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For theoretical neurobiologist and author Mark Changizi, "why" has always been more interesting than "how." While many scientists focus on the mechanics of how we do what we do, his research aims to grasp the ultimate foundations underlying why we think, feel and see as we do. Guided by this philosophy, he has made important discoveries on why we see in color, why we see illusions, why we have forward-facing eyes, why letters are shaped as they are, why the brain is organized as it is, why animals have as many limbs and fingers as they do, and why the dictionary is organized as it is.

Brain, bodily awareness, and the emergence of a conscious self: these entities and their relations are explored by Germanphilosopher and cognitive scientist Metzinger. Extensively working with neuroscientists he has come to the conclusion that, in fact, there is no such thing as a "self" -- that a "self" is simply the content of a model created by our brain - part of a virtual reality we create for ourselves. But if the self is not "real," he asks, why and how did it evolve? How does the brain construct the self? In a series of fascinating virtual reality experiments, Metzinger and his colleagues have attempted to create so-called "out-of-body experiences" in the lab, in order to explore these questions. As a philosopher, he offers a discussion of many of the latest results in robotics, neuroscience, dream and meditation research, and argues that the brain is much more powerful than we have ever imagined. He shows us, for example, that we now have the first machines that have developed an inner image of their own body -- and actually use this model to create intelligent behavior. In addition, studies exploring the connections between phantom limbs and the brain have shown us that even people born without arms or legs sometimes experience a sensation that they do in fact have limbs that are not there. Experiments like the "rubber-hand illusion" demonstrate how we can experience a fake hand as part of our self and even feel a sensation of touch on the phantom hand form the basis and testing ground for the idea that what we have called the "self" in the past is just the content of a transparent self-model in our brains. Now, as new ways of manipulating the conscious mind-brain appear on the scene, it will soon become possible to alter our subjective reality in an unprecedented manner. The cultural consequences of this, Metzinger claims, may be immense: we will need a new approach to ethics, and we will be forced to think about ourselves in a fundamentally new way. At

"Social interactions require fast and efficient person perception, which is best achieved through the process of categorization. However, this process can produce pernicious outcomes, particularly in the case of stigma. This study used fMRI to investigate the neural correlates involved in forming both explicit ("Do you like or dislike this person?") and implicit ("Is this a male or female?") judgments of people possessing well-established stigmatized conditions (obesity, facial piercings, transsexuality, and unattractiveness), as well as normal controls. Participants also made post-scan disgust ratings on all the faces that they viewed during imaging. These ratings were subsequently examined (modeled linearly) in a parametric analysis. Regions of interest that emerged include areas previously demonstrated to respond to aversive and disgust-inducing material (amygdala and insula), as well as regions strongly associated with inhibition and control (anterior cingulate and lateral prefrontal cortex). Further, greater differences in activation were observed in the implicit condition for both the amygdala and prefrontal cortical regions in response to the most negatively perceived faces. Specifically, as subcortical responses (e.g., amygdala) increased, cortical responses (e.g., lateral PFC and anterior cingulate) also increased, indicating the possibility of inhibitory processing. These findings help elucidate the neural underpinnings of stigma"

December 9th, 02005 - Sam Harris"The View From The End Of The World"This is an audio only presentation. This talk took place in the Conference Center Golden Gate Room, San Francisco. Quote: With gentle demeanor and tight argument, Sam Harris carried an overflow audience into the core of one of the crucial issues of our time: What makes some religions lethal? How do they employ aggressive irrationality to justify threatening and controlling non-believers as well as believers? What should be our response? Harris began with Christianity. In the US, Christians use irrational arguments about a soul in the 150 cells of a 3-day old human embryo to block stem cell research that might alleviate the suffering of millions. In Africa, Catholic doctrine uses tortured logic to actively discourage the use of condoms in countries ravaged by AIDS. "This is genocidal stupidity," Harris said. Faith trumps rational argument. Common-sense ethical intuition is blinded by religious metaphysics. In the US, 22% of the population are CERTAIN that Jesus is coming back in the next 50 years, and another 22% think that it's likely. The good news of Christ's return, though, can only occur following desperately bad news. Mushroom clouds would be welcomed. "End time thinking," Harris said, "is fundamentally hostile to creating a sustainable future." Harris was particularly critical of religious moderates who give cover to the fundamentalists by not challenging them. The moderates say that all is justified because religion gives people meaning in their life. "But what would they say to a guy who believes there's a diamond the size of a refrigerator buried in his backyard? The guy digs out there every Sunday with his family, cherishing the meaningthe quest gives them." "I've read the books," Harris said. "God is not a moderate." The Bible gives strict instructions to kill various kinds of sinners, and their relatives, and on occasion their entire towns. Yet slavery is challenged nowhere in the New or

In what may feel like a flashback to the porn wars of the '60s, a new study investigates the link between a country's relative gender equality and the degree of female "empowerment" in the X-rated entertainment it consumes. Researchers at the University of Hawaii focused on three countries in particular: Norway, the United States and Japan, which are respectively ranked 1st, 15th and (yikes) 54th on the United Nations' Gender Empowerment Measure (GEM). To simplify their analysis, their library of smut was limited to explicit photographs of women "from mainstream pornographic magazines and Internet websites, as well as from the portfolios of the most popular porn stars from each nation." Then they set out to evaluate each image on both a disempowerment and an empowerment scale, using respective measures like whether the woman is "bound and dominated" by "leashes, collars, gags, or handcuffs" or "whether she has a natural looking body." Their hypothesis was that societies with greater gender equity will consume pornography that has more representations of "empowered women" and less of "disempowered women." It turned out the former was true, but, contradictory as it may sound, the latter was not. "While Norwegian pornography offers a wider variety of body types -- conforming less to a societal ideal that is disempowering to the average woman -- there are still many images that do not promote a healthy respect for women," the researchers explain. In other words, Norwegian porn showed more signs of female empowerment, but X-rated images in all three countries equally depicted women in demeaning positions and scenarios. This, the researchers surmise, "suggests that empowerment and disempowerment within pornography are potentially different constructs." So, gender equality is accompanied by sexual interest in a broader range of beauty types but not a decrease in porn's infantilization of females, use of dominating fetish gear on women or any of the other characteristics th

The best of the bunch (so far) for the 2010 American Physical Society's Gallery of Fluid Motion Each year, the Fluid Dynamics division of the American Physical Society holds a conference. This year, the meeting is in Long Beach, California, in November. One of the highlights is the impressive set of videos of fluid motion that the delegates put together. These videos have already begun to appear on the arViv in impressive numbers. Videos are an effective and increasingly popular way of publishing research. Expect to see more like this. But there are clearly better ways to make them available other than as downloads from the arXiv or as videos in a room in Long Beach. One obvious option is to make them available on streaming websites such as YouTube andVimeo. As far as I can tell, they are not available like this. Another is to create a website that showcases them in advance, to make it a global, web-based event. Many of the videos are superb. Not only could they command a bigger audience, they deserve it. If plans are afoot to make the Gallery of Fluid Motion a bigger event, then great. If not, shame! Here is my selection of the highlights this year.

Squirrels are charismatic creatures that can bring joy and entertainment as they frolic in our backyards and parks. However, when these furry critters start invading our homes or wreaking havoc in our gardens, they can quickly become a nuisance. Squirrel control becomes particularly challenging as their behavior and habits change with the seasons. In this article, we will explore the unique challenges posed by squirrels at each time of year and discuss effective strategies to keep them at bay. Springtime Strategies: As spring arrives, squirrels become more active and enter the breeding season. They may choose to build nests in attics, crawl spaces, or chimneys to give birth and raise their young. To prevent these unwanted guests, it is crucial to inspect your property for any potential entry points and seal them off. Trim tree branches that hang near your roof, as squirrels can use them as bridges to access your home.

It's possible to get the mental equivalent of whiplash from the latest medical findings, as risk factors are identified one year and exonerated the next. According to a panel at the American Association for the Advancement of Science, this isn't a failure of medical research; it's a failure of statistics, and one that is becoming more common in fields ranging from genomics to astronomy. The problem is that our statistical tools for evaluating the probability of error haven't kept pace with our own successes, in the form of our ability to obtain massive data sets and perform multiple tests on them. Even given a low tolerance for error, the sheer number of tests performed ensures that some of them will produce erroneous results at random.

DiscOU is a resources discovery engine relying on a semantic index of Open University Open Content. It semantically analyses the content of an online resource, and matches it by similarity to other existing Open University content to retrieve the most relevant pieces. It currently works with BBC programme pages, as demonstrated in the video below, as well as from text entered/pasted in the DiscOU alfa interface.

DiscOU is a resources discovery engine relying on a semantic index of Open University Open Content. It semantically analyses the content of an online resource, and matches it by similarity to other existing Open University content to retrieve the most relevant pieces. It currently works with BBC programme pages, as demonstrated in the video below, as well as from text entered/pasted in the DiscOU alfa interface.

"What are we aiming for? We want to change the way research is communicated, both amongst researchers, as well as with health practitioners, patients and the wider public. Inspired by Beethoven, we want to build a research version of his repository and try to tackle the question "What if the public scientific record would be updated directly as research proceeds?""

Many newly diagnosed prostate cancers present as low Gleason score tumors that require no treatment intervention. Distinguishing the many indolent tumors from the minority of lethal ones remains a major clinical challenge. We now show that low Gleason score prostate tumors can be distinguished as indolent and aggressive subgroups on the basis of their expression of genes associated with aging and senescence. Using gene set enrichment analysis, we identified a 19-gene signature enriched in indolent prostate tumors. We then further classified this signature with a decision tree learning model to identify three genes-FGFR1, PMP22, and CDKN1A-that together accurately predicted outcome of low Gleason score tumors. Validation of this three-gene panel on independent cohorts confirmed its independent prognostic value as well as its ability to improve prognosis with currently used clinical nomograms. Furthermore, protein expression of this three-gene panel in biopsy samples distinguished Gleason 6 patients who failed surveillance over a 10-year period. We propose that this signature may be incorporated into prognostic assays for monitoring patients on active surveillance to facilitate appropriate courses of treatment.

The most distant known galaxy to host a supermassive black hole has been discovered in a galaxy that formed in the early history of the universe. The galaxy, as large as the Milky Way, is about 12.8 billion light-years away and harbors a supermassive black hole that contains at least a billion times as much matter as our sun.

"Darkness can conceal identity and encourage moral transgressions; thus Ralph Waldo Emerson wrote in "Worship" in The Conduct of Life (1860), "as gaslight is the best nocturnal police, so the universe protects itself by pitiless publicity." New research in Psychological Science, a journal of the Association for Psychological Science, shows that darkness may also induce a psychological feeling of illusory anonymity, just as children playing "hide and seek" will close their eyes and believe that other cannot see them, the experience of darkness, even one as subtle as wearing a pair of sunglasses, triggers the belief that we are warded from others' attention and inspections."

ScienceDaily (Jan. 13, 2011) - It is becoming well accepted that, as well as too little exercise, too much sitting is bad for people's health. Now a new study has found that it is not just the length of time people spend sitting down that can make a difference, but also the number of breaks that they take while sitting at their desk or on their sofa. Plenty of breaks, even if they are as little as one minute, seem to be good for people's hearts and their waistlines.

Peak Oil is the point at which petroleum production reaches its greatest rate just before going into perpetual decline. In "Peak Oil and a Changing Climate," a new video series from The Nation and On The Earth productions, radio host Thom Hartmann explains that the world will reach peak oil within the next year if it hasn't already. As a nation, the United States reached peak oil in 1974, after which it became a net oil importer. Bill McKibben, Noam Chomsky, Nicole Foss, Richard Heinberg and the other scientists, researchers and writers interviewed throughout "Peak Oil and a Changing Climate" describe the diminishing returns our world can expect as it deals with the consequences of peak oil even as it continues to pretend it doesn't exist. These experts predict substantially increased transportation costs, decreased industrial production, unemployment, hunger and social chaos as the supplies of the  fuels on which we rely dwindle and eventually disappear. Chomsky urges us to anticipate the official response to peak oil based on how corporations, news organizations and other institutions have responded to global warming: obfuscation, spin and denial. James Howard Kunstler says that we cannot survive peak oil unless we "come up with a consensus about reality that is consistent with the way things really are." This documentary series hopes to help build that consensus. Click here to watch the introductory video, and check back here for new videos each Wednesday.

It's not quite Cyclops, the sci-fi superhero from the X-Men franchise whose eyes produce destructive blasts of light, but for the first time a laser has been created using a biological cell. The human kidney cell that was used to make the laser survived the experience. In future such "living lasers" might be created inside live animals, which could potentially allow internal tissues to be imaged in unprecedented detail. It's not the first unconventional laser. Other attempts include lasers made of Jell-O and powered by nuclear reactors (see box below). But how do you go about giving a living cell this bizarre ability? Typically, a laser consists of two mirrors on either side of a gain medium - a material whose structural properties allow it to amplify light. A source of energy such as a flash tube or electrical discharge excites the atoms in the gain medium, releasing photons. Normally, these would shoot out in random directions, as in the broad beam of a flashlight, but a laser uses mirrors on either end of the gain medium to create a directed beam. As photons bounce back and forth between the mirrors, repeatedly passing through the gain medium, they stimulate other atoms to release photons of exactly the same wavelength, phase and direction. Eventually, a concentrated single-frequency beam of light erupts through one of the mirrors as laser light.

You may have more in common with Kanzi, Panbanisha and Nyota, three language-competent bonobos living at Great Ape Trust, than you thought. And those similarities, right at your fingertip, might one day tell scientists more about the effect of culture on neurological disorders that limit human expression. Among humans, pointing is a universal language, an alternative to spoken words to convey a message. Before they speak, infants point, a gesture scientists agree is closely associated with word learning. But when an ape points, scientists break rank on the question of whether pointing is a uniquely human behavior. Some of the world's leading voices in modern primatology have argued that although apes may gesture in a way that resembles human pointing, the genetic and cognitive differences between apes and humans are so great that the apes' signals have no specific intent. Not so, say Great Ape Trust scientists, who argued in a recently published scientific paper, "Why Apes Point: Pointing Gestures in Spontaneous Conversation of Language-Competent Pan/Homo Bonobos," that not only do Kanzi, Panbanisha and Nyota point with their index fingers in conversation as a human being might, these bonobos do so with specific intent and objectives in mind.

Soon the word "hella" may not be associated with California surfers as much as with scientists in lab coats. A physics student is petitioning to add "hella" to the International System of Units (SI) as the official designation of 10 to the 27th power, or a trillion trillions.