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wheelchairindia9

Chest Binder - 0 views

www.wheelchairindia.com/...Tynor-Chest-Binder

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shared by wheelchairindia9 on 06 Apr 16 - No Cached
  • wheelchairindia9 on 06 Apr 16
     
    Tynor Chest Binder Chest Binder is applied to the thoracic region to compress and bind the rib cage and provide splinting to the sternum while allowing sufficient flexibility for comfortable breathing. Anatomic chest pad. Controlled compression. Optimum chest splinting. Soft feel. Tynor Chest Binder Features 50 mm thick PUF pad hold and binds the fractured sternum without compromising on patient comfort. Strong elastic band gives good grip and helps in equidistribution of pressure. Reduces post operative pain and discomfiture. Facilitates phlegm expulsion after cardio thoracic surgery. Tynor Chest Binder Measurements Measure circumference around the chest.
Nathan Goodyear

The role of vitamin C in the treatment of pain: new insights - 0 views

www.ncbi.nlm.nih.gov/...PMC5391567

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shared by Nathan Goodyear on 18 Sep 17 - No Cached
  • recommended that during illness one should be careful about the intake of vitamin C, keeping in mind that acute illness rapidly depletes stores of ascorbic acid
  • it is possible that other hospital-associated pain may be partly due to vitamin C deficiency, which is relatively prevalent in hospital settings
  • Vitamin C deficiency (defined as plasma vitamin C concentrations <11 µmol/L
  • ...5 more annotations...
  • Vitamin C is cost effective and appears to be a safe and effective adjunctive therapy for specific pain relief
  • it decreases the requirement for opioid analgesics, particularly post surgically and for bone metastasis
  • recent research has indicated a positive impact of high dose vitamin C on cancer- and chemotherapy-related quality of life, including pain
  • Cameron and Campbell [81] reported a number of cases of dramatic to complete amelioration of bone pain in patients with severe cancer-related pain given both high dose oral and intravenous vitamin C
  • hypovitaminosis C (defined as plasma vitamin C concentrations <23 µmol/L
  • Nathan Goodyear on 18 Sep 17
     
    vitamin C reduces pain; mechanism of action likely anti-inflammatory antioxidant, but yet inconclusive.
Nathan Goodyear

The Effect of an EDTA-based Chelation Regimen on Patients With Diabetes Mellitus and Pr... - 0 views

circoutcomes.ahajournals.org/...CIRCOUTCOMES.113.000663

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shared by Nathan Goodyear on 05 Oct 17 - No Cached
  • Nathan Goodyear on 05 Oct 17
     
    Only abstract available here, but EDTA chelation found to reduce risk of death, reinfarction, stroke, hospitalization, angina in individuals with diabetes and prior MI from 38% to 25%.
Nathan Goodyear

Frontiers | The Clinical, Symptom, and Quality-of-Life Characterization of a Well-Defin... - 0 views

www.frontiersin.org/...full

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shared by Nathan Goodyear on 22 Feb 18 - No Cached
  • Nathan Goodyear on 22 Feb 18
     
    New Lyme disease article on PTLDS.
Nathan Goodyear

Vitamin C preferentially kills cancer stem cells in hepatocellular carcinoma via SVCT-2... - 0 views

www.nature.com/...s41698-017-0044-8

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shared by Nathan Goodyear on 30 Jan 18 - No Cached
  • Chen et al. have revealed that ascorbate at pharmacologic concentrations (0.3–20 mM) achieved only by intravenously (i.v.) administration selectively kills a variety of cancer cell lines in vitro, but has little cytotoxic effect on normal cells.
  • Ascorbic acid (the reduced form of vitamin C) is specifically transported into cells by sodium-dependent vitamin C transporters (SVCTs)
  • SVCT-1 is predominantly expressed in epithelial tissues
  • ...41 more annotations...
  • whereas the expression of SVCT-2 is ubiquitous
  • differential sensitivity to VC may result from variations in VC flow into cells, which is dependent on SVCT-2 expression.
  • high-dose VC significantly impaired both the tumorspheres initiation (Fig. 4d, e) and the growth of established tumorspheres derived from HCC cells (Fig. 4f, g) in a time-dependent and dose-dependent manner.
  • Hepatocellular carcinoma (HCC)
  • The antioxidant, N-acetyl-L-cysteine (NAC), preventing VC-induced ROS production (a ROS scavenger), completely restored the viability and colony formation among VC-treated cells
  • DNA double-strand damage was found following VC treatment
  • DNA damage was prevented by NAC
  • Interestingly, the combination of VC and cisplatin was even more effective in reducing tumor growth and weight
  • Consistent with the in vitro results, stemness-related genes expressions in tumor xenograft were remarkably reduced after VC or VC+cisplatin treatment, whereas conventional cisplatin therapy alone led to the increase of CSCs
  • VC is one of the numerous common hepatoprotectants.
  • Interestingly, at extracellular concentrations greater than 1 mM, VC induces strong cytotoxicity to cancer cells including liver cancer cells
  • we hypothesized that intravenous VC might reduce the risk of recurrence in HCC patients after curative liver resection.
  • Intriguingly, the 5-year disease-free survival (DFS) for patients who received intravenous VC was 24%, as opposed to 15% for no intravenous VC-treated patients
  • Median DFS time for VC users was 25.2 vs. 18 months for VC non-users
  • intravenous VC use is linked to improved DFS in HCC patients.
  • In this study, based on the elevated expression of SVCT-2, which is responsible for VC uptake, in liver CSCs, we revealed that clinically achievable concentrations of VC preferentially eradicated liver CSCs in vitro and in vivo
    • Nathan Goodyear
      Nathan Goodyear on 31 Jan 18
       
      the authors here made similar mistakes to the Mayo authors i.e. under doses here in this study.  They dosed at only 2 grams IVC.  A woefully low dose of IVC.
  • Additionally, we found that intravenous VC reduced the risk of post-surgical HCC progression in a retrospective cohort study.
    • Nathan Goodyear
      Nathan Goodyear on 31 Jan 18
       
      positive results despite a low dose used.
    • Nathan Goodyear
      Nathan Goodyear on 31 Jan 18
       
      Their comfort zone was 1mM.  They should have targeted 20-40 mM.
  • Three hundred thirty-nine participants (55.3%) received 2 g intravenous VC for 4 or more days after initial hepatectomy
  • As the key protein responsible for VC uptake in the liver, SVCT-2 played crucial roles in regulating the sensitivity to ascorbate-induced cytotoxicity
  • we also observed that SVCT-2 was highly expressed in human HCC samples and preferentially elevated in liver CSCs
  • SVCT-2 might serve as a potential CSC marker and therapeutic target in HCC
  • CSCs play critical roles in regulating tumor initiation, relapse, and chemoresistance
  • we revealed that VC treatment dramatically reduced the self-renewal ability, expression levels of CSC-associated genes, and percentages of CSCs in HCC, indicating that CSCs were more susceptible to VC-induced cell death
  • as a drug for eradicating CSCs, VC may represent a promising strategy for treatment of HCC, alone or particularly in combination with chemotherapeutic drugs
  • In HCC, we found that VC-generated ROS caused genotoxic stress (DNA damage) and metabolic stress (ATP depletion), which further activated the cyclin-dependent kinase inhibitor p21, leading to G2/M phase cell cycle arrest and caspase-dependent apoptosis in HCC cells
  • we demonstrated a synergistic effect of VC and chemotherapeutic drug cisplatin on killing HCC both in vitro and in vivo
  • Intravenous VC has also been reported to reduce chemotherapy-associated toxicity of carboplatin and paclitaxel in patients,38 but the specific mechanism needs further investigation
    • Nathan Goodyear
      Nathan Goodyear on 31 Jan 18
       
      so, exclude the benefit to patients until the exact mechanism of action, which will never be fully elicited?!?!?
  • Our retrospective cohort study also showed that intravenous VC use (2 g) was related to the improved DFS in HCC patients after initial hepatectomy
    • Nathan Goodyear
      Nathan Goodyear on 31 Jan 18
       
      Terribly inadequate dose.  Target is 20-40 mM which other studies have found occur with 50-75 grams of IVC.
  • several clinical trials of high-dose intravenous VC have been conducted in patients with advanced cancer and have revealed improved quality of life and prolonged OS
  • high-dose VC was not toxic to immune cells and major immune cell subpopulations in vivo
  • high recurrence rate and heterogeneity
  • tumor progression, metastasis, and chemotherapy-resistance
  • SVCT-2 was highly expressed in HCC samples in comparison to peri-tumor tissues
  • high expression (grade 2+/3+) of SVCT-2 was in agreement with poorer overall survival (OS) of HCC patients (Fig. 1c) and more aggressive tumor behavior
  • SVCT-2 is enriched in liver CSCs
  • these data suggest that SVCT-2 is preferentially expressed in liver CSCs and is required for the maintenance of liver CSCs.
  • pharmacologic concentrations of plasma VC higher than 0.3 mM are achievable only from i.v. administration
  • The viabilities of HCC cells were dramatically decreased after exposure to VC in dose-dependent manner
  • VC and cisplatin combination further caused cell apoptosis in tumor xenograft
  • These results verify that VC inhibits tumor growth in HCC PDX models and SVCT-2 expression level is associated with VC response
  • qPCR and IHC analysis demonstrated that expression levels of CSC-associated genes and percentages of CSCs in PDXs dramatically declined after VC treatment, confirming the inhibitory role of VC in liver CSCs
  • Nathan Goodyear on 30 Jan 18
     
    IV vitamin C in vitro and in vivo found to "preferentially" eradicate cancer stem cells.  In addition, IV vitamin C was found to be adjunctive to chemotherapy, found to be hepatoprotectant.  This study also looked at SVCT-2, which is the transport protein important in liver C uptake.
Rahul Sharma

Axiva - Find Best Quality Lab Filtration Products and Laboratory Filters - 0 views

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shared by Rahul Sharma on 21 Jun 18 - No Cached
  • Rahul Sharma on 21 Jun 18
     
    Axiva Sichem Pvt.Ltd is a global source of laboratory filtration products and laboratory filters. We offer a wide range of laboratory filtration equipment supplies including filter paper, filter funnels, syringe filters, vacuum filtration funnel and more.
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shared by trungtamnamkhoa on 25 Jun 19 - No Cached
  • trungtamnamkhoa on 25 Jun 19
     
    The penis gets pimples, white or red items make men worried because they don't know the cause. In most of the causes of penile acne, the group of causes of sexually transmitted diseases is the most dangerous. Genital skin is very sensitive, especially in the penis. Only a small change can cause abnormal symptoms such as tumors, irritation, irritation and discomfort. Men need to understand the reasons for effective prevention and treatment. Group of allergy causes: Men with acne in the penis due to local allergies, for example, the penis skin has been exposed to "strange" substances from poor quality condoms. In addition, wearing underwear that is too tight, fabric material is not guaranteed or new clothes bought without washing well and many dust and dirt also cause irritation and penile pimples. Eating allergenic foods can also irritate the skin and, if unfortunately, the skin is as delicate as the "genital area".
luvherbal

Extra Power Male Enhancement Supplement - 0 views

luvherbal.com/er-male-enhancement-supplement

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shared by luvherbal on 07 Mar 17 - No Cached
  • luvherbal on 07 Mar 17
     
    Extra Power Male Enhancement Supplement :-It is an all natural herbal preparation for male sexual performance. It is a exclusive blend of high quality ayurvedic mixture. It increases the blood circulation and expand the capillary tissue. Due to increased blood flow more oxygen and nutrients are supplied to male sex organ.
Nathan Goodyear

PLOS ONE: The Ketogenic Diet and Hyperbaric Oxygen Therapy Prolong Survival in Mice wit... - 0 views

journals.plos.org/...article

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shared by Nathan Goodyear on 17 Nov 16 - No Cached
  • This finding strongly supports the efficacy of the KD and HBO2T as therapies to inhibit tumor progression and prolong survival in animals with metastatic cancer.
  • We found that the KD fed ad libitum significantly increased mean survival time in mice with metastatic cancer
  • Ketogenic diets are also known to have an appetite suppressing effect which may contribute to body weight loss
  • ...5 more annotations...
  • the ketogenic diet may inhibit cancer progression in part by indirect dietary energy restriction
  • KD with HBO2T. Combining these therapies nearly doubled survival time in mice with metastatic cancer,
  • low carbohydrate or ketogenic diets promote weight loss in overweight individuals, they are also known to spare muscle wasting during conditions of energy restriction and starvation
  • dietary-induced therapeutic ketosis in a cancer patient would prevent muscle wasting similarly as it does with athletes undergoing intense exercise
  • when given as an adjuvant treatment to advanced cancer patients, the KD improves quality of life and enhances the efficacy of chemotherapy treatment in the clinic
  • Nathan Goodyear on 17 Nov 16
     
    mouse study finds that ketogenic diet plus hyperbaric O2 treatment prolongs survival.
  • Open TeleShop on 17 May 17
     
    Hey Dear Check Out Our Online Shopping store in all Over Pakistan.As Seen as On Tv Products Like as Health Beauty,Fitness,Homeware,Kitchenware,And Other Electronic Products in Pakistan Check Out Now| www.openTeleshop.Com
Nathan Goodyear

Efficiency of pulsed electromagnetic fields on pain, disability, anxiety, depression, a... - 0 views

www.ncbi.nlm.nih.gov/...PMC7018371

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shared by Nathan Goodyear on 21 Jan 21 - No Cached
  • Nathan Goodyear on 21 Jan 21
     
    PEMF found to be helpful in reducing cervical disk herniation associated pain.
dblendstore

https://dblendstore.com/which-antidepressant-is-right-for-you/ - 0 views

Finding the right antidepressant medication can feel like a "hit or miss" proposition. While it may appear that doctors choose which antidepressant to prescribe for you at random, there is some log...

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shared by ashleyobama on 15 Jun 20 - No Cached
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yellowredphotography.com/candid-photography

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shared by digitalorainfo on 20 May 20 - No Cached
  • digitalorainfo on 20 May 20
     
    We have an elite team of candid photographers equipped with people skills. With a friendly approach, they make you feel ease and help you face the camera without being nervous. They thump interesting conversation and intermingle just like your long known friend. This is the appreciable quality of our candid photographer that makes them your first preference over the traditional photographer.
Nathan Goodyear

Intravenous Vitamin C Administration Improved Blood Cell Counts and Health-Related Qual... - 0 views

www.ncbi.nlm.nih.gov/...PMC6070822

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shared by Nathan Goodyear on 29 May 20 - No Cached
  • Nathan Goodyear on 29 May 20
     
    Case study of IV vitamin C twice weekly for treatment of relapse AML.
digitalorainfo

Professional Photography - Candid Wedding Photographers in Banglore Hydrabad - 0 views

yellowredphotography.com/professional-photography

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shared by digitalorainfo on 21 May 20 - No Cached
  • digitalorainfo on 21 May 20
     
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বাংলাদেশ স্বাস্থ্য নিউজ আপডেট - সংবাদ মাধ্যম: ভারতের সার্ভিকাল স্পাইন সার্জনদ... - 0 views

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shared by spineneuro on 04 Jan 22 - No Cached
  • spineneuro on 04 Jan 22
     
    ভারত, ভারতের শীর্ষ 10 সার্ভিকাল মেরুদন্ডের সার্জনদের মাধ্যমে সরবরাহ করা চিকিৎসা যত্ন সহ বেশ সুনির্দিষ্ট এবং চিকিৎসা যোগাযোগও বেশ ভাল। +91-98604-32255 কল করুন বা enquiry@spineandneurosurgeryhospitalindia.com এ ইমেল করুন
spineneuro

French to India Medical Travel: Revenez à une vie de qualité avec les chirurg... - 0 views

frenchtoindiamedicaltravel.blogspot.com/...s-cervical-spine-surgeons.html

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shared by spineneuro on 09 Dec 21 - No Cached
  • spineneuro on 09 Dec 21
     
    Les chirurgiens indiens du rachis cervical ont une expérience et des compétences reconnues dans le monde entier pour la chirurgie de la laminoplastie cervicale. Des patients du monde entier viennent en Inde en raison de l'intérêt thérapeutique des 10 meilleurs chirurgiens de la colonne cervicale en Inde ou en raison de l'offre médicale plus élevée des chirurgiens de la colonne cervicale indiens qui pratiquent ces chirurgies aux taux les plus modérés. Cliquez ici pour un rendez-vous rapide ou appelez le +91-98604-32255 ou envoyez un courriel à enquiry@spineandneurosurgeryhospitalindia.com
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