Only abstract available here: Gut bacteria, lactobacillus reuteri, could be the key to colon cancer prevention through inflammation control. What is fascinating is how the gut bacteria influenced epigenetic expression of histidine decarboxylase to increase histamine production.
Histamine intolerance can develop through both increased availability of histamine and impaired histamine degradation
increased availability may be an endogenous histamine overproduction caused by allergies, mastocytosis,
bacterias, gastrointestinal bleeding, or increased exogenous ingestion of histidine or histamine by food or alcohol
Other
biogenic amines, such as putrescine, may also be involved in displacing histamine from its mucosal mucine linkage, which results
in an increase of free absorbable histamine in circulation
the main cause of histamine intolerance is an impaired
enzymatic histamine degradation caused by genetic or acquired impairment of the enzymatic function of DAO or HNMT
The
main enzyme for metabolism of ingested histamine is diamine oxidase (DAO)