Group items tagged

The United States Government (USG) seeks to enter into a Cooperative Agreement (the Agreement) for a five-year, $28 million Malaria Bilateral Program to address critical malaria prevention and control issues in Guinea. Specifically, the award recipient (the Awardee) will play the lead role in the President's Malaria Initiative (PMI) suite of programs to support the National Malaria Control Program (NMCP) through technical assistance and community based service support for the prevention, diagnosis and treatment of malaria in Guinea. The Malaria Bilateral Program will contribute towards achieving USAID/Guinea's Development Objective of "Utilization of Quality Health Services Increased" as outlined in its 2015-2019 Country Development Cooperation Strategy (CDCS). To maximize impact, USAID/Guinea expects that the Malaria Bilateral Program will work in concert with USAID-supported health programs in support of the national strategies and health sector development plans.

The purpose of this Funding Opportunity Announcement (FOA) is to solicit revision applications from currently funded International Centers of Excellence for Malaria Research (ICEMR) investigators. These awards will support the conduct and oversight of observational studies or implementation studies to evaluate the impact of in-country, approved vector control and malaria prevention interventions on the incidence, prevalence, and transmission of malaria. This program will leverage the baseline data, infrastructure, and capacity established by the ICEMRs. The studies will augment or use the established malaria surveillance systems to study the impact of the vector control and malaria prevention interventions on human health outcomes. This FOA solicits three distinct types of studies: Study Type 1 is a Controlled Environment study, Study Type 2 is an Observational study, and Study Type 3 is an Implementation study. For Study Type 3 (Implementation study) this FOA supports a "Go/No-Go" approach to funding, which is significantly different from most U19 projects. Continued funding for the full award duration is dependent upon achieving negotiated "Go/No-Go" criteria by the end of Year 2 of the revision award. Applications may propose only one project for each Study Type.  

The general objective of the activity is to improve the quality of malaria diagnosis and treatment services to 85% from baseline in project supported facilities. The specific project objectives are to: 1. Strengthen partnerships and coordination at national and regional levels 2. Strengthen and scale up quality assurance (QA) systems for malaria diagnosis and treatment 3. Improve infrastructures (minor renovation) and human resource capacity for malaria diagnosis and case management 4. Enhanced program learning and operational research to impact policy and programming related to malaria case management This Activity will be implemented consistent with the principles of collaborating learning and adapting (CLA). Consistent with CLA, this Agreement covers any activities that consistent with CLA principles will contribute to the four objectives and key results specified above, consistent with the implementation planning requirements and other provisions of the Agreement.

The purpose of the Tanzania Malaria Surveillance and Monitoring (TMSM) Cooperative Agreement is to support the Government of Tanzania (GOT) to reduce the burden of malaria and to move towards the long-term goal of malaria elimination. Under this Cooperative Agreement, USAID/Tanzania will fund malaria surveillance, entomological monitoring, and drug efficacy monitoring. Monitoring will include entomological monitoring, including insecticide resistance monitoring, and therapeutic efficacy monitoring. With the improved epidemiological and entomological data gained during the implementation of this Cooperative Agreement, the Recipient and government partners will be able to refine responses to outbreaks and foci of transmission and adjust IRS and other vector control interventions in zones with differing transmission profiles. The target populations of TMSM are pregnant women and children under five.

The purpose of the Tanzania Malaria Surveillance and Monitoring (TMSM) Cooperative Agreement is to support the Government of Tanzania to reduce the burden of malaria and to move towards the long-term goal of malaria elimination.

The purpose of this Notice of Funding Opportunity (NOFO) is: to assist with the implementation of malaria focused operations research, surveillance, and monitoring and evaluation activities, in Kenya. Through this funding announcement, the Division of Parasitic Diseases and Malaria seeks to fund critical operations research and evaluation activities with the potential to yield high impact public health findings and to improve strategies that will decrease the overall burden of malaria and increase the health and well-being of affected populations in Kenya.

The purpose of this initiative is to stimulate basic research, discovery, and early translational research to enable and accelerate the generation of highly efficacious pre-erythrocytic stage malaria vaccines, including sporozoite-based vaccines    . Cross-fertilization and collaboration among investigators from malaria vaccine research and other basic research areas such as parasite biology, parasite genomics, pathogenesis, and host immunology are highly encouraged. The goal is to generate one or more promising vaccine candidates against human malaria that exhibit performance superior to currently available sporozoite-based vaccines and are suitable for further downstream process development and future clinical evaluation.

The purpose of this Funding Opportunity Announcement (FOA) is to solicit applications for the Vaccine and Treatment Evaluation Units (VTEUs) to implement clinical site protocols (clinical research, clinical trials) for evaluating vaccines, other preventive biologics, therapeutics, diagnostics, including prognostic and predictive markers, and devices for the treatment and prevention of infectious diseases as part of NIAID Infectious Diseases Clinical Research Consortium (IDCRC). The VTEUs coordinate with the Leadership Group (LG) for the IDCRC, a program which provides for overall administrative and scientific leadership for the clinical research and clinical trials conducted. This initiative seeks to fund additional VTEUs with a specific focus on enhancing capability and capacity of current research in controlled human infection models for malaria and influenza, and implementation of treatment and prevention trials in endemic areas for malaria and neglected tropical diseases. While the scientific focus will be on product evaluation for NIAID priorities for this FOA, including malaria/neglected tropical diseases, the VTEUs must also provide capacity to perform clinical research on sexually transmitted infections, respiratory infections, and enteric diseases in infected patients and healthy volunteers, in addition to providing surge capacity to address emerging infectious diseases.

The overarching goal of the ICEMR program is to establish research centers in malaria-endemic settings that will provide the necessary knowledge, tools, and evidence-based strategies for use by government organizations and health care institutions to control and treat malaria. This program is not intended to support research which can be conducted primarily in U.S. institutions.

The purpose of this Funding Opportunity Announcement (FOA) is to support early phase translational research that will generate new malaria vaccine candidates suitable for further downstream development and clinical evaluation. This research opportunity encourages studies that will lead to discovery of new vaccine candidates that prevent infection, ameliorate disease, and/or interrupt transmission caused by human malaria parasites, especially P. falciparum and P. vivax.

Through this BAA addendum, USAID seeks creation of a malaria evaluation and research partnership, via an organization or group of organization, to conduct future program evaluation and research activities, establish consensus for new collaborative research ideas, synthesize and conduct meta-analaysis of existing malaria data, and provide solutions to improve evaluation and research data utilization.

Tubiteho means "Let's take care of them" in Kirundi, the national language of Burundi, and will be a "flagship" Activity in the USAID/Burundi Health Portfolio for Family Planning and Reproductive, Maternal, Neonatal and Child Health (RMNCH), as well as for malaria control at the household and health facility level, and for national and central level support of strengthening malaria case management activities.

This notice solicits applications for the Resilient and Responsive Health Systems (RRHS) Initiative - South Sudan, a multi-year program to strengthen human resources for health (HRH) to address public health challenges like HIV/AIDS, tuberculosis (TB) and malaria in South Sudan. This initiative also seeks to achieve health system resiliency by addressing fundamental health systems constraints that impede the availability of and access to quality health services by supporting the implementation of national health strategies and recovery plans to respond to emerging epidemics, prevent, manage and control HIV/AIDS, TB, malaria, and other communicable and non-communicable diseases, and improve population health outcomes.

The purpose of this announcement is to strengthen capacity of the Government of the Republic of Namibia through support for high-impact and evidence based interventions to prevent HIV transmission, increase access to quality HIV/AIDS care and support programs, strengthen the overall health system, and integrate HIV/AIDS programming with maternal and child healthcare, malaria, TB and other primary healthcare programs in an effective manner.

USAID/Cambodia seeks to make a five-year award focused on the goal of improving the quality of public and private health services in Cambodia in a sustainable manner through technical assistance to national and sub-national health systems. The activity will achieve this goal through four objectives: 1) improved policies, guidelines and standards for streamlined quality assurance; 2) increased efficiency and effectiveness of service delivery; 3) strengthened regulatory framework, implementation, and enforcement; and 4) strengthened pre-service public health training. Under these objectives, the award will support the Ministry of Health, Provincial Health Departments, Operational District Offices and Referral Hospital Management to improve the quality of health services through targeted technical assistance and limited introduction of new techniques, approaches, and technologies that improve quality of health services in both the public and private sector. The award will build upon existing, effective quality assurance systems and ensure that they incorporate a focus on USAID/Cambodia's technical priorities (maternal and child health, family planning, nutrition, tuberculosis, HIV and malaria). In addition, a major focus of the award will be ensuring quality of health services provided in the private sector. This will include, but is not limited to, strengthening licensing and regulation of service providers and monitoring of service quality in the private sector toward the development of an accreditation system for both public and private providers.

The United States Government, represented by the U.S. Agency for International Development (USAID) Mission in Mali, is seeking feedback for three planned activities: "Integrated Community Health, Nutrition and Governance" expected to cover Nutrition, Maternal, Newborn and Child Health, Malaria, Family Planning and Reproductive health interventions; "Health System Strengthening" to focus at strengthening systems at the national, regional, district and community levels; and "Quality Improvement" to focus on human resources for health and the quality of health services at all levels.

The purpose of this Funding Opportunity Announcement is to solicit applications for the Vaccine Treatment and Evaluation Units (VTEUs) to implement clinical site protocols (clinical research, clinical trials) for evaluating vaccines, other preventive biologics, therapeutics, diagnostics, including prognostic and predictive markers, and devices for the treatment and prevention of infectious diseases as part of NIAID Infectious Diseases Clinical Research Consortium (IDCRC). A companion FOA solicits applications for the Leadership Group for the Infectious Diseases Clinical Research Consortium, hereafter referred to as the Leadership Group (LG), which provides for overall administrative and scientific leadership for the clinical research and clinical trials conducted. While the primary scientific focus will be on product evaluation for NIAID priority areas, including malaria/neglected tropical diseases, sexually transmitted infections, respiratory infections, and enteric diseases, the VTEUs must also provide surge capacity to address emerging infectious diseases.

The purpose of this Funding Opportunity Announcement (FOA) is to solicit applications to form a Leadership Group for an Infectious Diseases Clinical Research Consortium, hereafter referred to as the Leadership Group (LG), to support the planning and implementation of clinical research that addresses the scientific priorities of NIAID in evaluating vaccines, other preventive biologics, therapeutics, diagnostics, including prognostic and predictive markers, and devices for the treatment and prevention of infectious diseases. A companion FOA solicits Vaccine and Treatment Evaluation Units (VTEUs), which will provide the scientific, administrative expertise and infrastructure to implement the clinical research. Although the scientific focus will be on malaria/neglected tropical diseases, sexually transmitted infections, respiratory infections, and enteric diseases, the LG and VTEU will work collaboratively to monitor, identify and adjust research priorities based on potential emerging infectious diseases.

PROBLEM: The global community has made great strides in reducing mortality around the world over the last 50 years, but progress in developing countries lags far behind that seen in developed countries. Every year an estimated 303,000 women die during pregnancy and childbirth, 5.9 million children die, and an even greater number become infected with life-threatening diseases like HIV/AIDS, malaria, diarrhea, pneumonia, and TB, among others. The vast majority of deaths due to these largely preventable causes occur in developing countries where access to health services is often poor. Outbreaks of emerging infectious diseases like Ebola and Zika only serve to further compound these health challenges, taxing already stressed health systems and elevating the risk of disease epidemics of global proportions.

The purpose of this NOFO is to reduce the overall burden of selected parasitic infections in the United States through public health practice and disease control activities. There are two components in the NOFO that address different parasitic infections, they are: Chagas disease and soil-transmitted helminths. This NOFO will continue the work of the Division of Parasitic Diseases and Malaria in CDC's Center for Global Health to strengthen health care providers' understanding, identification, treatment and prevention of parasitic infections in the U.S. One component of this NOFO will focus on using existing data to develop and disseminate strategies, educational tools, materials, and guidelines related to Chagas disease diagnosis and management in the United States to: improve healthcare provider knowledge and practices, increase testing and improve management of persons with or at risk of infection with the parasite that causes Chagas disease, increase awareness, availability and use of best practices, education training tools and materials. The other component of this NOFO will focus on the ongoing, public health practice and disease control activities receiving congressional funding to investigate and address infections with soil transmitted helminths in areas of Alabama and Mississippi where these infections have historically been endemic through testing, treatment and health education. Successful strategies should have the