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Very interesting read and one to take note of: initially, upregulating Nrf2 was thought to be a good thing i.e. tumor suppressor, but now it appears that upregulation of Nrf2 is critical to cancer cell survival.

Nrf2 inhibition decreased chemoresistance to artesunate in Patients with head and neck cancer resistant to cisplatin.

NRF2 could be a new target of therapy for people with Parkinson's and other neurodegenerative disorders.

Another mark for cucumin in the battle against cancer.  This article looked at the mechanism behind the inhibition of cell proliferation by curcumin.  The proposed mechanism is via Nrf2 induction in the MCF-7 cell culture lines.

Good review of the Nrf2 role in oxidative stress.

sulphoraphane activates Nrf2 pathway, which promotes Glutathione production, plays role in reducing oxidative damage and neuroinflammation

men with HIV have GSH depleted macrophages.  GSH is the reduced, ready to act form of Glutathione.  In contrast, the macrophages were high in the oxidized form of Glutathione--GSSG.  In HIV, the high inflammation increased oxidative stress, likely overwhelmed Nrf2 activation and resulted in decreased GSH synthase transcription and thus decreased Glutathione production balance.

sulforaphane upregulates Th1 immunity; which aging shifts to Th2 dominance

Protects cells against endogenous/exogenous stressors. Intermittent protects cells; chronic activation used by cancer to promote survival.

Oxidative Stress

Testosterone stimulates dopaminergic activity in rat study.