Group items tagged CB1 - Dr. Goodyear

The endocabbinoid system and the treatment of obesity - 0 views

diabesity.eu/annals.pdf

endocannabinoid endocannabinoid-mediated adiponectin obesity overweight weight-loss CB1

shared by Nathan Goodyear on 19 Mar 12 - No Cached

Nathan Goodyear on 19 Mar 12

nice review of CB1 receptors and the role they play in obesity. Endocabbinoid receptors play an important role in the hypothalamus control of metabolism and energy. CB1 is active both centrally and peripherally. Increased CB1 activity increases fat storage; decrease CB1 activity increases fatty acid oxidation through adiponectin.

<div class="cArrow"> </div><div class="cContentInner">nice review of CB1 receptors and the role they play in obesity. Endocabbinoid receptors play an important role in the hypothalamus control of metabolism and energy. CB1 is active both centrally and peripherally. Increased CB1 activity increases fat storage; decrease CB1 activity increases fatty acid oxidation through adiponectin.</div>

...

Cancel

Delta9-tetrahydrocannabinol induces apoptosis in C6 glioma cells. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...9771884

THC cancer glioblastoma medical marijuana

shared by Nathan Goodyear on 18 Sep 18 - No Cached

Nathan Goodyear on 18 Sep 18

THC induces apoptosis of glioblastoma cells via CB1 receptor signaling.

<div class="cArrow"> </div><div class="cContentInner">THC induces apoptosis of glioblastoma cells via CB1 receptor signaling.</div>

...

Cancel

Cannabigerol Action at Cannabinoid CB1 and CB2 Receptors and at CB1-CB2 Heteroreceptor ... - 0 views

www.ncbi.nlm.nih.gov/...PMC6021502

cannabinoid CBG

shared by Nathan Goodyear on 15 Jun 22 - No Cached

Opioid-induced nausea and vomiting - Smith - Annals of Palliative Medicine - 0 views

apm.amegroups.com/...1264

nausea

shared by Nathan Goodyear on 14 Aug 18 - No Cached

Some of the “emetogenic” receptors that have been proposed are dopamine-2 (D2), histamine-1 (H1), DOR, 5-hydroxytryptamine (serotonin) (5-HT3), acetylcholine (ACh), neurokinin-1 (NK-1), and cannabinoid receptor-1 (CB1)
...

Cancel
Olanzapine decreased morphine-induced nausea and vomiting in a dose-dependent manner.
...

Cancel

Nathan Goodyear on 14 Aug 18

Good review of meds for nausea.

<div class="cArrow"> </div><div class="cContentInner">Good review of meds for nausea.</div>

...

Cancel

The current state and future perspectives of cannabinoids in cancer biology - 0 views

www.ncbi.nlm.nih.gov/...PMC5852356

Cancer CBD THC cannabinoids

shared by Nathan Goodyear on 19 Sep 18 - No Cached

hoangkimchi liked it

The activation of each of them leads to an inhibition of adenylyl cyclase via G proteins (Gi/o), which in turn activates many metabolic pathways such as mitogen‐activated protein kinase pathway (MAPK), phosphoinositide 3‐kinase pathway (PI3K), cyclooxygenase‐2 pathway (COX‐2), accumulation of ceramide, modulation of protein kinase B (Akt), and ion channels
...

Cancel
phytocannabinoids, endocannabinoids, and synthetic cannabinoids
...

Cancel
Action of THC in human organism relies on mimicking endogenous agonists of CB receptors—endocannabinoids
...

Cancel
...8 more annotations...
The upregulated expression of CB receptors and the elevated levels of endocannabinoids have been observed in a variety of cancer cells (skin, prostate, and colon cancer, hepatocellular carcinoma, endometrial sarcoma, glioblastoma multiforme, meningioma and pituitary adenoma, Hodgkin lymphoma, chemically induced hepatocarcinoma, mantel cell lymphoma)
...

Cancel
concentration of endocannabinoids, expression level of their receptors, and the enzymes involved in their metabolism frequently are associated with an aggressiveness of cancer
...

Cancel
CB2 receptor contributes to human epidermal growth factor receptor (HER2) pro‐oncogenic signaling and an overexpression of CB2 increases susceptibility for leukemia development after leukemia viral infection
...

Cancel
endocannabinoid‐degrading enzymes are upregulated in cancer cell lines and in human tumors
...

Cancel
Many cannabinoids, ranging from phytocannabinoids (THC, CBD), endocannabinoids (2‐arachidonoylglycerol, anandamide), to synthetic cannabinoids (JWH‐133, WIN‐55,212‐2), have shown ability to inhibit proliferation, metastasis, and angiogenesis in a variety of models of cancer
...

Cancel
Despite some inconsistent data, the main effect of cannabinoids in a tumor is the inhibition of cancer cells’ proliferation and induction of cancer cell death by apoptosis
...

Cancel
CB1 and CB2 receptor agonists stimulate apoptotic cell death in glioma cells by induction of de novo synthesis of ceramide, sphingolipid with proapoptotic activity
...

Cancel
process of autophagy is upstream of apoptosis in mechanism of cell death induced by cannabinoids
...

Cancel