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thinkahol *

Artificial hippocampal system restores long-term memory, enhances cognition | KurzweilAI - 2 views

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    Theodore Berger and his team at the USC Viterbi School of Engineering's Department of Biomedical Engineering have developed a neural prosthesis for rats that is able to restore their ability to form long-term memories after they had been pharmacologically blocked. In a dramatic demonstration, Berger blocked the ability to rats to form long-term memories by using pharmacological agents to disrupt the neural circuitry that communicates between two subregions of the hippocampus, CA1 and CA3, which interact to create long-term memory, prior research has shown. The rats were unable to remember which lever to pull to gain a reward, or could only remember for 5-10 seconds, when previously they could remember for a long period of time. The researchers then developed an artificial hippocampal system that could duplicate the pattern of interaction between CA3-CA1 interactions. Long-term memory capability returned to the pharmacologically blocked rats when the team activated the electronic device programmed to duplicate the memory-encoding function. The researchers went on to show that if a prosthetic device and its associated electrodes were implanted in animals with a normal, functioning hippocampus, the device could actually strengthen the memory being generated internally in the brain and enhance the memory capability of normal rats. "These integrated experimental modeling studies show for the first time that with sufficient information about the neural coding of memories, a neural prosthesis capable of real-time identification and manipulation of the encoding process can restore and even enhance cognitive mnemonic processes," says the paper. Next steps, according to Berger and Deadwyler, will be attempts to duplicate the rat results in primates (monkeys), with the aim of eventually creating prostheses that might help human victims of Alzheimer's disease, stroke, or injury recover function. Ref.: "A Cortical Neural Prosthesis for Restoring and Enhancing
anonymous

A RFID Blocking Wallet Can Prevent Identity Theft - 0 views

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    How you can prevent identity theft with a RFID blocking wallet.
Erich Feldmeier

Michael Nielsen: Reinventing Discovery | Michael Nielsen - 0 views

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    The book is about networked science: the use of online tools to transform the way science is done. In the book I make the case that networked science has the potential to dramatically speed up the rate of scientific discovery, not just in one field, but across all of science. Furthermore, it won't just speed up discovery, but will actually amplify our collective intelligence, expanding the range of scientific problems which can be attacked at all. But, as I explain in the book, there are cultural obstacles that are blocking networked science from achieving its full potential. And so the book is also a manifesto, arguing that networked science must be open science if it is to realize its potential. Making the change to open science is a big challenge. In my opinion it's one of the biggest challenges our society faces, one that requires action on many fronts. One of those fronts is to make sure that everyone - including scientists, but also grant agencies, governments, libraries, and, especially, the general public -- understands how important the stakes are, and how urgent is the need for change.
Janos Haits

Open Access Button - 0 views

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    .. you can use to show the global effects of research paywalls - and to help get access to the research you need. Every time you hit a paywall blocking your research, click the button. Fill out a short form, add your experience to the map along with thousands of others.
Janos Haits

MIT App Inventor - 0 views

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    To use App Inventor, you do not need to be a professional developer. This is because instead of writing code, you visually design the way the app looks and use blocks to specify the app's behavior.
Walid Damouny

Taming the wild phonon - 0 views

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    "Researchers at MIT and elsewhere have succeeded in creating a synthetic crystal that can very effectively control the transmission of heat -- stopping it in its tracks and reflecting it back. This advance could lead to insulating materials that could block the escape of heat more effectively than any present insulator."
thinkahol *

YouTube - Sam Harris SALT - 2 views

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    December 9th, 02005 - Sam Harris"The View From The End Of The World"This is an audio only presentation. This talk took place in the Conference Center Golden Gate Room, San Francisco. Quote: With gentle demeanor and tight argument, Sam Harris carried an overflow audience into the core of one of the crucial issues of our time: What makes some religions lethal? How do they employ aggressive irrationality to justify threatening and controlling non-believers as well as believers? What should be our response? Harris began with Christianity. In the US, Christians use irrational arguments about a soul in the 150 cells of a 3-day old human embryo to block stem cell research that might alleviate the suffering of millions. In Africa, Catholic doctrine uses tortured logic to actively discourage the use of condoms in countries ravaged by AIDS. "This is genocidal stupidity," Harris said. Faith trumps rational argument. Common-sense ethical intuition is blinded by religious metaphysics. In the US, 22% of the population are CERTAIN that Jesus is coming back in the next 50 years, and another 22% think that it's likely. The good news of Christ's return, though, can only occur following desperately bad news. Mushroom clouds would be welcomed. "End time thinking," Harris said, "is fundamentally hostile to creating a sustainable future." Harris was particularly critical of religious moderates who give cover to the fundamentalists by not challenging them. The moderates say that all is justified because religion gives people meaning in their life. "But what would they say to a guy who believes there's a diamond the size of a refrigerator buried in his backyard? The guy digs out there every Sunday with his family, cherishing the meaningthe quest gives them." "I've read the books," Harris said. "God is not a moderate." The Bible gives strict instructions to kill various kinds of sinners, and their relatives, and on occasion their entire towns. Yet slavery is challenged nowhere in the New or
Infogreen Global

Smart Windows - Block Heat On Hot Days But Let In The Heat In Colder Weather - 0 views

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    New materials science research could hasten the creation of "smart" windows that reflect heat from the sun on hot summer days but let in the heat in colder weather.
thinkahol *

Stoner alert: McDonald's gets you legally high | KurzweilAI - 1 views

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    Fats in foods like potato chips and french fries make them nearly irresistible because they trigger natural marijuana-like chemicals in the body called endocannabinoids, researchers at the University of California, Irvine, have found. The researchers discovered that when rats tasted something fatty, cells in their upper gut started producing endocannabinoids, while sugars and proteins did not have this effect. How fats create, like, a buzz It starts on the tongue, where fats in food generate a signal that travels first to your brain, and then through a nerve bundle called the vagus to your intestines. There, the signal stimulates the production of endocannabinoids, which initiates a surge in cell signaling that prompts you to totally pig out - probably by initiating the release of digestive chemicals linked to hunger and satiety that compel us to eat more. And that leads to obesity, diabetes and cancer, the researchers said. But they suggest it might be possible to curb this process by obstructing endocannabinoid activity: for example, by using drugs that "clog" cannabinoid receptors. The trick: bypassing the brain to avoid creating anxiety and depression (which happens when endocannabinoid signaling is blocked in the brain). I'm guessing McDonald's won't be adding that drug to their fries. Ref.: Daniele Piomelli, et al., An endocannabinoid signal in the gut controls dietary fat intake, PNAS, 2011; in press
Erich Feldmeier

Evidence of a genetic 'fountain of youth' discovered | ExtremeTech - 0 views

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    Calico , ETH Zurich "One in particular, the bcat-1 gene, seemed to have disproportionate effect on aging. "When we blocked the effect of this gene, it significantly extended the mean lifespan of the nematode by up to 25 percent," explains Professor Michael Ristow, coordinating author of the recently published study and Professor of Energy Metabolism at ETH Zurich."
David Haow

Intercropping of maize and climbing bean: fodder yield, quality and nutrient compositio... - 1 views

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    A study was conducted to examine fodder yield and silage quality of maize (Zea mays L.) and climbing bean (Phaseolus vulgaris L.) intercropping with different planting structure. Maize was cultivated alone and intercropped with climbing bean as follows;1 row maize to 1 row climbing bean (1M1K), 1 row maize to 2 rows climbing bean (1M2K) and 2 rows maize to 1 row climbing bean (2M1K). The experiment was laid out in randomized complete block design with four treatments and three replications. The crops were harvested when the maize reached at milk stage and climbing bean at R7 stage. The results indicated significant increase in fresh biomass and dry matter production of maize fodder alone as compared to maize intercropped with climbing bean fodder. However, no difference (p>0.05) was observed in ether extract (EE), and ash (%) of nutrient composition of fodder among the four treatments After 45 days of ensiling period, silage samples were analysed for pH, organic acids (lactic, acetic, and butyric), ammonia-N(NH3-N), dry matter (DM), crude protein (CP), ether extract (EE), neutral detergent fibre (NDF), acid detergent fibre (ADF), water soluble carbohydrate (WSC), calcium (Ca), sodium (Na) and potassium (K). All intercropped silages had higher CP values (1M1K, 12.0%; 1M2K, 12.3%; 2M1K, 11.1%) than the monocrop maize (SM, 8.9%) silage. Higher organic acids and ammonia-N (p<0.05) were produced in the 1M2K silages as compared to others silages. The study showed that among all intercropped silages the 1M2K (1 row maize to 2 rows climbing bean) was preferable according to nutrient composition than other intercropped silages. This research work has been done by Maw Ni Soe Htet1, Rab Nawaz Soomro 2,Hai Jiang bo under College of Agronomy, Northwest A & F University, Yangling Shaanxi, P.R China and College of Animal Science and Technology, Northwest A & F University, Yangling Shaanxi, P.R. China.
Agtha Shan

Stimulate Your DNA Easily and Quickly! - 0 views

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    Stimulate Your DNA Easily and Quickly! Disclosure- Products mentioned on this page were not designed to treat ailments or medical conditions. So Whats The Deal? DNA is the most basic known building block of life.
Mike Chelen

RNA world easier to make : Nature News - 0 views

  • John Sutherland and his colleagues from the University of Manchester, UK
  • ribonucleotide
  • building block of RNA
  • ...29 more annotations...
  • Donna Blackmond, a chemist at Imperial College London.
  • strong evidence for the RNA world
  • 'RNA world' hypothesis, which suggests that life began when RNA, a polymer related to DNA that can duplicate itself and catalyse reactions
  • chemists had thought the subunits would probably assemble themselves first, then join to form a ribonucleotide
  • three distinct parts: a ribose sugar, a phosphate group and a base
  • RNA polymer is a string of ribonucleotides
  • efforts to connect ribose and base together have met with frustrating failure
  • researchers have now managed to synthesise
  • ribonucleotides
  • remedy is to avoid producing separate ribose-sugar and base subunits
  • makes a molecule whose scaffolding contains a bond that will
  • be the key ribose-base connection
  • atoms are then added around this skeleton
  • final connection is to add a phosphate group
  • influences the entire synthesis
  • acting as a catalyst, it guides small organic molecules into making the right connections
  • What we have ended up with is molecular choreography
  • objectors to the RNA-world theory say the RNA molecule as a whole is too complex to be created using early-Earth geochemistry
  • flaw is in the logic — that this experimental control by researchers in a modern laboratory could have been available on the early Earth
  • Robert Shapiro, a chemist at New York University
  • early-Earth scenarios
  • heating molecules in water, evaporating them and irradiating them with ultraviolet light
  • results showing that they can string nucleotides together
  • ultimate goal is to get a living system (RNA) emerging from a one-pot experiment
  • need to know what the constraints on the conditions are first
  • Shapiro sides with
  • another theory of life's origins
  • because RNA is too complex to emerge from small molecules, simpler metabolic processes
  • eventually catalysed the formation of RNA and DNA
Charles Daney

Comet Dust Harbors Life's Building Blocks / Science News - 0 views

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    Extraterrestrial source confirmed for comet's amino acids
Skeptical Debunker

Human cells exhibit foraging behavior like amoebae and bacteria - 0 views

  • "As far as we can tell, this is the first time this type of behavior has been reported in cells that are part of a larger organism," says Peter T. Cummings, John R. Hall Professor of Chemical Engineering, who directed the study that is described in the March 10 issue of the Public Library of Science journal PLoS ONE. The discovery was the unanticipated result of a study the Cummings group conducted to test the hypothesis that the freedom with which different cancer cells move - a concept called motility - could be correlated with their aggressiveness: That is, the faster a given type of cancer cell can move through the body the more aggressive it is. "Our results refute that hypothesis—the correlation between motility and aggressiveness that we found among three different types of cancer cells was very weak," Cummings says. "In the process, however, we began noticing that the cell movements were unexpectedly complicated." Then the researchers' interest was piqued by a paper that appeared in the February 2008 issue of the journal Nature titled, "Scaling laws of marine predator search behaviour." The paper contained an analysis of the movements of a variety of radio-tagged marine predators, including sharks, sea turtles and penguins. The authors found that the predators used a foraging strategy very close to a specialized random walk pattern, called a Lévy walk, an optimal method for searching complex landscapes. At the end of the paper's abstract they wrote, "...Lévy-like behaviour seems to be widespread among diverse organisms, from microbes to humans, as a 'rule' that evolved in response to patchy resource distributions." This gave Cummings and his colleagues a new perspective on the cell movements that they were observing in the microscope. They adopted the basic assumption that when mammalian cells migrate they face problems, such as efficiently finding randomly distributed targets like nutrients and growth factors, that are analogous to those faced by single-celled organisms foraging for food. With this perspective in mind, Alka Potdar, now a post-doctoral fellow at Case Western Reserve University and the Cleveland Clinic, cultured cells from three human mammary epithelial cell lines on two-dimensional plastic plates and tracked the cell motions for two-hour periods in a "random migration" environment free of any directional chemical signals. Epithelial cells are found throughout the body lining organs and covering external surfaces. They move relatively slowly, at about a micron per minute which corresponds to two thousandths of an inch per hour. When Potdar carefully analyzed these cell movements, she found that they all followed the same pattern. However, it was not the Lévy walk that they expected, but a closely related search pattern called a bimodal correlated random walk (BCRW). This is a two-phase movement: a run phase in which the cell travels primarily in one direction and a re-orientation phase in which it stays in place and reorganizes itself internally to move in a new direction. In subsequent studies, currently in press, the researchers have found that several other cell types (social amoeba, neutrophils, fibrosarcoma) also follow the same pattern in random migration conditions. They have also found that the cells continue to follow this same basic pattern when a directional chemical signal is added, but the length of their runs are varied and the range of directions they follow are narrowed giving them a net movement in the direction indicated by the signal.
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    When cells move about in the body, they follow a complex pattern similar to that which amoebae and bacteria use when searching for food, a team of Vanderbilt researchers have found. The discovery has a practical value for drug development: Incorporating this basic behavior into computer simulations of biological processes that involve cell migration, such as embryo development, bone remodeling, wound healing, infection and tumor growth, should improve the accuracy with which these models can predict the effectiveness of untested therapies for related disorders, the researchers say.
ghulammustafa

Top 5 Best Apps For Android Of The Month January 2019 - Useful Apps - Android Apps And ... - 0 views

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    Top 5 Best Android Apps Of The Month: Hello everyone I hope you all will be alright As you know that freeapksite.com is a site or platform which provide you best and premium android apps.These apps are very helpful and useful for you and your android phone so today I am here with top & best 5 amazing and awesome android apps.These apps are very popular and useful everyone should know about these 5 android apps and use them.You should use these android apps into your android phone.These apps will help you to make your android phone beautiful and amazing.These android apps are best apps of the month january 2019 So you should must use these apps in your phone once as a try.So lets start complete information about these 5 android apps. Apps Of The Month January 2019 Top 5 Best Apps For Android Of The Month January 2019 1. CPU-Z CPU-Z is most awesome & amazing android app available on google play store.If you want to buy an android phone or you want to know complete detail about your android phone then this android app is very useful for you and your android phone.CPU-Z is an android app which provide you complete detail about your android phone for example: Mobile modal number, Mobile brand name,Mobile board,Mobile hardware,Screen size,Screen resolution size,Screen density,Mobile weight,Mobile ram,Internal storage,Mobile Release date and many more.CPU-Z android app also provide you complete detail about your mobile's system for example:Android version,Api level,Security patch level,Bootloader etc.Download this amazing app from playstore or link given below. CPU-Z Free Download Here 2. Smart Lockscreen Protector Smart Lockscreen Protector have a beautiful and simple interface. This app made by Nez Droid developers. This android app have about 4.7 ratings on google play store. Install this lockscreen app from playstore and by clicking on given link below. First when you open it then you should enable lockscreen from its starting interface. This app show you two
Skeptical Debunker

New study shows sepsis and pneumonia caused by hospital-acquired infections kill 48,000... - 1 views

  • This is the largest nationally representative study to date of the toll taken by sepsis and pneumonia, two conditions often caused by deadly microbes, including the antibiotic-resistant bacteria MRSA. Such infections can lead to longer hospital stays, serious complications and even death. "In many cases, these conditions could have been avoided with better infection control in hospitals," said Ramanan Laxminarayan, Ph.D., principal investigator for Extending the Cure, a project examining antibiotic resistance based at the Washington, D.C. think-tank Resources for the Future. "Infections that are acquired during the course of a hospital stay cost the United States a staggering amount in terms of lives lost and health care costs," he said. "Hospitals and other health care providers must act now to protect patients from this growing menace." Laxminarayan and his colleagues analyzed 69 million discharge records from hospitals in 40 states and identified two conditions caused by health care-associated infections: sepsis, a potentially lethal systemic response to infection and pneumonia, an infection of the lungs and respiratory tract. The researchers looked at infections that developed after hospitalization. They zeroed in on infections that are often preventable, like a serious bloodstream infection that occurs because of a lapse in sterile technique during surgery, and discovered that the cost of such infections can be quite high: For example, people who developed sepsis after surgery stayed in the hospital 11 days longer and the infections cost an extra $33,000 to treat per person. Even worse, the team found that nearly 20 percent of people who developed sepsis after surgery died as a result of the infection. "That's the tragedy of such cases," said Anup Malani, a study co-author, investigator at Extending the Cure, and professor at the University of Chicago. "In some cases, relatively healthy people check into the hospital for routine surgery. They develop sepsis because of a lapse in infection control—and they can die." The team also looked at pneumonia, an infection that can set in if a disease-causing microbe gets into the lungs—in some cases when a dirty ventilator tube is used. They found that people who developed pneumonia after surgery, which is also thought to be preventable, stayed in the hospital an extra 14 days. Such cases cost an extra $46,000 per person to treat. In 11 percent of the cases, the patient died as a result of the pneumonia infection.
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    Two common conditions caused by hospital-acquired infections (HAIs) killed 48,000 people and ramped up health care costs by $8.1 billion in 2006 alone, according to a study released today in the Archives of Internal Medicine.
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