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Nathan Goodyear

Cruciferous Vegetables and Human Cancer Risk: Epidemiologic Evidence and Mechanistic Basis - 0 views

www.ncbi.nlm.nih.gov/...PMC2737735

DIM I3C indole-3-carbinol cruciferous vegetables vegetables cruciferous cancer

shared by Nathan Goodyear on 28 Mar 15 - No Cached
  • Nathan Goodyear on 28 Mar 15
     
    Cruciferous vegetables do appear to provide a means to attack Cancer risk.  In part through they are rich sources of DIM and I3C.
Nathan Goodyear

Cruciferous Vegetable Consumption Linked to Improved Breast Cancer Survival Rates - 0 views

www.aacr.org/...aacr-in-the-news.aspx

breast cancer cruciferous vegetables survival treatment shanghai breast cancer survival study

shared by Nathan Goodyear on 16 May 12 - No Cached
  • Nathan Goodyear on 16 May 12
     
    higher cruciferous vegetable intake associated with improved breast cancer survival rates according to Shanghai Breast Cancer Survival Study.
Nathan Goodyear

Selective Activation of Estrogen Receptor-β Target Genes by 3,3′-Diindolylmet... - 0 views

endo.endojournals.org/...1662.full

DIM 3 3'-Diindolylmethane ER beta cruciferous vegetables estrogen

shared by Nathan Goodyear on 18 Mar 13 - No Cached
  • Nathan Goodyear on 18 Mar 13
     
    DIM's anti-estrogenic effect is found through its increased stimulation for ER beta expression. ER beta has been shown to be both anti-proliferative and anti-inflammatory.   DIM is naturally found in cruciferous vegetables
Nathan Goodyear

Regulation of estrogen receptor α expression in human breast cancer cells by ... - 0 views

www.jnutbio.com/...abstract

sulforaphane ER alpha breast cancer cruciferous vegetables cancer estrogen

shared by Nathan Goodyear on 18 Mar 13 - No Cached
  • Nathan Goodyear on 18 Mar 13
     
    Sulforaphane shown to inhibit ER alpha expression in human breast cancer cell lines.  Sulforaphane is from cruciferous vegetables.
Nathan Goodyear

Plant-derived 3,3′-Diindolylmethane Is a Strong Androgen Antagonist in Human ... - 0 views

www.jbc.org/...21136.full

DIM I3C PSA AR androgen receptor prostate cancer men male hormone hormones androgen

shared by Nathan Goodyear on 05 Nov 14 - No Cached
  • Inhibition of Endogenous PSA Expression by DIM
  • DIM strongly inhibited DHT induction of androgen-responsive genes by more than 50%
  • antiandrogenic activity of DIM
  • ...8 more annotations...
  • DIM suppresses DHT-induced cell growth and PSA expression and exhibits no AR agonist activity
  • DIM has a strong affinity for both the mutant AR inLNCaP cells and for recombinant wild-type human AR
  • nuclear translocation and foci formation of DHT-bound AR are inhibited by DIM
  • Our investigation, leads to the conclusion that DIM is a strong, pure androgen antagonist.
  • The down-regulation of PSA by DIM
  • PSA has been reported to promote the proliferation, migration, and metastasis of prostate cancer cells through several mechanisms, including cleavage of insulin-like growth factor-binding protein-3 and degradation of extracellular matrix proteins fibronectin and laminin
  • PSA expression is regulated by the AR and is thought to function as a growth factor in LNCaP cells
  • down-regulation of PSA expression may be important in the antiproliferative effects of DIM in LNCaP cells
  • Nathan Goodyear on 05 Nov 14
     
    DIM, from cruciferous veggies often used to aid estrogen metabolism, is found to decrease PSA transcription and function as an androgen receptor antagonist in prostate cancer cell lines.
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