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The MME program supports fundamental research that enables the development of new and/or improved manufacturing machines and equipment, and optimization of their use, with a particular focus on equipment appropriate for the manufacture of mechanical and electromechanical devices, products, and systems featuring scales from microns to meters (proposals relating to nanomanufacturing should be submitted to the CMMI NanoManufacturing program, and those relating to the manufacture of electronic devices such as IC products should be submitted to the ECCS Division). 

The National Institutes of Health (NIH) Office of the Associate Director for Data Science (ADDS) announces a collaboration with the Wellcome Trust (WT) and the Howard Hughes Medical Institute (HHMI) to launch the ``Open Science Prize'' (the ``Challenge'') to encourage and support the prototyping and development of services, tools and/or platforms that enable open content--including publications, datasets, code and other research outputs--to be discovered, accessed and re-used in ways that will advance research, spark innovation, and generate new societal benefits. The Challenge is necessary to accelerate the field of ``open'' biomedical research beyond what current funding mechanisms can achieve.

The Materials Engineering and Processing (MEP) program supports fundamental research addressing the processing and mechanical performance of engineering materials by investigating the interrelationship of materials processing, structure, properties and/or life-cycle performance for targeted applications. Materials processing proposals should focus on manufacturing processes that convert material into useful form as either intermediate or final composition. These include processes such as extrusion, molding, casting, deposition, sintering and printing.

The purpose of the SCRI program is to address the critical needs of the specialty crop industry by awarding grants to support research and extension that address key challenges of national, regional, and multi-state importance in sustaining all components of food and agriculture, including conventional and organic food production systems. Projects must address at least one of five focus areas: Research in plant breeding, genetics, genomics, and other methods to improve crop characteristics; Efforts to identify and address threats from pests and diseases, including threats to specialty crop pollinators; Efforts to improve production efficiency, handling and processing, productivity, and profitability over the long term (including specialty crop policy and marketing); new innovations and technology, including improved mechanization and technologies that delay or inhibit ripening; and methods to prevent, detect, monitor, control, and respond to potential food safety hazards in the production efficiency, handling and processing of specialty crops.

Program supports two main types of research: (i) innovations in general-purpose methodology related to optimization, stochastic modeling, and decision and game theory; and (ii) research grounded in relevant applications that require the development of novel and customized analytical and computational methodologies. Both types of proposals must be motivated by an application area of interest to the program. Application areas of interest include supply chains and logistics; risk management; healthcare; environment; energy production and distribution; mechanism design and incentives; production planning, maintenance, and quality control; and national security

New NASA Research Announcement (NRA) 80JSC018N0001-SANS Countermeasures for Mitigation of Spaceflight Associated Neuro-ocular Syndrome NASA's Human Research Program (HRP) has released solicited research response area NRA 80JSC018N0001-SANS "Countermeasures for Mitigation of Spaceflight Associated Neuro-ocular Syndrome" that solicits applied research in support of HRP goals and objectives. This response area is Appendix C of the Human Exploration Research Opportunities (HERO) NRA (80JSC018N0001). Proposals are solicited by NASA in the areas of Mechanisms and Evaluation of Countermeasures for Mitigation of Spaceflight Associated Neuro-ocular Syndrome (SANS) in a Novel Ground-Based Head-Down Tilt Bed Rest Analog. Appendix C of the HERO NRA and associated documentation can be found at: https://tinyurl.com/HERO18-SANS.

In 2016, the National Science Foundation (NSF) unveiled a set of "Big Ideas," 10 bold, long-term research and process ideas that identify areas for future investment at the frontiers of science and engineering (see https://www.nsf.gov/news/special_reports/big_ideas/index.jsp). One of these ideas, "The Quantum Leap: Leading the Next Quantum Revolution," advances quantum technologies of the future: quantum computing, quantum communication, quantum simulations and quantum sensors. Recent advances in understanding and exploiting quantum mechanics are laying the foundation for generations of new discoveries that can benefit society in unforeseen ways. This "quantum revolution" requires a highly-trained workforce that can advance the envelope of what is possible, through research and development of practical solutions for quantum technologies. Academic faculty serve a vital role in the development of this workforce, by training the next generation of students while performing vital research.

The Cyberinfrastructure for Emerging Science and Engineering Research (CESER) program aims to catalyze new science and engineering discovery pathways through early-stage collaborative activities between disciplinary scientists and engineers as well as developers/implementers of innovative cyberinfrastructure (CI) capabilities, services, and approaches. Beginning in FY 2017, the CESER program replaced the Strategic Technologies for Cyberinfrastructure (STCI) program. CESER has retained STCI's focus on supporting innovation across the CI ecosystem with increased emphasis on addressing and enabling emerging areas of potentially transformative research, including NSF priority areas, national strategic directions, and international collaborative research. CESER accepts proposals pursuant to this Program Description year-round. From time to time, NSF may also issue Dear Colleague Letters pursuant to CESER to signal special thematic interests and opportunities. CESER employs existing NSF funding mechanisms to accomplish the program's goals such as EArly-concept Grants for Exploratory Research (EAGER) and Conference proposals

General Electric invites proposals for technologies, processes or methods to ensure that B-nut fitting assemblies are properly assembled and leak-proof. GE Aviation, a world-leading provider of commercial, military and business and general aviation jet and turboprop engines and components as well as avionics, electrical power and mechanical systems for aircraft. It also provides aftermarket services to support its products. A key objective for the organization to deliver a continually-growing installed bases of jet engines is to ensure that the approaches used to properly assemble components are efficient and effective.

The FY18 PH/TBIRP CTRR-CRA is intended to support clinical research focused on understanding the clinical sequelae and mechanisms of recovery associated with TBI and TBI rehabilitation interventions. The overarching goals of this award are to address TBI-related impairments and deficits, including multimodal, and cognitive dysfunction to (1) develop and validate rehabilitation outcome measures; (2) systematically analyze standard of care cognitive interventions to identify optimal treatment ingredients; and (3) improve clinician-driven assessment strategies to guide return-to-duty decision making.

The purpose of this FOA is to support the development and evaluation of innovative approaches to deliver genome editing machinery into somatic cells, with the ultimate goal of accelerating the development of genome editing therapeutics to treat human disease. Projects will be supported through a two-phase, UG3/UH3 award mechanism. The initial 3-year UG3 phase will support proof of concept studies of delivery technologies and independent validation of targeted cell and tissue delivery in vivo. The 1-year UH3 phase will support scale-up and testing of genome editing technologies in collaboration with Large Animal Testing Centers.

Mozambique is at a critical junction of controlling its HIV/AIDS epidemic in order to meet The Joint United Nations Programme on HIV/AIDS (UNAIDS) goal of 90-90-90 by 2020 and 95-95-95 by 2030. Reaching these goals not only requires robust clinical interventions, but simultaneously requires addressing social, cultural, and legal barriers that inhibit equal access to health services for all people living with and affected by HIV. This requires not only the training of those at a local level who interact with people living with HIV/AIDS (PLHIV) or other vulnerable populations but also building the capacity of civil society organizations that can assist with improving uptake of HIV services as well as improving retention and linkages. This NOFO will increase the availability, accessibility, acceptability, and quality of HIV services provided in health facilities or community level by implementing innovative activities that reduce stigma and discrimination, increase retention and linkages of HIV and TB services, improve health facilities’ redress mechanisms, optimize care for HIV and TB patients, and improve patient rights and access to quality services for PLHIV.

The NIH Blueprint for Neuroscience Research is a collaborative framework through which 14 NIH Institutes, Centers and Offices jointly support neuroscience-related research, with the aim of accelerating discoveries and reducing the burden of nervous system disorders. This Funding Opportunity Announcement (FOA) will solicit research projects focused on the development of new technology and tools, or novel mechanistic studies, or a combination of mechanistic and technology development studies specific to central nervous system (CNS, which includes retina) small blood and lymphatic vessels in health and disease, across the life span. The program aims at facilitating the development of tools and technology to image, profile and map CNS small blood and lymphatic vessels. Additional goals are to elucidate the mechanisms underlying CNS small blood and lymphatic vessels structural and functional heterogeneity, differential susceptibility to injury, role in disease and repair processes, and their responses to therapies. Preclinical studies using in vitro and/or animal models specific to CNS small blood and lymphatic vessels alone or in combination with pilot human studies are appropriate for this FOA.

The PRMRP Focused Program Award mechanism is intended to optimize research and accelerate the solution for a critical question related to at least one of the Congressionally directed FY17 PRMRP Topic Areas through a synergistic, multidisciplinary research program. The anticipated total costs budgeted for the entire period of performance for an FY17 PRMRP Focused Program Award will not exceed $10M.

The FY17 KCRP Concept Award supports highly innovative, untested, potentially groundbreaking novel concepts in kidney cancer. The Concept Award is not intended to support an incremental progression of an already established research project but, instead, allows Principal Investigators (PIs) the opportunity to pursue serendipitous observations. Preliminary data are not allowed. This award mechanism supports high-risk studies that have the potential to reveal entirely new avenues for investigation relevant to active duty Service members, Veterans, other military beneficiaries, and the American public. Applications must describe how the new idea will enhance the existing knowledge of kidney cancer or develop an innovative and novel course of investigation. Research completed through a Concept Award may generate sufficient preliminary data to enable the PI to prepare an application for future research. The anticipated direct costs budgeted for the entire period of performance for an FY17 KCRP Concept Award will not exceed $75,000. Refer to Section II.D.5, Funding Restrictions, for detailed funding information.

The purpose of this Funding Opportunity Announcement (FOA) is to invite Cooperative Agreement (U24) applications for the continued development and sustainment of high-value informatics research resources to serve current and emerging needs across the cancer research continuum including cancer biology, cancer treatment and diagnosis, cancer prevention, cancer control and epidemiology, and/or cancer health disparities. As a component of the NCIs Informatics Technology for Cancer Research (ITCR) Program, this FOA focuses on supporting activities necessary for improved user experience and availability of existing, widely-adopted informatics tools and resources.This is in contrast to early-stage and advanced development efforts to generate these tools and resources that are supported by companion ITCR FOAs. The central mission of ITCR is to promote research-driven informatics technology across the development lifecycle to address priority needs in cancer research. In order to be successful, the proposed sustainment plan must provide clear justifications for why the research resource should be maintained and how it has benefited and will continue to benefit the cancer research field.In addition, mechanisms for assessing and maximizing the value of the resource to researchers and supporting collaboration and/or deep engagement between the resource and the targeted research community should be described.

Computational neuroscience provides a theoretical foundation and a rich set of technical approaches for understanding complex neurobiological systems, building on the theory, methods, and findings of computer science, neuroscience, and numerous other disciplines. Through the CRCNS program, the National Science Foundation (NSF), the National Institutes of Health (NIH), the German Federal Ministry of Education and Research (Bundesministerium für Bildung und Forschung, BMBF), the French National Research Agency (Agence Nationale de la Recherche, ANR), the United States-Israel Binational Science Foundation (BSF), and Japan's National Institute of Information and Communications Technology (NICT) support collaborative activities that will advance the understanding of nervous system structure and function, mechanisms underlying nervous system disorders, and computational strategies used by the nervous system.

The International Research Experiences for Students (IRES) program supports international research and research-related activities for U.S. science and engineering students. The IRES program contributes to development of a diverse, globally-engaged workforce with world-class skills. IRES focuses onactive research participation by undergraduate or graduate students in high quality international research, education and professional development experiences in NSF-funded research areas. The overarching, long-term goal of the IRES program is to enhanceU.S. leadership in research and education and to strengthen economic competitiveness through training the next generation of research leaders. This solicitation features three mechanisms; proposers are required to select one of the following tracks to submit their proposal. Track I focuses on the development of world-class research skills in international cohort experiences.

NineSigma, representing a Global Consumer Coatings Company, invites proposals for materials and approaches that result in self-stratifying layers within a water-based liquid coating formulation. The client is interested in any approach that results in self-stratification of components, regardless of technical maturity. The proposed mechanism must ultimately be applicable to architectural coatings.

The purpose of this Request for Proposal (RFP) is to solicit proposals from firms experienced in the development and implementation of Robotics Process Automation (RPA) solutions. BWC is interested in evaluating solutions which would enable the agency to automate structured repetitive tasks to minimize manual intervention and introduce process efficiencies. Such processes will typically require the bots to access multiple systems, various formats of data like text, excel workbooks, word, databases and subsequently retrieve, populate and generate data fields based on responses. The proposed solution must have the capability to automate end to end processes and contain inherent logic handling mechanisms with exception handling.