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David Baum, University of Wisconsin, says: "All agree that eukaryotes arose from a symbiotic relationship between two cell types: bacteria that became mitochondria and a host cell, archaea, or a close relative of archaea, that became the cytoplasm and nucleus. This symbiosis explains the origin of mitochondria, but what about other eukaryotic structures, most notably the nucleus?" The Baums' inside-out theory provides a gradual path by which eukaryotic cells could have evolved. The first stage began with a bacterial cell whose outer membrane forms protrusions, which the Baums call 'blebs', that reached out from the cell. These protrusions trapped free-living mitochondria-like bacteria between them. Using the energy gained from being in close contact with bacteria (and using bacterial-derived lipids), cells were able to get bigger and expand the size of their blebs. The sides of the blebs formed the endoplasmic reticulum and their inner surfaces formed the outer membrane of the nucleus, with the original outer membrane of the archaeon becoming what we now call the inner nuclear membrane. Finally, the fusion of blebs with one another led to the formation of the plasma membrane. The result was the eukaryotic cell as we now know it. This inside-out theory is explained in more detail using a diagram in the research article (see notes to editors).

A new study by The Institute of Cancer Research, London (ICR) has shown that a genetic test for faults in DNA repair could enable targeted nuclear treatments for patients with prostate cancer.

"Levi and his co-authors, former Sauder PhD students Qianqian Du and Huasheng Gao, investigated the birth-date effect in a sample of 375 CEOs from S&P 500 companies between 1992 and 2009. "Our study adds to the growing evidence that the way our education system groups students by age impacts their lifelong success," says Prof. Levi. "We could be excluding some of the business world's best talent simply by enrolling them in school too early.""

"The results are published in Nature Medicine today. Co-author Stanley Hazen, head of cardiovascular medicine at the Cleveland Clinic in Ohio, says that the study could signal a new approach to diet and health. In some cases, an individual's collection of intestinal microbes may be as important to their diet as anything on a nutrition label, he says. "Bacteria make a whole slew of molecules from food," he says, "and those molecules can have a huge effect on our metabolic processes.""

"The same technology could potentially be used for bladder and multiple myeloma cancers, which also shed identifiable markers in urine. "Our goal is a device the size of a home pregnancy test priced around $10. Other prostate cancer tests coming to market cost up to $4,000 each. The UC Irvine team made price a key design factor of their work..The UC Irvine team developed a new type of sensor: They added nanoscale protein receptors to tiny, pencil-like viruses called phages that live only within bacteria. Double wrapping the phages with additional receptors greatly increases the capture and transmission of cancer molecule signals."

"According to the US Centers for Disease Control and Prevention's website: "Ricin works by getting inside the cells of a person's body and preventing the cells from making the proteins they need. Without the proteins, cells die... Death from ricin poisoning could take place within 36 to 72 hours of exposure, depending on the route of exposure (inhalation, ingestion, or injection) and the dose received."

"Nature: "A group called DIYgenomics has banded together to analyse their genomes, and even conduct and participate in small clinical trials" - October 2010 Nature Medicine: "...early adopters are showing how empowering and beneficial to science personal genetic information can be" - September 2010 WIRED: "...they wanted to build a model trial that could be easily replicated by citizen scientists anywhere" "

"We have sensitive body parts wired to the same area of the brain as rodents' fine-tuned whiskers. In people, "stimulating the fingers, lips or face in general could all have a similar effect," says UCI doctoral student Melissa Davis, co-author of the study, which appears in the June issue of PLoS ONE. "It's gender-neutral," adds co-author Ron Frostig, professor of neurobiology & behavior. He cautions that the research, funded by the National Institutes of Health, is a first step, albeit an important one.... "with the potential for maybe doing things before a victim even reaches the emergency room.""

The vision of a national digital library has been circulating among librarians, scholars, educators, and private industry representatives since the early 1990s, but it has not yet materialized. Efforts led by a range of organizations, including the Library of Congress, HathiTrust, and the Internet Archive, have successfully built resources that provide books, images, historical records, and audiovisual materials to anyone with Internet access. Many universities, public libraries, and other public-spirited organizations have digitized materials that could be brought together under the frame of the DPLA, but these digital collections often exist in silos.

"What they found here was a negative correlation. The MORE serotonin transporters you had, the less likely you were to reject unfair offers. The authors interpret this to mean that people with lower levels of serotonin transporter had a harsher sense of "fairness", than those with higher levels of serotonin transporter, and were more inclined to reject unfair offers. Why could this be the case? The authors looked at the personalities of the individuals. You might think that people with more aggressive personalities (or at least a tendency to get offended) might be more likely to reject unfair offers, but it turned out that this wasn't the case. Instead, it was people with more peaceful personalities, but stronger measures of trust, were more likely to reject the unfair offers. The authors believe that the people with higher trustfulness had higher standards of behavior, and thus were more likely to reject unfair offers, even if the rejected ended up badly for them"

"Performing short cycle sprints three times a week could be enough to prevent and possibly treat type 2 diabetes, a study suggests. Scientists at the University of Bath asked volunteers to perform two 20-second cycle sprints on exercise bikes, three times per week. After six weeks, researchers in the university's department of health saw a 28% improvement in their insulin function."

It refers to the experience of seeing firsthand the reality of the Earth in space, which is immediately understood to be a tiny, fragile ball of life, hanging in the void, shielded and nourished by a paper-thin atmosphere.  From space, the astronauts tell us, national boundaries vanish, the conflicts that divide us become less important and the need to create a planetary society with the united will to protect this "pale blue dot" becomes both obvious and imperative.  Even more so, many of them tell us that from the Overview perspective, all of this seems imminently achievable, if only more people could ha

Solve for X is a place where the curious can go to hear and discuss radical technology ideas for solving global problems. Radical in the sense that the solutions could help billions of people. Radical in the sense that the audaciousness of the proposals makes them sound like science fiction.

"Seasonal influenza epidemics are a major public health concern, causing tens of millions of respiratory illnesses and 250,000 to 500,000 deaths worldwide each year1. In addition to seasonal influenza, a new strain of influenza virus against which no previous immunity exists and that demonstrates human-to-human transmission could result in a pandemic with millions of fatalities2. Early detection of disease activity, when followed by a rapid response, can reduce the impact of both seasonal and pandemic influenza3, 4. One way to improve early detection is to monitor health-seeking behaviour in the form of queries to online search engines, which are submitted by millions of users around the world each day. Here we present a method of analysing large numbers of Google search queries to track influenza-like illness in a population."

"Our results indicate that communities where species are evenly and distantly related to one another are more stable compared to communities where phylogenetic relationships are more clumped. This result could be explained by a phylogenetic sampling effect, where some lineages show greater stability in productivity compared to other lineages, and greater evolutionary distances reduce the chance of sampling only unstable groups. However, we failed to find evidence for similar stabilities among closely related species. Alternatively, we found evidence that plot biomass variance declined with increasing phylogenetic distances, and greater evolutionary distances may represent species that are ecologically different (phylogenetic complementarity). Accounting for evolutionary relationships can reveal how diversity in form and function may affect stability."

Dr Simon Archer and his team at Surrey University were particularly interested in looking at the genes that were switched on or off in our volunteers by changes in the amount that we had made them sleep. "We found that overall there were around 500 genes that were affected," Archer explained. "Some which were going up, and some which were going down." What they discovered is that when the volunteers cut back from seven-and-a-half to six-and-a-half hours' sleep a night, genes that are associated with processes like inflammation, immune response and response to stress became more active. The team also saw increases in the activity of genes associated with diabetes and risk of cancer. The reverse happened when the volunteers added an hour of sleep. So the clear message from this experiment was that if you are getting less than seven hours' sleep a night and can alter your sleep habits, even just a little bit, it could make you healthier

"Igor Efimov, Sarah Gutbrod Using an inexpensive 3-D printer, biomedical engineers have developed a custom-fitted, implantable device with embedded sensors that could transform treatment and prediction of cardiac disorders. The 3-D elastic membrane is made of a soft, flexible, silicon material that is precisely shaped to match the heart's outer layer of the wall. Current technology is two-dimensional and cannot cover the full surface of the epicardium or maintain reliable contact for continual use without sutures or adhesives. The team can then print tiny sensors onto the membrane that can precisely measure temperature, mechanical strain and pH, among other markers, or deliver a pulse of electricity in cases of arrhythmi"

"Sleep and its role in memory consolidation The role of sleep in the honeybee memory consolidation has been addressed in our lab in two studies so far. Hussaini et al. (2009; http://www.neurobiologie.fu-berlin.de/menzel/Pub_AGmenzel/Sleep Deprivation.pdf) found reduced retention after extinction learning in an olfactory PER experiment if bees are prevented from sleep during the night following extinction learning. Beyaert, Greggers and Menzel tested freely flying bees after navigation learning and found reduced homing rates if the bees could not sleep the night after novel navigation learning (see Beyaert L, Greggers U and Menzel R (2012) Honeybees consolidate navigation memory during sleep. Journal of Experimental Biology 215, 3981-3988"

"It is important to be aware that 20th century media ecosystem is a very unusual aberration in the way people communicated throughout history. Means of production were expensive. Very few people could afford to own printing presses, radio and TV studios, etc. Running all that complicated equipment required technical expertise and professional training. Thus media became locked up in silos, hierarchical, broadcast-only with little-to-none (and then again centrally controlled) means for feedback. There was a wealthy, vocal minority that determined what was news, and how to frame it, and the vast majority was consuming the news in silence"