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Nathan Goodyear

Amygdala - Scholarpedia - 0 views

www.scholarpedia.org/...Amygdala

amygdala stress HPA axis stress response brain

shared by Nathan Goodyear on 03 Sep 17 - No Cached
  • Nathan Goodyear on 03 Sep 17
     
    Great article on the amygdala and its processing of the stress response.
Nathan Goodyear

Salivary Testosterone and a Trinucleotide (CAG) Length Polymorphism in the Androgen Rec... - 0 views

www.ncbi.nlm.nih.gov/...PMC2825741

CAG androgen receptors AR androgen receptor Testosterone hormone hormones male men

shared by Nathan Goodyear on 22 Jun 15 - No Cached
  • Testosterone correlated inversely with participant age (r = −0.39, p = 0.012) and positively with number of CAG repeats
  • transactivation potential of the AR appears to decline in graded relation to an increasing number of CAG repeats, which are distributed over a normative range of 11–37 and, in Caucasian populations, commonly average 21–22 repeats
  • When activated by androgens, ARs translocate to the cell nucleus, where they exert transcriptional control of androgen-dependent genes by binding to androgen response elements within gene regulatory sequences
  • ...10 more annotations...
  • some evidence suggests a high number of CAG repeats may be associated with cognitive aging
  • androgens (like other steroid hormones) promote or repress the expression of genes specifying an array of cellular proteins
  • diurnal variation in testosterone levels
  • salivary testosterone correlated negatively with participant age and positively with CAG length variation in the AR gene
  • CAG repeat number varied inversely with reactivity of the ventral amygdala to facial expressions of negative affect
  • higher salivary testosterone was likewise associated with a greater number of AR CAG repeats
  • relative androgen insensitivity in ARs with a larger number of CAG repeats
  • Because circulating testosterone is regulated via negative feedback through the hypothalamic-pituitary-gonadal axis, diminished androgen sensitivity at higher CAG repeat lengths may reduce feedback suppression of luteinizing hormone (LH). LH would then be maintained at higher levels, in turn promoting higher testosterone production
  • Testosterone up-regulates AVP expression in the amygdala
  • Oxytocin exerts an inhibitory influence on AVP expression in the central amygdala, and the synthesis of oxytocin is mediated by estrogen and estrogen receptors
  • Nathan Goodyear on 22 Jun 15
     
    Study used saliva to measure Testosterone levels in men.  Testosterone levels were inversely associated with age, but positively associated with CAG repeat sequences in the AR.
Nathan Goodyear

Lower sexual interest in postpartum women: relati... [Horm Behav. 2013] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...23085496

oxytocin libido hormone hormones intranasal

shared by Nathan Goodyear on 29 Jul 13 - No Cached
  • Nathan Goodyear on 29 Jul 13
     
    The right amygdala appears to play a role in the postpartum decline in libido in women.  This study found no difference with intranasal oxytocin spray.
Nathan Goodyear

Molecular mechanism of amygdalin action in vitro: review of the latest research: Immuno... - 0 views

www.tandfonline.com/...08923973.2018.1441301

cancer amygdalin

shared by Nathan Goodyear on 17 Jul 19 - No Cached
  • Nathan Goodyear on 17 Jul 19
     
    amygdala has multiple effects agains cancer: inhibition of IL-1, inhibition of NF-kappaB, inhibition of cell proliferation...only abstract available.
Nathan Goodyear

Influence of pediatric vaccines on amygdala growth and opioid ligand binding in rhesus ... - 0 views

www.ane.pl/7020.pdf

vaccination ASD autism vaccinations

shared by Nathan Goodyear on 15 May 12 - No Cached
  • Nathan Goodyear on 15 May 12
     
    vaccinations as given between 1994 and 1999 were administered to rhesus macaque monkeys. The challenge group showed altered brain development versus the control group of saline. This was a small pilot study, but well designed.
Nathan Goodyear

Concussive Brain Injury Enhances Fear Learning and Excitatory Processes in the Amygdala - 0 views

www.biologicalpsychiatryjournal.com/...abstract

TBI PTSD traumatic brain injury post-traumatic stress disorder

shared by Nathan Goodyear on 17 Feb 12 - No Cached
  • Nathan Goodyear on 17 Feb 12
     
    Link between TBI and PTSD.
Nathan Goodyear

Effects of Elevation of Brain Magnesium on Fear Conditioning, Fear Extinction, and Syna... - 0 views

www.jneurosci.org/...14871.long

magnesium neuroplasticity brain

shared by Nathan Goodyear on 04 Nov 13 - No Cached
  • Nathan Goodyear on 04 Nov 13
     
    Magnesium, in this study Magnesium Threonate, shown to increase neuroplasticity
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