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Nathan Goodyear

Sex hormones influence on the immune system: basic and... [Lupus. 2004] - PubMed - NCBI - 0 views

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    Estrogens appear to have an immune stimulatory effect in the presence of inflammatory cytokines.  The estrogens appear to increase inflammation through activation of NFkappaB.  But of course, not all estrogens are equal.  This article is primarily referencing E2.  I would expect E1 due to its preference for ER alpha, but not E3, due to its ER beta preference.
Nathan Goodyear

NFkappaB-mediated metabolic inflammation in periph... [Cell Cycle. 2009] - PubMed result - 0 views

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    NF-KappaB mediated inflammation
Nathan Goodyear

Omega-3 Fatty Acids and Inflammatory Processes - 0 views

  • marine n-3 PUFAs have also been shown to alter the production of inflammatory proteins including chemokines, cytokines, growth factors and matrix proteases
  • Two transcription factors that are likely to play a role in inflammation are nuclear factor κ B (NFκB) and PPAR-γ
  • NFκB is the principal transcription factor involved in upregulation of inflammatory cytokine, adhesion molecule and cyclooxygenase-2 genes
  • ...3 more annotations...
  • PPAR-γ, is believed to act in an anti-inflammatory manner
  • PPAR-γ directly regulates inflammatory gene expression, it also interferes with the activation of NFκB creating an intriguing interaction between these two transcription factors
  • Both NFκB and PPAR-γ may be regulated by n-3 PUFAs.
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    great review of the anti-inflammatory effects of omega 3 DHA and EPA.  EPA inhibits COX and 5-LOX and their downstream prostaglandin and leukotrienes.  EPA/DHA inhibited endotoxin-stimulated IL-6, IL-8,TNF-alpha, and NFkappaB.
Nathan Goodyear

Vitamin D decreases NFkappaB activit... [Nephrol Dial Transplant. 2006] - PubMed - NCBI - 0 views

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    Vitamin D inhibits NF-kappaB and thus inflammatory signaling.
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