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"Hudnall: I really do believe that repression makes you sick. I'm big believer of what is coming out in the neuroscience and therapy community. Brene Brown, who is a shame and guilt expert, said it best: "We have an epidemic of shame in this country." If you keep things inside and have no one to talk to - and this is not crystals and patchouli - you will get sick, you will be miserable, you will ruin your relationships, and you will be unhappy. I know people whose lives were ruined by silence. Especially women. The one thing that has really opened my eyes while teaching is just what we do to our women. Only my women students have said to me, "I don't know if I have anything worth saying." It smacks me in the face every day. We are really fucking up our women"

"Kathryn Taylor, associate professor in the Cancer Control Program, on conflicting advice about men getting tested for prostate cancer: "We tell men that there's no right or wrong answer [regarding prostate-specific antigen testing] at present, and it really comes down to a personal choice. And the onus, unfortunately, is on them to really educate themselves about the potential benefits as well as the potential harms." American Cancer Society Stands By Cancer Screening Guidelines October 22, 2009, MSN"

Many newly diagnosed prostate cancers present as low Gleason score tumors that require no treatment intervention. Distinguishing the many indolent tumors from the minority of lethal ones remains a major clinical challenge. We now show that low Gleason score prostate tumors can be distinguished as indolent and aggressive subgroups on the basis of their expression of genes associated with aging and senescence. Using gene set enrichment analysis, we identified a 19-gene signature enriched in indolent prostate tumors. We then further classified this signature with a decision tree learning model to identify three genes-FGFR1, PMP22, and CDKN1A-that together accurately predicted outcome of low Gleason score tumors. Validation of this three-gene panel on independent cohorts confirmed its independent prognostic value as well as its ability to improve prognosis with currently used clinical nomograms. Furthermore, protein expression of this three-gene panel in biopsy samples distinguished Gleason 6 patients who failed surveillance over a 10-year period. We propose that this signature may be incorporated into prognostic assays for monitoring patients on active surveillance to facilitate appropriate courses of treatment.

"Evolution likes to keep what works best. The rest falls by the wayside. In theory, this means that the most "fit" variations, say, a color that looks poisonous or one particularly attractive to the ladies, would become the most common. By this logic, the many colors of the guppy should have conformed to a single common pattern long ago. But they haven't. Instead, the male guppies continue to show not only bright colors but also a high diversity of colors. What keeps the variety going? The rare-male effect. Female guppies prefer the males that are rare, no matter what their color pattern actually is. This effect has been documented in the laboratory in guppies and in other species like fruit flies."

Scientists had thought that there was a single species of housecat-sized Brazilian tigrina. However, the molecular data now show that tigrina populations in northeastern versus southern Brazil are completely separate, with no evidence of interbreeding between them. As such, they are best described as two distinct species.

"Ein paar Wochen später: Valentin Möller schickt einen weiteren Youtube-link. Diesmal auf ein Video in seinem offiziellen Kanal mit fast 35.000 Abonnenten. Der Titel: „Fünf Gründe für ein Tablet!" Eine Argumentationshilfe, wie man seine Eltern davon überzeugt, dass so ein Tablet total gut ist. Grund No.1: „Fortbildung" - zum Beispiel in Form von „Spektrum - Die Woche". Das Video wurde bislang fast 10.000 mal angeguckt - virales Marketing für 8 Euro! Einfach, weil der Verlag das gemacht hat, was selbstverständlich ist. Nur dass es dank Social Media auch andere mitbekommen haben."

Stack Overflow is a collaboratively edited question and answer site for programmers - regardless of platform or language. It's 100% free, no registration required.

We got the same measurement no matter which method we used, finding out that 25-30% of the total energy of the Universe is in some type of matter. But, only about 0.5% of the total energy is in stars, which means that nearly all of this matter doesn't give off light! So what is the rest of this matter?

"Renegade husband and wife philosophers Pat and Paul Churchland met forty years ago in a college Plato class. Their instincts as philosophers - then and now - run outside the philosophy mainstream. Where most philosophers looked to reason and logic to apprehend the human mind, the Churchlands looked - and look - to science. There is no independent "mind", these two practically say, just the human brain, three pounds of tissue and water, firing away behind all our emotions, beliefs, actions. Consciousness itself, they say, is straight biology, a machine. Once, that sounded esoteric. now, it's on the frontline of debate over law, soul and life."

I read an interesting article this morning from the Burlington Free Press featuring the work of Josh Bongard, hired by the University of Vermont as an assistant professor of computer science. The article focused much of its attention on Bongard's self-aware robot, Black Starfish.

Amazing what can be made from a bit of background noise in the GEO600 with a bit of imagination (or desire). Intriguing article from 12 months ago. no new information since....

New results from digital sky surveys highlight more inconsistencies in our understanding of early galaxies, which, in contrast to today's galaxies, were compact and rapidly moving.

What connects human intelligence to the unsung cunning of slime moulds? An electric component that no one thought existed, explains Justin Mullins

People should not be afraid of dark energy. Remember that the problem with the cosmological constant isn't that it's mysterious and ill-motivated - it's that it's too small! The naive theoretical prediction is larger than what's required by observation by a factor of 10^120. That's a puzzle, no doubt, but setting it equal to zero doesn't make the puzzle go away - then it's smaller than the theoretical prediction by a factor of infinity.

Finding genes that have evolved in humans among our genome's 3 billion bases is no easy feat. But now, a team has pinpointed three genes that arose from noncoding DNA and may help make our species unique.

Purpose of review: Autism is a biologically based disorder of brain development. Genetic factors - mutations, deletions, and copy number variants - are clearly implicated in causation of autism. However, they account for only a small fraction of cases, and do not easily explain key clinical and epidemiological features. This suggests that early environmental exposures also contribute. This review explores this hypothesis. Recent findings: Indirect evidence for an environmental contribution to autism comes from studies demonstrating the sensitivity of the developing brain to external exposures such as lead, ethyl alcohol and methyl mercury. But the most powerful proof-of-concept evidence derives from studies specifically linking autism to exposures in early pregnancy - thalidomide, misoprostol, and valproic acid; maternal rubella infection; and the organophosphate insecticide, chlorpyrifos. There is no credible evidence that vaccines cause autism. Summary: Expanded research is needed into environmental causation of autism. Children today are surrounded by thousands of synthetic chemicals. Two hundred of them are neurotoxic in adult humans, and 1000 more in laboratory models. Yet fewer than 20% of high-volume chemicals have been tested for neurodevelopmental toxicity. I propose a targeted discovery strategy focused on suspect chemicals, which combines expanded toxicological screening, neurobiological research and prospective epidemiological studies.

You may have more in common with Kanzi, Panbanisha and Nyota, three language-competent bonobos living at Great Ape Trust, than you thought. And those similarities, right at your fingertip, might one day tell scientists more about the effect of culture on neurological disorders that limit human expression. Among humans, pointing is a universal language, an alternative to spoken words to convey a message. Before they speak, infants point, a gesture scientists agree is closely associated with word learning. But when an ape points, scientists break rank on the question of whether pointing is a uniquely human behavior. Some of the world's leading voices in modern primatology have argued that although apes may gesture in a way that resembles human pointing, the genetic and cognitive differences between apes and humans are so great that the apes' signals have no specific intent. not so, say Great Ape Trust scientists, who argued in a recently published scientific paper, "Why Apes Point: Pointing Gestures in Spontaneous Conversation of Language-Competent Pan/Homo Bonobos," that not only do Kanzi, Panbanisha and Nyota point with their index fingers in conversation as a human being might, these bonobos do so with specific intent and objectives in mind.

ScienceDaily (Jan. 12, 2011) - Scientists have found that the pleasurable experience of listening to music releases dopamine, a neurotransmitter in the brain important for more tangible pleasures associated with rewards such as food, drugs and sex. The new study from The Montreal Neurological Institute and Hospital -- The Neuro at McGill University also reveals that even the anticipation of pleasurable music induces dopamine release [as is the case with food, drug, and sex cues]. Published in the journal Nature Neuroscience, the results suggest why music, which has no obvious survival value, is so significant across human society.

December 9th, 02005 - Sam Harris"The View From The End Of The World"This is an audio only presentation. This talk took place in the Conference Center Golden Gate Room, San Francisco. Quote: With gentle demeanor and tight argument, Sam Harris carried an overflow audience into the core of one of the crucial issues of our time: What makes some religions lethal? How do they employ aggressive irrationality to justify threatening and controlling non-believers as well as believers? What should be our response? Harris began with Christianity. In the US, Christians use irrational arguments about a soul in the 150 cells of a 3-day old human embryo to block stem cell research that might alleviate the suffering of millions. In Africa, Catholic doctrine uses tortured logic to actively discourage the use of condoms in countries ravaged by AIDS. "This is genocidal stupidity," Harris said. Faith trumps rational argument. Common-sense ethical intuition is blinded by religious metaphysics. In the US, 22% of the population are CERTAIN that Jesus is coming back in the next 50 years, and another 22% think that it's likely. The good news of Christ's return, though, can only occur following desperately bad news. Mushroom clouds would be welcomed. "End time thinking," Harris said, "is fundamentally hostile to creating a sustainable future." Harris was particularly critical of religious moderates who give cover to the fundamentalists by not challenging them. The moderates say that all is justified because religion gives people meaning in their life. "But what would they say to a guy who believes there's a diamond the size of a refrigerator buried in his backyard? The guy digs out there every Sunday with his family, cherishing the meaningthe quest gives them." "I've read the books," Harris said. "God is not a moderate." The Bible gives strict instructions to kill various kinds of sinners, and their relatives, and on occasion their entire towns. Yet slavery is challenged nowhere in the New or