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Come work with us Interested in working with researchers from different disciplines within the Harvard, MIT and Broad community and an unique opportunity to participate in world-class research to make an impact on human health? Come work with us! We are looking for a computational biologists to handle data from a wide variety of experimental methods, focusing on next-gen sequencing technologies. Keep Reading...  SCDE is live The Stem Cell Discovery Engine (SCDE) is an integrated platform that allows users to consistently describe, share and compare cancer and tissue stem cell data. It is made up of an online database of curated experiments coupled to a customized instance of the Galaxy analysis engine with tools for gene list manipulation and molecular profile comparisons. The SCDE currently contains more than 50 stem cell-related experiments. Each has been manually curated and encoded using the ISA-Tab standard to ensure the quality of the data and its annotation. Keep Reading...  The Center for Health Bioinformatics at the Harvard School of Public Health provides consults to researchers for the management, integration and contextual analysis of biological high-throughput data. We are a member of the Center for Stem Cell Bioinformatics, the Environmental Statistics and Bioinformatics Core at the Harvard NIEHS Center for Environmental Health and the Genetics & Bioinformatics Consulting group for Harvard Catalyst and work closely with our colleagues in the Department of Biostatistics and the Program in Quantitative Genomics to act as a single point of contact for computational biology,

"There is a biological story with information. I have been repeating that in a natural environment, a stressor is information. So too much information would be too much stress, exceeding the threshold of antifragility. In medicine, we are discovering the healing powers of fasting, as the avoidance of too much hormonal rushes that come with the ingestion of food. Hormones convey information to the different parts of our system and too much of it confuses our biology. Here again, as with the story of the news received at too high a frequency, too much information becomes harmful. And in Chapter x (on ethics) I will show how too much data (particularly when sterile) causes statistics to be completely meaningless. Now let's add the psychological to this: we are not made to understand the point, so we overreact emotionally to noise. The best solution is to only look at very large changes in data or conditions, never small ones"

In another study, in which volunteers saw the same pictures while having their brain scanned using MRI, she found that people had a stronger response in the hippocampus and amygdala - areas of the brain associated with fear - when they were shown fearful faces at systole than when they saw them at diastole. In other words, half a heartbeat was all it took for a person to experience a significantly different response to the same scary stimulus.

"Rather, these successful men needed to also be blessed with "zeal and with capacity for hard labour." This study is a first glimpse into those essential qualities described by Galton, helping us map out the individual differences that make it slightly easier for some people to engage in hard labor. These diligent souls seem to get a bit more pleasure from the possibility of reward, but they also seem less sensitive to their inner complainer, that disruptive voice reminding them that minesweeper is more fun than editing, or that the ballgame on television is much more entertaining than their homework. At any given moment, there is a tug of war unfolding in our head, determining whether or not we're willing to put in the effort. This sentence only exists because, for a few minutes at least, I was able to win the war."

"Our knowledge of species and functional composition of the human gut microbiome is rapidly increasing, but it is still based on very few cohorts and little is known about variation across the world. By combining 22 newly sequenced faecal metagenomes of individuals from four countries with previously published data sets, here we identify three robust clusters (referred to as enterotypes hereafter) that are not nation or continent specific. We also confirmed the enterotypes in two published, larger cohorts, indicating that intestinal microbiota variation is generally stratified, not continuous. This indicates further the existence of a limited number of well-balanced host-microbial symbiotic states that might respond differently to diet and drug intake."

"Bacterial signaling controlling biofilm formation and pathogenicity Opportunistic bacterial pathogens cause a variety of infectious diseases. Their ability to sense and respond to different microenvironments, particularly during the transition from a free-living to an indwelling pathogenic lifestyle, is largely dependent on a variety of adaptational strategies (Hall-Stoodley et al., 2004). Examples include phenotypic variation, biofilm formation, resistance to antibiotic treatments and virulence gene expression, suggested to be interlinked phenotypes largely dependent on bacterial signaling and changes in their transcription profiles "

"In our recent paper, we take a different approach. We consider how measurements work in the macroworld, finding that some quantum features are simply unobservable. Most remarkably, this approach shows that something called quantum nonlocality disappears for objects big enough to contain roughly the Avogadro number of atoms-the number of atoms you'd expect in a few grams of matter."

The AIFB Web Portal is the public web site of the Institute of Applied Informatics and Formal Description Methods (AIFB) at Karlsruhe Institute of Technology. It uses Semantic MediaWiki to provide a highly customised Content Management System. The site provides content in two languages (German and English), and it offers rich views for browsing different kinds of data. The content of the AIFB Web Portal is regularly edited by most members of the institute, from secretary to professor, but it is not open for public editing.

"However, anthropological datasets show enormous complexity in how and why men and women behave the ways that they do [vi]. Studies in human biology and anthropology regularly demonstrate a dynamic flexibility and complex biocultural context for all human behavior, and this is especially true for gender.... No matter how much some want it to be true, it is just not that simple; there are no clear cut and easy answers to why we do what we do, and why men and women sometimes have problems getting along. To ignore the enormous wealth of data on how men and women are similar AND different and to try to tackle this enormously complex reality via one-dimensional approaches is just poor science."

"Our Juliets (as parents longing for grandchildren will recognize with a sigh) may experience the tumult of love for 20 years before they settle down into motherhood. And our Romeos may be poetic lunatics under the influence of Queen Mab until they are well into graduate school. What happens when children reach puberty earlier and adulthood later? The answer is: a good deal of teenage weirdness. Fortunately, developmental psychologists and neuroscientists are starting to explain the foundations of that weirdness. Photos: The Trials of Teenagers View Slideshow [SB10001424052970204573704577187080963983566] Everett Collection James Dean in the 1955 film 'Rebel Without A Cause' The crucial new idea is that there are two different neural and psychological systems that interact to turn children into adults"

Some argue that these genes bring benefits - mental illness and genius have a long-standing link - but archaeologist Penny Spikins at the University of York, UK, goes further. She believes that mental illness and conditions such as autism persist at such high levels because in the past they were advantageous to humanity. "I think that part of the reason Homo sapiens were so successful is because they were willing to include people with different minds in their society - people with autism or schizophrenia, for example."

"Social interactions require fast and efficient person perception, which is best achieved through the process of categorization. However, this process can produce pernicious outcomes, particularly in the case of stigma. This study used fMRI to investigate the neural correlates involved in forming both explicit ("Do you like or dislike this person?") and implicit ("Is this a male or female?") judgments of people possessing well-established stigmatized conditions (obesity, facial piercings, transsexuality, and unattractiveness), as well as normal controls. Participants also made post-scan disgust ratings on all the faces that they viewed during imaging. These ratings were subsequently examined (modeled linearly) in a parametric analysis. Regions of interest that emerged include areas previously demonstrated to respond to aversive and disgust-inducing material (amygdala and insula), as well as regions strongly associated with inhibition and control (anterior cingulate and lateral prefrontal cortex). Further, greater differences in activation were observed in the implicit condition for both the amygdala and prefrontal cortical regions in response to the most negatively perceived faces. Specifically, as subcortical responses (e.g., amygdala) increased, cortical responses (e.g., lateral PFC and anterior cingulate) also increased, indicating the possibility of inhibitory processing. These findings help elucidate the neural underpinnings of stigma"

"Our results indicate that communities where species are evenly and distantly related to one another are more stable compared to communities where phylogenetic relationships are more clumped. This result could be explained by a phylogenetic sampling effect, where some lineages show greater stability in productivity compared to other lineages, and greater evolutionary distances reduce the chance of sampling only unstable groups. However, we failed to find evidence for similar stabilities among closely related species. Alternatively, we found evidence that plot biomass variance declined with increasing phylogenetic distances, and greater evolutionary distances may represent species that are ecologically different (phylogenetic complementarity). Accounting for evolutionary relationships can reveal how diversity in form and function may affect stability."

The goals of this effort is to design and implement a configurable and extensible semantic eScience framework. Configuration will require some research into accommodating different levels of semantic expressivity and user requirements from use cases. Extensibility will be achieved in a modular approach to the semantic encodings (i.e. ontologies) performed in a community setting, i.e. an ontology framework into which specific applications all the way up to communities can extend the semantics for their needs.

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"But Young's new theory will face scrutiny of its own. Commenting on the theory, Rutgers University anthropologist Fran Mascia-Lees, who has written extensively about the evolutionary role of breasts, said one concern is that not all men are attracted to them. "Always important whenever evolutionary biologists suggest a universal reason for a behavior and emotion: how about the cultural differences?" Mascia-Lees wrote in an email. In some African cultures, for example, women don't cover their breasts, and men don't seem to find them so, shall we say, titillating. Young says that just because breasts aren't covered in these cultures "doesn't mean that massaging them and stimulating them is not part of the foreplay in these cultures. As of yet, there are not very many studies that look at [breast stimulation during foreplay] in an anthropological context," he said. Young elaborates on his theory of breast love, and other neurological aspects of human sexuality, in a new book, "The Chemistry Between Us" (Current Hardcover, 2012), co-authored by Brian Alexander."

"And again, in this expanded group, she found the same association between the variation of the DRD4 gene and a willingness to take risks on the slopes. The variant's overall effect was slight, explaining only about 3 percent of the difference in behavior between risk takers and the risk averse, but was statistically significant and remained intact"

"Sciencenet - Towards a global search and share engine for all scientific knowledge Modern biological experiments create vast amounts of data which are geographically distributed. These datasets consist of petabytes of raw data and billions of documents. Yet to the best of our knowledge, a search engine technology that searches and crosslinks all different data types in life sciences does not exist."

The Tree of Life Web Project (ToL) is a collaborative effort of biologists and nature enthusiasts from around the world. On more than 10,000 World Wide Web pages, the project provides information about biodiversity, the characteristics of different groups of organisms, and their evolutionary history (phylogeny).

"The best learning experience. That means something different for everyone. Expect more than an old one-size-fits-all LMS. Brightspace is an online teaching and learning platform that's easy, flexible, and smart."