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This case study synthesizes students' knowledge of the central dogma and cell structure by examining a rare health disorder in order to understand protein targeting and its medical consequences. Students first identify the molecular alteration in affected members of a family with renal Fanconi syndrome as reported in the New England Journal of Medicine (2014). Students then use an online bioinformatics tool to analyze the wildtype and mutant proteins and examine their subcellular localization. Finally, students use this information to explain the symptoms of affected family members. The case is delivered with a PowerPoint presentation that includes a selection of brainstorming prompts and "clicker questions." Students complete a worksheet (included in the teaching notes) before class, making the activity suitable for a flipped classroom. A second worksheet (also included in the teaching notes) is completed during class. The case is written for an introductory biology course for majors, but could also be used as a unit capstone in a non-majors human biology course; the case is also scalable to upper division courses in physiology that specifically explore kidney function.

This case study presents a realistic example of drinking water contamination within a fictional local community and leads students through an abbreviated human health risk assessment. Students are provided background information about the extent of the contamination and a description of the contaminated site and are then required to calculate both the cancer and non-cancer risks to the community. This exercise is appropriate for an environmental toxicology or environmental risk assessment course. It works well after a lecture on the basics of risk assessment including how to calculate exposure intakes and risk estimates.

n this interrupted case study, students learn about the influence of early fetal nutritional conditions on the expression of genes related to metabolism and growth. Beginning with the true event of a food and fuel embargo that led to famine in the western Netherlands toward the end of World War II, students learn about the historical background of the Dutch Hunger Winter and its social impact. Using real data from the study conducted by Heijmans and coauthors (2008), students then compare the methylation level of a specific gene between individuals conceived during the famine and their unaffected siblings, and how changes in the expression of this metabolically important gene may impact the risk of developing type 2 diabetes. Supported by other studies on mice and in humans, students conclude that in utero events may impact the health of individuals later in life through epigenetic mechanisms. The case is ideally suited for a molecular or cell biology course, but is also appropriate for an introductory biology course in which students have an understanding of descriptive statistics, interpretation of statistical test results, eukaryotic gene structure, and regulation of gene expression.

Online museum in UK.   Explore the home of human ingenuity online. Find out about our objects, arts projects and medical collection, play educational games and discover climate science. Plus check out our blogs, a tabloid history of science and the latest contemporary science news from the Antenna team.

Scientists said Wednesday a new drug tested on monkeys provided an astonishingly effective shield against an animal version of the AIDS virus, a major gain in the quest for an HIV vaccine. Macaque monkeys given the drug were able to fend off high, repeated doses of the simian version of the human immunodeficiency virus (HIV), they reported in the journal Nature.

If the lab technique works in the field, it could offer a new way of stopping the biting insects from spreading malaria to humans, they say. The scientists put a new "resistance" gene into the mosquito's own DNA, using a gene editing method called Crispr. And when the GM mosquitoes mated - their offspring inherited the same resistance, PNAS journal reports. In theory, if these mosquitoes bite people, they should not be able to pass on the parasite that causes malaria.

For a study published Tuesday in the journal Nature Communications, Partridge and other researchers from Philadelphia suspended premature lambs, a close animal model for human fetuses, in a liquid-filled, artificial womb, allowing them to further develop for four weeks-longer than in past similar attempts.

Organic food has become the fastest-growing sector of the U.S. food industry, with sales that increase by double digits annually. That's a lot of kale flying off the shelves. Buying it makes us feel like we're helping ourselves and the planet. But here's the truth: There are no health benefits from eating organic food. And it is likely worse for the environment.

China is engulfed in an extreme amount of pollution, and it's causing health problems for people living in this area! How can we help fight some of these diseases? Laci explains how broccoli could incredibly helpful when it comes to ridding the body of deadly toxins! Follow DNews on Twitter: http://www.twitter.com/dnews Follow Laci on Twitter: http://www.twitter.com/gogreen18  Read More: China's toxic air pollution resembles nuclear winter, say scientists http://www.theguardian.com/world/2014... "Air pollution now impeding photosynthesis and potentially wreaking havoc on country's food supply, experts warn."

An outbreak of plague that affected four people and a dog in Colorado might be the first instance of person-to-person transmission of plague in the United States in 90 years, officials said Thursday. It started with a sick pit bull, and its owner, two vet techs and a close personal contact of the dog's owner all ended up infected. The dog died but all four people were treated with antibiotics and are okay.

Around the world, disease-carrying mosquitoes are advancing at speed, taking viruses such as dengue and Zika, plus a host of lesser-known ills such as chikungunya and St. Louis encephalitis, into new territories from Europe to the Pacific. "The concern is that we have these species spreading everywhere. Today the focus is on Zika but they can carry many different viruses and pathogens," said Anna-Bella Failloux, head of the department that tracks mosquito viruses at France's Institut Pasteur.

comprehensive data repository and analysis tools with many data sources to graph and investigate

A major new study of smoking and death has banged more nails into the coffin of cigarette smoking, though chances are it will do little to persuade any of the 42 million American smokers to quit. If current smokers have not already responded to the well-established links between smoking and 21 diseases that together cause 480,000 deaths each year, adding another five diseases and 60,000 deaths to this grisly total is unlikely to make a difference - at least not by itself.

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animated narrated slide show