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The purpose of this Funding Opportunity Announcement (FOA) is to invite Cooperative Agreement (U24) applications for the continued development and sustainment of high-value informatics research resources to serve current and emerging needs across the cancer research continuum including cancer biology, cancer treatment and diagnosis, cancer prevention, cancer control and epidemiology, and/or cancer health disparities. As a component of the NCIs Informatics Technology for Cancer Research (ITCR) Program, this FOA focuses on supporting activities necessary for improved user experience and availability of existing, widely-adopted informatics tools and resources.This is in contrast to early-stage and advanced development efforts to generate these tools and resources that are supported by companion ITCR FOAs. The central mission of ITCR is to promote research-driven informatics technology across the development lifecycle to address priority needs in cancer research. In order to be successful, the proposed sustainment plan must provide clear justifications for why the research resource should be maintained and how it has benefited and will continue to benefit the cancer research field.In addition, mechanisms for assessing and maximizing the value of the resource to researchers and supporting collaboration and/or deep engagement between the resource and the targeted research community should be described.

The CDS&E-MSS program accepts proposals that confront and embrace the host of mathematical and statistical challenges presented to the scientific and engineering communities by the ever-expanding role of computational modeling and simulation on the one hand, and the explosion in production of digital and observational data on the other. The goal of the program is to promote the creation and development of the next generation of mathematical and statistical theories and tools that will be essential for addressing such issues. To this end, the program will support fundamental research in mathematics and statistics whose primary emphasis will be on meeting the aforementioned computational and data-related challenges. This program is part of the wider Computational and Data-enabled Science and Engineering (CDS&E) enterprise in NSF that seeks to address this emerging discipline. The research supported by the CDS&E-MSS program will aim to advance mathematics or statistics in a significant way and will address computational or big-data challenges.

The goal of the interagency Smartand Connected Health (SCH): Connecting Data, People and Systems program is to accelerate the development and integration of innovative computer and information scienceand engineering approaches to support the transformation of health and medicine. Approaches that partner technology-based solutions with biomedical and biobehavioral research are supported by multiple agencies of the federal government including the National Science Foundation (NSF) and the National Institutes of Health (NIH). The purpose of this program is to develop next-generation multidisciplinary science that encourages existing and new research communities to focus on breakthrough ideas in a variety of areas of value to health, such as networking, pervasive computing, advanced analytics, sensor integration, privacy and security, modeling of socio-behavioral and cognitive processes and system and process modeling. Effective solutions must satisfy a multitude of constraints arising from clinical/medical needs, barriers to change, heterogeneity of data, semantic mismatch and limitations of current cyberphysical systems and an aging population.Such solutions demand multidisciplinary teams ready to address issues ranging from fundamental science and engineering to medical and public health practice.

The Advanced Technologies and Instrumentation (ATI) program provides grants to support the development and construction of state-of-the-art astronomical detectors and instruments for the visible, infrared, submillimeter, and radio regions of the spectrum.  Successful proposals will involve the application of new hardware and software technology and/or innovative techniques in astronomical research in any of a broad range of fields, including (but not limited to) imaging instruments and spectrometers, semiconducting and superconducting detector arrays for astronomy, precision radial velocity hardware, polarization measurement hardware and techniques, correlator hardware, interferometric imaging, and adaptive optics.

The Advanced Technologies and Instrumentation (ATI) program provides grants to support the development and construction of state-of-the-art astronomical detectors and instruments for the visible, infrared, submillimeter, and radio regions of the spectrum.  Successful proposals will involve the application of new hardware and software technology and/or innovative techniques in astronomical research in any of a broad range of fields, including (but not limited to) imaging instruments and spectrometers, semiconducting and superconducting detector arrays for astronomy, precision radial velocity hardware, polarization measurement hardware and techniques, correlator hardware, interferometric imaging, and adaptive optics.

The National Science Foundation (NSF) through its Divisions of Electrical, Communications and Cyber Systems (ECCS); Chemical, Bioengineering, Environmental and Transport Systems (CBET); Civil, Mechanical and Manufacturing Innovation (CMMI); Information and Intelligent Systems (IIS); and Mathematical Sciences (DMS) announces a solicitation on Multimodal Sensor Systems for Precision Health enabled by Data Harnessing, Artificial Intelligence (AI), and Learning. Next-generation multimodal sensor systems for precision health integrated with AI, machine learning (ML), and mathematical and statistical (MS) methods for learning can be envisioned for harnessing a large volume of diverse data in real time with high accuracy, sensitivity and selectivity, and for building predictive models to enable more precise diagnosis and individualized treatments. It is expected that these multimodal sensor systems will have the potential to identify with high confidence combinations of biomarkers, including kinematic and kinetic indicators associated with specific disease and disability. This focused solicitation seeks high-risk/high-return interdisciplinary research on novel concepts, innovative methodologies, theory, algorithms, and enabling technologies that will address the fundamental scientific issues and technological challenges associated with precision health.

This single-source funding opportunity announcement (FOA) Enhancing Public Health Emergency Preparedness and Response Capacities in the Americas in Collaboration with the National Center for Prevention Programs and Disease Control (CENAPRECE) in Mexico invites an application for a five-year cooperative agreement between the Department of Health and Human Services(HHS) Office of the Assistant Secretary for Preparedness and Response (ASPR) and the U.S.-Mexico Foundation for Science (FUMEC) to support CENAPRECE (an agency within Mexico Secretariat of Health [SALUD]). The envisioned ASPR-FUMEC-CENAPRECE collaboration sustains and advances the long-standing relationship between the United States and Mexico aimed at safeguarding each country from public health threats and fulfilling the goals of multiple international frameworks and agreements, including the International Health Regulations (2005) (IHR) (http://www.who.int/ihr/publications/9789241580496/en/). Projects and activities proposed by CENAPRECE for this agreement will combine strategic coordination of public health preparedness and emergency response programs as well as technical collaborations to strengthen the capacities of both countries and the region to prevent, detect, report, and respond to public health emergencies of all types, focusing on pandemic influenza, other emerging infectious diseases, and chemical, biological, and radiological (terrorism) hazards.

The Engineering Design and Systems Engineering (EDSE) program supports fundamental research into the basic processes and phenomena of engineering design and systems engineering. The program seeks proposals leading to improved understanding about how processes, organizational structure, social interactions, strategic decision making, and other factors impact success in the planning and execution of engineering design and systems engineering projects. It also supports advances pertaining to engineering design and systems engineering in areas that include, but are not limited to, decision making under uncertainty, including preference and demand modeling; problem decomposition and decision delegation; applications of reverse game theory (mechanism design); computer-aided design; design representation; system performance modeling and prediction; design optimization; uncertainty quantification; domain- or concern-specific design methods; and advanced computational techniques for supporting effective human cognition, decision making, and collaboration. Competitive proposals for novel methods will include a plan to evaluate rigorously the effectiveness and performance of the proposed approach. The EDSE program encourages multidisciplinary collaborations of experts in design and systems engineering with experts in other domains. Of particular interest is research on the design of engineering material systems that leverages the unique aspects of a particular material system to realize advanced design methods that are driven by performance metrics and incorporate processing/manufacturing considerations.

DOE-NE's mission is to encourage development and exploration of advanced nuclear science and technology. DOE-NE promotes nuclear energy as a resource capable of meeting the nation's energy, environmental, and national security needs by resolving scientific, technical, and regulatory challenges through research, development, and demonstration. IUP supports DOE-NE's Nuclear Energy University Program (NEUP), which enables outstanding, cutting-edge, and innovative research at U.S. IHEs through the following: * Integrating research and development (R&D) at U.S. IHEs, national laboratories, and industry to revitalize nuclear education and support NE'sPrograms * Attracting the brightest students to the nuclear professions and supporting the nation's intellectual capital in science and engineering disciplines * Improving U.S. IHE's infrastructure for conducting R&D and educating students * Facilitating knowledge transfer to the next generation ofworkers Educating undergraduate and graduate students in NS&E will: * Support the ongoing need for personnel who can develop and maintain the nation's nuclear power technology * Enhance the R&D capabilities of U.S. IHEs * Fulfill national demand for highly trained scientists and engineers to work in NS&E areas

The USDOT seeks to develop, evaluate, and test vehicle-to-infrastructure (V2I) applications for the light vehicle fleet that are intended to transform surface transportation safety, mobility, and environmental performance through a connected vehicle environment. These efforts are outlined in RITA's ITS Strategic Research Plan, 2010-2014. The FHWA has a lead role in the selection, development, and testing of the applications. V2I applications are those applications wherein vehicle-based sensors and vehicle-to-vehicle (V2V) communications are not considered adequate for development of information, alerts, or warnings for drivers. Rather, additional information is required from the infrastructure in order to enable the applications. These applications, however, are vehicle-based, in that they are programs resident in the on-board equipment of the vehicle. The on-board systems use information from vehicle-based sensors, V2V communications, and V2I communications to determine if information, alerts, or warnings should be provided to the driver. Automobile manufacturers (OEMs) are critical partners in development of vehicle-based applications and processes. The Crash Avoidance Metrics Partnership (CAMP) partnership was formed between Ford Motor Company and General Motors to accelerate development and implementation of crash avoidance countermeasures in light vehicles to improve traffic safety. The CAMP partnership forms a consortium of all OEMs that desire to cooperatively work together and with the USDOT on specific research areas, such as V2I applications. This cooperative agreement is with CAMP and is intended to facilitate the selection, development, and evaluation of V2I safety, mobility and environmental applications, and to conduct other Connected Vehicle program work that involves communications between vehicles, infrastructure, and pedestrians and bicyclists.

The Department of Homeland Security (DHS) Domestic Nuclear Detection Office (DNDO) National Technical Nuclear Forensics Center (NTNFC) is inviting U.S. colleges and universities to apply for the Nuclear Forensics Research Award (NFRA). The NFRA supports the establishment of a team of faculty, students, and technical staff at the national or defense laboratories to conduct research in the field of nuclear forensics. NTNFC was tasked with two core missions: to provide national-level integration, centralized planning, and stewardship for the National Technical Nuclear Forensics (NTNF) community; and to lead the U.S. Government (USG) in establishing a robust and enduring pre-detonation radiological/nuclear materials forensics capability. A top priority of DNDO/NTNFC's stewardship mission is to lead USG efforts in addressing the enduring challenge of sustaining a preeminent Nuclear Forensics (NF) workforce of recognized technical experts and leaders through fostering scholastic and research collaboration between and among academia, the national and defense laboratories, and the NTNF Interagency.

The Department of Homeland Security (DHS) Domestic Nuclear Detection Office (DNDO) National Technical Nuclear Forensics Center (NTNFC) is inviting U.S. colleges and universities to apply for the Nuclear Forensics Research Award (NFRA). The NFRA supports the establishment of a team of faculty, students, and technical staff at the national or defense laboratories to conduct research in the field of nuclear forensics. NTNFC was tasked with two core missions: to provide national-level integration, centralized planning, and stewardship for the National Technical Nuclear Forensics (NTNF) community; and to lead the U.S. Government (USG) in establishing a robust and enduring pre-detonation radiological/nuclear materials forensics capability. A top priority of DNDO/NTNFC's stewardship mission is to lead USG efforts in addressing the enduring challenge of sustaining a preeminent Nuclear Forensics (NF) workforce of recognized technical experts and leaders through fostering scholastic and research collaboration between and among academia, the national and defense laboratories, and the NTNF Interagency.

The goal of the CPS program is to develop the core system science needed to engineer complex cyber-physical systems that people can use or interact with and depend upon. Some of these may require high-confidence or provable behaviors. The program aims to foster a research community committed to advancing research and education in CPS and to transitioning CPS science and technology into engineering practice. By abstracting from the particulars of specific systems and application domains, the CPS program seeks to reveal cross-cutting fundamental scientific and engineering principles that underpin the integration of cyber and physical elements across all application sectors. To expedite and accelerate the realization of cyber-physical systems in a wide range of applications, the CPS program also supports the development of methods, tools, and hardware and software components based upon these cross-cutting principles, along with validation of the principles via prototypes and testbeds. We have also seen a convergence of CPS technologies and research thrusts that underpin Smart & Connected Communities (S&CC) and the Internet of Things (IoT). These domains offer new and exciting challenges for foundational research and provide opportunities for maturation at multiple time horizons.

The Civil Infrastructure Systems (CIS) program supports research leading to the engineering of infrastructure systems for resilience and sustainability without excluding other key performance issues. Areas of interest include intra- and inter-physical, information and behavioral dependencies of infrastructure systems, infrastructure management, construction engineering, and transportation systems. Special emphasis is on the design, construction, operation, and improvement of infrastructure networks with a focus on systems engineering and design, performance management, risk analysis, life-cycle analysis, modeling and simulation, behavioral and social considerations not excluding other methodological areas or the integration of methods.This program does not encourage research proposals primarily focused on structural engineering, materials or sensors that support infrastructure system design, extreme event modeling, hydrological engineering, and climate modeling, since they do not fall within the scope of the CIS program. Researchers focused in these areas are encouraged to contact the Infrastructure Management and Extreme Events (IMEE), Geotechnical Engineering (GTE), Hazard Mitigation and Structural Engineering (HSME), Structural Materials and Mechanics (SMM), or the Sensors and Sensing Systems (SSS) program within CMMI. Additionally, researchers may consider contacting the Hydrologic Sciences program in the Earth Sciences Division (EAR) or the Physical and Dynamic Meteorology (PDM) program in the Atmospheric and Geospace Sciences Division (AGS) of the Directorate for Geosciences.

The competition for individual sites will be for consideration of large and small university-based user facilities, including those at minority-serving institutions, that are geographically distributed and with diverse and complementary capabilities to support current and anticipated future user needs across the broad spectrum of nanoscale science, engineering, and technology domains. The selected individual sites will have autonomy in their operation and management, but will be required to act in concert with a Coordinating Office that will be separately competed and chosen at a later stage. Some sites may choose to partner with facilities at regional or smaller institutions that would bring specific capabilities for users and benefits to student training. The overall collection of selected sites and their capabilities will provide users with cost-effective access both to the specialized tools, processes, and expertise to support complex multi-step fabrication at the nanoscale level for structures, materials, devices, and systems, as well as to the associated instrumentation for characterization, analysis, and probing at these dimensions. The program aims to make these capabilities broadly available to the nation's researchers in academe, industry, and government to help catalyze new discoveries in science and engineering and to stimulate technological innovation.

The objective of the DARPA Biological Control program is to build new capabilities for the control of biological systems across scales - from nanometers to centimeters, seconds to weeks, and biomolecules to populations of organisms - using embedded controllers made of biological parts to program system-level behavior. This program will apply and advance existing control theory to design and implement generalizable biological control strategies analogous to conventional control engineering, for example, for mechanical and electrical systems. The resulting advances in fundamental understanding and capabilities will create new opportunities for engineering biology. Specifically, the Biological Control program will demonstrate tools to rationally design and implement multiscale, closed-loop control of biological systems, through the development of biological controllers, testbeds to evaluate control of system-level behavior, and theory and models to predict and design effective control strategies. The resulting capabilities will be inherently generalizable to a variety of biological systems. Successful teams will integrate and apply these capabilities to demonstrate a practical proof-of-principle biological solution to a proposer-defined application relevant to the U.S. Department of Defense (DoD).

The objective of the DARPA Biological Control program is to build new capabilities for the control of biological systems across scales - from nanometers to centimeters, seconds to weeks, and biomolecules to populations of organisms - using embedded controllers made of biological parts to program system-level behavior. This program will apply and advance existing control theory to design and implement generalizable biological control strategies analogous to conventional control engineering, for example, for mechanical and electrical systems. The resulting advances in fundamental understanding and capabilities will create new opportunities for engineering biology. Specifically, the Biological Control program will demonstrate tools to rationally design and implement multiscale, closed-loop control of biological systems, through the development of biological controllers, testbeds to evaluate control of system-level behavior, and theory and models to predict and design effective control strategies. The resulting capabilities will be inherently generalizable to a variety of biological systems. Successful teams will integrate and apply these capabilities to demonstrate a practical proof-of-principle biological solution to a proposer-defined application relevant to the U.S. Department of Defense (DoD).

The purpose of the SCRI program is to address the critical needs of the specialty crop industry by awarding grants to support research and extension that address key challenges of national, regional, and multi-state importance in sustaining all components of food and agriculture, including conventional and organic food production systems. Projects must address at least one of five focus areas: Research in plant breeding, genetics, genomics, and other methods to improve crop characteristics; Efforts to identify and address threats from pests and diseases, including threats to specialty crop pollinators; Efforts to improve production efficiency, handling and processing, productivity, and profitability over the long term (including specialty crop policy and marketing); new innovations and technology, including improved mechanization and technologies that delay or inhibit ripening; and methods to prevent, detect, monitor, control, and respond to potential food safety hazards in the production efficiency, handling and processing of specialty crops.

The purpose of the Jobs Plus Pilot program is to develop locally-based, job-driven approaches to increase earnings and advance employment outcomes through work readiness, employer linkages, job placement, educational advancement, technology skills, and financial literacy for residents of public housing. The place-based Jobs Plus Pilot program addresses poverty among public housing residents by incentivizing and enabling employment through earned income disregards for working families, and a set of services designed to support work including employer linkages, job placement and counseling, educational advancement, and financial counseling. Ideally, these incentives will saturate the target developments, building a culture of work and making working families the norm. The Jobs Plus Pilot program consists of the following three core components: Employment-Related Services Financial Incentives – Jobs Plus Earned Income Disregard (JPEID) Community Supports for Work Applicants are encouraged to develop key partnerships to connect participants with any other needed services to remove barriers to work. An Individualized Training and Services Plan (ITSP) should be developed for each participant to establish goals and service strategies, and to track progress. Background HUD, the Rockefeller Foundation, and the MDRC, through a public-private partnership, designed and supported the Jobs Plus program model between 1998 and 2003. HUD has issued two separate evaluation reports on the demonstration, in an effort to identify and document the most promising approaches to increasing employment among families in public housing. Each evaluation showed ongoing positive effects for residents when the program was well-implemented and included the three core elements.

The Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative is aimed at revolutionizing neuroscience through development and application of innovative technologies to map neural circuits, monitor and modulate their activity, and understand how they contribute to thoughts, sensations, emotions and behavior. NIH has issued a variety of Funding Opportunity Announcements (FOAs) that will support projects that apply technologies to understand neural circuit function in the context of specific circuits, resulting in a diverse portfolio of research into the fundamental biology of nervous system function. The purpose of this announcement is to notify the research community that NIH welcomes BRAIN Initiative applications targeting central nervous system nociceptive and pain circuits, as appropriate to the goals and requirements of specific BRAIN Initiative FOAs. Pain conditions represent an important public health problem and NIH continues to support research into pain pathologies through normal Institute and Center appropriations. However, pain and nociception are also components of normal nervous system function, and the BRAIN Initiative is committed to understanding pain circuits along with brain circuits underlying other sensory, motor, cognitive and emotional functions. It is expected that the unique opportunities of the BRAIN Initiative will enable production of detailed maps of pain circuits, and the adoption of powerful new tools for monitoring and modulating pain circuit activity, leading to significant advances in the understanding of pain and nociception. For a list of past and open BRAIN Initiative FOAs, see https://braininitiative.nih.gov/funding/.

This BAA is intended to solicit extramural research and development ideas, and is issued under the provisions of the Competition in Contracting Act of 1984 (Public Law 98-369), as implemented in Federal Acquisition Regulation 6.102(d) (2) and 35.016. This announcement provides a general description of USSOCOM's research areas of interest, general information, evaluation and selection criteria, and proposal/application preparation instructions. In accordance with FAR 6.102, projects funded under this announcement must be for basic and applied research and that part of development not related to the development of a specific system or hardware procurement. Projects must be for scientific study and experimentation directed toward advancing the state-of-the-art or increasing knowledge or understanding. Projects that are for the development of a specific system or hardware procurement will not be considered. The selection process is highly competitive and the quantity of meaningful proposal/applications (both pre-proposal/pre-applications and full proposal/full applications) typically received exceed the number of awards that available funding can support. This BAA provides a general description of USSOCOM's research and development programs, including research areas of interest, evaluation and selection criteria, pre-proposal/pre-application and full proposal/application preparation instructions, and general administrative information. Specific submission information and additional administrative requirements can be found in the document titled "General Submission Instructions" available in Grants.gov along with this BAA.

The Engineering for Natural Hazards (ENH) program supports fundamental research that advances knowledge for understanding and mitigating the impact of natural hazards on constructed civil infrastructure.  Natural hazards considered by the ENH program include earthquakes, windstorms (such as tornadoes and hurricanes), tsunamis, storm surge, and landslides.  The constructed civil infrastructure supported by the ENH program includes building systems, such as the soil-foundation-structure-envelope-nonstructural system, as well as the façade and roofing, and other structures, geostructures, and underground facilities, such as tunnels.  While research may focus on a single natural hazard, research that considers civil infrastructure performance over its lifetime in the context of multiple hazards, that is, a multi-hazard approach, is encouraged.  Research may integrate geotechnical, structural, and architectural engineering advances with discoveries in other science and engineering fields, such as earth and atmospheric sciences, materials science, mechanics of materials, dynamic systems and control, systems engineering, decision theory, risk analysis, high performance computational modeling and simulation, and social, behavioral, and economic sciences.  Multi-disciplinary and international collaborations are encouraged.  The ENH program encourages research integrated with knowledge dissemination and activities that can lead to broader societal benefit for reducing the impact of natural hazards on civil infrastructure.

The Catalysis program is part of the Chemical Process Systems cluster, which also includes: 1) the Electrochemical Systems program; 2) the Interfacial Engineering program; and 3) the Process Systems, Reaction Engineering, and Molecular Thermodynamics program. The goals of the Catalysis program are to increase fundamental understanding in catalytic engineering science and to advance the development of catalytic materials and reactions that are beneficial to society. Research in this program should focus on new concepts for catalytic materials and reactions, utilizing synthetic, theoretical, and experimental approaches. Target applications include fuels, specialty and bulk chemicals, environmental catalysis, biomass conversion to fuels and chemicals, conversion of greenhouse gases, and generation of solar hydrogen, as well as efficient routes to energy utilization. Heterogeneous catalysis represents the main thrust of the program. Proposals related to both gas-solid and liquid-solid heterogeneous catalysis are welcome, as are proposals that incorporate concepts from homogeneous catalysis. Topic areas that are of particular interest include: · Renewable energy-related catalysis with applications in electrocatalysis, photocatalysis, and catalytic conversion of biomass-derived chemicals. Catalysis aimed at closing the carbon cycle (especially conversion of CO2, methane, and natural gas to fuels and chemical intermediates). · Catalytic alternatives to traditionally non-catalytic reaction processes, as well as new catalyst designs for established catalytic processes. · Environmental catalysis (including energy-efficient and green routes to fuels and chemicals). ·