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Nathan Goodyear

Unveiling the Mechanisms for Decreased Glutathione in Individuals with HIV Infection - 0 views

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    men with HIV have GSH depleted macrophages.  GSH is the reduced, ready to act form of Glutathione.  In contrast, the macrophages were high in the oxidized form of Glutathione--GSSG.  In HIV, the high inflammation increased oxidative stress, likely overwhelmed Nrf2 activation and resulted in decreased GSH synthase transcription and thus decreased Glutathione production balance.
Nathan Goodyear

Curcumin inhibits proliferation of breast cancer cells through Nrf2-mediated down-regul... - 0 views

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    Another mark for cucumin in the battle against cancer.  This article looked at the mechanism behind the inhibition of cell proliferation by curcumin.  The proposed mechanism is via Nrf2 induction in the MCF-7 cell culture lines.
Nathan Goodyear

NRF2 activation restores disease related metabolic ... [PLoS One. 2011] - PubMed - NCBI - 0 views

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    NRF2 could be a new target of therapy for people with Parkinson's and other neurodegenerative disorders.
Nathan Goodyear

Mary Ann Liebert, Inc. - Journal of Neurotrauma - 0(ja): - 0 views

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    sulphoraphane activates Nrf2 pathway, which promotes Glutathione production, plays role in reducing oxidative damage and neuroinflammation
Nathan Goodyear

Nrf2 activation by sulforaphane restores the age-related decrease of TH1 immunity: Role... - 0 views

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    sulforaphane upregulates Th1 immunity; which aging shifts to Th2 dominance
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