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Lottie Peppers

Project Information - 0 views

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    Autism is rooted in genetics, including the mutation of certain genes that result in a failure of neurons in the brain to properly connect. Based on earlier genetic research funded by Autism Speaks, such as the Autism Genome Project (AGP), scientists have discovered some of these genes. But much more gene discovery needs to take place. The Autism Genome 10K Project will mark a substantial leap forward on this journey. The Autism Genome 10K Project builds on the successes of Autism Speaks' Autism Genetic Resource Exchange program (AGRE), a high-quality collection of more than 12,000 DNA samples from families affected by autism. The AGRE program has facilitated many high-impact scientific discoveries in recent years, including the risk genes discovered by the AGP and other researchers. With BGI sequencing the full complement of 10,000 samples collected by AGRE and collaborators in China, Autism Genome 10K leverages BGI's cutting-edge expertise and globally unrivaled capacity for high-quality genome sequencing.
Lottie Peppers

Steve Silberman: The forgotten history of autism - YouTube - 0 views

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    Decades ago, few pediatricians had heard of autism. In 1975, 1 in 5,000 kids was estimated to have it. Today, 1 in 68 is on the autism spectrum. What caused this steep rise? Steve Silberman points to "a perfect storm of autism awareness" - a pair of doctors with an accepting view, an unexpected pop culture moment and a new clinical test. But to really understand, we have to go back further to an Austrian doctor by the name of Hans Asperger, who published a pioneering paper in 1944. Because it was buried in time, autism has been shrouded in misunderstanding ever since. (This talk was part of a TED2015 session curated by Pop-Up Magazine: popupmagazine.com or @popupmag on Twitter.)
Lottie Peppers

Monkeys Built to Mimic Autism-Like Behaviors May Help Humans - The New York Times - 0 views

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    Scientists have genetically engineered monkeys so that they exhibit behaviors similar to autism, with a goal of testing potential therapies on the animals in hopes that their resemblance to humans will yield more answers about the disorder. The scientists found that the monkeys showed "very similar behaviors related to human autism patients, including repetitive behaviors, increased anxiety and, most importantly, defects in social interactions," said Zilong Qiu, a leader of the research at the Institute of Neuroscience at the Chinese Academy of Sciences in Shanghai. The team is now imaging the brains of the monkeys, he said, "trying to identify the deficiency in the brain circuits that is responsible for the autism-like behavior."
Lottie Peppers

New Breakthrough in What Causes Autism - 0 views

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    Scientists are now one step closer to understanding how genetic mutations contribute to autism. In a study released Thursday in the journal Cell, experts from UNC School of Medicine discovered how one specific autism-linked gene mutation actually works
Lottie Peppers

Autism's Gut-Brain Connection | Fast Forward | OZY - 0 views

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    Research has revealed striking differences in the trillions of bacteria - a.k.a., the microbiome - in the intestines of children with and without autism. But the gut bacteria in individuals with autism aren't just different. Researchers at the California Institute of Technology have shown for the first time that they may actually contribute to the disorder. They reported in the journal Cell in December 2013 that an experimental probiotic therapy alleviated autism-like behaviors in mice and are already planning a clinical trial.
Lottie Peppers

JAMA Network | JAMA | Autism Occurrence by MMR Vaccine Status Among US Children With Ol... - 0 views

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    Importance  Despite research showing no link between the measles-mumps-rubella (MMR) vaccine and autism spectrum disorders (ASD), beliefs that the vaccine causes autism persist, leading to lower vaccination levels. Parents who already have a child with ASD may be especially wary of vaccinations. Objective  To report ASD occurrence by MMR vaccine status in a large sample of US children who have older siblings with and without ASD.
Lottie Peppers

What causes autism? What we know, don't know and suspect - 0 views

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    Since this time, research has focused on biological factors that may lead to autistic behaviours. This has found very clearly there is no one cause of autism. A variety of genetic factors are likely to be the ultimate cause of most cases of autism. These may work by themselves, or in combination with environmental factors, to lead a child's brain to develop differently and result in autistic behaviours.
Lottie Peppers

Autism Genes Activate During Fetal Brain Development - 0 views

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    Scientists at the University of California, San Diego School of Medicine have found that mutations that cause autism in children are connected to a pathway that regulates brain development.
Lottie Peppers

How Mutations In A Suspect Gene May Give Rise To Autism, Schizophrenia - Forbes - 0 views

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    Now, scientists at the Salk Institute for Biological Studies in La Jolla, Calif., have pinpointed a gene linked to these disorders that seems to be crucial for normal brain structure in prenatal development. The findings, which appear in an open-access article in the Jan. 14 issue of Cell Reports, shed new light on the mechanistic workings of a gene called MDGA1, previously implicated in autism, schizophrenia and bipolar disorder.
Lottie Peppers

More Differences Than Similarities Are Found in Autistic Siblings - NYTimes.com - 0 views

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    Most siblings with a diagnosis of autism do not share the same genetic risk factors for the disorder and are as distinct in their behaviors as any brothers and sisters, scientists reported on Monday in a study that came as a surprise to many doctors, if not to parents.
Lottie Peppers

Why Fathers Really Matter - NYTimes.com - 0 views

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    Biology is making it clearer by the day that a man's health and well-being have a measurable impact on his future children's health and happiness. 
Lottie Peppers

Genes to Cognition Online - 0 views

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    Genes to Cognition (G2C) Online is about modern neuroscience. It focuses on cognitive disorders, cognitive processes, and research approaches. Use the dynamic network maps to explore our library of 750+ unique items. Or, use the linear Selected Items menu on top of each map to tour selected content.  Explore, interact, and have fun! 
Lottie Peppers

Medicine in the Genomic Era | HHMI's BioInteractive - 0 views

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    In the 2013 Holiday Lectures on Science, Charles L. Sawyers of Memorial Sloan-Kettering Cancer Center and Christopher A. Walsh of Boston Children's Hospital will reveal the breathtaking pace of discoveries into the genetic causes of various types of cancers and diseases of the nervous system, and discuss the impact of those discoveries on our understanding of normal human development and disease.
Lottie Peppers

Lessons - Resources - Life Sciences Learning Center - University of Rochester Medical C... - 0 views

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    Extensive lessons from hands on inquiry lab at University of Rochester, developed/written with research funds.
Lottie Peppers

Foundation for Biomedical Research | Home | Foundation for Biomedical Research - 0 views

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    Highlighting role of animal research in human health.  A visually appealing website with an array of research summaries.
Lottie Peppers

CDC - Science Ambassador Program - Lesson Plan - High School - 0 views

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    Lesson plans from a 5 day summer workshop through the CDC
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