) was determined. EC50 was <10 mM for 75% of tumor cells tested, whereas cytotoxicity was not evident in normal cells with >20 mM ascorbate
  • The addition of catalase to the medium ameliorated death of ovarian carcinoma (Ovcar5), pancreatic carcinoma (Pan02), and glioblastoma (9L) cells exposed to 10 mM ascorbate (1 h), indicating cytotoxicity was mediated by H2O2
  • ...8 more annotations...
  • A treatment dose of 4 g ascorbate/kg body weight either once or twice daily did not produce any discernible adverse effects
  • Xenograft experiments showed that parenteral ascorbate as the only treatment significantly decreased both tumor growth and weight by 41–53%
  • Peak plasma concentrations of ascorbate approached 30 mM
  • Pharmacologic concentrations of ascorbate decreased tumor volumes 41–53% in diverse cancer types known for both their aggressive growth and limited treatment options.
  • Our findings showed that pharmacologic ascorbic acid concentrations were cytotoxic to many types of cancer cells in vitro (Fig. 1A) and significantly impeded tumor progression in vivo without toxicity to normal tissues
  • The amelioration of ascorbate cytotoxicity in vitro by the addition of catalase was consistent among sensitive cancer cells (Fig. 1B) and points unambiguously to H2O2 generation in the extracellular medium
  • the current in vivo data support that pharmacologic ascorbate concentrations, which can readily be achieved in humans (Fig. 3E), diminished growth of several aggressive cancer types in mice (Fig. 2) without causing apparent adverse effects.
  • These intratumoral H2O2 concentrations of >125 μM persisted for >3 h after ascorbate administration
  • Nathan Goodyear on 18 Sep 13
     
    Tumor xenograft model in mice finds reduction in growth rates of ovarian cancer, pancreatic cancer, and glioblastoma with daily IV vitamin C.
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