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Nathan Goodyear

Effects of Testosterone on Coronary Vasomotor Regulation in Men With Coronary Heart Dis... - 0 views

circ.ahajournals.org/...1690.full

Testosterone heart cardiovascular disease men male hormone hormones

shared by Nathan Goodyear on 03 Dec 13 - No Cached
  • Nathan Goodyear on 03 Dec 13
     
    Intracoronary Testosterone infusion of Testosterone found to increase arterial dilation and improve blood flow.
Nathan Goodyear

Cardiovascular Diabetology | Full text | Improvement of the diabetic foot upon testoste... - 0 views

www.cardiab.com/19

diabetes type II diabetes therapy treatment low T Testosterone cardiovascular disease PAD peripheral arterial disease foot

shared by Nathan Goodyear on 13 May 14 - No Cached
  • Nathan Goodyear on 13 May 14
     
    Case report of 3 cases finds improvement in diabetic foot complications, including neuropathy, in men treated with Testosterone.  This makes sense as the Testosterone will improve insulin function, improve HgbA1c and reduce inflammation in these men.
Nathan Goodyear

Testosterone Deficiency, Cardiac Health, and Older Men - 0 views

www.hindawi.com/...143763

low T Testosterone obesity type II diabetes diabetes health wellness metabolic syndrome lipids cholesterol hypogonadism TDS testicular dysgenesis syndrome men male hormone hormones prostate cancer

shared by Nathan Goodyear on 12 May 14 - No Cached
  • Studies have shown pharmacological doses of testosterone to relax coronary arteries when injected intraluminally [39] and to produce modest but consistent improvement in exercise-induced angina and reverse associated ECG changes [40]. The mechanism of action is via blockade of calcium channels with effect of similar magnitude to nifedipine
    • Nathan Goodyear
      Nathan Goodyear on 12 May 14
       
      This directly refutes the recent studies (3) that Testosterone therapy increases cardiovascular events.
    • Nathan Goodyear
      Nathan Goodyear on 13 May 14
       
      Testosterone acts as a calcium channel blocker inducing vasodilation.
  • men with chronic stable angina pectoris, the ischaemic threshold increased after 4 weeks of TRT and a recent study demonstrates improvement continuing beyond 12 months [
  • Exercise capacity in men with chronic heart failure increased after 12 weeks
  • ...36 more annotations...
  • Studies have shown an inverse relationship between serum testosterone and fasting blood glucose and insulin levels
  • Medications such as chronic analgesics, anticonvulsants, 5ARIs, and androgen ablation therapy are associated with increased risk of testosterone deficiency and insulin resistance
  • Women with T2D or metabolic syndrome characteristically have low SHBG and high free testosterone
    • Nathan Goodyear
      Nathan Goodyear on 12 May 14
       
      This stands in polar opposite of that with men.
  • Hypogonadism is a common feature of the metabolic syndrome
  • The precise interaction between insulin resistance, visceral adiposity, and hypogonadism is, as yet, unclear but the important mechanisms are through increased aromatase production, raised leptin levels, and increase in inflammatory kinins
  • levels of testosterone are reduced in proportion to degree of obesity
  • Men should be encouraged to combine aerobic exercise with strength training. As muscle increases, glucose will be burned more efficiently and insulin levels will fall. A minimum of 30 minutes exercise three times weekly should be advised
  • Testosterone increases levels of fast-twitch muscle fibres
  • By increasing testosterone, levels of type 2 fibres increase and glucose burning improves
  • Weight loss will increase levels of testosterone
  • studies now clearly show that low testosterone leads to visceral obesity and metabolic syndrome and is also a consequence of obesity
  • In the case of MMAS [43], a baseline total testosterone of less than 10.4 nmol/L was associated with a greater than 4-fold incidence of type 2 diabetes over the next 9 years
  • There is high level evidence that TRT improves insulin resistance
  • Low testosterone predicts increased mortality and testosterone therapy improves survival in 587 men with type 2 diabetes
  • A similar retrospective US study involved 1031 men with 372 on TRT. The cumulative mortality was 21% in the untreated group versus 10% ( ) in the treated group with the greatest effect in younger men and those with type 2 diabetes
  • the presence of ED has been shown to be an independent risk factor, particularly in hypogonadal men, increasing the risk of cardiac events by over 50%
  • A recent online publication on ischaemic heart disease mortality in men concluded optimal androgen levels are a biomarker for survival
  • inverse associations between low TT or FT (Table 2) and the severity of CAD
  • A recent 10 year study from Western Australia involving 3690 men followed up from 2001–2010 concluded that TT and FT levels in the normal range were associated with decreased all-cause and cardiovascular mortality, for the first time suggesting that both low and DHT are associated with all-cause mortality and higher levels of DHT reduced cardiovascular risk
  • TDS is associated with increased cardiovascular and all-cause mortality
  • The effect of treatment with TRT reduced the mortality rate of treated cohort (8.4%) to that of the eugonadal group whereas the mortality for the untreated remained high at 19.2%
  • hypogonadal men had slightly increased triglycerides and HDL
  • Men with angiographically proven CAD (coronary artery disease) have significantly lower testosterone levels [29] compared to controls ( ) and there was a significant inverse relationship between the degree of CAD and TT (total testosterone) levels
  • TRT has also been shown to reduce fibrinogen to levels similar to fibrates
  • men treated with long acting testosterone showed highly significant reductions in TC, LDL, and triglycerides with increase in HDL, associated with significant reduction in weight, BMI, and visceral fat
  • Low androgen levels are associated with an increase in inflammatory markers
  • In the Moscow study, C-reactive protein was reduced by TRT at 30 weeks versus placebo
  • In some studies, a decline in diastolic blood pressure has been observed, after 3–9 months [24, 26] and in systolic blood pressure
  • A decline was noted in IL6 and TNF-alpha
  • No studies to date show an increase in LUTS/BPH symptoms with higher serum testosterone levels
  • TRT has been shown to upregulate PDE5 [65] and enhance the effect of PDE5Is (now an accepted therapy for both ED and LUTS), it no longer seems logical to advice avoidance of TRT in men with mild to moderate BPH.
    • Nathan Goodyear
      Nathan Goodyear on 12 May 14
       
      What about just starting with normalization of Testosterone levels first.
  • Several meta-analyses have failed to show a link between TRT and development of prostate cancer [66] but some studies have shown a tendency for more aggressive prostate cancer in men with low testosterone
    • Nathan Goodyear
      Nathan Goodyear on 12 May 14
       
      And if one would have looked at their estrogen levels, I guarantee they would have been found to be elevated.
  • low bioavailable testosterone and high SHBG were associated with a 4.9- and 3.2-fold risk of positive biopsy
  • Current EAU, ISSAM, and BSSM guidance [1, 2] is that there is “no evidence TRT is associated with increased risk of prostate cancer or activation of subclinical cancer.”
  • Men with prostate cancer, treated with androgen deprivation, develop an increase of fat mass with an altered lipid profile
  • Erectile dysfunction is an established marker for future cardiovascular risk and the major presenting symptom leading to a diagnosis of low testosterone
star yu

Porqué Despúes de la Diálisis la Presión Arterial Conviene en Más Alta y Cómo... - 0 views

www.enfermedad-renal.com/...2519.html

Micro-Medicina China osmoterapia

shared by star yu on 15 Sep 15 - No Cached
  • star yu on 15 Sep 15
     
    Porqué después de la diálisis la presión arterial conviene en más alta y cómo tratarla
Nathan Goodyear

Telomere Length Trajectory and Its Determinants in Persons with Coronary Artery Disease... - 0 views

www.telomerescience.com/...-from-the-heart-and-soul-study

Telomere length cardiovascular disease CVD

shared by Nathan Goodyear on 19 Jul 11 - No Cached
  • Nathan Goodyear on 19 Jul 11
     
    telomere length may play a role in cardiovascular disease development
Nathan Goodyear

Plasma Homocysteine Levels and Mortality in Patients with Coronary Artery Disease - NEJM - 0 views

www.nejm.org/...NEJM199707243370403

homocysteine mortality cardiovascular disease CAD risk

shared by Nathan Goodyear on 03 Aug 11 - No Cached
  • Plasma total homocysteine levels are a strong predictor of mortality in patients with angiographically confirmed coronary artery disease
  • Nathan Goodyear on 03 Aug 11
     
    elevated homocysteine strong predictor of mortality
Nathan Goodyear

An Oculocerebrovasculometric Analysis of the Improvement in Arterial Stenosis Following... - 0 views

drcranton.com/...study3.htm

EDTA improvement stenosis chelation therapy arterial

shared by Nathan Goodyear on 07 Jul 11 - No Cached
  • Eighty-eight percent of patients treated with EDTA chelation therapy showed objective improvements in measured cerebrovascular blood flow.
  • Nathan Goodyear on 07 Jul 11
     
    EDTA chelation shows 88% improvement in cerebrovascular blood flow
Nathan Goodyear

Association of serum testosterone with lipid abnormalities in patients with angiographi... - 0 views

www.ncbi.nlm.nih.gov/...PMC3872686

Testosterone male men hormone hormones lipids HDL LDL cholesterol CAD coronary artery disease coronary heart disease

shared by Nathan Goodyear on 08 Jan 14 - No Cached
  • Nathan Goodyear on 08 Jan 14
     
    This study looked at Total serum Testosterone and lipid profiles in men with CAD.  What they found is that serum Total Testosterone is positively associated with HDL and negatively associated with LDL.
Nathan Goodyear

American College of Cardiology Foundation | Article - 0 views

content.onlinejacc.org/...article.aspx

CoQ10 aged garlic extract AGE LP-PLA2 heart health lipoprotein-associated phospholipase A2 CAD CVD cardiovascular disease

shared by Nathan Goodyear on 15 Apr 15 - No Cached
  • Nathan Goodyear on 15 Apr 15
     
    Poster found that aged garlic extract plus CoQ10 slowed coronary artery calcification and decreased Lp-PLA2 compared to placebo.
star yu

PKD con Función Renal Normal pero la Presión Arterial Alta - 0 views

www.hospitalrenal.com/...653.html

enfermedad renal poliquística tratamiento

shared by star yu on 15 Apr 15 - No Cached
  • star yu on 15 Apr 15
     
    Tengo la enfermedad renal poliquística y soy a los 27 años Ahora, mi función renal y el nivel de creatinina es normal, pero mi presión arterial es alta. Riñón derecho es de 13.3 * 7.1 cm, y la izquierda es 14.3 * 7.7cm.
star yu

Cómo Tratar la Nefropatía Diabética con la Creatinina 2.6 - 0 views

www.enfermedad-renal.com/...2672.html

el tratamiento La nefropatía diabética Mixro-Medicina China osmoterapia

shared by star yu on 21 Nov 15 - No Cached
  • star yu on 21 Nov 15
     
    He sufrido la presión arterial alta varios años y ahora mi nivel de creatinina aumenta a 2.6.¿El doctor me dijo que el alto nivel de creatinina es causada por la presión arterial, es eso cierto?¿Hay manera de tratarla?
star yu

Puede Nefropatía Hipertensiva Ser Tratado por Top Siete Tratamientos - 0 views

www.hospitalrenal.com/...1075.html

La nefropatía hipertensivael tratamientoTop Siete Tratamientosla presión arterial

shared by star yu on 10 Dec 15 - No Cached
  • star yu on 10 Dec 15
     
    De hecho ,la nefropatía hipertensiva es una enfermedad secundaria de la presión arterial alta ,así que si quieres tratar bien esta enfermedad ,debe controlar bien la presión artería alta primero .
star yu

Cómo Restaurar la Función Renal Dañado en la Hipertensión Nefropatía - 0 views

www.enfermedad-renal.com/...2701.html

Se sabe que los largos términos de presión arterial alta harán daño a riñones y es difícil restaurar.

shared by star yu on 02 Dec 15 - No Cached
  • star yu on 02 Dec 15
     
    Cómo Restaurar la Función Renal Dañado en la Hipertensión NefropatíaSe sabe que los largos términos de presión arterial alta harán daño a los riñones, y es difícil de restaurar.
Nathan Goodyear

Renin-angiotensin system and cancer: A review - 0 views

www.oatext.com/system-and-cancer-A-review.php

renin angiotensin system cancer

shared by Nathan Goodyear on 10 Sep 18 - No Cached
  • crucial role of the RAS in the development and maintenance of cancer
  • kidneys, which produce renin in response to decreased arterial pressure, reduced sodium in the distal tubule, or sympathetic nervous system activity via the β-adrenergic receptors
  • Renin is secreted from the juxtaglomerular cells into the bloodstream where it encounters angiotensinogen (AGN), normally produced by the liver
  • ...22 more annotations...
  • Renin catalyses the conversion of AGN to angiotensin I (ATI), which is quickly cleaved by angiotensin converting enzyme (ACE) to form angiotensin II (ATII)
  • ATII triggers the release of aldosterone from the adrenal glands, which stimulates reabsorption of sodium and water and thereby increases blood volume and blood pressure
  • ATII also acts on smooth muscle to cause vasoconstriction of the arterioles
  • ATII promotes the release of antidiuretic hormone from the posterior pituitary gland, which results in water retention and triggers the thirst reflex
  • ability of non-CSCs to ‘de-differentiate’ into CSCs due to epigenetic or environmental factors, which further increases the complexity of tumour biology and treatment
  • efficacy of RAS modulators on cancer in both cancer models and cancer patients
  • A localised (‘paracrine’) RAS mechanism has been identified in many types of cancers, and interruption of the control of the RAS is thought to be the basis for its role in cancer
  • Components of the RAS are expressed by these CSCs, supporting the hypothesis of the presence of a ‘paracrine RAS’ in regulating these CSCs
  • Renin is an enzyme normally released by the kidneys in response to falling arterial pressure
  • a study of GBM demonstrating overexpression of PRR coupled with the observation that inhibition of renin reduces cellular proliferation and promotes apoptosis
  • PRR has been found to be vital for normal Wnt signalling
  • A major focus of PRR research is its relationship with Wnt signalling
  • suggest a crucial role for PRR activation on the proliferation of CSCs, possibly via Wnt/β-catenin signalling, leading to carcinogenesis.
  • Angiotensin converting enzyme (ACE), also known as CD143, is the endothelial-bound peptidase which physiologically converts ATI to ATII
  • ACE is crucial in the regulation of blood pressure, angiogenesis and inflammation
  • results suggest that an overactive ACE promotes cancer growth and progression, and an inhibited or low-activity ACE may have cancer-protective effects
  • When bound to ATII or ATIII it causes vasoconstriction by stimulating the release of vasopressin, reabsorption of water and sodium by promoting secretion of aldosterone and insulin, fibrosis, cellular growth and migration, pro-inflammation, glucose release from the liver, increased plasma triglyceride concentration, and reduced gluconeogenesis
  • ATIIR1 is a G-protein-coupled receptor, with downstream signalling involved in vasodilation, hypertrophy and NF-κB activation leading to TNF-α and PAI-1 expression
  • ATIIR1 has well-documented links with cancer, with one study demonstrating its overexpression in ~20% of breast cancer patients
  • the effect of RAS dysregulation has been associated with increased VEGF expression and angiogenesis in cancers
  • In ovarian and cervical cancer, ATIIR1 overexpression has been shown to be an indicator of tumour invasiveness
  • administration of ATIIR1 blockers (ARBs) have been associated with reduced tumour size, reduction in tumour vascularisation, lower occurrence of metastases, and lower VEGF levels
  • Nathan Goodyear on 10 Sep 18
     
    Great review on RAS in cancer.
Nathan Goodyear

What does my patient's coronary artery calcium score mean? Combining information from t... - 0 views

www.ncbi.nlm.nih.gov/...PMC515311

calcium score heart disease coronary calcium score CVD cardiovascular disease

shared by Nathan Goodyear on 05 Oct 17 - No Cached
  • Nathan Goodyear on 05 Oct 17
     
    good review of the coronary calcium score and associated risk estimates.
Nathan Goodyear

Calcification in coronary artery disease can be reversed by EDTA-tetracycline long-term... - 0 views

www.ncbi.nlm.nih.gov/...15364120

EDTA coronary calcium score CAD coronary artery disease CVD cardiovascular disease

shared by Nathan Goodyear on 05 Oct 17 - No Cached
  • Nathan Goodyear on 05 Oct 17
     
    Study finds that 57% of study participants saw a 14% reduction in coronary calcium score with combined EDTA plus tetracycline.  The reduction may seem modest, and it is, but the delivery method of the EDTA is going to limit the effects.  EDTA should be given IV.
Nathan Goodyear

Inflammation and cortisol response in coronary artery disease: Annals of Medicine: Vol ... - 0 views

www.tandfonline.com/...07853890802508934

HPA axis HPA inflammation hormones stress cortisol CAD coronary artery disease

shared by Nathan Goodyear on 12 Oct 16 - No Cached
  • Nathan Goodyear on 12 Oct 16
     
    Inflammation disrupts HPA axis.  This is no surprise as we Know that inflammation can disrupt Testosterone in men and progesterone production in women.  This study suggests that this HPA axis disruption contributes to CAD.
cityxrayclinic

CT Angiography in Delhi - Coronary Angiography in Delhi - 0 views

www.cityxrayclinic.com/...ct-angiography

Coronary Angiography in Delhi CT

shared by cityxrayclinic on 07 Jun 17 - No Cached
  • cityxrayclinic on 07 Jun 17
     
    CT Angiography or CTA stands for "Computed Tomography Angiography". It is a computed tomography technique which is mainly used to study the arteries and veins of the body. City x-ray and Scan Clinic (P) Ltd is one of the best diagnostic center in Delhi, which offers best CT Angiography facilities. You can book a test and get the reports online. Here you will have Somatom Definition AS 194 slice/sec most advanced Multi Slice Spiral CT Scanner from Siemens.
indiacardiacsurg

Dr. T S Kler Predict Contrast-Associated Kidney Injury After Percutaneous Coronary Inte... - 0 views

www.briefingwire.com/...utaneous-coronary-intervention

Dr. T S Kler Best cardiologist Delhi interventional cardiologists Dr. T S Kler Best cardiologist Delhi Best Interventional Cardiologist in Delhi India

shared by indiacardiacsurg on 24 Nov 21 - No Cached
  • indiacardiacsurg on 24 Nov 21
     
    Dr. T S Kler Best cardiologist Delhi uses x-ray imaging, known as angiography, to determine which arteries have the most intense blockages, and inject a fluid referred to the as iodinated evaluation into the bloodstream to make the blockages seen on x-ray. That fluid is toxic, and high-risk agencies could have kidney issues as an end result. For Consultation Dr.TS Kler Email - drtskler@indiacardiacsurgerysite.com Call for Appointment- +91-9370586696
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