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Come work with us Interested in working with researchers from different disciplines within the Harvard, MIT and Broad community and an unique opportunity to participate in world-class research to make an impact on human health? Come work with us! We are looking for a computational biologists to handle data from a wide variety of experimental methods, focusing on next-gen sequencing technologies. Keep Reading...  SCDE is live The Stem Cell Discovery Engine (SCDE) is an integrated platform that allows users to consistently describe, share and compare cancer and tissue stem cell data. It is made up of an online database of curated experiments coupled to a customized instance of the Galaxy analysis engine with tools for gene list manipulation and molecular profile comparisons. The SCDE currently contains more than 50 stem cell-related experiments. Each has been manually curated and encoded using the ISA-Tab standard to ensure the quality of the data and its annotation. Keep Reading...  The Center for Health Bioinformatics at the Harvard School of Public Health provides consults to researchers for the management, integration and contextual analysis of biological high-throughput data. We are a member of the Center for Stem Cell Bioinformatics, the Environmental Statistics and Bioinformatics Core at the Harvard NIEHS Center for Environmental Health and the Genetics & Bioinformatics Consulting group for Harvard Catalyst and work closely with our colleagues in the Department of Biostatistics and the Program in Quantitative Genomics to act as a single point of contact for computational biology,

The PROOF (Prevention of Organ Failure) Centre is a not-for-profit organization that develops and implements blood-based biomarker tests to better manage patients with heart, lung and kidney failure and prevent disease progression. By embracing a cross-disciplinary team of people and uniting organizations including commercial partners, we can speed up the development of these tests, applying them sooner to improve and save lives.

""Experiments with amoebae that usually live as individuals but must also join with others to form multicellular bodies to complete their life cycles showed that cooperation depends on kinship. If amoebae occur in well-mixed cosmopolitan groups, then cheaters will always be able to thrive by freeloading on their cooperative neighbors. But if groups derive from a single cell, cheaters will usually occur in all-cheater groups and will have no cooperators to exploit. A multicellular body like the human body is an incredibly cooperative thing," Queller says, "and sociobiologists have learned that really cooperative things are hard to evolve because of the potential for cheating. "It's the single-cell bottleneck that generates high relatedness among the cells that, in turn, allows them to cooperate, " he says."

"Bacterial signaling controlling biofilm formation and pathogenicity Opportunistic bacterial pathogens cause a variety of infectious diseases. Their ability to sense and respond to different microenvironments, particularly during the transition from a free-living to an indwelling pathogenic lifestyle, is largely dependent on a variety of adaptational strategies (Hall-Stoodley et al., 2004). Examples include phenotypic variation, biofilm formation, resistance to antibiotic treatments and virulence gene expression, suggested to be interlinked phenotypes largely dependent on bacterial signaling and changes in their transcription profiles "

http://www.ted.com In his lab, Martin Hanczyc makes "protocells," experimental blobs of chemicals that behave like living cells. His work demonstrates how life might have first occurred on Earth ... and perhaps elsewhere too.

Professional Home for Life for Engineers and TechniciansSharing and advancing knowledge, the IET and its members seek to enhance people's lives around the world.

course teaches the engineering fundamentals for long-lived software using the highly-productive Agile development method for Software as a Service (SaaS) using Ruby on Rails.

UnCollege isn't just an idea or a website. It's a movement. It's a lifestyle. We believe that college isn't the only path to success. UnCollege is a social movement changing the notion that going to college is the only path to success. We empower students to hack their education through resources, writing, and workshops. We believe that everyone can live an UnCollege life by hacking their education.

plan to promote innovation as the key to create entrepreneurship in the cultural field.

"If we are putting our time and resources into communicating science but we're not on social media, we're like a tree falling in an empty forest-yes, we're making noise, but no one is listening." "Only 17% of Americans can name a living scientist. That statistic crushes my heart.""

"In short, this site is a record of my learning process as I try to understand aspects of colony health and productivity, and the reasons why various management techniques work (or don't). If you are a beginning beekeeper looking for basic information, or an experienced beekeeper looking for a summary of mite treatment options, I suggest that you go directly to Basic Beekeeping. I started keeping bees as a hobbyist in 1967, and then went on to get university degrees in biological sciences, specializing in entomology. In 1980 I began to build a migratory beekeeping operation in California, and currently run about 1000 hives with my two sons, from which we make our livings. In 1993, the varroa mite arrived in California, and after it wiped out my operation for the second time in 1999, I decided to "hit the books" and use my scientific background to learn to fight back"

"Hudnall: I really do believe that repression makes you sick. I'm big believer of what is coming out in the neuroscience and therapy community. Brene Brown, who is a shame and guilt expert, said it best: "We have an epidemic of shame in this country." If you keep things inside and have no one to talk to - and this is not crystals and patchouli - you will get sick, you will be miserable, you will ruin your relationships, and you will be unhappy. I know people whose lives were ruined by silence. Especially women. The one thing that has really opened my eyes while teaching is just what we do to our women. Only my women students have said to me, "I don't know if I have anything worth saying." It smacks me in the face every day. We are really fucking up our women"

"Gears are ubiquitous in the man-made world, found in items ranging from wristwatches to car engines, but it seems that nature invented them first. A species of plant-hopping insect, Issus coleoptratus, is the first living creature known to possess functional gears, a new study finds. The two interlocking gears on the insect's hind legs help synchronize the legs when the animal jumps."

In our Universe, a black hole is bounded by a spherical surface called an event horizon. Whereas in ordinary three-dimensional space it takes a two-dimensional object (a surface) to create a boundary inside a black hole, in the bulk universe the event horizon of a 4D black hole would be a 3D object - a shape called a hypersphere. When Afshordi's team modelled the death of a 4D star, they found that the ejected material would form a 3D brane surrounding that 3D event horizon, and slowly expand. The authors postulate that the 3D Universe we live in might be just such a brane - and that we detect the brane's growth as cosmic expansion. "Astronomers measured that expansion and extrapolated back that the Universe must have begun with a Big Bang - but that is just a mirage," says Afshordi.

"An accurate and colorful discription of a gout attack was elegantly written in 1683 by Dr. Thomas Sydenham who was himself a sufferer of gout: The victim goes to bed and sleeps in good health. About 2 o'clock in the morning, he is awakened by a severe pain in the great toe; more rarely in the heel, ankle or instep. This pain is like that of a dislocation, and yet the parts feel as if cold water were poured over them. Then follows chills and shiver and a little fever. The pain which at first moderate becomes more intense. With its intensity the chills and shivers increase. After a time this comes to a full height, accommodating itself to the bones and ligaments of the tarsus and metatarsus. Now it is a violent stretching and tearing of the ligaments- now it is a gnawing pain and now a pressure and tightening. So exquisite and lively meanwhile is the feeling of the part affected, that it cannot bear the weight of bedclothes nor the jar of a person walking in the room. "

"Note that the antimicrobial peptides are produced largely in the fat bodies-so there would be less of this sort of response in forager bees, which don't maintain their fat bodies. This makes sense, since foragers aren't expected to live for long. However, keep in mind that the bees in protein-hungry colonies are unable to develop their fat bodies fully-this one point where nutrition ties in to immunity. Surprisingly, Jay Evans found that these genes are not upregulated in bees from CCD colonies, even though the bees are full of pathogens! There are a few potential explanations for this finding that come to mind: The bee hemocytes are not recognizing the pathogens as foreign (suppression of recognition systems, perhaps by viruses?). The colonies could be protein-starved. Something is suppressing the transcription of the genes, or their translation to peptides. Note that viruses can do this very thing, which I feel may be a big clue!"

Here are the most interesting, amazing and unusual things that happened in the world of science this week. A recap of Live Science's

Bats, birds, box turtles, humans and many other animals share at least one thing in common: They sleep. Humans, in fact, spend roughly one-third of their lives asleep, but sleep researchers still don't know why.

Researchers at Fermilab are building a "holometer" so they can disprove everything you thought you knew about the universe. More specifically, they are trying to either prove or disprove the somewhat mind-bending notion that the third dimension doesn't exist at all, and that the 3-D universe we think we live in is nothing more than a hologram. To do so, they are building the most precise clock ever created.