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Nathan Goodyear

Template Paper - 0 views

www.ijbs.org/...ContentFullText.aspx

estriol E3 progesterone hormone hormones BHRT anti-inflammatory neuroprotective inflammation

shared by Nathan Goodyear on 07 Jun 12 - No Cached
  • Nathan Goodyear on 07 Jun 12
     
    This article briefly discusses the anti-inflammatory and neuroprotective effects of estriol (E3) and progesterone 
Nathan Goodyear

Kinetic analysis of estrogen receptor/ligand interactions - PNAS - 0 views

www.pnas.org/...8562.full

Estriol estrogen breast cancer bioidentical hormones

shared by Nathan Goodyear on 09 Nov 10 - No Cached
  • Nathan Goodyear on 09 Nov 10
     
    Estriol binds receptors that inhibit breast cell growth more than those that promote growth 3:1
Nathan Goodyear

Quantitative structure-activity relationship of va... [Endocrinology. 2006] - PubMed re... - 0 views

www.ncbi.nlm.nih.gov/...16728493

Estriol estrogen breast cancer bioidentical hormones

shared by Nathan Goodyear on 09 Nov 10 - No Cached
  • Nathan Goodyear on 09 Nov 10
     
    Estriol favors inhibition of breast growth 3:1
Nathan Goodyear

A comparison of saliva, plasma unconjugated and plasma total oestriol levels throughout... - 0 views

onlinelibrary.wiley.com/...abstract

saliva salivary testing estriol

shared by Nathan Goodyear on 18 Jan 11 - No Cached
  • It seems probable that measurement of salivary E3 could adequately replace that of plasma unconjugated E3 in the assessment of fetoplacental function.
  • Nathan Goodyear on 18 Jan 11
     
    salivary testing of estriol in pregnancy validated
Nathan Goodyear

Steroid hormones in multiple sclerosis. [J Neurol Sci. 2005] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...15878598

MS multiple sclerosis multiple sclerosis hormone hormones pregnancy women Estriol E3 progesterone

shared by Nathan Goodyear on 07 Jan 14 - No Cached
  • Nathan Goodyear on 07 Jan 14
     
    Pregnancy has a positive effect on MS patients, especially during the 3rd trimester.  Rebound of MS increases in the postpartum period.  Estriol is the dominant pregnancy estrogen.  Progesterone is also produced at high levels.  The withdrawal of these hormones in the postpartum period are likely to lead to this rebound in MS.
Nathan Goodyear

Gender and sex hormones in multiple sclerosis pathology and therapy - 0 views

www.ncbi.nlm.nih.gov/...PMC2689399

hormones MS multiple Sclerosis Estriol progesterone

shared by Nathan Goodyear on 11 Jan 17 - No Cached
  • It is now well recognized that the disease manifestation is reduced in pregnant women with relapsing-remitting MS
  • This occurs particularly during the third trimester when levels of estrogens (estradiol and estriol) and progesterone (see Table 2) are elevated up to about 20 times
  • This seems well correlated with a decrease in active white matter lesions detected by MRI
  • ...12 more annotations...
  • This clinical improvement is however followed by temporary rebound exacerbations at post-partum, when the hormone levels decline
  • a shift from Th1 to Th2 immune response, expansion of suppressive regulatory T lymphocytes and decrease in the number of circulating CD16+ natural killer (NK)-cells
  • Th1 lymphocytes secrete proinflammatory cytokines (e.g. IL-2, IFNgamma, lymphotoxin) while Th2 cells secrete anti-inflammatory cytokines (e.g. IL-4, IL-5, IL-10), which favor humoral-mediated responses
  • Th2 cytokines are associated with down-regulation of Th1 cytokines and this Th2 shift is believed to provide protection from allograft rejection during pregnancy as well as from Th1-mediated autoimmune disease
  • it is worth noting that the levels of other hormones with anti-inflammatory activity (1,25-dihydroxy-vitamin D3, norepinephrine, cortisol) also increase by 2 to 4 times during late pregnancy
  • 1,25-dihydroxy vitamin D3 induces regulatory T-cell function important for development of self-tolerance
  • breast-feeding does not alter the relapse rate in women with MS
  • Leptin is a pleiotropic hormone produced primarily by adipocytes but also by T lymphocytes and neurons
  • Several lines of evidence indicate that leptin contributes to EAE/MS pathogenesis, influencing its onset and clinical severity, by acting as a proinflammatory cytokine which promotes regulatory T cell (Treg) anergy and hyporesponsiveness, resulting in increased Th1 (TNFalpha, INFgamma) and reduced Th2 (IL-4) cytokine production
  • circulating leptin levels are increased in relapsing-remitting MS patients (men and women analyzed together) while the CD4+CD25+Treg population decreases
  • As the leptin plasma concentrations are proportional to the amount of fat tissue, obese/overweight individuals produce higher levels of leptin
  • Nielsen et al found that estradiol and progesterone exert neuroprotection against glutamate neurotoxicity, while MPA antagonizes the neuroprotective effect of estradiol and exacerbated neuron death induced by glutamate excitotoxicity
  • Nathan Goodyear on 11 Jan 17
     
    very good review of the differences in MS and hormones between the sexes.
Nathan Goodyear

Saliva estriol measurements: an alternative to the... [J Clin Endocrinol Metab. 1983] -... - 0 views

www.ncbi.nlm.nih.gov/...6822646

saliva salivary testing hormone estriol evaluation

shared by Nathan Goodyear on 12 Jul 11 - No Cached
  • Nathan Goodyear on 12 Jul 11
     
    statement, "assay of saliva E3 should replace serum E3 measurement..."  Saliva testing is very sound science!
Nathan Goodyear

Effects of Estrone, Estradiol, and Estriol on Hormone responsive Human Breast Cancer in... - 0 views

estrone breast estradiol estriol cancer

shared by Nathan Goodyear on 19 Aug 19 - No Cached
  • Nathan Goodyear on 19 Aug 19
     
    Older study that found that E3 provides estrogenic signaling per macro molecular proliferation. This was a cell MCF-7 study. This study did not differentiate between ERalpha and ERbeta.
Nathan Goodyear

Rapid determination of natural steroidal hormones in saliva for the clinical diagnoses - 0 views

www.ncbi.nlm.nih.gov/...PMC3351364

hormone hormones saliva salivary testing estrone estradiol estriol progesterone testosterone natural

shared by Nathan Goodyear on 15 Oct 12 - No Cached
  • Nathan Goodyear on 15 Oct 12
     
    recent study proves the scientific validity of sex hormone evaluation via saliva.  Most labs today use ELIZA.  The new future will be mass spectroscopy.
Nathan Goodyear

ScienceDirect - Pathologie Biologie : Saliva assays in clinical and research biology - 0 views

www.sciencedirect.com/...S0369811401002280

saliva salivary stress sex hormones cortisol estradiol estriol progesterone testosterone testing evaluation BHRT

shared by Nathan Goodyear on 26 Nov 11 - No Cached
  • the saliva concentration reflects the free blood concentration.
  • Nathan Goodyear on 26 Nov 11
     
    saliva testing of stress and sex hormones have been utilized since the early 1980's and described as "well validated" in the literature.
Nathan Goodyear

The Diagnostic Applications of Saliva- A Review - 0 views

cro.sagepub.com/...197.long

saliva salivary hormone hormones testing cortisol testosterone estradiol estrone estriol DHEA aldosterone insulin androstendione

shared by Nathan Goodyear on 14 Aug 12 - No Cached
  • Nathan Goodyear on 14 Aug 12
     
    Fantastic article on the review of the clinical use of saliva testing.  Of note, is the extensive documentation of the validation studies of hormone saliva testing.  Clearly, if a physician is against saliva testing, it is because of a lack of knowledge on the subject.
Nathan Goodyear

Oestriol in the treatment of postmenopausal urgenc... [Maturitas. 1993] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...8107615

estriol E3 treatment

shared by Nathan Goodyear on 30 Mar 11 - No Cached
  • oestriol produced both subjective and objective improvement in lower urinary tract function
  • Nathan Goodyear on 30 Mar 11
     
    oestriol produced both subjective and objective improvement in lower urinary tract function
Nathan Goodyear

Multiple sclerosis and pregnancy. [Neurol Clin. 2004] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...15474765

multiple sclerosis multiple sclerosis pregnancy hormone hormones estriol E3 women

shared by Nathan Goodyear on 07 Jan 14 - No Cached
  • Nathan Goodyear on 07 Jan 14
     
    Pregnancy has a neutral to likely positive effect during pregnancy.  This is due to the high E3 production.
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